scholarly journals Primary Esophageal Melanoma with Aberrant CD56 Expression: A Potential Diagnostic Pitfall

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Hani Katerji ◽  
John M. Childs ◽  
Laura E. Bratton ◽  
Christian G. Peyre ◽  
Aaron R. Huber
Keyword(s):  
Malignant Melanoma ◽  
Malignant Neoplasms ◽  
Aggressive Disease ◽  
Immunohistochemical Markers ◽  
Diagnostic Pitfall ◽  
Divergent Differentiation ◽  
Erroneous Diagnosis ◽  
Cd56 Expression ◽  
Poorly Differentiated ◽  
Esophageal Malignant Melanoma

Primary esophageal malignant melanoma (MM) is rare and extremely aggressive. For pathologists, it can be challenging to diagnose and differentiate from other poorly differentiated malignant neoplasms in the esophagus. Complicating this fact, MM can have divergent differentiation and express nonmelanocytic immunohistochemical markers including epithelial markers (cytokeratins) and rarely neuroendocrine markers. Lack of awareness of this fact by a pathologist can lead to an erroneous diagnosis and delay treatment for an already aggressive disease. Herein, we report a case of primary esophageal malignant melanoma with aberrant CD56 expression without accompanying synaptophysin or chromogranin expression.

scholarly journals Primary malignant melanoma of vagina: a case report

2020 ◽  
Vol 9 (8) ◽  
pp. 3499
Author(s):  
Smruti Shambharkar ◽  
Tarachand Sharma
Keyword(s):  
Malignant Melanoma ◽  
Firm Growth ◽  
Histopathological Examination ◽  
Lateral Wall ◽  
Primary Malignant Melanoma ◽  
Malignant Neoplasms ◽  
Vaginal Examination ◽  
Aggressive Disease ◽  
History Of ◽  
Worse Prognosis

Primary malignant melanoma of the vagina is a rare and aggressive disease with worse prognosis as compared with non-genital melanomas or other vaginal malignant neoplasms. Presented here is a case of 42 years female with 3 months history of amenorrhea and vaginal discharge. On vaginal examination, a firm growth of size approximately 7-8 cm was found attached to the left postero-lateral wall of vagina and extending up to the introitus. On biopsy and histopathological examination, it was diagnosed as a case of high-grade malignant melanoma of amelanotic type. Radiotherapy was started as a part of treatment after consultation with an oncologist, considering non-resectable nature of the mass. The patient received first 5 cycles of radiotherapy but succumbed to the disease during treatment.

scholarly journals Primary urethral small cell melanoma with neuroendocrine differentiation: a case report

2020 ◽  
Vol 32 (1) ◽  
Author(s):  
Tripti Nakra ◽  
Rohit Dadhwal ◽  
Rishi Nayyar ◽  
Sameer Rastogi ◽  
Aanchal Kakkar ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Tumor Cells ◽  
Neuroendocrine Differentiation ◽  
Small Cell ◽  
Ultrastructural Examination ◽  
Female Urethra ◽  
Case Presentation ◽  
Divergent Differentiation ◽  
Poorly Differentiated ◽  
Large Primary

Abstract Background Primary malignant melanoma of the female urethra is an exceedingly rare tumor. It represents 0.2% of all malignant melanomas. Divergent differentiation towards non-melanocytic lineages has not been reported in urethral melanoma. Case presentation We report a rare case of neuroendocrine differentiation in a large primary small cell malignant melanoma involving the urethra, in a 62-year-old lady, who presented with obstructive urinary symptoms. Clinical and radiological workup revealed a large urethral mass with liver and lymph nodal metastases. A biopsy was performed from the urethral and liver lesions which showed poorly differentiated tumor cells with small cell morphology and presence of melanin pigment. These cells were immunopositive for melanocytic and neuroendocrine markers. Ultrastructural examination showed presence of melanosomes and neurosecretory granules in the tumor cells. Conclusions Although malignant melanoma with neuroendocrine differentiation is exceptionally rare, it needs to be recognized among the other well-known variants of malignant melanoma.

scholarly journals Plasma cells in multiple myeloma express a natural killer cell- associated antigen: CD56 (NKH-1; Leu-19)

Blood ◽  
1990 ◽  
Vol 76 (2) ◽  
pp. 377-382 ◽  
Author(s):  
B Van Camp ◽  
BG Durie ◽  
C Spier ◽  
M De Waele ◽  
I Van Riet ◽  
...  
Keyword(s):  
Multiple Myeloma ◽  
Natural Killer Cell ◽  
Natural Killer ◽  
Plasma Cells ◽  
Killer Cell ◽  
Neoplastic Tissue ◽  
Aggressive Disease ◽  
Reactive Plasma ◽  
Gut Mucosa ◽  
Cd56 Expression

Abstract Bone marrow samples from 55 patients with multiple myeloma (MM) and 23 patients with monoclonal gammopathy of undertermined significance (MGUS) were evaluated with a broad panel of monoclonal antibodies. Plasma cells from 78% (43/55) of patients with MM strongly expressed the natural killer cell antigen CD56 (NKH-1, Leu-19). Of the 23 patients with MGUS, none showed strong CD56 reactivity, although three had weak reactivity in less than 20% of plasma cells. Myeloma cells expressing CD56 did not coexpress the CD57 or CD16 antigens. Patients with CD56-positive plasma cells had both indolent and aggressive disease. However, the 12 CD56-negative patients had predominantly aggressive disease with an unexpected preponderance of kappa Bence Jones only myeloma (5/10[50%] evaluable patients). Polyclonal plasma cells from non-neoplastic tissue sites (normal bone marrows, lymph nodes, tonsillar biopsies, and gut-mucosa biopsies) showed a near absence of CD56. We conclude that isolated, strong CD56 expression is common in MM, but not in MGUS or reactive plasma cells. The potential biologic importance of CD56 positivity in myeloma is reviewed.

scholarly journals Rare Cases in ENT

2018 ◽  
Vol 26 (2) ◽  
pp. 150-154
Author(s):  
Kalyan Pal ◽  
Dipanjan Chakraborty ◽  
Sohag Kundu ◽  
Subrata Mukhopadhyay
Keyword(s):  
Squamous Cell Carcinoma ◽  
Malignant Melanoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Paranasal Sinuses ◽  
Small Proportion ◽  
Neck Region ◽  
Malignant Neoplasms ◽  
Head And Neck Region ◽  
Nose And Paranasal Sinuses

In our day to day ENT practice we commonly come across diseases involving the larynx, the oral cavity and the paranasal sinuses. These range from inflammatory disorders to benign and malignant neoplasms. Carcinomas involving the head and neck region are most commonly squamous cell carcinoma. However, a small proportion of cases present with other variants of carcinoma or infective pathology uncommon for the site. In this study we present three rare cases encountered in the out-patient department, namely, Primary Malignant Melanoma of the larynx, Neuroendocrine Tumor of the nose and paranasal sinuses and Rhinosporidiosis of cheek.

Desmoplastic malignant melanoma of the oral mucosa: An underrecognized diagnostic pitfall

Cancer ◽  
1996 ◽  
Vol 78 (3) ◽  
pp. 383-389 ◽  
Author(s):  
Scott E. Kilpatrick ◽  
Wain L. White ◽  
J. Dale Browne
Keyword(s):  
Malignant Melanoma ◽  
Oral Mucosa ◽  
Diagnostic Pitfall

Epithelial-Type and Neural-Type Cadherin Expression in Malignant Noncarcinomatous Neoplasms With Epithelioid Features That Involve the Soft Tissues

2002 ◽  
Vol 126 (4) ◽  
pp. 425-431 ◽  
Author(s):  
William B. Laskin ◽  
Markku Miettinen
Keyword(s):  
Malignant Melanoma ◽  
Synovial Sarcoma ◽  
Soft Tissues ◽  
Clear Cell ◽  
Epithelioid Sarcoma ◽  
Clear Cell Sarcoma ◽  
Extraskeletal Myxoid Chondrosarcoma ◽  
Cell Sarcoma ◽  
Myxoid Chondrosarcoma ◽  
Poorly Differentiated

Abstract Context.—Transmembrane adhesion molecules, epithelial-type cadherin (ECAD) and neural-type cadherin (NCAD), help in regulating transformations between epithelial and mesenchymal cells in the developing embryo and in maintaining the epithelioid phenotype. Consequently, the presence of epithelioid cells in certain malignant noncarcinomatous neoplasms raises speculation that the expression of ECAD and NCAD in these neoplasms may have diagnostic significance. Objective.—To investigate the utility of ECAD and NCAD immunoexpression in distinguishing malignant (noncarcinomatous) neoplasms with epithelioid features that involve the soft tissues. Design.—Membranous immunoreactivity of anti-ECAD and anti-NCAD was evaluated on archived cases selected from the files of the Armed Forces Institute of Pathology. Results.—Epithelial-type cadherin was found in biphasic synovial sarcoma (35 of 35 cases), malignant melanoma (13/21), monophasic fibrous synovial sarcoma (13/26), clear cell sarcoma (4/9), poorly differentiated synovial sarcoma (3/13), diffuse mesothelioma (4/20), malignant epithelioid peripheral nerve sheath tumor (1/6), and epithelioid sarcoma (5/62). Neural-type cadherin was observed in chordoma (11/11), biphasic synovial sarcoma (30/35), diffuse mesothelioma (14/20), malignant melanoma (14/25), epithelioid sarcoma (24/63), epithelioid angiosarcoma (1/4), poorly differentiated synovial sarcoma (2/13), clear cell sarcoma (1/10), and monophasic fibrous synovial sarcoma (1/26). Eighteen cases of primary cutaneous squamous cell carcinomas all tested positive for ECAD, whereas NCAD was focally observed in 5 cases. No expression of either molecule was observed in cases of epithelioid hemangioendothelioma (n = 9), alveolar soft part sarcoma (n = 8), and extraskeletal myxoid chondrosarcoma (n = 7). Conclusions.—Epithelial-type and neural-type cadherins are found in a variety of noncarcinomatous neoplasms with epithelioid features that involve the soft tissues and can be utilized, in association with other immunomarkers, in distinguishing chordoma (100% NCAD) from extraskeletal myxoid chondrosarcoma and conventional chondrosarcoma of bone (0% NCAD), squamous cell carcinoma (100% ECAD) from epithelioid sarcoma (8% ECAD), and biphasic synovial sarcoma (100% ECAD) from diffuse mesothelioma (20% ECAD).

E-Cadherin Expression in Blastic Plasmacytoid Dendritic Cell Neoplasms: An Unrecognized Finding and Potential Diagnostic Pitfall

2020 ◽  
pp. 106689692093813
Author(s):  
Patrick Shenjere ◽  
Richard Chasty ◽  
Anshuman Chaturvedi ◽  
Michael W. Dennis ◽  
Angelia Ong ◽  
...  
Keyword(s):  
Dendritic Cell ◽  
Plasmacytoid Dendritic Cell ◽  
Primary Myelofibrosis ◽  
Diagnostic Pitfall ◽  
Strong Expression ◽  
Erythroid Precursors ◽  
Cell Neoplasm ◽  
Erroneous Diagnosis ◽  
History Of ◽  
E Cadherin

E-cadherin is expressed in hematopoietic erythroid precursors, but to our knowledge, its expression in blastic plasmacytoid dendritic cell neoplasm (BPDCN) has not been described. We report a case of BPDCN showing strong expression of E-cadherin, arising in a patient with history of primary myelofibrosis. Four more cases of BPDCN tested all showed strong expression of E-cadherin. Lack of awareness of this pattern of expression may lead to erroneous diagnosis of acute erythroid leukemia. It is increasingly becoming important to correctly identify this group of neoplasms, as approved new anti-CD123–targeted therapies are becoming available.

Synchronous primary mucosal melanoma and mucoepidermoid carcinoma of the maxillary antrum

1991 ◽  
Vol 105 (5) ◽  
pp. 370-372 ◽  
Author(s):  
J. P. Davis ◽  
K. A. Maclennan ◽  
J. B. Schofield ◽  
J. C. Watkinson ◽  
P. Gluckman
Keyword(s):  
Malignant Melanoma ◽  
Mucoepidermoid Carcinoma ◽  
Maxillary Antrum ◽  
Mucosal Melanoma ◽  
Primary Malignant Melanoma ◽  
Divergent Differentiation ◽  
Single Tumour

AbstractWe present a case of contiguous primary malignant melanoma of the nose and maxillary antrum and mucoepidermoid carcinoma of the maxillary antrum. We believe that this association has not been previously recorded; whether this represents divergent differentiation in a single tumour or ‘collision’ of two separate tumours is uncertain.

Amelanotic Malignant Melanoma of the Male Urethra: A Potential Diagnostic Pitfall

2020 ◽  
Vol 28 (5) ◽  
pp. 510-513
Author(s):  
Alessandro Caputo ◽  
Alfonso Califano ◽  
Marco Fabiano ◽  
Vincenzo Altieri ◽  
Pio Zeppa ◽  
...  
Keyword(s):  
Malignant Melanoma ◽  
Common Disease ◽  
High Grade ◽  
Male Urethra ◽  
Unusual Site ◽  
Diagnostic Pitfall ◽  
Melanoma In Situ ◽  
Amelanotic Malignant Melanoma ◽  
Histological Characteristics

A rare disease in an unusual site can closely mimic a typical presentation of a common disease, sometimes with devastating consequences. We present a case of primary amelanotic malignant melanoma of the urethra in a male, with clinical and histological characteristics that could have led to a mistaken diagnosis of high-grade urothelial carcinoma. Amelanotic mucosal melanoma should be suspected in all cases of high-grade mucosal tumors with practically any appearance (epithelioid, sarcomatoid, anaplastic, mixed). Morphological hints pointing toward melanoma—such as the presence of sparse melanin pigment or melanoma in situ—should be sought, and if absent, an immunohistochemical panel comprising S100 and HMB45 should be performed.

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