scholarly journals Altered Brain Functional Activity in Infants with Congenital Bilateral Severe Sensorineural Hearing Loss: A Resting-State Functional MRI Study under Sedation

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Shuang Xia ◽  
TianBin Song ◽  
Jing Che ◽  
Qiang Li ◽  
Chao Chai ◽  
...  

Early hearing deprivation could affect the development of auditory, language, and vision ability. Insufficient or no stimulation of the auditory cortex during the sensitive periods of plasticity could affect the function of hearing, language, and vision development. Twenty-three infants with congenital severe sensorineural hearing loss (CSSHL) and 17 age and sex matched normal hearing subjects were recruited. The amplitude of low frequency fluctuations (ALFF) and regional homogeneity (ReHo) of the auditory, language, and vision related brain areas were compared between deaf infants and normal subjects. Compared with normal hearing subjects, decreased ALFF and ReHo were observed in auditory and language-related cortex. Increased ALFF and ReHo were observed in vision related cortex, which suggest that hearing and language function were impaired and vision function was enhanced due to the loss of hearing. ALFF of left Brodmann area 45 (BA45) was negatively correlated with deaf duration in infants with CSSHL. ALFF of right BA39 was positively correlated with deaf duration in infants with CSSHL. In conclusion, ALFF and ReHo can reflect the abnormal brain function in language, auditory, and visual information processing in infants with CSSHL. This demonstrates that the development of auditory, language, and vision processing function has been affected by congenital severe sensorineural hearing loss before 4 years of age.

1975 ◽  
Vol 18 (2) ◽  
pp. 261-271 ◽  
Author(s):  
Ellen M. Danaher ◽  
J. M. Pickett

Discrimination of second-formant (F2) transitions in synthetic vowels was measured with and without the first formant (F1) present, with F1 and F2 presented monotically vs dichotically, and with the onset of F1 delayed relative to the onset of F2. Twenty-three subjects with sensorineural loss were tested. When F2 was presented alone, discrimination thresholds were the same as those of normal-hearing subjects. In most sensorineural subjects, discrimination was reduced whenever F1 was present in the stimulus. F1 produced three types of masking that reduced the ability to discriminate F2 transitions: upward spread of masking and backward masking occurred when F1 and F2 were presented to the same ear; a type of central masking occurred when F1 and F2 were presented to opposite ears.


1975 ◽  
Vol 18 (4) ◽  
pp. 773-794 ◽  
Author(s):  
Charlotte Reed

The speech encoding ability of eight persons with sensorineural hearing loss and three persons with normal hearing was studied in identification and discrimination paradigms. In the identification task a feature analysis of transmitted information for VC syllables was used to study encoding ability. Transmitted information was reduced from normal for persons with hearing loss, indicating a loss of ability to encode consonants. In the discrimination task, coding ability was studied by measuring reaction times (RTs) for “same” and “different” decisions. The RTs for individuals with impaired hearing were found to be significantly different from those subjects with normal hearing. The trend was for faster “same” than “different” RTs among the normal subjects and faster “different” than “same” RTs among the hearing-impaired persons. The results are interpreted as indicating that the two groups of subjects used different processing modes in discriminating between pairs of phonemes.


1981 ◽  
Vol 24 (4) ◽  
pp. 506-513 ◽  
Author(s):  
David Y. Chung

Quiet and masked thresholds were obtained from 5 subjects with normal hearing and 31 subjects with sensorineural hearing loss. Maskers were pure tones varying in frequency and intensity. The hearing-impaired subjects showed an abnormal spread of masking when masking was measured in terms of masked threshold. The abnormal spread of masking seems to be related to both the hearing threshold of the masker and the quiet threshold of the test signal. The notch due to detection of combination tones found on the high-frequency slope of masked audiograms of normal subjects (obscuring the actual extent to which the signal is masked) tends to accentuate the apparent abnormal upward spread of masking in the hearing-impaired subjects. The abnormal spread in the latter case is real, but comparison with the normal case must take the notch into account.


2015 ◽  
Vol 136 (2) ◽  
pp. 159-163 ◽  
Author(s):  
Ah Ra Jung ◽  
Myung Gu Kim ◽  
Sung Su Kim ◽  
Sang Hoon Kim ◽  
Seung Geun Yeo

Author(s):  
Jawahar Antony P ◽  
Animesh Barman

Background and Aim: Auditory stream segre­gation is a phenomenon that splits sounds into different streams. The temporal cues that contri­bute for stream segregation have been previ­ously studied in normal hearing people. In peo­ple with sensorineural hearing loss (SNHL), the cues for temporal envelope coding is not usually affected, while the temporal fine structure cues are affected. These two temporal cues depend on the amplitude modulation frequency. The present study aimed to evaluate the effect of sin­usoidal amplitude modulated (SAM) broadband noises on stream segregation in individuals with SNHL. Methods: Thirty normal hearing subjects and 30 subjects with mild to moderate bilateral SNHL participated in the study. Two experi­ments were performed; in the first experiment, the AB sequence of broadband SAM stimuli was presented, while in the second experiment, only B sequence was presented. A low (16 Hz) and a high (256 kHz) standard modulation fre­quency were used in these experiments. The subjects were asked to find the irregularities in the rhythmic sequence. Results: Both the study groups could identify the irregularities similarly in both the experi­ments. The minimum cumulative delay was sli­ghtly higher in the SNHL group. Conclusion: It is suggested that the temporal cues provided by the broadband SAM noises for low and high standard modulation frequencies were not used for stream segregation by either normal hearing subjects or those with SNHL. Keywords: Stream segregation; sinusoidal amplitude modulation; sensorineural hearing loss


2019 ◽  
Vol 162 (1) ◽  
pp. 129-136 ◽  
Author(s):  
Evette A. Ronner ◽  
Liliya Benchetrit ◽  
Patricia Levesque ◽  
Razan A. Basonbul ◽  
Michael S. Cohen

Objective To assess quality of life (QOL) in pediatric patients with sensorineural hearing loss (SNHL) with the Pediatric Quality of Life Inventory 4.0 (PedsQL 4.0) and the Hearing Environments and Reflection on Quality of Life 26 (HEAR-QL-26) and HEAR-QL-28 surveys. Study Design Prospective longitudinal study. Setting Tertiary care center. Subjects and Methods Surveys were administered to patients with SNHL (ages 2-18 years) from July 2016 to December 2018 at a multidisciplinary hearing loss clinic. Patients aged >7 years completed the HEAR-QL-26, HEAR-QL-28, and PedsQL 4.0 self-report tool, while parents completed the PedsQL 4.0 parent proxy report for children aged ≤7 years. Previously published data from children with normal hearing were used for controls. The independent t test was used for analysis. Results In our cohort of 100 patients, the mean age was 7.7 years (SD, 4.5): 62 participants had bilateral SNHL; 63 had mild to moderate SNHL; and 37 had severe to profound SNHL. Sixty-eight patients used a hearing device. Mean (SD) total survey scores for the PedsQL 4.0 (ages 2-7 and 8-18 years), HEAR-QL-26 (ages 7-12 years), and HEAR-QL-28 (ages 13-18 years) were 83.9 (14.0), 79.2 (11.1), 81.2 (9.8), and 77.5 (11.3), respectively. Mean QOL scores for patients with SNHL were significantly lower than those for controls on the basis of previously published normative data ( P < .0001). There was no significant difference in QOL between children with unilateral and bilateral SNHL or between children with SNHL who did and did not require a hearing device. Low statistical power due to small subgroup sizes limited our analysis. Conclusion It is feasible to collect QOL data from children with SNHL in a hearing loss clinic. Children with SNHL had significantly lower scores on validated QOL instruments when compared with peers with normal hearing.


2018 ◽  
Vol 39 (10) ◽  
pp. e950-e955
Author(s):  
Chi Kyou Lee ◽  
Jong Bin Lee ◽  
Kye Hoon Park ◽  
Ho Yun Lee ◽  
Mi-Jin Choi ◽  
...  

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