scholarly journals Corrigendum to “Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation”

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Xiaoliang Gan ◽  
Dandan Xing ◽  
Guangjie Su ◽  
Shun Li ◽  
Chenfang Luo ◽  
...  
Keyword(s):  
Mast Cell ◽  
Nadph Oxidase ◽  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Cell Activation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Mast Cell Activation ◽  
Small Intestinal ◽  
Intestinal Ischemia Reperfusion

scholarly journals Propofol Attenuates Small Intestinal Ischemia Reperfusion Injury through Inhibiting NADPH Oxidase Mediated Mast Cell Activation

2015 ◽  
Vol 2015 ◽  
pp. 1-15 ◽  
Author(s):  
Xiaoliang Gan ◽  
Dandan Xing ◽  
Guangjie Su ◽  
Shun Li ◽  
Chenfang Luo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Mast Cell ◽  
Nadph Oxidase ◽  
Intestinal Ischemia ◽  
Cell Activation ◽  
Ischemia Reperfusion ◽  
Mast Cell Activation ◽  
Lipid Peroxidation Product ◽  
Small Intestinal ◽  
Intestinal Ischemia Reperfusion

Both oxidative stress and mast cell (MC) degranulation participate in the process of small intestinal ischemia reperfusion (IIR) injury, and oxidative stress induces MC degranulation. Propofol, an anesthetic with antioxidant property, can attenuate IIR injury. We postulated that propofol can protect against IIR injury by inhibiting oxidative stress subsequent from NADPH oxidase mediated MC activation. Cultured RBL-2H3 cells were pretreated with antioxidant N-acetylcysteine (NAC) or propofol and subjected to hydrogen peroxide (H2O2) stimulation without or with MC degranulator compound 48/80 (CP). H2O2significantly increased cells degranulation, which was abolished by NAC or propofol. MC degranulation by CP further aggravated H2O2induced cell degranulation of small intestinal epithelial cell, IEC-6 cells, stimulated by tryptase. Rats subjected to IIR showed significant increases in cellular injury and elevations of NADPH oxidase subunits p47phoxand gp91phoxprotein expression, increases of the specific lipid peroxidation product 15-F2t-Isoprostane and interleukin-6, and reductions in superoxide dismutase activity with concomitant enhancements in tryptase andβ-hexosaminidase. MC degranulation by CP further aggravated IIR injury. And all these changes were attenuated by NAC or propofol pretreatment, which also abrogated CP-mediated exacerbation of IIR injury. It is concluded that pretreatment of propofol confers protection against IIR injury by suppressing NADPH oxidase mediated MC activation.

Measuring platelet aggregation to estimate small intestinal ischemia-reperfusion injury

2004 ◽  
Vol 122 (2) ◽  
pp. 195-200 ◽  
Author(s):  
Kazuhisa Arakawa ◽  
Izumi Takeyoshi ◽  
Masato Muraoka ◽  
Koshi Matsumoto ◽  
Yasuo Morishita
Keyword(s):  
Platelet Aggregation ◽  
Reperfusion Injury ◽  
Intestinal Ischemia ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Small Intestinal ◽  
Intestinal Ischemia Reperfusion
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