scholarly journals Effects of Liver Fibrosis Progression on Tissue Relaxation Times in Different Mouse Models Assessed by Ultrahigh Field Magnetic Resonance Imaging

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Andreas Müller ◽  
Katrin Hochrath ◽  
Jonas Stroeder ◽  
Kanishka Hittatiya ◽  
Günther Schneider ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Liver Fibrosis ◽  
Disease Severity ◽  
Spin Echo ◽  
Relaxation Times ◽  
Fast Spin Echo ◽  
Spin Echo Sequence ◽  
Fast Spin Echo Sequence ◽  
Tissue Relaxation

Recently, clinical studies demonstrated that magnetic resonance relaxometry with determination of relaxation times T1 andT2⁎may aid in staging and management of liver fibrosis in patients suffering from viral hepatitis and steatohepatitis. In the present study we investigated T1 andT2⁎in different models of liver fibrosis to compare alternate pathophysiologies in their effects on relaxation times and to further develop noninvasive quantification methods of liver fibrosis. MRI was performed with a fast spin echo sequence for measurement of T1 and a multigradient echo sequence for determination ofT2⁎. Toxic liver fibrosis was induced by injections of carbon tetrachloride (1.4 mL CCl4per kg bodyweight and week, for 3 or 6 weeks) in BALB/cJ mice. Chronic sclerosing cholangitis was mimicked using the ATP-binding cassette transporter B4 knockout(Abcb4 -/-)mouse model. Untreated BALB/cJ mice served as controls. To assess hepatic fibrosis, we ascertained collagen contents and fibrosis scores after Sirius red staining. T1 andT2⁎correlate differently to disease severity and etiology of liver fibrosis.T2⁎shows significant decrease correlating with fibrosis in CCl4treated animals, while demonstrating significant increase with disease severity inAbcb4 -/-mice. Measurements of T1 andT2⁎may therefore facilitate discrimination between different stages and causes of liver fibrosis.

scholarly journals Combining non-contrast enhanced magnetic resonance thoracic ductography with vascular contrast-enhanced computed tomography to identify the canine thoracic duct

2020 ◽  
Vol 10 (1) ◽  
pp. 68-73
Author(s):  
Kenji Kutara ◽  
Teppei Kanda ◽  
Noritaka Maeta ◽  
Yohei Mochizuki ◽  
Fumiko Ono ◽  
...  
Keyword(s):  
Computed Tomography ◽  
Magnetic Resonance ◽  
Thoracic Duct ◽  
Spin Echo ◽  
Fast Spin Echo ◽  
Single Shot ◽  
Anatomical Structures ◽  
Contrast Enhanced ◽  
Spin Echo Sequence ◽  
Fast Spin Echo Sequence

Background: In humans, visualization of the thoracic duct by magnetic resonance imaging (MRI) has been attempted, and recent advances have enabled clinicians to visualize the thoracic duct configuration in a less invasive manner. Moreover, MRI does not require contrast media, and it enables visualization of morphological details of the thoracic structures. In veterinary practice, the thoracic duct has not been visualized three dimensionally in MRI.Aim: This study aimed to assess the performance of our magnetic resonance thoracic ductography (MRTD) technique to visualize the thoracic duct and the surrounding 3D anatomical structures by combining MRTD and vascular contrastenhanced thoracic computed tomography (CT) images in dogs.Methods: Five adult male beagle dogs (11.4–12.8 kg) were included in this study. Sagittal and transverse T2-weighted images were scanned in MRI. Scanning in MRTD used a single-shot fast spin echo sequence with a respiratory gate. CT was performed after the intravenous injection of contrast medium. All MRTD and CT images were merged using a workstation.Results: The thoracic ducts were identified in MRTD images of all dogs, and the surrounding anatomical structures were located with the aid of contrast-enhanced thoracic CT. In all dogs, the thoracic ducts coursed along the rightdorsal side of the aorta, cranially from the L2 level. Thereafter, these bent to the left side at the aortic arch and curved at the left external jugular vein angle. A comparison of the number of thoracic ducts at each vertebra between transverse T2WI and MRTD did not reveal any significant differences for all vertebrae.Conclusion: The results from our study suggest that MRTD using the single-shot fast spin echo sequence could be a useful tool for visualization of the thoracic duct. Furthermore, the image merged from MRTD and vascular-enhanced images provided detailed anatomical annotation of the thorax. The MRTD protocol described in this study is safe and easily adaptable, without the need for contrast medium injection into the lymph system. In addition, the images fused from MRTD and vascular contrast-enhanced CT image of the thorax could provide detailed anatomical annotations for preoperative planning. Keywords: Computed tomography, Dog, Magnetic resonance imaging, Thoracic duct, Thoracic ductography.

Unenhanced MR Portography With a Half-Fourier Fast Spin-Echo Sequence and Time-Space Labeling Inversion Pulses: Preliminary Results

2009 ◽  
Vol 193 (1) ◽  
pp. 106-112 ◽  
Author(s):  
Kotaro Shimada ◽  
Hiroyoshi Isoda ◽  
Tomohisa Okada ◽  
Toshikazu Kamae ◽  
Shigeki Arizono ◽  
...  
Keyword(s):  
Spin Echo ◽  
Fast Spin Echo ◽  
Preliminary Results ◽  
Time Space ◽  
Spin Echo Sequence ◽  
Fast Spin Echo Sequence ◽  
Fast Spin ◽  
Inversion Pulses
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