scholarly journals Adenoid Cystic Carcinoma of the Uterine Cervix: A Report of 2 Cases

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Meryem Rais ◽  
Jinane Kharmoum ◽  
Soumaya Ech-Charif ◽  
Basma El Khannoussi
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Uterine Cervix ◽  
Clinical Course ◽  
Invasive Squamous Cell Carcinoma ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Pathological Characteristics ◽  
Adenoid Cystic ◽  
Intraepithelial Lesion ◽  
Aggressive Clinical Course

Adenoid cystic carcinoma is malignant tumor that exceptionally occurs in the uterine cervix. It is mostly seen in postmenopausal women and has an aggressive clinical course. We report two cases of an adenoid cystic carcinoma associated with a high grade squamous intraepithelial lesion and invasive squamous cell carcinoma of the uterine cervix and discuss briefly its clinical and pathological characteristics.

scholarly journals Adenoid Basal Carcinoma of Cervix: A Rare Case Report

2020 ◽  
Vol 3 (2) ◽  
pp. 392-394
Author(s):  
Alina Karna ◽  
Nisha Sharma
Keyword(s):  
Pap Smear ◽  
Total Abdominal Hysterectomy ◽  
Abdominal Hysterectomy ◽  
Low Grade ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Adenoid Cystic ◽  
Carcinoma Of Cervix ◽  
Rare Case Report ◽  
Intraepithelial Lesion

Adenoid basal carcinoma of the uterine cervix is a rare low-grade tumor and its cell origin is still obscure. Adenoid basal carcinoma can be confused with adenoid basal hyperplasia, adenoid cystic carcinoma, and basaloid squamous cell carcinoma of the cervix. We present here a case of a 59 year-old-female who initially presented with a high-grade squamous intraepithelial lesion on Pap smear. Total abdominal hysterectomy with bilateral salpingo-oophorectomy was performed. Histopathology revealed focal invasive adenoid basal carcinoma with extensive areas of a high-grade squamous intraepithelial lesion involving the endocervical gland. The immunohistochemical stain was positive for p16.

Case Report: Coexistence of Adenoid Cystic Carcinoma and Adenoid Basal Carcinoma in the Uterine Cervix

2020 ◽  
Vol 154 (Supplement_1) ◽  
pp. S44-S45
Author(s):  
T T Tran ◽  
R Bhuyan ◽  
S Peng
Keyword(s):  
Adenoid Cystic Carcinoma ◽  
Tumor Cells ◽  
Uterine Cervix ◽  
Poor Prognosis ◽  
Histopathological Examination ◽  
Punch Biopsy ◽  
Good Prognosis ◽  
Positive Staining ◽  
Invasive Squamous Cell Carcinoma ◽  
Adenoid Cystic

Abstract Introduction/Objective Adenoid cystic carcinoma (ACC) and adenoid basal carcinoma (ABC) are very rare tumors, accounting for less than 1% of all cervical adenocarcinomas. ACC is an aggressive neoplasm and has poor prognosis while ABC has a favorable prognosis. Coexistence of ACC or ABC and squamous intraepithelial lesion/invasive squamous cell carcinoma in the uterine cervix has been reported in the literature; however, coexistence of ACC and ABC in the uterine cervix is very rare. Methods Case presentation: Here we present a case of coexistence ACC and ABC in a 66-year-old woman who suffered from heavy bloody vaginal discharge for one year with weight fluctuations. The cervical exam and CT scan showed a friable mass at the uterine cervix, measuring up to 5.5 cm, and cervical mass punch biopsy was performed. Histopathological examination of the specimen revealed an intact nonkeratinizing stratified squamous epithelium overlying proliferation of nests punctuated by small round spaces, resembling cribriform pattern in the stroma. The tumor cells were small and basaloid with hyperchromatic nuclei and scant cytoplasm. Palisading of tumor cells at the peripheral of the tumor nests were observed in some areas. Mitotic figures and necrosis were not seen. Immunohistochemical stains were performed and showed two distinct patterns of ACC and ABC. ACC tumor cells were positive for CD117, focally positive for CAM5.2 and S100, and negative for p63. ABC tumor cells were positive for p63 and EMA and negative for CD117 and S100. Both ACC and ABC components were positive for p16, Sox 10, BCL-2 and vimentin and negative for CK7, p40, CEA and ER. PAS stain showed positive staining in the basement membrane-like material in ACC component. A final pathologic diagnosis of coexistence of ACC and ABC of the uterine cervix were made. Conclusion Literature review revealed that this was an exceedingly rare case of coexistence of ACC and ABC in the uterine cervix. It is extremely important to correctly diagnose ACC and ABC as there is very poor prognosis in the former and good prognosis in the latter.

Adenoid basal carcinoma with adenoid cystic-like features—a rare diagnostic dilemma

2021 ◽  
Vol 156 (Supplement_1) ◽  
pp. S77-S77
Author(s):  
N Salahi ◽  
A Jabbar ◽  
D Lavitan
Keyword(s):  
Metastatic Potential ◽  
Squamous Intraepithelial Lesion ◽  
Diagnostic Dilemma ◽  
Ki 67 ◽  
Adenoid Cystic ◽  
Special Stain ◽  
Intraepithelial Lesion ◽  
Aggressive Clinical Course ◽  
Shed Light

Abstract Introduction/Objective Adenoid basal carcinoma (ABC) of the cervix is a rare, indolent tumor with no known metastatic potential. The tumor is composed of small nests of bland, basaloid cells, which do not elicit a desmoplastic response within the surrounding stroma. Cystic and clear cell change, as well as glandular differentiation, are not unusual. As such, it is important to differentiate ABC from adenoid cystic carcinoma (ACC), particularly on account of the aggressive clinical course of the latter. We herein present a rare case of ABC with adenoid cystic-like features. Methods/Case Report A 74-year-old woman with an incidental ABC, diagnosed on an excisional procedure performed for a prior diagnosis of a high grade squamous intraepithelial lesion. Subsequent hysterectomy revealed a tumor composed of nests of basaloid cells, extending into the outer third of the cervical wall, but exhibiting no peri- tumoral desmoplasia. Cribriforming associated with increased mitotic activity was focally present and showed increased Ki-67 labeling compared to the solid nests of tumor. PAS special stain highlighted rare pseudolumina with basement membrane-like material. While these features were concerning for an ACC—the lack of any significant cytologic atypia, destructive stromal invasion, and a clinically apparent lesion—was consistent with an ABC with so- called adenoid cystic-like features. Results (if a Case Study enter NA) NA Conclusion Making an accurate diagnosis requires clinicopathologic correlation and awareness of histologic overlap. Additionally, adenoid cystic-like morphology in ABCs is a little-studied phenomenon, which necessitates further research to shed light on potential clinical implications.

scholarly journals Hemangioma of uterine cervix associated with high-grade squamous intraepithelial lesion

2015 ◽  
Vol 72 (6) ◽  
pp. 541-544
Author(s):  
Matilda Djolai ◽  
Tamara Boskovic ◽  
Srdjan Djurdjevic ◽  
Sandra Trivunic-Dajko ◽  
Bojana Andrejic-Visnjic ◽  
...  
Keyword(s):  
Microscopic Analysis ◽  
High Grade ◽  
Squamous Intraepithelial Lesion ◽  
Pathological Characteristics ◽  
Surrounding Connective Tissue ◽  
Everyday Work ◽  
Cavernous Hemangiomas ◽  
Intraepithelial Lesion ◽  
Postmenopausal Female ◽  
Epithelial Lesion

Introduction. Benign, especially polypoid, lesions of the cervix are common in everyday work. Rare tumors of this region are vascular ones, particularly capillary and/or cavernous hemangiomas. Cervical hemangiomas are especially rare, usually asymptomatic and only one third of the cases is clinically manifested as vaginal bleeding, polyps, etc. Case report. We reported a 54-year-old postmenopausal female patient who had undergone conization due to high-grade squamous intra-epithelial lesion (H-SIL). Microscopic analysis of slices confirmed the existence of dysplastic changes in the endocervical epithelium and in small part in the epithelium of the gland of H-SIL type. In 2 of 15 slices, within the walls of the cervix, dilated, amplified and abnormal blood vessels lined with endothelium were observed, vaguely limited by the surrounding connective tissue of lamina propria and smooth muscle wall of the cervix. According to the pathological characteristics, the change corresponded to the hemangioma. Both changes were completely removed. Conclusion. In comparison with the available literature data, the presented case is the first to describe the association of hemangioma and dysplastic changes in the endocervical epithelium. Hemangioma was incidentally discovered in the histological sections of the material after the conization in a postmenopausal women.

scholarly journals Clinicopathological Characteristics of Pleomorphic High-Grade Squamous Intraepithelial Lesion of the Uterine Cervix: A Single-Institutional Series of 31 Cases

Diagnostics ◽  
2020 ◽  
Vol 10 (8) ◽  
pp. 595
Author(s):  
Hyunjin Kim ◽  
Sangjoon Choi ◽  
Sung-Im Do ◽  
Sang Hwa Lee ◽  
Nara Yoon ◽  
...  
Keyword(s):  
Uterine Cervix ◽  
Clinicopathological Characteristics ◽  
Surface Epithelium ◽  
Invasive Squamous Cell Carcinoma ◽  
High Grade ◽  
Ki 67 ◽  
Nuclear Atypia ◽  
Intraepithelial Lesion ◽  
Intraepithelial Lesions ◽  
Nuclear Enlargement

We investigated the clinicopathological characteristics of 31 cases of pleomorphic high-grade squamous intraepithelial lesions (PHSIL) of the uterine cervix. We reviewed electronic medical records and all available slides to collect clinical and pathological information. PHSILs were histologically characterized by significant nuclear enlargement, marked pleomorphism, hyperchromasia, increased mitotic activity, and frequent atypical mitoses. In the majority of cases (24/31; 77.4%), this striking nuclear atypia involved both the surface epithelium and the endocervical glands. In the remaining seven cases, pleomorphic cells were observed in the surface epithelium only. PHSILs involving both the surface epithelium and glands showed higher mitotic counts and Ki-67 labelling indices than the surface-only PHSILs. Invasive squamous cell carcinoma was present in only one case (3.2%), and none developed recurrent disease. Our observations of striking nuclear atypia in cases of HSIL did not indicate increased aggressiveness. Further investigations are required for confirmation of our data in larger cohorts.

Adenoid Cystic Carcinoma of Lacrimal Gland

JMS SKIMS ◽  
2012 ◽  
Vol 15 (1) ◽  
pp. 76-77
Author(s):  
Mohd Athar ◽  
K S Sodhi ◽  
S Kala ◽  
R K Maurya ◽  
S Chauhan ◽  
...  
Keyword(s):  
Local Recurrence ◽  
Natural History ◽  
Adenoid Cystic Carcinoma ◽  
Salivary Glands ◽  
Hard Palate ◽  
Clinical Course ◽  
Fatal Outcome ◽  
Minor Salivary Glands ◽  
Adenoid Cystic ◽  
History Of

Adenoid cystic carcinoma is a relatively uncommon tumour of salivary, glands and is characterised by a prolonged clinical course and a fatal outcome. It was first described as `cylindroma' by Billroth in 1859. Half of these tumors occur in glandular tissues other than the major salivary glands; principally in the hard palate, but they can also arise in the tongue and minor salivary glands. Unusual locations include the external auditory canal, nasopharynx, lacrimal glands, breast, vulva, esophagus, cervix and Cowper glands. The long natural history of this tumor and its tendency for local recurrence are well known. JMS 2012;15(1):76-77.

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