scholarly journals Thermal Synthesis of Polypeptides from N-Butyloxycarbonyl Oligopeptides Containing Aspartyl Residue at C-Terminus

2017 ◽  
Vol 2017 ◽  
pp. 1-16
Author(s):  
Toratane Munegumi ◽  
Takafumi Yamada
Keyword(s):  
Aspartic Acid ◽  
Organic Synthesis ◽  
Prebiotic Chemistry ◽  
Average Molecular Weight ◽  
Carboxyl Terminus ◽  
Peptide Bonds ◽  
Thermal Synthesis ◽  
Thermal Reactions ◽  
C Terminus ◽  
Aspartyl Residue

The thermal reactions of amino acids have been investigated for pure organic synthesis, materials preparation in industry, and prebiotic chemistry. N-t-Butyloxycarbonyl aspartic acid (Boc-Asp) releases 2-butene and carbon dioxide upon heating without solvents. The resulting mixture of the free molten aspartic acid was dehydrated to give peptide bonds. This study describes the thermal reactions of N-t-butyloxycarbonyl peptides (Boc-Gly-L-Asp, Boc-L-Ala-L-Asp, Boc-L-Val-L-Asp, and Boc-Gly-Gly-L-Asp) having an aspartic residue at the carboxyl terminus. The peptides were deprotected upon heating at a constant temperature between 110 and 170°C for 1 to 24 h to afford polypeptides in which the average molecular weight reached 7800.

ChemInform Abstract: High-Temperature Organic Synthesis. Part 38. Thermal Synthesis of 1,2- Dithiole-3-thiones from Polysulfides.

ChemInform ◽  
2010 ◽  
Vol 24 (9) ◽  
pp. no-no
Author(s):  
L. P. TURCHANINOVA ◽  
E. N. SUKHOMAZOVA ◽  
N. A. KORCHEVIN ◽  
E. N. DERYAGINA ◽  
M. G. VORONKOV
Keyword(s):  
High Temperature ◽  
Organic Synthesis ◽  
Thermal Synthesis

Nmr study of poly(aspartic acid). II. α- and β-Peptide bonds in poly(aspartic acid) prepared by common methods

Biopolymers ◽  
1981 ◽  
Vol 20 (8) ◽  
pp. 1615-1623 ◽  
Author(s):  
V. Saudek ◽  
H. Pivcová ◽  
J. Drobník
Keyword(s):  
Aspartic Acid ◽  
Peptide Bonds ◽  
Nmr Study

scholarly journals PTHrP Nuclear Localization and Carboxyl Terminus Sequences Modulate Dental and Mandibular Development in Part via the Action of p27

Endocrinology ◽  
2016 ◽  
Vol 2016 (1) ◽  
pp. 72-84 ◽  
Author(s):  
Wen Sun ◽  
Jun Wu ◽  
Linying Huang ◽  
Hong Liu ◽  
Rong Wang ◽  
...  
Keyword(s):  
Nuclear Localization ◽  
Alveolar Bone ◽  
Bone Volume ◽  
Carboxyl Terminus ◽  
Nuclear Localization Sequence ◽  
Wild Type ◽  
Mineral Density ◽  
C Terminus ◽  
Localization Sequence ◽  
Dentin Sialoprotein

Abstract To determine whether the action of the PTHrP nuclear localization sequence and C terminus is mediated through p27 in modulating dental and mandibular development, compound mutant mice, which are homozygous for both p27 deletion and the PTHrP1–84 knock-in mutation (p27−/−PthrpKI/KI), were generated. Their teeth and mandibular phenotypes were compared with those of p27−/−, PthrpKUK\ and wild-type mice. At 2 weeks of age, the mandibular mineral density, alveolar bone volume, osteoblast numbers, and dental volume, dentin sialoprotein-immunopo-sitive areas in the first molar were increased significantly in p27−/− mice and decreased dramatically in both PthrpKI/KI and p27−/− PthrpKI/KI mice compared with wild-type mice; however, these parameters were partly rescued in p27−/− PthrpKI/KI mice compared with PthrpKI/KI mice. These data demonstrate that the deletion of p27 in PthrpKI/KI mice can partially rescue defects in dental and mandibular development. Furthermore, we found that deletion of p27 in PthrpKI/KI mice partially corrected the dental and mandibular phenotype by modulating cell cyclin-regulating molecules and antioxidant enzymes. This study therefore indicates that the p27 pathway may function downstream in the action of PTHrP nuclear localization sequence to regulate dental and mandibular development. (Endocrinology 157: 1372–1384, 2016)

scholarly journals Gamma Irradiation of Aqueos Solution of L-Aspartic Acid, L-Aspartic Acid in Solid State, and L-Aspartic Acid Adsorbed into Na-Montmorillonite: Its Relevance in Chemistry Prebiotic

2021 ◽  
Vol 8 (2) ◽  
pp. 105-108
Author(s):  
A. Meléndez-López ◽  
M. F. García-Hurtado ◽  
J. Cruz-Castañeda ◽  
A. Negrón-Mendoza ◽  
S. Ramos-Bernal ◽  
...  
Keyword(s):  
Organic Matter ◽  
Amino Acid ◽  
Solid State ◽  
Aspartic Acid ◽  
Prebiotic Chemistry ◽  
High Energy ◽  
Energy Conditions ◽  
Gamma Radiolysis ◽  
The Stability

Aspartic acid is an amino acid present in the modern proteins, however, is considered a primitive amino acid hence its importance in prebiotic chemistry experiments studies. In some works of prebiotic chemistry have been studied the synthesis and the stability of organic matter under high energy sources, and the role of clays has been highlighted due to clays that can affect the reaction mechanisms in the radiolytic processes. The present work is focused on the study of the role of Namontmorillonite in the gamma radiolysis processes of L-aspartic acid. Gamma radiolysis processes were carried out in three different systems a) L-aspartic acid in aqueous solution; b) L-aspartic acid in solid-state; and c) L-aspartic acid adsorbed into Na-montmorillonite. L-aspartic acid was analyzed by high-performance liquid chromatography−electrospray ionization−mass spectrometry (HPLCESI-MS). The results showed that the decomposition of L-aspartic acid considerably decreased in the presence of clay thus highlighting the protector role of clays and favors the stability of organic matter even under the possible high energy conditions of primitive environments. The principal product ofgamma radiolysis of L-aspartic acid was succinic acid produced by deamination reaction. On the other hand, when aspartic acid was irradiated in solid-state the main product was the L-aspartic acid dimer. Both radiolysis products are important for chemical evolution processes for L-aspartic acid in primitive environments.

Nmr study of poly(aspartic acid). I. α- and β-Peptide bonds in poly(aspartic acid) prepared by thermal polycondensation

Biopolymers ◽  
1981 ◽  
Vol 20 (8) ◽  
pp. 1605-1614 ◽  
Author(s):  
H. Pivcová ◽  
V. Saudek ◽  
J. Drobník ◽  
J. Vlasák
Keyword(s):  
Aspartic Acid ◽  
Peptide Bonds ◽  
Nmr Study ◽  
Thermal Polycondensation
Sign in / Sign up

Export Citation Format

Share Document