scholarly journals Chronic Kidney Dysfunction Can Increase the Risk of Deep Vein Thrombosis after Total Hip and Knee Arthroplasty

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Qiangqiang Li ◽  
Bingyang Dai ◽  
Yao Yao ◽  
Kai Song ◽  
Dongyang Chen ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Kidney Function ◽  
Female Gender ◽  
Normal Kidney ◽  
Prothrombotic State ◽  
Kidney Dysfunction ◽  
Vein Thrombosis ◽  
Hip And Knee Arthroplasty ◽  
Postoperative Prophylaxis ◽  
Deep Vein

Background. Deep vein thrombosis (DVT) is one of the major complications of total joint arthroplasty (TJA). Chronic kidney dysfunction (CKD) has proven to promote a proinflammatory and prothrombotic state and is prevalent among patients undergoing TJA. The purpose of this study is to identify whether CKD increase the risk of DVT following TJA. Methods. In a retrospective study, 1274 patients who underwent primary TJA were studied. CKD is graded in 5 stages. Univariate and multivariate analysis were used to identify the association of CKD and its severity with postoperative DVT. Results. There were 1139 (89.4%) participants with normal kidney function, 103 (8.1%) with mildly decreased kidney function, and 32 (2.5%) with stage 3 and 4 CKD. A total of 244 patients (19.2%) were diagnosed with DVT. Sixty-four patients (5.0%) developed symptomatic DVT. Advanced age, female gender, malignancy, and eGFR showed significant association with total DVT. BMI, thrombosis history, malignancy, and eGFR were associated with symptomatic DVT. After adjusting for age, gender, BMI, and malignancy, eGFR was found to be related to both total and symptomatic DVT. Conclusions. CKD is an important risk factor for both total and symptomatic DVT following TJA. Postoperative prophylaxis should be made a priority in this population.

Physician compliance with guidelines for deep-vein thrombosis prevention in total hip and knee arthroplasty

2008 ◽  
Vol 24 (1) ◽  
pp. 87-97 ◽  
Author(s):  
Richard J. Friedman ◽  
Alexander S. Gallus ◽  
Fred D. Cushner ◽  
Gordon Fitzgerald ◽  
Frederick A. Anderson ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Knee Arthroplasty ◽  
Total Hip ◽  
Vein Thrombosis ◽  
Physician Compliance ◽  
Hip And Knee Arthroplasty ◽  
Deep Vein

scholarly journals Symptomatic In-Hospital Deep Vein Thrombosis and Pulmonary Embolism Following Hip and Knee Arthroplasty Among Patients Receiving Recommended Prophylaxis

JAMA ◽  
2012 ◽  
Vol 307 (3) ◽  
Author(s):  
Jean-Marie Januel ◽  
Guanmin Chen ◽  
Christiane Ruffieux ◽  
Hude Quan ◽  
James D. Douketis ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Knee Arthroplasty ◽  
Vein Thrombosis ◽  
Hip And Knee Arthroplasty ◽  
Deep Vein

scholarly journals The role of newer anticoagulants in prevention of deep vein thrombosis following joint replacements

2016 ◽  
Vol 3 (1) ◽  
pp. 4
Author(s):  
Anandha Prabu ◽  
Jambu N. ◽  
Ganesh Babu
Keyword(s):  
Deep Vein Thrombosis ◽  
Knee Arthroplasty ◽  
Factor Xa ◽  
Lower Limbs ◽  
Venous Stasis ◽  
Joint Replacements ◽  
Vein Thrombosis ◽  
Hip And Knee Arthroplasty ◽  
Newer Anticoagulants ◽  
Deep Vein

<p class="abstract"><strong>Background:</strong> Deep vein thrombosis following orthopedic surgeries particularly hip and knee arthroplasty is due to the accompanying blood vessel trauma, venous stasis, coagulation activation and older age in most of the patients. This study aims to study the efficacy of newer anticoagulants such as direct thrombin and direct factor Xa inhibitors in prevention of deep vein thrombosis (DVT) following arthroplasties<span lang="EN-IN">.</span></p><p class="abstract"><strong>Methods:</strong> Tablet Apixaban 2.5 mg twice daily was administered for 15 days following total knee replacement (TKR) and 30 days following total hip replacement (THR) or hemiarthroplasties.  Patients were examined clinically and radiologically with colour doppler of both lower limbs from 5th-13th and 30th-42th day postoperatively during follow up.<strong></strong></p><p class="abstract"><strong>Results:</strong> Only 3 out of 53 patients who underwent hip/knee arthroplasty developed DVT (p &lt;0.05) which were found to be significant<span lang="EN-IN">. </span></p><p class="abstract"><strong>Conclusions:</strong> The prevention of DVT in hip and knee arthoplasty using newer anticoagulant Apixaban was more efficacious, well tolerated with low rate of bleeding<span lang="EN-IN">.</span></p>

Residual venous obstruction in patients with a single episode of deep vein thrombosis and in patients with recurrent deep vein thrombosis

2005 ◽  
Vol 94 (07) ◽  
pp. 93-95 ◽  
Author(s):  
Matteo Galli ◽  
Alessandro Squizzato ◽  
Francesco Dentali ◽  
Elisa Manfredi ◽  
Luigi Steidl ◽  
...  
Keyword(s):  
Deep Vein Thrombosis ◽  
Lower Limbs ◽  
First Episode ◽  
Prothrombotic State ◽  
Venous Obstruction ◽  
Single Episode ◽  
Index Event ◽  
Vein Thrombosis ◽  
Potential Marker ◽  
Deep Vein

SummaryResidual venous obstruction (RVO) in patients with previous deep vein thrombosis (DVT) of the lower limbs has been suggested as an independent risk factor for recurrent venous thromboembolism (VTE).RVO could be a marker of a persistent prothrombotic state. We have compared the rate of RVO in patients with DVT and a personal history of at least one previous episode of VTE to the rate of RVO among patients with a first episode of DVT. All patients underwent compression ultrasonography (CUS) of the lower limbs 1 year after index DVT. RVO was arbitrarily defined as a thrombus occupying, at maximal compressibility, more than 20% of the vein area in the absence of compression. 50 consecutive patients with recurrent DVT and 50 age and sex-matched patients with a single episode of DVT were enrolled. The index event was idiopathic in 62% of patients with recurrent DVT and in 60% of patients with a single episode. In 74% of patients with recurrent DVT the index event occurred in either the contralateral leg or in a different segment of the ipsilateral leg. RVO was detected in 50% of patients with a single episode of DVT and in 88% of patients with recurrent DVT (p<0.00001). The prevalence of RVO is significantly higher in patients with recurrent DVT than in patients with a single episode. This finding supports the importance of RVO as a potential marker of a persistent prothrombotic state.

Symptomatic In-Hospital Deep Vein Thrombosis and Pulmonary Embolism Following Hip and Knee Arthroplasty Among Patients Receiving Recommended Prophylaxis

2012 ◽  
Vol 56 (5) ◽  
pp. 244-245
Author(s):  
Jean-Marie Januel ◽  
Guanmin Chen ◽  
Christiane Ruffieux ◽  
Hude Quan ◽  
James D. Douketis ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Deep Vein Thrombosis ◽  
Knee Arthroplasty ◽  
Vein Thrombosis ◽  
Hip And Knee Arthroplasty ◽  
Deep Vein
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