scholarly journals Anti-Yo Mediated Paraneoplastic Cerebellar Degeneration Associated with Pseudobulbar Affect in a Patient with Breast Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Allison N. Martin ◽  
Patrick M. Dillon ◽  
David E. Jones ◽  
David R. Brenin ◽  
David A. Lapides
Keyword(s):  
Breast Cancer ◽  
Paraneoplastic Syndrome ◽  
Radical Mastectomy ◽  
Cerebellar Degeneration ◽  
Paraneoplastic Syndromes ◽  
Paraneoplastic Cerebellar Degeneration ◽  
Modified Radical Mastectomy ◽  
Stage Iiia ◽  
Pseudobulbar Affect ◽  
New Onset

Paraneoplastic cerebellar degeneration (PCD) is a rare anti-Yo mediated paraneoplastic syndromes rarely that is infrequently associated with breast cancer. We present a case of a 52-year-old female presenting with diplopia, gait instability, dysarthria, dysphagia, nystagmus, and, most notably, new onset paroxysmal episodes of uncontrollable crying concerning for pseudobulbar affect (PBA). Serologic testing showed anti-Yo antibodies. The patient was found to have stage IIIA breast cancer as the inciting cause of the paraneoplastic syndrome. The patient was treated with neoadjuvant chemotherapy, modified radical mastectomy, adjuvant Herceptin, and pertuzumab. She was given IVIG for paraneoplastic syndrome, antidepressants, and dextromethorphan-quinidine (Nuedexta), the first FDA-approved therapy for PBA. With multimodality therapy, she demonstrated significant improvement in neurologic and mood symptoms associated with PCD and PBA.

scholarly journals EVALUATION OF POSTURE AND QUALITY OF LIFE IN FEMALES UNDERGONE MODIFIED RADICAL MASTECTOMY

2021 ◽  
Vol 10 (4) ◽  
pp. 3233-32337
Author(s):  
Shruti Deshpande
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Social Life ◽  
Radical Mastectomy ◽  
Improve Quality ◽  
Modified Radical Mastectomy ◽  
Social Domain ◽  
Common Cancer ◽  
Environment Domain

Breast cancer is most common cancer in females. Modified radical mastectomy is operation in female which affects social life and physical life. There is also slightly moderate in quality of life in female undergone modified radical mastectomy. The aim of the study was to find “Evaluation of Posture and Quality Of Life in Females undergone Modified Radical Mastectomy’’ This study was carried out in Physiotherapy OPD, Ravi Nair Physiotherapy College and AVBRH, Sawangi (Meghe), Wardha. The objectives included to evaluate posture in female’s undergone Modified radical mastectomy and to evaluate Quality of life. The present study titled “Evaluation of Posture and Quality of Life in females undergone Modified Radical Mastectomy” which comprised of 35 females. The present study showed that slight changes in posture in females undergone modified radical mastectomy and moderately hampered in social domain of quality of life. From the present study we concluded that there is slight changes in posture in female patients undergone MRM and there is good quality of life in physical , psychological , environment domain and moderate quality of life in social domain. This study will helps in evaluating posture and QOL after Modified radical mastectomy. Hence after every modified radical mastectomy conditions, therapists always follow ergonomics to prevent bad posture and improve quality of life. Hence, the evaluation of posture and QOL should be include in all assessment proformas related MRM conditions.

scholarly journals Comparison of the Effectiveness of Full Negative Pressure with Half Negative Pressure on Suction Drain in Reducing Post-Modified Radical Mastectomy Seroma

2019 ◽  
Vol 2 (2) ◽  
pp. 24-31
Author(s):  
Gulraj Singh ◽  
Mulawan Umar ◽  
Nur Qodir
Keyword(s):  
Breast Cancer ◽  
Negative Pressure ◽  
Radical Mastectomy ◽  
Control Group ◽  
Breast Cancer Patients ◽  
Modified Radical Mastectomy ◽  
Pressure Groups ◽  
Suction Drain ◽  
Significant Difference ◽  
June July

Abstract Introduction: Modified radical mastectomy (MRM) is a breast cancer treatment option that is still operable. One of the postoperative complications that can be found is the formation of seroma. High negative suction drain is done to treat seroma after surgery but it can contribute to increase the length of stay in hospital. Methods: This study was a clinical randomized control trial (cRCT) conducted on 30 breast cancer patients in June - July 2019 at Moehammad Hoesin Hospital in Palembang. This study divided the two sample groups, each group consisting of 15 patients. One group was given half negative pressure on suction drain (experimental group) and the other used full negative pressure on suction drain (control group). Results: There was a significant difference (p <0.005) between the full and half negative pressure groups where there were more seroma events in the full vacuum group in 9 (60%) cases and half vacuum in 2 (30%) but there were no significant differences in long period of stay (p> 0.005). Conclusion: Half negative pressure is more effective in treating seroma than full negative pressure.

scholarly journals Immunohistochemistry profile and its relation with prognosis in locally advanced breast cancer

2019 ◽  
Vol 6 (12) ◽  
pp. 4507
Author(s):  
Naseef Kannanavil ◽  
Nabeel Thommil Padinjarenalakath ◽  
Ahsan Vilayapoyilil ◽  
Abidali Karatparambil
Keyword(s):  
Breast Cancer ◽  
Triple Negative ◽  
Locally Advanced ◽  
Radical Mastectomy ◽  
Response To Therapy ◽  
Advanced Breast ◽  
Age Group ◽  
Modified Radical Mastectomy ◽  
Number Of Patients ◽  
Related Mortality

Background: Breast cancer is one of the most common malignancy and leading cause of cancer related deaths in women worldwide. Immunohistochemistry (IHC) is done to characterize intracellular proteins or cell-surface antigens and is used to assess tumour subtypes, confirm diagnosis, predict prognosis and response to therapy. The aim of the present study was to evaluate the relationship of IHC profile- ER, PR and HER2 neu and prognosis of patients who underwent modified radical mastectomy for locally advanced breast cancer.Methods: A retrospective cohort study was conducted at MES Medical College Hospital from October 2015 to November 2017 in patients who underwent modified radical mastectomy for locally advanced breast carcinoma. A total of 65 women were enrolled in the study. 5 years survival was taken as the prognostic indicator.Results: Majority of the patients belong to the age group of 40-49 years with 40% patients followed by 33.84% patients in the age group of 50-59 years. Maximum number of patients was found in 2B stage of tumour. Maximum patients belonged to the ER/PR+, HER2- subgroup (27), followed by triple negative (ER/PR-, HER2) subgroup (16). There was no disease related mortality in ER/PR+, HER2+ and ER/PR+, HER2- subgroups. There were 1 and 2 disease related mortality in ER/PR-, HER2+ and triple negative subgroups respectively.Conclusions: In the present study the worst prognosis was observed in triple negative (ER/PR-,HER2-) IHC subgroup followed by the HER2 enriched (ER/PR-, HER2+) subgroup. 

Paraneoplastic cerebellar degeneration diagnosed by anti-Yo determination in a young woman with early breast cancer

2020 ◽  
Vol 13 (8) ◽  
pp. e233863 ◽  
Author(s):  
Oriol Mirallas ◽  
María Alejandra Rezqallah Arón ◽  
Nadia Saoudi Gonzalez ◽  
Santiago Escrivá-de-Romaní
Keyword(s):  
Breast Cancer ◽  
Early Breast Cancer ◽  
Brain Mri ◽  
Neoadjuvant Treatment ◽  
Cerebellar Degeneration ◽  
Paraneoplastic Cerebellar Degeneration ◽  
Her2 Positive ◽  
Limb Weakness ◽  
Fluid Analysis ◽  
Positron Emission

A 44-year-old woman diagnosed with a HER2 positive early breast cancer, receiving neoadjuvant treatment with paclitaxel and targeted agents, trastuzumab together with pertuzumab, presented to the emergency room with gait instability and upper right limb weakness. The neurological examination was compatible with cerebellar alteration showing right dissymmetry of the finger-nose and heel-knee manoeuvre. A head CT and a brain MRI were performed and negative. The electromyography showed alterations of the pyramidal pathway and somatosensory pathway. In order to determine the cause of the cerebellar affection, a lumbar puncture was performed. The cerebrospinal fluid analysis was non-specific, but the antineuronal anti-Yo antibody was positive, being diagnosed of a paraneoplastic cerebellar degeneration (PCD). A positron emission tomography CT ruled out metastatic disease. The patient completed four cycles of antiHER2 blockade and weekly paclitaxel, achieving a complete pathological response. One year later, she maintains a complete remission but the PCD still prevails.

Physical Therapistsʼ Knowledge Regarding Treatment of Women Following Modified Radical Mastectomy for Breast Cancer

2011 ◽  
Vol 29 (2) ◽  
pp. 3
Author(s):  
Anne Swisher ◽  
Krystal Arose ◽  
Anna Meckley ◽  
Megan Rymer ◽  
Samantha Stickley ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Radical Mastectomy ◽  
Modified Radical Mastectomy
Sign in / Sign up

Export Citation Format

Share Document