scholarly journals Sex Differences in the Effect of Resveratrol on DSS-Induced Colitis in Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-12 ◽  
Author(s):  
Alexandra Wagnerova ◽  
Janka Babickova ◽  
Robert Liptak ◽  
Barbora Vlkova ◽  
Peter Celec ◽  
...  
Keyword(s):  
Weight Loss ◽  
Sex Differences ◽  
Pure Water ◽  
Spleen Weight ◽  
Protective Properties ◽  
Natural Polyphenol ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
First Time ◽  
Colitis Model

Resveratrol is a natural polyphenol studied for its possible protective properties in inflammatory bowel diseases. Moreover, it has been shown to interact with estrogen receptors. In the present study, we aimed to investigate possible diverse effects of resveratrol on female and male mice in DSS-induced colitis. Thirty-seven C57BL/6 mice (21 female and 16 male) were divided into three groups for each sex. The first group received pure water (CTRL). The other two groups received 1.5% dextran sulfate sodium (DSS) to induce colitis from which one group was treated with resveratrol (DSS + RSV). Intake of 1.5% DSS caused weight loss in all DSS groups compared to control mice. Weight loss, stool consistency, and discomfort did not show any protective effect of resveratrol in males and showed even adverse effects in females. In females, the activity of myeloperoxidase was lower compared to that in males. However, colon length and spleen weight showed no sex differences, which can indicate the induction of only mild colitis in mice. Resveratrol did not have any effect on TNF-alpha levels. Taken together, these results for the first time propose possible diverse effects of resveratrol in DSS-induced colitis model depending on the sex of the animal. However, this conclusion must be confirmed by further analyses.

Curative Ayurvedic approach to Ulcerative colitis - A Case Report

2016 ◽  
Vol 1 (2) ◽  
Author(s):  
Dr. Sumedh Wasnik ◽  
Anita Ghodke ◽  
Vaibhav Sulakhe
Keyword(s):  
Ulcerative Colitis ◽  
Weight Loss ◽  
Immune Suppression ◽  
Inflammatory Bowel Diseases ◽  
Life Style ◽  
Intravenous Fluids ◽  
Genetic Origin ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Difficult Issue

Westernization and today’s changing life style is resulting in various health problems like Inflammatory Bowel diseases, which is a common entity encountered in surgical practise. Ulcerative colitis is the most common among them. Though it is believed to have auto immune and genetic origin, today’s life style, environment, diet and stress plays an important role in aetiology. The disease is prevalent in middle aged western and northern people characterised by abdominal pain with bloody diarrhoea, weight loss, anaemia and general debility. This condition has remissions and exacerbations. One should always keep in mind that inflammatory bowel diseases can have anorectal manifestations. Diagnosis is made on the basis of symptoms, stool exam. and endoscopy. Management is symptomatic i.e. antibiotics, anti-inflammatory, anti-spasmodic, multivitamins, immune suppression and if required admission, intravenous fluids. if no response colectomy. As such there is no satisfactory treatment till date, so it remains the difficult issue. Here we need to have an alternative, safe, convenient treatment. Ayurveda has an answer for such cases.

The Effect of Dream Anxiety on Sleep Quality in Inflammatory Bowel Diseases

2019 ◽  
Vol 38 (5) ◽  
pp. 380-389
Author(s):  
Haluk Tarik Kani ◽  
Ayse Sakalli Kani ◽  
Uzay Dural ◽  
Emre Basgoze ◽  
Cagri Aksu ◽  
...  
Keyword(s):  
Sleep Quality ◽  
Trait Anxiety ◽  
Daytime Sleepiness ◽  
State Anxiety ◽  
Depression And Anxiety ◽  
Anxiety Trait ◽  
Significant Difference ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
First Time

Introduction: Declining sleep quality is a well-known issue in inflammatory bowel disease (IBD), but dream characteristics of patients with IBD and their role in sleep quality are unknown. In this study, we aimed to examine whether and how patients with ulcerative colitis (UC) and Crohn’s disease (CD) differ on sleep quality, sleepiness level, and dream anxiety (DA) level compared to healthy controls (HC), controlling for their depressive and anxious tendencies. Methods: Patients and HCs were enrolled prospectively into the study. The Van DA Scale, Pittsburg Sleep Quality Index, Epworth Sleepiness Scale, Beck Depression Index, and State-Trait Anxiety Inventories were used to assess DA, sleep quality, sleepiness, depression, and anxiety, respectively. Results: Patients with IBD had significantly lower depression (p = 0.004), state anxiety (p = 0.0001), trait anxiety (p = 0.004), and DA (p = 0.0001) than HCs. Although no statistically significant difference in sleep quality was found (p = 0.99), daytime sleepiness was more common in HCs than in IBD patients (p = 0.0001). No statistically significant difference was seen in depression, state anxiety, trait anxiety, DA, sleep quality, and daytime sleepiness between patients with CD and those with UC. No correlation was found between disease activity indices and psychological parameters. Conclusion: In contrast to previous studies, this study found lower anxiety and depression levels in patients with IBD than in HCs. Moreover, DA score was higher in HCs. For the first time, we revealed that DA may be one of the factors leading to sleep disturbance in patients with IBD.

scholarly journals Pharmacological Evaluation of the SCID T Cell Transfer Model of Colitis: As a Model of Crohn's Disease

2012 ◽  
Vol 2012 ◽  
pp. 1-11 ◽  
Author(s):  
Thomas Lindebo Holm ◽  
Steen Seier Poulsen ◽  
Helle Markholst ◽  
Stine Reedtz-Runge
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Adoptive Transfer ◽  
Inflammatory Bowel Diseases ◽  
Transfer Model ◽  
Drug Candidates ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
T Cell Transfer ◽  
Colitis Model

Animal models are important tools in the development of new drug candidates against the inflammatory bowel diseases (IBDs) Crohn's disease and ulcerative colitis. In order to increase the translational value of these models, it is important to increase knowledge relating to standard drugs. Using the SCID adoptive transfer colitis model, we have evaluated the effect of currently used IBD drugs and IBD drug candidates, that is, anti-TNF-α, TNFR-Fc, anti-IL-12p40, anti-IL-6, CTLA4-Ig, anti-α4β7 integrin, enrofloxacin/metronidazole, and cyclosporine. We found that anti-TNF-α, antibiotics, anti-IL-12p40, anti-α4β7 integrin, CTLA4-Ig, and anti-IL-6 effectively prevented onset of colitis, whereas TNFR-Fc and cyclosporine did not. In intervention studies, antibiotics, anti-IL-12p40, and CTLA4-Ig induced remission, whereas the other compounds did not. The data suggest that the adoptive transfer model and the inflammatory bowel diseases have some main inflammatory pathways in common. The finding that some well-established IBD therapeutics do not have any effect in the model highlights important differences between the experimental model and the human disease.

scholarly journals Animal models for inducing inflammatory bowel diseases: integrative review

2021 ◽  
Vol 11 (1) ◽  
pp. 80-87
Author(s):  
Nadja Maria da Costa Melo ◽  
Marília Virgo Silva Almeida ◽  
Daniel Melo de Oliveira Campos ◽  
Claudio Bruno Silva de Oliveira ◽  
Jonas Ivan Nobre Oliveira
Keyword(s):  
Acetic Acid ◽  
Animal Models ◽  
Inflammatory Bowel Diseases ◽  
Intestinal Inflammation ◽  
Integrative Review ◽  
Chemical Models ◽  
Experimental Induction ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Colitis Model

Objective: To identify and describe comparatively the chemical models of the induction of inflammatory bowel diseases (IBD) in rodents most used and that best mimic the pathogenesis in humans. Methods: Based on an integrative review in the MEDLINE and LILACS databases, it was investigated which experimental induction models were most cited in articles published from 2004 to 2020, with the descriptors "Colitis/CI", "Colitis model ulcerative" and "Intestinal inflammation model." All empirical articles that addressed one or more inflammation models in rats or mice were included. Results: 239 articles were identified; of these, only ten empirical articles were selected. The most used models were colitis induced by TNBS acid, DSS, and colitis induced by acetic acid (AA). Conclusion: It was possible to identify the most used models to promote the induction of intestinal inflammation in rats, and both models proved to be effective according to the limitations observed in the models described, suggesting the need for new works that use more well-defined protocols and that more fully represent the pathophysiological complexity of the disease.

A refined and translationally relevant model of chronic DSS colitis in BALB/c mice

2017 ◽  
Vol 52 (3) ◽  
pp. 240-252 ◽  
Author(s):  
Maximilian Hoffmann ◽  
Ulla Schwertassek ◽  
Aleksandra Seydel ◽  
Klaus Weber ◽  
Werner Falk ◽  
...  
Keyword(s):  
Dextran Sulfate ◽  
Significant Loss ◽  
Refined Model ◽  
Relevant Model ◽  
Dss Colitis ◽  
Clinical Scores ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Colitis Model ◽  
Pro Inflammatory Cytokines

Inflammatory bowel diseases (IBD) are chronic relapsing disorders of the gastrointestinal tract. Several mouse models for IBD are available, but the acute dextran sulfate sodium (DSS)-induced colitis model is mostly used for preclinical studies. However, this model lacks chronicity and often leads to significant loss of mice. The aim of this study was to establish a refined and translationally relevant model of DSS chronic colitis in BALB/c mice. In the first part, we compared several standard therapeutic (ST) treatments for IBD in the acute DSS colitis model to identify the optimal treatment control for a DSS colitis model as compared to literature data. In the second part, we tested the two most effective ST treatments in a refined model of chronic DSS colitis. Cyclosporine A (CsA) and 6-thioguanine (6-TG) caused considerable reduction of clinical scores in acute DSS colitis. The clinical outcome was confirmed by the results for colon length and by histopathological evaluation. Moreover, CsA and 6-TG considerably reduced mRNA expression of several pro-inflammatory cytokines in spleen and colon. Both compounds also showed a substantial therapeutic effect in the refined model of chronic DSS colitis with regard to clinical scores and histopathology as well as the expression of inflammatory markers. The refined model of chronic DSS colitis reflects important features of IBD and is well suited to test potential IBD therapeutics.

scholarly journals Uso de probióticos na nutrição de cães com Doença Inflamatória Intestinal (DII) – uma atualização

2021 ◽  
Vol 4 (5) ◽  
pp. 75-87
Author(s):  
Cláudio Marcos Rocha-de-Souza ◽  
◽  
Ana Carolina Aor Zaqueu ◽  
Lívia Rodrigues da Cruz ◽  
Marcelo Gomes de Souza ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Weight Loss ◽  
Antibiotic Therapy ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Immunosuppressive Drugs ◽  
Intestinal Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Digestive Disorders

Canine Inflammatory Bowel Disease (IBD) is the term used to designate a group of chronic intestinal diseases, manifested by persistent or recurrent gastrointestinal signs. Known symptoms are vomiting, diarrhea, changes in appetite and weight loss. Treatment consists of a diet combined with antibiotic therapy and immunosuppressive drugs. It is currently known that changes in the microbiota profile can be used as way to prevent digestive disorders, since some probiotics offer benefits to patients with IBD, reducing symptoms and improving their immunity, however, can say that there is still no consensus regarding the recommendation of the use probiotics in inflammatory bowel diseases.

scholarly journals Effect of Milk Fermented with Lactobacillus fermentum on the Inflammatory Response in Mice

Nutrients ◽  
2018 ◽  
Vol 10 (8) ◽  
pp. 1039 ◽  
Author(s):  
Lourdes Santiago-López ◽  
Adrián Hernández-Mendoza ◽  
Verónica Mata-Haro ◽  
Belinda Vallejo-Córdoba ◽  
Abraham Wall-Medrano ◽  
...  
Keyword(s):  
Fermented Milk ◽  
Lactobacillus Fermentum ◽  
Spleen Weight ◽  
T Helper ◽  
Bacterial Concentration ◽  
T Helper 17 ◽  
Th17 Response ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Infusion Protocol

Currently, the effect of fermented milk on the T-helper 17 response in inflammatory bowel diseases (IBDs) is unknown. The aim of the present study was to evaluate the effect of milks fermented with Lactobacillus fermentum on the Th1/Th17 response in a murine model of mild IBD. Exopolysaccharide (EPS), lactic acid (LA), and total protein (TP) contents and bacterial concentration were determined. Male C57Bl/6 mice intragastrically received either raw (FM) or pasteurized (PFM) fermented milk before and during a dextran sulfate infusion protocol. Blood, spleen, and colon samples were collected at Weeks 6 and 10. IL-6, IL-10, and TNFα were determined in serum, and IL-17, IL-23, and IFNγ were determined in intestinal mucosa and serum. The FM groups did not differ in cell concentration, LA, or TP content (p > 0.05); FM-J28 had the highest EPS content. Spleen weight and colon length did not differ among the FM groups (p > 0.05). In the FM-J20 and PFM-J20 groups, IL-17 and IFNγ decreased, and the IL-10 concentration was enhanced (p < 0.05) at Week 6. IL-6, TNFα, IL-23, and IFNγ did not differ in serum and mucosa (p > 0.05), and IL-17 was lowest in FM-J28 and FM-J20. Therefore, FM appears to potentially play a role in decreasing the Th17 response. However, further studies are needed to elucidate the FM-mediated anti-inflammatory mechanisms in IBD.

Surgery

2021 ◽  
pp. 473-506
Author(s):  
Jennie Burch ◽  
Brigitte Collins
Keyword(s):  
Bariatric Surgery ◽  
Inflammatory Bowel Disease ◽  
Rectal Cancer ◽  
Weight Loss ◽  
Nursing Care ◽  
Enhanced Recovery ◽  
Gastrointestinal Surgery ◽  
Surgical Patients ◽  
Bowel Diseases ◽  
Inflammatory Bowel

The surgery chapter discusses surgical treatment for bowel diseases. There are many surgical procedures that are explored with inclusion of the indication for surgery, such as cancer or inflammatory bowel disease, and any common surgical complications so that the nurse is aware of observations to undertake. Nursing advice is added where appropriate to ensure that the nurse knows what advice might be necessary to give to the patient. Operations discussed include anterior resection to remove part of the rectum for a rectal cancer and bariatric surgery to help weight loss. Diagrams help to explain what the operation entails. Nursing care of surgical patients on the enhanced recovery pathway is included with details on preoperative, intraoperative, and postoperative care. Concise exploration of gastrointestinal surgery within this chapter can be used within clinical practice by the nurse.

Engineered biomimetic nanovesicles show intrinsic anti-inflammatory properties for the treatment of inflammatory bowel diseases

Nanoscale ◽  
2017 ◽  
Vol 9 (38) ◽  
pp. 14581-14591 ◽  
Author(s):  
Claudia Corbo ◽  
Walter E. Cromer ◽  
Roberto Molinaro ◽  
Naama E. Toledano Furman ◽  
Kelly A. Hartman ◽  
...  
Keyword(s):  
Inflammatory Bowel Disease ◽  
Inflammatory Bowel Diseases ◽  
Bowel Disease ◽  
Bowel Diseases ◽  
Inflammatory Bowel ◽  
Anti Inflammatory ◽  
First Time

We debut for the first time specialized leukosomes (SLKs) for the treatment of inflammatory bowel disease.

scholarly journals Sex Differences in Response to TNF-Inhibiting Drugs in Patients With Spondyloarthropathies or Inflammatory Bowel Diseases

2019 ◽  
Vol 10 ◽  
Author(s):  
Bruno Laganà ◽  
Angelo Zullo ◽  
Maria Lia Scribano ◽  
Maria Sole Chimenti ◽  
Alberto Migliore ◽  
...  
Keyword(s):  
Sex Differences ◽  
Inflammatory Bowel Diseases ◽  
Bowel Diseases ◽  
Inflammatory Bowel
Sign in / Sign up

Export Citation Format

Share Document