scholarly journals Serum Metabolomics Profiling to Identify Biomarkers for Unstable Angina

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Wei Yao ◽  
Yuxia Gao ◽  
Zheng Wan
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Unstable Angina Pectoris ◽  
Control Groups ◽  
Serum Samples ◽  
Mortality And Morbidity ◽  
H Nmr ◽  
And Control ◽  
Insight Into ◽  
Serum Metabolomics

Although statistical evidence is clear regarding the dangerousness of unstable angina (UA), a form of coronary heart disease (CHD) characterised by high mortality and morbidity globally, it is important to recognise that diagnostic precision for the condition is unfavourable. In the present research, to gain insight into candidate biomarkers, the author draws on1H NMR-based serum metabolic profiling to analyze the unstable angina pectoris (UAP) metabolic signatures; this constitutes an effective way to produce medical diagnosis. 101 unstable angina pectoris patients and 132 healthy controls were enrolled and 22 serum samples from each group were analyzed. Effective separation was noted regarding the UAP and control groups, and, for the former group considered in relation to their counterpart, the serum concentrations of Lac, m-I, lipid, VLDL, 3-HB, and LDL were higher whereas the concentrations of Thr, Cr, Cho, PC/GPC, Glu, Gln, Lys, HDL, Ile, Leu, and Val were lower. The conclusion drawn in view of the results is that the plasma metabolomics examined by1H NMR displayed promise for biomarker identification for UA. In addition to this, the analysis illuminated the metabolic processes of UA.

scholarly journals Serum Levels of Growth Differentiation Factor-15 as an Inflammatory Marker in Patients with Unstable Angina Pectoris

2021 ◽  
Author(s):  
Fariba Raygan ◽  
Aniseh Etminan ◽  
Hanieh Mohammadi ◽  
Hossein Akbari ◽  
Hassan Nikoueinejad
Keyword(s):  
Angina Pectoris ◽  
Serum Level ◽  
Unstable Angina ◽  
Serum Levels ◽  
Unstable Angina Pectoris ◽  
Risk Scores ◽  
Growth Differentiation Factor 15 ◽  
Differentiation Factor ◽  
The Mean ◽  
And Control

Background: Growth differentiation factor-15 (GDF-15), a member of transforming growth factors, is a stress-responsive marker whose levels may significantly increase in response to pathological stresses associated with inflammatory tissue injuries such as unstable angina pectoris (USAP). This study evaluated the diagnostic value of GDF-15 in patients with USAP. Methods: The present cross-sectional study recruited 39 patients with USAP criteria and 30 patients with stable angina pectoris (SAP), referred to Shahid Beheshti Hospital, Kashan, Iran. All the patients with USAP had at least 1 coronary artery stenosis (>50%) in angiography. The control group comprised 42 healthy individuals. The serum levels of GDF-15 were measured in all the participants by ELISA. Also analyzed were the relationship between GDF-15 levels and thrombolysis in myocardial infarction (TIMI) and the Global Registry of Acute Coronary Events (GRACE) risk scores in the patients with USAP to determine the severity of the disease. Result: The study population consisted of 111 subjects, 62 women and 49 men, divided into 3 groups of USAP (n=39, mean age=60.07±14.10 y), SAP (n=30, mean age=67.56±9.88 y), and control (n=42, mean age=61.21±7.76 y). The mean serum level of GDF-15 in the USAP group was significantly different from the other 2 groups (P<0.001), while no significant difference was observed in this regard between the SAP and control groups (P=0.797). No correlation was found between the mean GDF-15 serum level and the GRACE (P=0.816) and TIMI (P=0.359) risk scores in the USAP group. Conclusion:  The mean serum level of GDF-15 exhibited a rise in our patients with USAP. GDF-15 may be a diagnostic biomarker of USAP and its severity.

scholarly journals Circulating level of fibroblast growth factor 21 is independently associated with the risks of unstable angina pectoris

2018 ◽  
Vol 38 (5) ◽  
Author(s):  
Jing Cheng ◽  
Xing Su ◽  
Lei Qiao ◽  
Chungang Zhai ◽  
Wenqiang Chen
Keyword(s):  
Risk Factors ◽  
Growth Factor ◽  
Angina Pectoris ◽  
Unstable Angina ◽  
Fibroblast Growth Factor ◽  
Unstable Angina Pectoris ◽  
Fibroblast Growth Factor 21 ◽  
Fibroblast Growth ◽  
Fgf21 Level ◽  
And Control

There is increasing evidence that serum adipokine levels are associated with higher risks of cardiovascular diseases. As an important adipokine, fibroblast growth factor 21 (FGF21) has been demonstrated to be associated with atherosclerosis and coronary artery disease (CAD). However, circulating level of FGF21 in patients with angina pectoris has not yet been investigated. Circulating FGF21 level was examined in 197 patients with stable angina pectoris (SAP, n=66), unstable angina pectoris (UAP, n=76), and control subjects (n=55) along with clinical variables of cardiovascular risk factors. Serum FGF21 concentrations on admission were significantly increased more in patients with UAP than those with SAP (Ln-FGF21: 5.26 ± 0.87 compared with 4.85 ± 0.77, P<0.05) and control subjects (natural logarithm (Ln)-FGF21: 5.26 ± 0.87 compared with 4.54 ± 0.72, P<0.01). The correlation analysis revealed that serum FGF21 concentration was positively correlated with the levels of cardiac troponin I (cTnI) (r2  =  0.026, P=0.027) and creatine kinase-MB (CK-MB) (r2  =  0.023, P= 0.04). Furthermore, FGF21 level was identified as an independent factor associated with the risks of UAP (odds ratio (OR): 2.781; 95% CI: 1.476–5.239; P=0.002), after adjusting for gender, age, and body mass index (BMI). However, there were no correlations between serum FGF21 levels and the presence of SAP (OR: 1.248; 95% CI: 0.703–2.215; P=0.448). The present study indicates that FGF21 has a strong correlation and precise predictability for increased risks of UAP, that is independent of traditional risk factors of angina pectoris.

Unstable angina pectoris: management based on available information.

Circulation ◽  
1982 ◽  
Vol 65 (7) ◽  
pp. 72-77 ◽  
Author(s):  
R O Russell ◽  
C E Rackley ◽  
N T Kouchoukos
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Unstable Angina Pectoris ◽  
Available Information

Unstable angina pectoris: Morbidity and mortality in 57 consecutive patients evaluated angiographically

1973 ◽  
Vol 32 (6) ◽  
pp. 745-750 ◽  
Author(s):  
C. Richard Conti ◽  
Robert K. Brawley ◽  
Lawrence S.C. Griffith ◽  
Bertram Pitt ◽  
J. O'Neal Humphries ◽  
...  
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Unstable Angina Pectoris ◽  
Morbidity And Mortality

Unstable Angina Pectoris

2000 ◽  
Vol 342 (2) ◽  
pp. 101-114 ◽  
Author(s):  
Yerem Yeghiazarians ◽  
Joel B. Braunstein ◽  
Arman Askari ◽  
Peter H. Stone
Keyword(s):  
Angina Pectoris ◽  
Unstable Angina ◽  
Unstable Angina Pectoris
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