scholarly journals Heparanase Inhibition Reduces Glucose Levels, Blood Pressure, and Oxidative Stress in Apolipoprotein E Knockout Mice

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Shadi Hamoud ◽  
Rabia Shekh Muhammad ◽  
Niroz Abu-Saleh ◽  
Ahmad Hassan ◽  
Yaniv Zohar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Apolipoprotein E ◽  
Serum Glucose ◽  
The Other ◽  
Control Group ◽  
Glucose Levels ◽  
Disease States ◽  
Apolipoprotein E Knockout Mice ◽  
And Oxidative Stress

Background.Atherosclerosis is a multifactorial process. Emerging evidence highlights a role of the enzyme heparanase in various disease states, including atherosclerosis formation and progression.Objective.The aim of the study was to investigate the effect of heparanase inhibition on blood pressure, blood glucose levels, and oxidative stress in apoE−/− mice.Methods.Male apoE−/− mice were divided into two groups: one treated by the heparanase inhibitor PG545, administered intraperitoneally weekly for seven weeks, and the other serving as control group (injected with saline). Blood pressure was measured a day before sacrificing the animals. Serum glucose levels and lipid profile were measured. Assessment of oxidative stress was performed as well.Results.PG545 significantly lowered blood pressure and serum glucose levels in treated mice. It also caused significant reduction of the serum oxidative stress. For safety concerns, liver enzymes were assessed, and PG545 caused significant elevation only of alanine aminotransferase, but not of the other hepatic enzymes.Conclusion.Heparanase inhibition by PG545 caused marked reduction of blood pressure, serum glucose levels, and oxidative stress in apolipoprotein E deficient mice, possibly via direct favorable metabolic and hemodynamic changes caused by the inhibitor. Possible hepatotoxic and weight wasting effects are subject for future investigation.

scholarly journals Swimming Attenuates Blood Pressure and Oxidative Stress in Hypertensive Rats

2021 ◽  
Vol 0 (0) ◽  
Author(s):  
Anica Petkovic ◽  
Marko Ravic ◽  
Sasa Plecevic ◽  
Jovana Jeremic ◽  
Ivan Srejovic ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Diastolic Pressure ◽  
Control Group ◽  
Albino Rats ◽  
Positive System ◽  
Hypertensive Rats ◽  
Stress Markers ◽  
Antioxidant Parameters ◽  
And Oxidative Stress

Abstract Hypertension presents one of the main risk factors for cardiovascular diseases which are the leading cause of morbidity and mortality worldwide. Structural and mechanical changes of the heart and blood vessels as well as overproduction of reactive oxygen species may occur due to the increased blood pressure. Therewith, the goal of our study was to estimate the effects and duration of swimming as a possible therapy approach on blood pressure and oxidative stress parameters in normotensive and hypertensive rats. The study was conducted on 60 male Wistar albino rats divided into two groups, normotensive and hypertensive rats. Each of these groups was divided into three subgroups according to the swimming protocol. The swimming training was kept constant (60 min/day, for five days a week) with two days of rest. After six or nine weeks of the swimming protocol, blood pressure and oxidative stress markers were measured. The control group rats were put in water for one minute a day, in order to avoid water-induced stress. Training significantly reduced systolic blood pressure in hypertensive rats, while diastolic pressure did not change in the group that swam six or nine weeks. The results showed that swimming increases the activity of all measured antioxidative parameters, while values of prooxidants varied depending on the training protocol. Our results confirmed that swimming, as an aerobic exercise, decreases blood pressure and has time-dependent positive system adaptations, especially on the antioxidant parameters.

scholarly journals EFEK ANTIOKSIDAN IKAN SALUANG (Rasbora spp.) TERHADAP KADAR MALONDIALDEHID (MDA) OTAK TIKUS PUTIH (Rattus norvegicus) MALNUTRISI

2016 ◽  
Vol 12 (2) ◽  
pp. 229
Author(s):  
Yuli Rakhmawati ◽  
Triawanti Triawanti ◽  
Ari Yunanto
Keyword(s):  
Oxidative Stress ◽  
Experimental Study ◽  
Rattus Norvegicus ◽  
The Other ◽  
Control Group ◽  
Control Group Design ◽  
Whitney Test ◽  
Group Design ◽  
Antioxidant Effects ◽  
And Oxidative Stress

Abstract: Malnutrition because of protein deficiency on diet caused antioxidant deficiency state and oxidative stress on brain that marked by increased MDA level. The aim of this study was to analyze the antioxidant effects of saluang (Rasbora spp.) on brain MDA level in malnourished rats. This was an experimental study with a Posttest Only with Control Group Design, consisted of malnutrition control group (M), group that feed with saluang (S), group that given standard feeding (P), and group that given standard feeding added with DHA supplement (D). Brain MDA level measured with TBARS method in spectrophotometer. Mean brain MDA level for each group in a row is M = 210,750 μΜ, S = 194,125 μΜ, P = 202,625 μΜ, and D = 200,875 μΜ. Kruskal-Wallis and Mann Whitney test showed that there were significant differences between the group that feed with saluang and the other groups (p<0.05). Based on this research, concluded that the administration of saluang (Rasbora spp.) significantly affects the decrease of brain MDA level in malnourished rats. Keywords: antioxidant, saluang fish, MDA, malnutrition Abstrak: Malnutrisi karena defisiensi protein akan menimbulkan keadaan kekurangan antioksidan dan menimbulkan stres oksidatif pada otak yang ditandai dengan peningkatan kadar MDA. Tujuan penelitian ini untuk menganalisis efek antioksidan ikan saluang terhadap kadar MDA otak tikus putih malnutrisi. Penelitian ini merupakan penelitian eksperimental dengan Posttest Only with Control Group Design, terdiri dari kelompok kontrol malnutrisi (M), kelompok pemberian pakan saluang (S), kelompok pemberian pakan standar (P), dan kelompok pemberian pakan standar yang ditambah suplemen DHA (D). Kadar MDA otak diukur dengan menggunakan metode TBARS secara spektrofotometer. Rerata kadar MDA otak masing-masing kelompok perlakuan berturut-turut adalah M = 210,750 μΜ, S = 194,125 μΜ, P = 202,625 μΜ, dan D = 200,875 μΜ. Uji Kruskal-Wallis dan uji Mann Whitney menunjukkan bahwa terdapat perbedaan bermakna antara kelompok yang diberi pakan saluang dengan kelompok lainnya (p<0,05). Berdasarkan penelitian yang dilakukan dapat diambil kesimpulan bahwa pemberian ikan saluang (Rasbora spp.) berpengaruh secara bermakna terhadap penurunan kadar MDA otak tikus putih malnutrisi. Kata-kata kunci: antioksidan, ikan saluang, MDA, malnutrisi

The Correlation of Anxiety, Dyslipidemia and Oxidative stress in Prehypertensive and Hypertensive patients

2020 ◽  
Vol 11 (2) ◽  
pp. 2614-2619
Author(s):  
Elsa Mathew ◽  
Mukkadan J. K.
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Trait Anxiety ◽  
Normal Blood ◽  
Control Group ◽  
National Committee ◽  
Normal Blood Pressure ◽  
Hypertensive Patients ◽  
Normotensive Subjects ◽  
And Oxidative Stress

Studies have evaluated that high blood pressure kills nine million people annually Persistent. Psychological factors can be considered as a primary threat to the increase of hypertension. It may lead to cardiovascular disease, stroke and kidney disease. The current work was conducted to analyze the disparity of anxiety, dyslipidemia and oxidative stress in pre-hypertensive and hypertensive subjects. This was a cross-sectional study conducted among 180 subjects. Based on the Joint National Committee 8 Criteria, participants were divided into hypertensive patients (n₌60) and pre-hypertensive patients (n₌63). Fifty-seven healthy subjects with normal blood pressure were served as the control group. Anthropometric measurements and blood pressure were measured using the standard procedure. The biochemical parameters for measuring oxidative stress, blood glucose levels, and lipid profile were estimated. Anxiety level was assessed with the State-trait anxiety inventory (STAI) questionnaire. It is observed that the serum MalonDiAldehyde (MDA) levels (nmol/ml) were significantly higher in pre-hypertensive (3.74±0.33) and hypertensive (4.7±0.38) compared to normotensive subjects (3.05±0.38). The Superoxide Dismutase (SOD) activity (U/ml) was higher in subjects with normal blood pressure (12.67±2.31) than pre-hypertensive (11.16±2.43) and hypertensive subjects (8.98±2.32). The MDA had a significant positive correlation, and SOD had a negative association with waist-hip ratio, systolic blood pressure, diastolic blood pressure, fasting blood sugar, high-density lipoprotein, and state and trait anxiety. The present study confirmed that pre-hypertensive and hypertensive subjects suffered from more oxidative stress than normotensive subjects.

scholarly journals Oxidative Status and Acute Phase Reactants in Patients with Environmental Asbestos Exposure and Mesothelioma

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Cengizhan Sezgi ◽  
Mahsuk Taylan ◽  
Hadice Selimoglu Sen ◽  
Osman Evliyaoğlu ◽  
Halide Kaya ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Acute Phase ◽  
Asbestos Exposure ◽  
Oxidative Status ◽  
The Other ◽  
Stress Index ◽  
Control Group ◽  
Acute Phase Reactants ◽  
Total Antioxidant ◽  
And Oxidative Stress

Background and Objectives. The aim of this study was to investigate inflammatory indicators and oxidative status in patients with asbestos exposure with and without mesothelioma and to compare results with data from healthy subjects.Methods. Eighty people with exposure to environmental asbestos and without any disease, 46 mesothelioma patients, and a control group of 50 people without exposure to environmental asbestos were enrolled in this prospective study. Serum total oxidant level (TOL), total antioxidant capacity (TAC), and oxidative stress index (OSI), CRP, transferrin, ceruloplasmin,α-1 antitrypsin, ferritin, and copper levels were measured.Results. Mesothelioma group exhibited higher TOL, OSI,α1-antitrypsin, ferritin and copper levels as compared to the other groups (P<0.001,P=0.007,P<0.0001,P<0.001, andP<0.001, resp.). Transferrin was lower in the mesothelioma group than in the other two groups (P<0.001). The asbestos group had higher TOL, TAC,α1-antitrypsin, and transferrin levels (P<0.001,P<0.001,P<0.001, andP<0.001, resp.), as well as lower OSI and ferritin levels as compared to the control group (P<0.001andP<0.001).Conclusions. We believe that elevated acute phase reactants and oxidative stress markers (TOL and OSI) in the mesothelioma group can be used as predictive markers for the development of asbestos-related malignancy.

scholarly journals The Therapeutic Effect of Music on Oxidative Stress Markers and Anxiety in Hypertension

2021 ◽  
pp. 825-833
Author(s):  
Elsa Mathew ◽  
J. K. Mukkadan
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Music Therapy ◽  
Therapeutic Effect ◽  
Instrumental Music ◽  
Lifestyle Modification ◽  
Oxidative Stress Marker ◽  
Control Group ◽  
Mortality And Morbidity ◽  
And Oxidative Stress

Objective : Cardiovascular disease is amenable to mortality and morbidity in India and worldwide. The asymptomatic nature of hypertension made it a silent killer. Evidence suggests the role of oxidative stress and anxiety in the pathogenesis of hypertension. Lifestyle modification can control hypertension and, thus, can prevent complications. Music therapy is a non-invasive, non-pharmacological, and economic practice used for the management of hypertension, anxiety, and oxidative stress. The present study aims to evaluate the therapeutic effect of Raga Ananda Bhairavi on oxidative stress and anxiety in hypertensive patients. Materials and Methods: This randomized control study comprises of a total of 120 participants of age between 30-60years. All the study participants were divided into an experimental and control group. The instrumental music of Raga Ananda Bhairavi was provided to the experimental group for three months. The anthropometric measurements, blood pressure assessment, and estimation of oxidative stress parameters were done in all subjects before and after three months of intervention. Results: The systolic blood pressure, diastolic blood pressure, anxiety levels, and oxidative stress marker malondialdehyde significantly reduced after music therapy, and the superoxide dismutase level significantly improved after the intervention. Conclusion: Music can be used as an adjunct therapy for the management of hypertension.

scholarly journals Retinal Protection from LED-Backlit Screen Lights by Short Wavelength Absorption Filters

Cells ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 3248
Author(s):  
Celia Sanchez-Ramos ◽  
Cristina Bonnin-Arias ◽  
Vanesa Blázquez-Sánchez ◽  
Victoria Aguirre-Vilacoro ◽  
Teresa Cobo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Extracellular Matrix ◽  
Growth Factors ◽  
Blue Light ◽  
Short Wavelength ◽  
Group Structure ◽  
The Other ◽  
Control Group ◽  
Led Light ◽  
And Oxidative Stress

(1) Background: Ocular exposure to intense light or long-time exposure to low-intensity short-wavelength lights may cause eye injury. Excessive levels of blue light induce photochemical damage to the retinal pigment and degeneration of photoreceptors of the outer segments. Currently, people spend a lot of time watching LED screens that emit high proportions of blue light. This study aims to assess the effects of light emitted by LED tablet screens on pigmented rat retinas with and without optical filters. (2) Methods: Commercially available tablets were used for exposure experiments on three groups of rats. One was exposed to tablet screens, the other was exposed to the tablet screens with a selective filter and the other was a control group. Structure, gene expression (including life/death, extracellular matrix degradation, growth factors, and oxidative stress related genes), and immunohistochemistry in the retina were compared among groups. (3) Results: There was a reduction of the thickness of the external nuclear layer and changes in the genes involved in cell survival and death, extracellular matrix turnover, growth factors, inflammation, and oxidative stress, leading decrease in cell density and retinal damage in the first group. Modulation of gene changes was observed when the LED light of screens was modified with an optical filter. (4) Conclusions: The use of short-wavelength selective filters on the screens contribute to reduce LED light-induced damage in the rat retina.

scholarly journals Accumulation of α-Synuclein in Cerebellar Purkinje Cells of Diabetic Rats and Its Potential Relationship with Inflammation and Oxidative Stress Markers

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Volkan Solmaz ◽  
Hatice Köse Özlece ◽  
Hüseyin Avni Eroglu ◽  
Hüseyin Aktuğ ◽  
Oytun Erbaş ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Marker ◽  
Diabetic Rats ◽  
Diabetic Group ◽  
Control Group ◽  
Pentraxin 3 ◽  
Oxidative Stress Markers ◽  
Glucose Levels ◽  
Stress Markers ◽  
And Oxidative Stress

Objective. The present study was conducted to evaluate the relationship between plasma oxidative stress markers such as malondialdehyde (MDA) and glutathione (GSH), inflammatory marker pentraxin-3 (PTX3), and cerebellar accumulation of α-synuclein in streptozotocin- (STZ-) induced diabetes model in rats. Methods. Twelve rats were included in the study. Diabetes (n=6) was induced with a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). Diabetes was verified after 48 h by measuring blood glucose levels. Six rats served as controls. Following 8 weeks, rats were sacrificed for biochemical and immunohistochemical evaluation. Results. Plasma MDA levels were significantly higher in diabetic rats when compared with the control rats (p<0.01), while plasma GSH levels were lower in the diabetic group than in the control group (p<0.01). Also, plasma pentraxin-3 levels were statistically higher in diabetic rats than in the control rats (p<0.01). The analysis of cerebellar α-synuclein immunohistochemistry showed a significant increase in α-synuclein immunoexpression in the diabetic group compared to the control group (p<0.01). Conclusion. Due to increased inflammation and oxidative stress in the chronic period of hyperglycemia linked to diabetes, there may be α-synuclein accumulation in the cerebellum and the plasma PTX3 levels may be assessed as an important biomarker of this situation.

Evaluation of Salivary Antioxidants and Oxidative Stress Markers in Type 2 Diabetes Mellitus: A Retrospective Cohort Study

2020 ◽  
Vol 20 (4) ◽  
pp. 584-590 ◽  
Author(s):  
Shima Fathi ◽  
Shiva Borzouei ◽  
Mohammad Taghi Goodarzi ◽  
Jalal Poorolajal ◽  
Fatemeh Ahmadi-Motamayel
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Control Group ◽  
Oxidative Stress Markers ◽  
Stress Markers ◽  
Type 2 Dm ◽  
Patients With Diabetes ◽  
The Difference ◽  
And Oxidative Stress

Background: Diabetes Mellitus (DM) is a progressive metabolic disorder. Objective: The aim of this study was to investigate the relationship between antioxidant and oxidative stress markers in the saliva of patients with type 2 DM and a healthy control group. Methods: In this study, 20 patients with diabetes and 20 healthy individuals were evaluated. Salivary antioxidants markers consisted of total antioxidant capacity (TAC), uric acid (UA), peroxidase and catalase. Oxidative stress markers included total oxidant status (TOS), malondealdehyde (MDA) and total thiol (SH). Sialochemical analysis was performed with spectrophotometric assay. All the statistical analyses were conducted using STATA software. Results: TAC decreased significantly in patients with diabetes. Although salivary UA and peroxidase were lower in patients with diabetes compared to the control group, the difference was not significant. Salivary catalase in patients with diabetes was significantly lower than that in the control group. MDA and TOS exhibited significantly higher levels in type 2 DM. SH levels were slightly higher in DM. Conclusions: According to the results of the present study, there were some changes in the salivary levels of some antioxidants and oxidative stress markers in patients with type 2 DM and could be measured as an indicator of serum changes..

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