scholarly journals Effects of rhBMP-2 Loaded Titanium Reinforced Collagen Membranes on Horizontal Bone Augmentation in Dogs

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Ki-Sun Lee ◽  
Yu-Sung Jeon ◽  
Sang-Wan Shin ◽  
Jeong-Yol Lee
Keyword(s):  
Growth Factor ◽  
Long Term Results ◽  
Bone Augmentation ◽  
Friedman Test ◽  
Titanium Mesh ◽  
Histomorphometric Analysis ◽  
New Bone Formation ◽  
Beagle Dogs ◽  
Collagen Membranes

The aim of this study was to evaluate the efficacy of growth factor loaded collagen membranes on new bone formation during horizontal bone augmentation. Mandibular defects (4 × 4 × 4 mm) were surgically prepared in six male beagle dogs, which were then protected with one of three types of membranes: (1) titanium mesh, (2) titanium reinforced collagen, or (3) rhBMP-2 loaded titanium reinforced collagen. Animals were euthanized 8 and 16 weeks after surgery, and nondecalcified specimens were prepared and histomorphologically investigated to determine the degree of osteogenesis. Data were analyzed with Friedman test. With respect to the degree of osteogenesis at earlier stage (8 weeks after surgery), there was significantly higher new bone ratio in rhBMP-2 loaded membrane group (p>0.05). However, with respect to the long-term results (16 weeks after surgery), there were no significant differences among the three membranes (p>0.05). Based on histomorphometric analysis, there were no significant differences in horizontal bone gaining ratio (p>0.05).

scholarly journals Long-Term Results of Orbital Roof Repair with Titanium Mesh in a Case of Traumatic Intraorbital Encephalocele: A Case Report and Review of Literature

2016 ◽  
Vol 9 (3) ◽  
pp. 255-259 ◽  
Author(s):  
Erhan Arslan ◽  
Selçuk Arslan ◽  
Selçuk Kalkısım ◽  
Ahmet Arslan ◽  
Kayhan Kuzeyli
Keyword(s):  
Case Report ◽  
Maxillofacial Trauma ◽  
Long Term Results ◽  
Titanium Mesh ◽  
Review Of Literature ◽  
Orbital Roof ◽  
Period 2 ◽  
Child Patient ◽  
Orbital Roof Fractures

Orbital roof fractures associated with cranial and maxillofacial trauma are rarely encountered. Traumatic intraorbital encephaloceles due to orbital roof fractures developing in the early posttraumatic period are even rarer. A variety of materials, such as alloplastic implants or autogenous materials, have been used for the reconstruction of orbital roof, but data regarding the long-term results of these materials are very limited. We report a case of intraorbital encephalocele developing in the early posttraumatic period (2 days) in a child patient and the long-term results of titanium mesh used for the reconstruction of the orbital roof. The case is presented with a pertinent review of literature.

Long-Term Results of Swanson Silastic Arthroplasty in the Rheumatoid Wrist

1993 ◽  
Vol 18 (3) ◽  
pp. 381-388 ◽  
Author(s):  
J. K. STANLEY ◽  
A. R. TOLAT
Keyword(s):  
Long Term Results ◽  
Fracture Rate ◽  
New Bone Formation ◽  
Wrist Movement ◽  
Carpal Collapse ◽  
Limited Mobility ◽  
Long Term Follow Up ◽  
Quiescent Disease

We report a long-term follow-up of 6 to 11.8 years (mean = 8 years) of our first 50 Swanson wrist arthroplasties. All patients had long standing sero-positive rheumatoid arthritis with a mean age of 48 years. A detailed clinical and radiologic assessment was carried out on all the wrists. There was excellent sustained pain relief (mean score = 1.7) with improved activities of daily living. A mean range of wrist movement of 25° of extension and 31° of flexion was obtained. The prosthetic fracture rate was 22% of which 14% were symptomatic and needed re-operation. Carpal collapse was seen in all wrists, but was often symmetrical and accompanied by radial new bone formation on X-ray (86%). We feel that our long-term results justify the continued selective use of the Swanson wrist in the low-demand patient with quiescent disease who desires pain-free limited mobility and sophisticated grasp.

Ulnar Lengthening and Radial Recession Procedures for Kienböck’s Disease

1996 ◽  
Vol 21 (2) ◽  
pp. 169-171 ◽  
Author(s):  
I. A. TRAIL ◽  
R. L. LINSCHEID ◽  
D. E. QUENZER ◽  
P. A. SCHERER
Keyword(s):  
Long Term Results ◽  
Radiological Evaluation ◽  
New Bone Formation ◽  
Kienböck’S Disease ◽  
Kienböck's Disease ◽  
Number Of Patients ◽  
Ulnar Lengthening ◽  
Lunate Fossa ◽  
Kienbock’S Disease

Twenty patients with Kienböck’s disease who had undergone a joint levelling procedure, were reviewed at a mean of 11 years following surgery. Clinical and radiological evaluation revealed good long-term results with all patients complaining of less pain than before surgery and with statistically significant increases in range of motion and grip strength. Radiologically a significant number of patients were found still to have lunate fractures and fragmentation. In addition, 13 patients have developed new bone formation in the lunate fossa, and 12 show osteoarthritic changes, particularly at the radioscaphoid interface. Radial shortening was felt to be superior to ulnar lengthening in that there were fewer problems with bone union.

Ultrastructural investigations of MDL 19,660-induced effects on the canine platelet and megakaryocyte

1990 ◽  
Vol 48 (3) ◽  
pp. 374-375
Author(s):  
D.E. Loudy ◽  
J. Sprinkle-Cavallo ◽  
J.T. Yarrington ◽  
F.Y. Thompson ◽  
J.P. Gibson
Keyword(s):  
Antidepressant Drug ◽  
Beagle Dogs ◽  
Long Term Effects ◽  
Short Term ◽  
Platelet Counts ◽  
Toxicological Studies ◽  
Induced Aggregation ◽  
Internal Architecture

Previous short term toxicological studies of one to two weeks duration have demonstrated that MDL 19,660 (5-(4-chlorophenyl)-2,4-dihydro-2,4-dimethyl-3Hl, 2,4-triazole-3-thione), an antidepressant drug, causes a dose-related thrombocytopenia in dogs. Platelet counts started to decline after two days of dosing with 30 mg/kg/day and continued to decrease to their lowest levels by 5-7 days. The loss in platelets was primarily of the small discoid subpopulation. In vitro studies have also indicated that MDL 19,660: does not spontaneously aggregate canine platelets and has moderate antiaggregating properties by inhibiting ADP-induced aggregation. The objectives of the present investigation of MDL 19,660 were to evaluate ultrastructurally long term effects on platelet internal architecture and changes in subpopulations of platelets and megakaryocytes.Nine male and nine female beagle dogs were divided equally into three groups and were administered orally 0, 15, or 30 mg/kg/day of MDL 19,660 for three months. Compared to a control platelet range of 353,000- 452,000/μl, a doserelated thrombocytopenia reached a maximum severity of an average of 135,000/μl for the 15 mg/kg/day dogs after two weeks and 81,000/μl for the 30 mg/kg/day dogs after one week.

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