scholarly journals A Review on Platelet Activating Factor Inhibitors: Could a New Class of Potent Metal-Based Anti-Inflammatory Drugs Induce Anticancer Properties?

2017 ◽  
Vol 2017 ◽  
pp. 1-19 ◽  
Author(s):  
Vasiliki D. Papakonstantinou ◽  
Nefeli Lagopati ◽  
Effie C. Tsilibary ◽  
Constantinos A. Demopoulos ◽  
Athanassios I. Philippopoulos
Keyword(s):  
Organic Compounds ◽  
Platelet Activating Factor ◽  
Inhibitory Effect ◽  
Anticancer Properties ◽  
New Class ◽  
Structure Activity ◽  
Rabbit Platelets ◽  
First Results ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

In this minireview, we refer to recent results as far as the Platelet Activating Factor (PAF) inhibitors are concerned. At first, results of organic compounds (natural and synthetic ones and specific and nonspecific) as inhibitors of PAF are reported. Emphasis is given on recent results about a new class of the so-called metal-based inhibitors of PAF. A small library of 30 metal complexes has been thus created; their anti-inflammatory activity has been further evaluated owing to their inhibitory effect against PAF in washed rabbit platelets (WRPs). In addition, emphasis has also been placed on the identification of preliminarystructure-activityrelationships for the different classes of metal-based inhibitors.

Gastric ulceration induced by nonsteroidal anti-inflammatory drugs is a neutrophil-dependent process

1990 ◽  
Vol 259 (3) ◽  
pp. G462-G467 ◽  
Author(s):  
J. L. Wallace ◽  
C. M. Keenan ◽  
D. N. Granger
Keyword(s):  
Platelet Activating Factor ◽  
Gastric Ulceration ◽  
Gastric Damage ◽  
Blue Staining ◽  
Vascular Endothelial ◽  
Cyclooxygenase Activity ◽  
Inhibit Prostaglandin Synthesis ◽  
Inflammatory Drugs ◽  
Anti Inflammatory ◽  
Endothelial Integrity

The hypothesis that neutrophils play an important role in the pathogenesis of gastric ulceration induced by nonsteroidal anti-inflammatory drugs (NSAIDs) was tested in rats. Rats made neutropenic by prior treatment with an antibody to rat neutrophils raised in goat were found to be significantly more resistant to the gastric-damaging actions of indomethacin or naproxen than were control rats or rats pretreated with normal goat serum. The reduction of damage in neutropenic rats was not due to effects of the antineutrophil serum on either gastric acid secretion or the ability of indomethacin or naproxen to inhibit prostaglandin synthesis. Gastric cyclooxygenase activity was inhibited by greater than 95% in both normal and neutropenic rats that received indomethacin or naproxen. Reduction of circulating neutrophil numbers by treating rats with methotrexate also resulted in a significant reduction in the susceptibility to gastric damage induced by indomethacin. Since activation of circulating neutrophils appeared to be important in the development of gastric erosions after administration of indomethacin, and in the significant changes in vascular endothelial integrity (Monastral Blue staining) observed within 15 min of indomethacin administration, we investigated the possibility that leukotrienes (LTs) and platelet-activating factor (PAF) might be involved in the pathogenesis of indomethacin-induced ulceration. Changes in gastric LTB4 synthesis were not observed after indomethacin administration. Pretreatment with either an LTD4 antagonist or a PAF antagonist was without significant effect on the extent of gastric damage induced by indomethacin. These results suggest an important role for neutrophils in the pathogenesis of NSAID-induced gastric ulceration. Neutrophils may be important in the vascular injury that occurs early after administration of these compounds.

scholarly journals Reduction of Pulmonary Inflammation by pH Modifiers

2022 ◽  
Author(s):  
Wei-ping Zeng
Keyword(s):  
Pulmonary Inflammation ◽  
Inflammatory Cells ◽  
Pathological Feature ◽  
Successful Therapy ◽  
Mucus Hypersecretion ◽  
Adverse Side Effects ◽  
New Class ◽  
Asthma Model ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Pulmonary inflammation is a common pathological feature of a variety of diseases, ofwhich successful therapy with currently available anti-inflammatory drugs is limited byresistance and adverse side effects. Using the ovalbumin-induced mouse allergic asthma model,the present study shows that treatments with pH modifiers, particularly simple acids such asacetate or hydrochloric acid, effectively depleted inflammatory cells in the lungs and blood aswell as hyperplastic lung tissue cells while preserving the structure of the blood vessels and lungparenchyma. The acid treatments also suppressed mucus hypersecretion. These resultsdemonstrated pH modifiers as a new class of broad-spectrum anti-inflammatory agents with antiproliferationand mucus suppression activities.

scholarly journals Chemotherapeutic Properties of Phospho-Nonsteroidal Anti-Inflammatory Drugs, a New Class of Anticancer Compounds

2011 ◽  
Vol 71 (24) ◽  
pp. 7617-7627 ◽  
Author(s):  
Liqun Huang ◽  
Gerardo G. Mackenzie ◽  
Yu Sun ◽  
Nengtai Ouyang ◽  
Gang Xie ◽  
...  
Keyword(s):  
Anticancer Compounds ◽  
New Class ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

scholarly journals Inhibitory Effect of Herbal Remedy PERVIVO and Anti-Inflammatory Drug Sulindac on L-1 Sarcoma Tumor Growth and Tumor Angiogenesis in Balb/c Mice

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
P. Skopiński ◽  
B. J. Bałan ◽  
J. Kocik ◽  
R. Zdanowski ◽  
S. Lewicki ◽  
...  
Keyword(s):  
Tumor Growth ◽  
Tumor Angiogenesis ◽  
Herbal Remedy ◽  
Inhibitory Effect ◽  
Inflammatory Drug ◽  
Anticancer Effects ◽  
Biologic Response ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Anticancer activity of many herbs was observed for hundreds of years. They act as modifiers of biologic response, and their effectiveness may be increased by combining multiple herbal extracts . PERVIVO, traditional digestive herbal remedy, contains some of them, and we previously described its antiangiogenic activity. Numerous studies documented anticancer effects of nonsteroidal anti-inflammatory drugs. We were the first to show that sulindac and its metabolites inhibit angiogenesis. In the present paper the combinedin vivoeffect of multicomponent herbal remedy PERVIVO and nonsteroidal anti-inflammatory drug sulindac on tumor growth, tumor angiogenesis, and tumor volume in Balb/c mice was studied. These effects were checked after grafting cells collected from syngeneic sarcoma L-1 tumors into mice skin. The strongest inhibitory effect was observed in experimental groups treated with PERVIVO and sulindac together. The results of our investigation showed that combined effect of examined drugs may be the best way to get the strongest antiangiogenic and antitumor effect.

scholarly journals Use of nonsteroidal anti-inflammatory drugs and breast cancer risk in a prospective cohort of postmenopausal women

2020 ◽  
Vol 22 (1) ◽  
Author(s):  
Manon Cairat ◽  
Marie Al Rahmoun ◽  
Marc J. Gunter ◽  
Gianluca Severi ◽  
Laure Dossus ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Postmenopausal Women ◽  
Prospective Cohort ◽  
Cox Regression ◽  
Insurance Plan ◽  
Anticancer Properties ◽  
Hazard Ratios ◽  
Reimbursement Database ◽  
Inflammatory Drugs ◽  
Anti Inflammatory

Abstract Background Although anti-inflammatory agents could theoretically have anticancer properties, results from cohort studies on nonsteroidal anti-inflammatory drugs (NSAIDs) and breast cancer (BC) risk are inconsistent. Methods We investigated the association between NSAID use and BC incidence in the French E3N prospective cohort, which includes 98,995 women born between 1925 and 1950 and insured by a health insurance plan that covers mostly teachers. Self-reported information on lifestyle and medical history has been collected biennially by questionnaires and matched with data from a drug reimbursement database covering the period 2004–2014. Women who self-reported current NSAID use in the 2000 or 2002 questionnaires or with at least two reimbursements in any previous 3-month period were defined as exposed to NSAIDs. Multivariable Cox regression models were used to estimate hazard ratios (HRs) for the association of NSAID use with BC risk. Results In the current analysis, 62,512 postmenopausal women were followed between 2004 and 2014 (9 years on average, starting at a mean age of 63 years; 2864 incident BC). In multivariable models, there was no statistically significant association between NSAID use and BC risk [HR = 1.00 (0.92–1.08), compared with non-exposed women]. The NSAID-BC associations did not differ by NSAID types, BC subtypes, risk factors, and comorbidities, nor by duration and dose of use. However, a statistically significant interaction was observed by proton pump inhibitor (PPI) drug use (Pinteraction = 0.01) whereby a decreased risk of BC with NSAID use was only observed among women who also used PPI before. Conclusion Only women who used NSAIDs after having used PPI had a lower risk of BC. This result is novel and requires replication in other studies.

A new family of 2-hydroxy fatty acids as a new class of non-steroid anti-inflammatory drugs

2010 ◽  
Vol 163 ◽  
pp. S41 ◽  
Author(s):  
Daniel Horacio López ◽  
María Laura Martín ◽  
María Antonia Noguera-Salva ◽  
Silvia Terés ◽  
Gwendolyn Barceló Coblijn ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Hydroxy Fatty Acids ◽  
New Class ◽  
New Family ◽  
Inflammatory Drugs ◽  
Anti Inflammatory
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