scholarly journals Efficacy of Administration of an Angiotensin Converting Enzyme Inhibitor for Two Years on Autonomic and Peripheral Neuropathy in Patients with Diabetes Mellitus

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Triantafyllos Didangelos ◽  
Konstantinos Tziomalos ◽  
Charalambos Margaritidis ◽  
Zisis Kontoninas ◽  
Ioannis Stergiou ◽  
...  

Aim. To evaluate the effect of quinapril on diabetic cardiovascular autonomic neuropathy (CAN) and peripheral neuropathy (DPN).Patients and Methods. Sixty-three consecutive patients with diabetes mellitus [43% males, 27 with type 1 DM, mean age 52 years (range 22–65)], definite DCAN [abnormal results in 2 cardiovascular autonomic reflex tests (CARTs)], and DPN were randomized to quinapril 20 mg/day (group A,n=31) or placebo (group B,n=32) for 2 years. Patients with hypertension or coronary heart disease were excluded. To detect DPN and DCAN, the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE), measurement of vibration perception threshold with biothesiometer (BIO), and CARTs [R-R variation during deep breathing [assessed by expiration/inspiration ratio (E/I), mean circular resultant (MCR), and standard deviation (SD)], Valsalva maneuver (Vals), 30 : 15 ratio, and orthostatic hypotension (OH)] were used.Results. In group A, E/I, MCR, and SD increased (pfor all comparisons < 0.05). Other indices (Vals, 30 : 15, OH, MNSIQ, MNSIE, and BIO) did not change. In group B, all CART indices deteriorated, except Vals, which did not change. MNSIQ, MNSIE, and BIO did not change.Conclusions.Treatment with quinapril improves DCAN (mainly parasympathetic dysfunction). Improved autonomic balance may improve the long-term outcome of diabetic patients.

2020 ◽  
Vol 18 (5) ◽  
pp. 517-522 ◽  
Author(s):  
Ioanna Zografou ◽  
Fotios Iliadis ◽  
Christos Sambanis ◽  
Triantafyllos Didangelos

Objective: Sudomotor dysfunction is a feature of Diabetic Peripheral Neuropathy (DPN). The indicator plaster Neuropad can provide an easy and accurate way to diagnose DPN. The aim of the present study was to evaluate Neuropad’s specificity, sensitivity and accuracy in detecting DPN in patients with Diabetes Mellitus (DM). Methods: A total of 174 patients with DM (79 with type 1 DM, 88 women), mean age 49.8 ± 16.1 years and mean DM duration 17.3 ± 7.7 years were included in the present study. The following methods were used to diagnose DPN: the Michigan Neuropathy Screening Instrument Questionnaire and Examination (MNSIQ and MNSIE, respectively), application of 10 g monofilament (MONO) and measurement of vibration perception threshold with biothesiometer (BIO). Neuropad was applied to both feet in all patients and according to the presence or absence of color change of the sticker, patients were divided in two groups: group A (n = 82, complete change in color from blue to pink, depicting normal perspiration) and group B (n = 92, incomplete or no change, depicting abnormal perspiration). Results: MNSIQ and MNSIE were positive for DPN in 111 and 119 patients, respectively. BIO was abnormal in 109 and MONO in 59 patients. Sensitivity of Neuropad testing was 95% vs. MONO, 73% vs. BIO, 73% vs. MNSIE and 75% vs. ΜNSIQ. Specificity was 69, 81, 90 and 92%, respectively and accuracy of the test was 78, 76, 78 and 83%, respectively. Conclusion: Neuropad has a high sensitivity and specificity in detecting DPN vs. MNSIQ, MNSIE and BIO. Neuropad has a high sensitivity but moderate specificity vs. MONO. The accuracy of the test was high in all measurements.


2017 ◽  
Vol 4 (1) ◽  
pp. 10
Author(s):  
Gurinder Mohan ◽  
Ranjeet Kaur ◽  
Aakash Aggarwal ◽  
Parminder Singh

Background: Diabetes mellitus is a hypercoagulable state associated with atherosclerosis leading to development of vascular complications, including microvascular complications.Methods: In our study a total of 60 diabetic patients with duration of diabetes more than 5 years, attending the OPD/ indoor of SGRDIMSR, Amritsar, Punjaqqb, India were included. They were divided in two groups, group A of 30 patients including diabetics with any of the three microvascular complications (diabetic nephropathy, diabetic retinopathy and diabetic neuropathy) and group B of 30 patients including diabetics without any microvascular complication. Group C comprised of 30 age and sex matched non-diabetic subjects who served as controls. Subjects with liver cirrhosis, malignancy or coagulation disorder were excluded. After taking the consent, detailed history taking and detailed physical examination and relevant investigations were done. The serum fibrinogen (hemostasis marker), HBA1C and UACR (urine albumin creatinine ratio) along with routine investigations were measured.Results: It was observed that serum fibrinogen levels were significantly higher in diabetic patients (266.16±54.73 mg/dl) as compared to non-diabetic controls (174.66±18.32 mg/dl); p <0.001.Further, serum fibrinogen levels were found to be significantly higher in diabetic patients with microvascular complications (293.43±51.09 mg/dl) as compared to those without microvascular complications (238.90±44.12); p<0.001.Conclusions: Significantly high serum fibrinogen level was found in diabetic patients as compared to controls and was in positive correlation with development of microvascular complications.


2019 ◽  
Vol 2019 ◽  
pp. 1-9 ◽  
Author(s):  
Erica Shih-Wei Hung ◽  
Shih-Ching Chen ◽  
Fan-Chien Chang ◽  
Yaojung Shiao ◽  
Chih-Wei Peng ◽  
...  

Purpose. This study evaluated the effects of interactive video game-based (IVGB) exercise on balance in diabetic patients with peripheral neuropathy. Materials and Methods. Twenty-four patients were randomly assigned to two groups (12 participants per group). Group A received IVGB training for the first 6 weeks, with no exercise in the subsequent 6 weeks. Group B had no exercise for the first 6 weeks and then underwent IVGB training in the subsequent 6 weeks. For all participants, the Modified Falls Efficacy Scale (MFES), Time Up and Go (TUG) test, Berg Balance Scale (BBS), and Unipedal Stance Test (UST) were employed at weeks 0, 6, and 12 of the experiment. Results. BBS, right-leg UST, and TUG test scores significantly improved after IVGB intervention, whereas MFES and left-leg UST tended to improve after IVGB intervention. Conclusions. This study revealed that 6-week balance-based exercise training using the IVGB system exerted positive effects on functional balance in patients with diabetic peripheral neuropathy (DPN).


2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e18212-e18212
Author(s):  
Ernesto Gil Deza ◽  
Julio Cesar Bragagnolo ◽  
Eduardo L. Morgenfeld ◽  
Marta Dragosky ◽  
Natasha Gercovich ◽  
...  

e18212 Background: Numerous studies have evaluated the unfavorable impact of diabetes mellitus (DM) on cancer evolution. The objective of this paper is to study the coexistence of DM and cancer diagnosis; and its influence on the evolution of a cohort followed at IOHM. Methods: Between 9/26/2012 and 11/28/2018 all new patients (Pt) admitted to IOHM filled out a Past Medical History Form (PMHF) (ASCO 2013 ABST. e17539) with their preexisting clinical conditions.The database was locked and anonymized. Those with a history of DM or who were taking insulin and/ or oral antidiabetics were selected (Group A). The stage and evolution of their tumors were compared with those of non-diabetic patients (Group B). Results: Out of 15,617 Pt, 1,829 Pt (11,7%) had DM (Group A); 1,087 Pt were being treated with oral hypoglycemics (59%); 178 Pt with insulin (10%) and 564 Pt (31%) were not on antidiabetics drugs. They were compared to 13,788 Pt without DM (Group B). Oncological treatment was similar in both groups. Mortality was greaterin DM Patients adjusted by sex, age, PS, BMI, Dx and stage; Multivariate Cox Regression (p = 0.0001). The results are presented in the chart below. Conclusions: 1) In a cohort of 15,617 cancer Pt, 11,7% had DM. 2) DM Pt's tumors were more advanced. 3) Under similar treatments, DM Pt presented higher mortality. 4) Based on this, we advocate for DM in oncological Pt to be considered as an independent adverse factor.[Table: see text]


2020 ◽  
Vol 25 (2) ◽  
pp. 116-124
Author(s):  
Uzzal Chandra Ghosh ◽  
Md Abu Yusuf Fakir ◽  
Husne Qumer Osmany ◽  
Dipankar Lodh ◽  
Md Zahirul Islam ◽  
...  

Background: Diabetes mellitus (DM) is a chronic systemic disease characterized by hyperglycemia due to absolute or relative deficiency of insulin and affects several systems including hearing. It was evidenced that hearing loss is twice as common in people with diabetes in comparison to other non-diabetic individuals. Although there is no epidemiological information are available in Bangladesh, but it can assume that the number would not be less. Methods: This study was a hospital based case-control study conducted at department of ENT & department of Endocrinology for 1.5 year following approval of the protocol. Total 110 people (55 cases and 55 controls) were selected and analysed in this study. All the patients were divided into two groups: Group A (all patients with Diabetes) and Group B (persons without diabetes). For analysis group A were considered as case and group B were as control. Written informed consent was taken from all case and control subjects. A detailed history taking including hearing loss, duration, onset, associated symptoms & diabetes duration, treatment were obtained from the subject. A detailed ENT examination including otoscopic examination and tuning fork test were also conducted for each patient. Moreover, audiometric assessment-PTA, blood investigation-RBS, HbA1C, & renal parameters like blood urea & serum creatinine were tested in each cases. Data analysis was done in the statistical program Statistical Package for Social Science (SPSS) version 16.0. Results: Out of total 55 patients in each group, mean age of Diabetic and non-diabetic were 46.78±8.02 SD and 46.72±8.09 SD (years) with slight female predominance (45.5% vs 54.5% in diabetic group and 49.1% vs 50.9% in non-diabetic group). Bangladesh J Otorhinolaryngol; October 2019; 25(2): 116-124


Author(s):  
Bantupalli Suranjan ◽  
Atluri Deekshit ◽  
Bala Yaswanth Kumar S ◽  
Gutha Bala Teja

Background and Objectives: The purpose of this study is to evaluate the pulmonary functions in patients with diabetes. Many studies additionally counsel that the respiratory organ as an organ in diabetes and glycemic exposure could also be an effort issue for reduced respiratory organ operate. Systemic inflammation, hypoxemia, oxidative stress, altered gas exchange, and changes in lung tissues were the major impacts on the respiratory system which were induced by hypoglycemia. Methods: Forty individual patients of both sexes were involved in the study and divided into two groups depending on their conditions. Group A consists of individuals without any complications or any disease conditions and group B consists of diabetic patients excluding smokers and divided into twenty to each group. Results: SPSS software was used for the analysis and spirometry was the device used to determine the pulmonary function. Values of Forced Expiratory Volume 1, Forced Vital Capacity, Forced Expiratory Flow, FEV% were only considered in the study and the study results conclude that diabetes shows its effect on the lungs in long term and leads to a decrease in lung function. Conclusion: It was concluded that that monitoring the Pulmonary function tests of the diabetic patients helps the individuals to avoid any complications further ahead and also it helps to ease the flow of the recovery and also prevent further more comorbidity that might arise in the future.                           Peer Review History: Received: 1 September 2021; Revised: 10 October; Accepted: 4 October, Available online: 15 November 2021 Academic Editor:  Dr. A.A. Mgbahurike, University of Port Harcourt, Nigeria, [email protected] UJPR follows the most transparent and toughest ‘Advanced OPEN peer review’ system. The identity of the authors and, reviewers will be known to each other. This transparent process will help to eradicate any possible malicious/purposeful interference by any person (publishing staff, reviewer, editor, author, etc) during peer review. As a result of this unique system, all reviewers will get their due recognition and respect, once their names are published in the papers. We expect that, by publishing peer review reports with published papers, will be helpful to many authors for drafting their article according to the specifications. Auhors will remove any error of their article and they will improve their article(s) according to the previous reports displayed with published article(s). The main purpose of it is ‘to improve the quality of a candidate manuscript’. Our reviewers check the ‘strength and weakness of a manuscript honestly’. There will increase in the perfection, and transparency.  Received file:                Reviewer's Comments: Average Peer review marks at initial stage: 5.5/10 Average Peer review marks at publication stage: 7.0/10 Reviewers: Kolawole Oyetunji Timothy, Department of Pharmacology and Therapeutics, Ladoke Akintola University of Technology, Ogbomoso, Nigeria. [email protected] Dr. Nuray Arı, Ankara University, Turkiye, [email protected] Rima Benatoui, Laboratory of Applied Neuroendocrinology, Department of Biology, Faculty of Science, Badji Mokhtar University Annaba, BP12 E L Hadjar–Algeria, [email protected] Similar Articles: CLINICAL COURSE AND DISEASE OUTCOME IN COVID-19 PATIENTS WITH DIABETES MELLITUS THE RELATIONSHIP BETWEEN DIABETES MELLITUS AND TUBERCULOSIS IN REVIEW OF PREVALENCE, DIAGNOSTICS AND PREVENTION


2018 ◽  
Vol 10 (1) ◽  
pp. 72-76
Author(s):  
Dipesh Karki ◽  
Amar Nagila ◽  
Niraj Dhakal ◽  
Sumit Chhetri

Background: Diabetic peripheral neuropathy (DPN) is a most common micro vascular complication of diabetes posing significant morbidity and mortality with early and insidious onset. Studies has variably pointed that older age, gender, duration of diabetes, dyslipidemia, are linked with development of DPN. Aims and Objectives: To determine the prevalence of neuropathy in diabetic patients and see its link with age, gender, duration of diabetes, therapy and ethnicity. Materials and Methods: This is a cross-sectional study involving 110 clinically diagnosed diabetic patients, meeting the inclusion criteria. Basic demographic data were taken during clinical examination. Presence of degree of neuropathy was screened by measuring vibration perception threshold using Biothesiometer. Data was entered on SPSS and were categorized, necessary non parametric statistical tests were applied to these categorical variables as needed. The level of significance was set at p value less than 0.05. Results: Presence of neuropathy was measured in 110 diabetic patients. The overall prevalence of DPN was 45.45%. Frequency of neuropathy was higher with increase in age with 72.7% in more than 60 years of age and 23.5% in less than or equal to 40 years of age group (p=0.007). Similarly, the increasing trend of DPN with increase in duration of DM was evident in this study with DPN present in more than 55% of patients with more than 5 years of diabetes(p=0.004). Conclusion: The prevalence rate of DPN in diabetes was observed to be higher (45.45%). Our result suggested that DPN is associated with old age and the duration of diabetes mellitus. Asian Journal of Medical Sciences Vol.10(1) 2019 72-76


2019 ◽  
Vol 48 (1) ◽  
pp. 5-12
Author(s):  
Shaila Sharmin ◽  
Fatema Newaz ◽  
Syed Mozaffor Ahmed ◽  
Abu Shahin ◽  
Md Israt Hasan ◽  
...  

Diabetes mellitus is associated with several musculoskeletal (MSK) disorders. Due to increased incidence and life expectancy causes increased prevalence and clinical importance of MSK alterations in diabetic subjects. It is difficult to find out the direct relation with metabolic control. This study was conducted to explore the pattern of musculoskeletal disorders in the diabetic patients. A cross-sectional study was conducted from January' 2016 to June' 2016 at Department of Physical Medicine and Rehabilitation, Bangabandhu Sheikh Mujib Medical University, Dhaka with 190 cases divided in two groups. Patients aged 40-70 years with musculoskeletal disorder with diabetes mellitus (type 2) for five years attending in the department of Physical Medicine and Rehabilitation were included in group A. Patients with MSK disorder without diabetes aged 40- 70 years were included in group B. Main outcome measures were done by Chi square test and unpaired t test were calculated by using SPSS-20. Out of 190 patients, more than half (53.68%) patients were belonged to age 51- 60 years in group A and 49(51.58%) in group B. Majority (56.84%) patients were female in group A and 43(45.26%) in group B. Twenty three (24.21%) patients were house wives in group A and 25(26.32%) in group B. Fifty two (54.73%) patients had osteoarthritis of knee in group A and 26(27.36%) in group B. Twenty one (22.11%) patients had frozen shoulder in group A and 9(9.47%) in group B. Sixteen (16.84%) patients had Flexor tenosynovitis in group A and 04(4.21%) in group B. Fifteen (15.78%) patients had Fibromyalgia in group A and 05(5.26%) in group B. Twelve (12.63%) patients had Planter fascities in group A and 03(3.16%) in group B. Which were statistically significant (p<0.05) but other musculoskeletal disorders were not statistically significant (p>0.05) between two groups. More than half patients were belonged to age 51-60 years and female were predominate in both groups. Common musculoskeletal disorders in diabetic patients were osteoarthritis of knee, frozen shoulder, Flexor tenosynovitis, Fibromyalgia, Planter fascities, Rheumatoid arthritis, Carpel tunnel syndrome, Lumbar spondylosis, Cervicalspondylosis and DISH. This study will also be helpful for different organizations working in this area including physiatrist in their program for delivering a comprehensive treatment service. As a result patients were more benefited. Bangladesh Med J. 2019 Jan; 48 (1): 5-12


2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Shan Lu ◽  
Zhiheng Xing ◽  
Shiyu Zhao ◽  
Xianglu Meng ◽  
Juhong Yang ◽  
...  

COVID-19 is a kind of pneumonia with new coronavirus infection, and the risk of death in COVID-19 patients with diabetes is four times higher than that in healthy people. It is unclear whether there is a difference in chest CT images between type 2 diabetes mellitus (T2DM) and non-diabetes mellitus (NDM) COVID-19 patients. The aim of this study was to investigate the differences in chest CT images between T2DM and NDM patients with COVID-19 based on a quantitative method of artificial intelligence. A total of 62 patients with COVID-19 pneumonia were retrospectively enrolled and divided into group A (T2DM COVID-19 pneumonia group, n = 15) and group B (NDM COVID-19 pneumonia group, n = 47). The clinical and laboratory examination information of the two groups was collected. Quantitative features (volume of consolidation shadows and ground glass shadows, proportion of consolidation shadow (or ground glass shadow) to lobe volume, total volume, total proportion, and number) of chest spiral CT images were extracted using Dr. Wise @Pneumonia software. The results showed that among the 26 CT image features, the total volume and proportion of bilateral pulmonary consolidation shadow in group A were larger than those in group B ( P = 0.031 and 0.019, respectively); there was no significant difference in the total volume and proportion of bilateral pulmonary ground glass density shadow between the two groups ( P > 0.05 ). In group A, the blood glucose level was correlated with the volume of consolidation shadow and the proportion of consolidation shadow to right middle lobe volume, and higher than those patients in group B. In conclusion, the inflammatory exudation in the lung of COVID-19 patients with diabetes is more serious than that of patients without diabetes based on the quantitative method of artificial intelligence. Moreover, the blood glucose level is positively correlated with pulmonary inflammatory exudation in COVID-19 patients.


2006 ◽  
Vol 13 (04) ◽  
pp. 508-510
Author(s):  
MOHAMMAD JAWAID SABZWARI ◽  
MUKHTAR AHMAD ◽  
MUHAMMAD TAHIR MAJEED ◽  
Muhammad Riaz ◽  
Muhammad Umair

Sialic Acid (SA) is an acetylated product of neuraminic acid. In presentstudy, the relationship between sialic acid and type II diabetic patients was investigated. Ninety (90) subjects, 41 malesand 49 females, were included in the study. They were divided into two groups according to presence or absence oftype II diabetes mellitus (DM). Group A comprised of 72 patients with type II DM and group B 18 subjects withoutdiabetes mellitus as a control group. The following parameters were assessed: sialic acid, blood glucose, lipid profile(serum triglycerides and total cholesterol) and HbA1c. Type II DM Patients had higher levels (P<0.05) of sialic acid(2.259±0.252 mmol/L) as compared to the control group (2.048±0.32 mmol/L).


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