scholarly journals Prenatal Diagnosis of Atrioventricular Block and QT Interval Prolongation by Fetal Magnetocardiography in a Fetus with Trisomy 18 and SCN5A R1193Q Variant

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Lisheng Lin ◽  
Miho Takahashi-Igari ◽  
Yoshiaki Kato ◽  
Yoshihiro Nozaki ◽  
Mana Obata ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Atrioventricular Block ◽  
Qt Interval ◽  
Ventricular Arrhythmias ◽  
Sinus Bradycardia ◽  
Trisomy 18 ◽  
Interval Prolongation ◽  
Fetal Magnetocardiography ◽  
Qt Interval Prolongation ◽  
Ultrasound Findings

We report a case of fetal trisomy 18 with SCN5A R1193Q variant that presented with sinus bradycardia, 2 : 1 atrioventricular block (AVB), and QT interval prolongation. These complex arrhythmias were diagnosed by fetal magnetocardiography combined with ultrasound findings. Advanced AVB and ventricular arrhythmias were confirmed after birth. Genetic testing of the baby revealed a SCN5A R1193Q variant, which we considered could account for the various arrhythmias in this case.

scholarly journals Persistent bradycardia after hypoglycaemia: a case report and a brief literature review

2019 ◽  
Vol 5 (1) ◽  
Author(s):  
Beatrice Gasperini ◽  
Pierpaolo Lamanna ◽  
Rocco Serra ◽  
Roberto Montanari ◽  
Antonio Cherubini ◽  
...  
Keyword(s):  
Cardiac Arrhythmias ◽  
Qt Interval ◽  
Ventricular Arrhythmias ◽  
Clinical Case ◽  
Sinus Bradycardia ◽  
Qt Prolongation ◽  
Hypoglycaemic Episode ◽  
Supraventricular Arrhythmias ◽  
Interval Prolongation ◽  
Qt Interval Prolongation

Hypoglycaemia can cause cardiac arrhythmias such as QT interval prolongation and ventricular arrhythmias. Supraventricular arrhythmias and sinus bradycardia were rarely reported. We present the clinical case of an 84- year-old man who developed a persistent bradycardia after a hypoglycaemic episode. After restoration of normoglycaemia, bradycardia persisted for almost eighteen hours, without QT prolongation or any symptoms. Hypoglycaemia is an unusual cause of bradyarrhytmias mainly mediated by neurologic and endocrine systems. Our clinical case supports recent recommendations for more relaxed inpatient glycaemic targets in frail older adults who may be particularly vulnerable to hypoglycaemia and its consequences.

scholarly journals QT interval prolongation in patients with acute ischemic stroke: a report in northwest China

2019 ◽  
Vol 47 (12) ◽  
pp. 5986-5995
Author(s):  
Jine Wu ◽  
Dilimulati Nizhamuding ◽  
Peng Liu ◽  
Yongrong Jiang ◽  
Hua Qiang ◽  
...  
Keyword(s):  
Ischemic Stroke ◽  
Acute Ischemic Stroke ◽  
Qt Interval ◽  
Sinus Bradycardia ◽  
Clinical Information ◽  
Interval Prolongation ◽  
Stroke Patients ◽  
Neurological Intensive Care Unit ◽  
Qt Interval Prolongation ◽  
Malignant Arrhythmia

Aims QT interval prolongation is common in patients with stroke and increases the risk of malignant arrhythmia and sudden death. Our aim was to analyze differences in the QT interval and electrocardiogram abnormalities between acute ischemic stroke patients and controls. Methods We retrospectively collected data from 273 patients with acute ischemic stroke from the neurological intensive care unit and 495 controls from other departments. A standard 12-lead electrocardiogram was recorded within 24 hours of hospitalization. Clinical information, the QT interval corrected for heart rate (QTc), and the incidence of electrocardiogram abnormalities were compared between groups. Results There was no difference in age, sex, or the prevalence of hypertension or diabetes mellitus between the acute ischemic stroke group and controls. Acute ischemic stroke patients showed a significantly longer QTc and a higher incidence of both sinus bradycardia and ST-T changes compared with controls. We also showed that the changes in electrocardiogram results observed in acute ischemic stroke might be transient. Conclusion Acute ischemic stroke patients may have a longer QT interval and a higher incidence of electrocardiogram abnormalities. In clinical practice, careful attention should be paid to acute ischemic stroke patients to prevent malignant arrhythmia.

scholarly journals Transient Long QT Development in a Patient with Takotsubo Cardiomyopathy

2016 ◽  
Vol 2 (2) ◽  
pp. 81-84
Author(s):  
Dániel Czuriga ◽  
Andrea Szegedi ◽  
Ferenc Győry ◽  
Attila Szilágyi ◽  
Sándor Sipka ◽  
...  
Keyword(s):  
Takotsubo Cardiomyopathy ◽  
Long Qt Syndrome ◽  
Qt Interval ◽  
Ventricular Arrhythmias ◽  
Interval Prolongation ◽  
Long Qt ◽  
Electrolyte Disturbances ◽  
Acquired Long Qt Syndrome ◽  
Qt Interval Prolongation ◽  
Qt Syndrome

Abstract QT interval prolongation on the electrocardiogram is considered a precursory sign for imminent, potentially lethal ventricular arrhythmias. Beside the inherited condition of long QT syndrome, numerous drugs, certain electrolyte disturbances and early transmural ischemia have been identified to induce reversible prolongation of the QT interval, collectively called as acquired long QT syndrome. Herein we describe a case of a patient with transient QT prolongation and Takotsubo cardiomyopathy, a rather infrequent cause of long QT development. Serial changes of the repolarization pattern were documented to demonstrate progression and resolution of the abnormal QT interval.

scholarly journals Life Threatening Severe QTc Prolongation in Patient with Systemic Lupus Erythematosus due to Hydroxychloroquine

2016 ◽  
Vol 2016 ◽  
pp. 1-4 ◽  
Author(s):  
John P. O’Laughlin ◽  
Parag H. Mehta ◽  
Brian C. Wong
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Qt Interval ◽  
Ventricular Arrhythmias ◽  
Interval Prolongation ◽  
Systemic Lupus ◽  
Qt Interval Prolongation ◽  
Life Threatening ◽  
Stage Renal Disease ◽  
End Stage

We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discontinued and the patient’s QT interval shortened. The patient was treated with mexiletine to prevent sudden ventricular arrhythmias, which was unique compared to other documented cases in which lidocaine was used. The patient was noted to have mild prolongation of the QT interval on electrocardiogram prior to initiation of hydroxychloroquine therapy which was exacerbated by its use and may have been caused due to toxicity from underlying renal failure.

scholarly journals Opioids and Cardiac Arrhythmia: A Literature Review

2018 ◽  
Vol 27 (5) ◽  
pp. 401-414 ◽  
Author(s):  
Mina Behzadi ◽  
Siyavash Joukar ◽  
Ahmad Beik
Keyword(s):  
High Risk ◽  
Qt Interval ◽  
Sinus Bradycardia ◽  
Torsades De Pointes ◽  
Interval Prolongation ◽  
Long Qt ◽  
Qt Interval Prolongation ◽  
Long Qt Interval ◽  
High Doses ◽  
Cardiac Block

Objective: One of the most important side effects of opioids is their influence on the electrical activity of the heart. This review focusses on the effects of opioids on QT interval prolongation and their arrhythmogenic liability. Methods: By using various keywords, papers published up to 2018 in different databases were searched and identified. The search terms were opioids names, corrected QT interval, human-ether-a-go-go gene, torsades de pointes (TdP), cardiac arrhythmias, opioid dependence and other relevant terms. It emphasized the effects of each opioid agent alone on electrocardiogram (ECG) and some interactions. Results: Available data indicate that some opioids such as methadone are high-risk even at low doses, and have potential for prolongation of the QT interval and development of TdP, a dangerous ventricular tachycardia. A number of opioids such as tramadol and oxycodone are intermediate risk drugs and may develop long QT interval and TdP in high doses. Some other opioids such as morphine and buprenorphine are low-risk drugs and do not produce QT interval prolongation and TdP at least in routine doses. Opium-consumers are at higher risk of supra-ventricular arrhythmias, sinus bradycardia, cardiac block and atrial fibrillation. Conclusion: The cardiac arrhythmogenicity of various opioids is different. Methadone has a higher capability to induce long QT interval and dangerous arrhythmias in conventional doses than others. To reduce of arrhythmogenic risk, high doses of opioids must be used cautiously with periodic monitoring of ECG in high-risk consumers such as patients under opioid maintenance treatment.

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