scholarly journals Aqueous Extracts of Herba Cistanche Promoted Intestinal Motility in Loperamide-Induced Constipation Rats by Ameliorating the Interstitial Cells of Cajal

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Shuai Yan ◽  
Yin-zi Yue ◽  
Xiao-peng Wang ◽  
Hong-li Dong ◽  
Shu-guang Zhen ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Colonic Motility ◽  
Functional Constipation ◽  
Serum Levels ◽  
Interstitial Cells ◽  
Slow Transit Constipation ◽  
Mrna Levels ◽  
Aqueous Extracts ◽  
Slow Transit ◽  
Cells Of Cajal

Traditional Chinese medicine was reported to have good effects in treating functional constipation. This work attempted to prove the effects of aqueous extracts of Herba Cistanche (AEHC) on STC treatment and to determine the possible mechanisms by a loperamide-induced slow transit constipation (STC) model. HPLC was performed for identification and confirmation of the bioactive components in the AEHC. It was found that AEHC attenuated STC responses based on increased fecal quantity, moisture content, and intestinal transit rate, as well as serum levels of GAS, MTL, SS, and CGRP. The protein and mRNA levels of c-kit, a labeling of interstitial cells of Cajal (ICC), also increased. Meanwhile, only the protein level of SCF, a ligand of c-kit, increased. The analysis of our data suggested that AEHC could obviously improve the function of ICC via a signaling pathway involving PI3K, SCF, and c-kit and enhance colonic motility indices such as GAS, MTL, SS, and CGRP. It is interesting to note that AEHC appeared to be effective on constipation, so further experiments are necessary to clarify the exact mechanisms involved.

265 Immunoreactivity for Ano1 Detects Depletion of Interstitial Cells of Cajal in Patients with Slow Transit Constipation

2009 ◽  
Vol 136 (5) ◽  
pp. A-51
Author(s):  
Purna C. Kashyap ◽  
Pedro J. Gomez-pinilla ◽  
Matthew S. Lurken ◽  
Robert R. Cima ◽  
Eric J. Dozois ◽  
...  
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Interstitial Cells ◽  
Slow Transit Constipation ◽  
Slow Transit ◽  
Cells Of Cajal ◽  
Transit Constipation

scholarly journals Interstitial cells of Cajal and human colon motility in health and disease

2021 ◽  
Author(s):  
Jan D. Huizinga ◽  
Amer Hussain ◽  
Ji-Hong Chen
Keyword(s):  
Interstitial Cells Of Cajal ◽  
Colonic Motility ◽  
Human Colon ◽  
Interstitial Cells ◽  
Motor Dysfunction ◽  
Slow Transit Constipation ◽  
Motor Patterns ◽  
Colonic Motor ◽  
Cells Of Cajal

Our understanding of human colonic motility, and autonomic reflexes that generate motor patterns, has increased markedly through high-resolution manometry. Details of the motor patterns are emerging related to frequency and propagation characteristics that allow linkage to interstitial cells of Cajal (ICC) networks. In studies on colonic motor dysfunction requiring surgery, ICC are almost always abnormal or significantly reduced. However, there are still gaps in our knowledge about the role of ICC in the control of colonic motility and there is little understanding of a mechanistic link between ICC abnormalities and colonic motor dysfunction. This review will outline the various ICC networks in the human colon and their proven and likely associations with the enteric and extrinsic autonomic nervous systems. Based on our extensive knowledge of the role of ICC in the control of gastrointestinal motility of animal models and the human stomach and small intestine, we propose how ICC networks are underlying the motor patterns of the human colon. The role of ICC will be reviewed in the autonomic neural reflexes that evoke essential motor patterns for transit and defecation. Mechanisms underlying ICC injury, maintenance, and repair will be discussed. Hypotheses are formulated as to how ICC dysfunction can lead to motor abnormalities in slow transit constipation, chronic idiopathic pseudo-obstruction, Hirschsprung's disease, fecal incontinence, diverticular disease, and inflammatory conditions. Recent studies on ICC repair after injury hold promise for future therapies.

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