scholarly journals Atlantoaxial Misalignment Causes High Blood Pressure in Rats: A Novel Hypertension Model

2017 ◽  
Vol 2017 ◽  
pp. 1-8
Author(s):  
Zong-Bao He ◽  
You-Kui Lv ◽  
Hui Li ◽  
Qiong Yao ◽  
Ke-Ming Wang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Animal Model ◽  
High Blood Pressure ◽  
Underlying Mechanism ◽  
Heart Rates ◽  
Surgery Group ◽  
Before And After ◽  
The Relationship

Atlantoaxial disorders are often correlated with hypertension in practice. In order to study the relationship between atlantoaxial disorder and hypertension, we attempted to construct an animal model. In this work, we presented an animal model where their atlantoaxial joints were misaligned. We investigated the changes of blood pressure before and after treatments of the modeled rats. We had the following results. (1) SBP and DBP of each surgery group were significantly higher than those of control and sham groups. (2) After the second operation (the fixture was removed), SBP and DBP of both surgery groups decreased and got closer to the control and sham groups after 7 days. (3) Heart rates got significantly higher in both surgery groups, compared to control and sham groups. (4) The blood Ach levels of the surgery groups were significantly lower than those of control and sham groups. With these results, we concluded that we successfully constructed cervical atlantoaxial disorder models in rats that showed hypertension symptom. However, the underlying mechanism connecting atlantoaxial disorder and hypertension still requires further study.

Risk assessment of occupational and occupationally conditioned diseases connection to noise when exceeding maximum permissible levels

2019 ◽  
pp. 17-19
Author(s):  
Vladimir A. Fokin ◽  
Dmitrii M. Shlyapnikov ◽  
Svetlana V. Red’ko
Keyword(s):  
Blood Pressure ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
High Blood Pressure ◽  
Noise Exposure ◽  
Physical Factors ◽  
Autonomic Nervous ◽  
Permissible Levels ◽  
The Relationship ◽  
Perm Region

In accordance with the requirements of paragraph 3.2.6 of sanitary rules and norms «Sanitary and epidemiological requirements for physical factors at workplace», in the event of exceeding noise level at workplace above 80 dBA, an employer is obliged to assess the health risk of workers and confirm an acceptable risk to their health. The connection between the incidence of occupational and occupationally conditioned diseases with noise exposure exceeding the maximum permissible levels (80 dBA) was estimated. The assessment was carried out at a food industry enterprise of Perm Region. Assessing the relationship between morbidity and noise exposure is the first step in evaluation of occupational health risks for workers exposed to noise exceeding MAL. If a reliable relationship between morbidity and noise exposure is established, an assessment of occupational risk is conducted. The odds ratio (OR) for diseases characterized by high blood pressure and disorders of autonomic nervous system was <1 (confidence interval CI=0.11–1.61 and CI=0.08–2.78, respectively). The relative risk (RR) for diseases characterized by high blood pressure and disorders of autonomic nervous system was <1. The received data testify absence of connection of morbidity with exposure to industrial noise, calculation of etiological share of responses and levels of risk is not required.

scholarly journals Effect of Music on Blood Pressure and Heart Rate in Patients Undergoing Cataract Extraction Surgery

2021 ◽  
Vol 10 (20) ◽  
pp. 1474-1478
Author(s):  
Aditi Gadegone ◽  
Sachin Daigavane ◽  
Ruta Walavalkar
Keyword(s):  
Blood Pressure ◽  
Local Anaesthesia ◽  
Large Population ◽  
Cost Effective ◽  
Cataract Extraction ◽  
Topical Anaesthesia ◽  
Heart Rates ◽  
Prevalence Studies ◽  
Before And After ◽  
Anxiety Levels

BACKGROUND Music is an inexpensive, easily available anxiolytic known to mankind since ages. Cataract extraction surgery is one of the widely performed surgeries under local anaesthesia. India is a developing country where limited resources are spent over health infrastructure which has to cater to a large population. In our study we have tried to utilize the anxietolytic effect of music in combating the anxiety and stress patients suffer during surgery. METHODS In this prospective, interventional study, 300 patients diagnosed with senile cataract were selected. The sample size was decided taking into consideration various prevalence studies. The patients were consequently recruited for the study considering the inclusion and exclusion criteria. Patients were divided into three groups - one undergoing phacoemulsification surgery under topical anaesthesia and two groups undergoing phacoemulsification surgery under local anaesthesia by the same surgeon in a same operating room. Two groups including the one where topical anaesthesia was used were made to listen to ‘Classical Sitar Music’ whereas one group was not made to listen to music. Blood pressure and heart rates were measured before and after surgery and compared in all patients. RESULTS Blood pressure and heart rates were statistically significantly normalized (lowered) post-operatively when compared to their pre-operative values in groups which were made to listen to music. There was a marked decrease in the anxiety levels in patients who were operated under topical anaesthesia when compared to those operated under local anaesthesia. CONCLUSIONS Music can be widely used in decreasing anxiety levels in patients undergoing cataract extraction surgery thereby improving the post-operative prognosis in patients in a cost-effective way. KEY WORDS Phacoemulsification Surgery, Classical Sitar Music, Peri-Bulbar Block, Topical Anaesthesia, Anxiety, Blood Pressure, Pulse Rate

scholarly journals Low Birthweight Is Associated with Higher Risk of High Blood Pressure in Chinese Girls: Results from a National Cross-Sectional Study in China

2019 ◽  
Vol 16 (16) ◽  
pp. 2898
Author(s):  
Xijie Wang ◽  
Yanhui Dong ◽  
Zhiyong Zou ◽  
Jun Ma ◽  
Zhaogeng Yang ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Low Birthweight ◽  
Cross Sectional Study ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
School Based ◽  
Chi Squared ◽  
Chinese Girls ◽  
The Relationship

Objective: To investigate the relationship between low birthweight (LBW) and blood pressure and to assess whether LBW leads to a higher risk of high blood pressure (HBP) by gender in Chinese students aged 6–18 years. Also, to investigate whether the association was affected by childhood obesity. Methods: Data was obtained from a baseline dataset of a national school-based program. Anthropometric parameters, including height, weight, and blood pressure, were measured, while birthweight and other characteristics were obtained from questionnaires. Stratified chi-squared tests were used to compare the prevalence of HBP between LBW and normal birthweight (NBW) groups in each age and sex category. Multivariable logistic regressions were conducted to estimate the HBP risks in each birthweight group. Results: Both systolic and diastolic blood pressure showed a U-shaped relationship with increased birthweight. Compared to NBW groups, LBW girls showed a higher HBP risk, with an odds ratio of 1.29 (95% confidence interval (CI): 1.02, 1.64, p = 0.033), regardless of their current body mass index status, while no significant association in boys was found. Conclusions: Low birthweight is associated with higher HBP risk in adolescent girls, regardless of their childhood BMI status.

scholarly journals Contribution of BKCa channels to local metabolic coronary vasodilation: effects of metabolic syndrome

2010 ◽  
Vol 298 (3) ◽  
pp. H966-H973 ◽  
Author(s):  
Léna Borbouse ◽  
Gregory M. Dick ◽  
Gregory A. Payne ◽  
Brittany D. Payne ◽  
Mark C. Svendsen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Heart Rate ◽  
Atherogenic Diet ◽  
Bkca Channels ◽  
Selective Blockade ◽  
Before And After ◽  
Lactate Uptake ◽  
Exercise Induced ◽  
The Relationship

This investigation was designed to examine the hypothesis that impaired function of coronary microvascular large-conductance Ca2+-activated K+ (BKCa) channels in metabolic syndrome (MetS) significantly attenuates the balance between myocardial oxygen delivery and metabolism at rest and during exercise-induced increases in myocardial oxygen consumption (MV̇o2). Studies were conducted in conscious, chronically instrumented Ossabaw swine fed a normal maintenance diet (11% kcal from fat) or an excess calorie atherogenic diet (43% kcal from fat, 2% cholesterol, 20% kcal from fructose) that induces many common features of MetS. Data were collected under baseline/resting conditions and during graded treadmill exercise before and after selective blockade of BKCa channels with penitrem A (10 μg/kg iv). We found that the exercise-induced increases in blood pressure were significantly elevated in MetS swine. No differences in baseline cardiac function or heart rate were noted. Induction of MetS produced a parallel downward shift in the relationship between coronary venous Po2 and MV̇o2 ( P < 0.001) that was accompanied by a marked release of lactate (negative lactate uptake) as MV̇o2 was increased with exercise ( P < 0.005). Inhibition of BKCa channels with penitrem A did not significantly affect blood pressure, heart rate, or the relationship between coronary venous Po2 and MV̇o2 in lean or MetS swine. These data indicate that BKCa channels are not required for local metabolic control of coronary blood flow under physiological (lean) or pathophysiological (MetS) conditions. Therefore, diminished function of BKCa channels does not contribute to the impairment of myocardial oxygen-supply demand balance in MetS.

The Relationship between Religious Activities and Blood Pressure in Older Adults

1998 ◽  
Vol 28 (2) ◽  
pp. 189-213 ◽  
Author(s):  
Harold G. Koenig ◽  
Linda K. George ◽  
Judith C. Hays ◽  
David B. Larson ◽  
Harvey J. Cohen ◽  
...  
Keyword(s):  
Blood Pressure ◽  
Older Adults ◽  
High Blood Pressure ◽  
Religious Activity ◽  
Religious Activities ◽  
The Bible ◽  
Lower Blood ◽  
Religious Services ◽  
Blood Pressures ◽  
The Relationship

Objective: To examine the relationship between religious activities and blood pressure in community-dwelling older adults. Method: Blood pressure and religious activities were assessed in a probability sample of 3,963 persons age sixty-five years or older participating in the Duke EPESE survey. Participants were asked if their doctor had ever informed them that they had high blood pressure and if they were currently taking medication for high blood pressure. After the interview, systolic and diastolic blood pressures were measured following a standardized protocol. Data were available for three waves of the survey (1986, 1989–90, and 1993–94). Analyses were stratified by age (65–74 vs. over 75) and by race (Whites vs. Blacks) and were controlled for age, race, gender, education, physical functioning, body mass index, and, in longitudinal analyses, blood pressure from the previous wave. Results: Cross-sectional analyses revealed small (1–4 mm Hg) but consistent differences in measured systolic and diastolic blood pressures between frequent (once/wk) and infrequent (< once/wk) religious service attenders. Lower blood pressures were also observed among those who frequently prayed or studied the Bible (daily or more often). Blood pressure differences were particularly notable in Black and younger elderly, in whom religious activity at one wave predicted blood pressures three years later. Among participants who both attended religious services and prayed or studied the Bible frequently, the likelihood of having a diastolic blood pressure of 90 mm Hg or higher was 40 percent lower than found in participants who attended religious services infrequently and prayed or studied the Bible infrequently (OR 0.60, 95% CI, 0.48–0.75, p < .0001). Among participants told they had high blood pressure, religiously active persons were more likely to be taking their blood pressure medication; this could not, however, explain the differences in blood pressure observed. While most religious activity was associated with lower blood pressure, those who frequently watched religious TV or listened to religious radio actually had higher blood pressures. Conclusions: Religiously active older adults tend to have lower blood pressures than those who are less active. This applies to attendance at religious services and private religious activities, but not to religious media. Physiological mechanisms are discussed.

scholarly journals THE RELATIONSHIP OF CORTISOL LEVELS WITH HIGH BLOOD PRESSURE IN RESIDENTS OF ST. PETERSBURG

2021 ◽  
Vol 39 (Supplement 1) ◽  
pp. e240
Author(s):  
Anastasia Erin ◽  
O. Rotar ◽  
E. Kolesova ◽  
M. Boyarinova ◽  
A. Alieva ◽  
...  
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Cortisol Levels ◽  
Relationship Of ◽  
The Relationship

scholarly journals CARDIOPROTECTIVE POTENTIAL OF PLANTS AND PLANT-DERIVED PRINCIPLES – A REVIEW

2019 ◽  
pp. 46-56
Author(s):  
NIKITHA G ◽  
RAJENDRA SANDUR V
Keyword(s):  
Blood Pressure ◽  
High Blood Pressure ◽  
Hypertensive Heart Disease ◽  
Underlying Mechanism ◽  
Blood Cholesterol ◽  
Pharmacological Effects ◽  
Coronary Artery Diseases ◽  
Ancient Times ◽  
Extraction Processes ◽  
Lack Of Exercise

Cardiovascular diseases (CVDs) are a class of diseases involving heart or blood vessels. Coronary artery diseases include angina, myocardial infarction (MI), stroke, heart failure, hypertensive heart disease, cardiomyopathy, and arrhythmias. CVDs are the leading cause of death globally. Risk factors include high blood pressure, smoking, obesity, poor diet, blood cholesterol, and lack of exercise. It is approximated that 90% of CVDs is preventable. High blood pressure results in 13% of CVD deaths, whereas tobacco outcomes in 9%, diabetes and lack of exercise in around 6%, and obesity in 5%. Due to certain medications such as anticancer drugs like doxorubicin, adverse effects result in MI. Since ancient times, medicinal plants have been widely used in the treatment of diseases. This information may serve as a primer in identifying novel prophylactic as well as therapeutic studies of plant-derived principles. The parts of the plants such as seeds, leaves, flowers, roots, and bark contain these phytoconstituents which are obtained through different extraction processes. Phytoconstituents are broadly classified into alkaloids, saponins, polyphenols, essential oils, carotenoids, glycosides, omega fatty acids, and flavonoids. Each class is responsible for its own pharmacological effects. The underlying mechanism in which they exert the action is different. This review presents an overview of the MI and therapeutic strategies of plant-derived principles that are available to mitigate the effect of MI.

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