scholarly journals Acute Hemorrhagic Edema of Infancy after Coronavirus Infection with Recurrent Rash

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Hannah Chesser ◽  
Jeffrey M. Chambliss ◽  
Eric Zwemer
Keyword(s):  
Laboratory Testing ◽  
Leukocytoclastic Vasculitis ◽  
Rapid Onset ◽  
Initial Presentation ◽  
Small Vessel ◽  
Low Grade ◽  
Large Target ◽  
The Face ◽  
Coronavirus Infection ◽  
Purpuric Rash

Purpura, particularly when accompanied by fever, is a worrisome finding in children. Acute hemorrhagic edema of infancy (AHEI) is a benign type of small-vessel leukocytoclastic vasculitis that presents with progressive purpura and has an excellent prognosis. Patients with AHEI present with large, target-like purpuric plaques affecting the face, ear lobes, and extremities. While the rapid onset of these skin findings can be dramatic, the child with AHEI is usually well appearing with reassuring laboratory testing. We describe a case of a previously healthy 8-month-old female who presented with progressive purpura in a nondependent distribution, low-grade fevers, and extremity swelling. An extensive workup was performed prior to making the diagnosis of AHEI. Coronavirus was implicated as the likely triggering pathogen, and the patient suffered a recurrence of purpuric rash and swelling several weeks after her initial presentation.

scholarly journals Case Report: Acute hemorrhagic edema of infancy (Seidlmayer purpura) – a dramatic presentation for a benign disease

F1000Research ◽  
2019 ◽  
Vol 8 ◽  
pp. 1771
Author(s):  
Elena Carboni ◽  
Maria Scavone ◽  
Ettore Stefanelli ◽  
Valentina Talarico ◽  
Stefania Zampogna ◽  
...  
Keyword(s):  
Leukocytoclastic Vasculitis ◽  
Skin Lesions ◽  
Rapid Onset ◽  
Cutaneous Lesions ◽  
Laboratory Findings ◽  
Distinct Disease ◽  
The Face ◽  
Clinical Conditions ◽  
Dramatic Presentation ◽  
Schonlein Purpura

We present a case of an 11-month-old girl who was referred to our unit for an erythematous rash that appeared on the face and extremities. Personal and family history was not relevant. Laboratory tests were normal. During recovery, diameter and colour intensity of the cutaneous lesions increased, but after some weeks, lesions had a self-limited resolution without any treatment. Based on clinical and laboratory findings, a diagnosis of acute hemorrhagic edema of infancy (AHEI) was made.  AHEI is a rare cutaneous leukocytoclastic vasculitis that usually affects children aged between 4 and 24 months. Etiology is unknown but almost of 75% of cases are preceded by infectious episodes, vaccinations or use of medications. In contrast to the dramatic cutaneous eruption, clinical conditions are usually optimal. Classically, AHEI is characterized by a triad of symptoms: fever, edema and purpura. Skin lesions are erythematous, annular, medallion-like, purpuric plaques that have a rapid onset and appear on the face and extremities, sparing trunk and mucosal membranes. Initially interpreted as a variant of Henoch-Schönlein purpura, now it is considered a distinct disease. In the majority of cases the disease is benign and self-limited without a visceral involvement, so a conservative approach is most often chosen.

scholarly journals Atypical Bacterial Pathogens and Small-Vessel Leukocytoclastic Vasculitis of the Skin in Children: Systematic Literature Review

Pathogens ◽  
2021 ◽  
Vol 10 (1) ◽  
pp. 31
Author(s):  
Céline Betti ◽  
Pietro Camozzi ◽  
Viola Gennaro ◽  
Mario G. Bianchetti ◽  
Martin Scoglio ◽  
...  
Keyword(s):  
Mycoplasma Pneumoniae ◽  
Legionella Pneumophila ◽  
Leukocytoclastic Vasculitis ◽  
Systemic Vasculitis ◽  
Bacterial Pathogen ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Systemic Involvement ◽  
Symptomatic Disease ◽  
Atypical Pathogen

Leukocytoclastic small-vessel vasculitis of the skin (with or without systemic involvement) is often preceded by infections such as common cold, tonsillopharyngitis, or otitis media. Our purpose was to document pediatric (≤18 years) cases preceded by a symptomatic disease caused by an atypical bacterial pathogen. We performed a literature search following the Preferred Reporting of Systematic Reviews and Meta-Analyses guidelines. We retained 19 reports including 22 cases (13 females and 9 males, 1.0 to 17, median 6.3 years of age) associated with a Mycoplasma pneumoniae infection. We did not find any case linked to Chlamydophila pneumoniae, Chlamydophila psittaci, Coxiella burnetii, Francisella tularensis, or Legionella pneumophila. Patients with a systemic vasculitis (N = 14) and with a skin-limited (N = 8) vasculitis did not significantly differ with respect to gender and age. The time to recovery was ≤12 weeks in all patients with this information. In conclusion, a cutaneous small-vessel vasculitis with or without systemic involvement may occur in childhood after an infection caused by the atypical bacterial pathogen Mycoplasma pneumoniae. The clinical picture and the course of cases preceded by recognized triggers and by this atypical pathogen are indistinguishable.

Predictors of tumor progression among children with gangliogliomas

2009 ◽  
Vol 3 (6) ◽  
pp. 461-466 ◽  
Author(s):  
Mostafa El Khashab ◽  
Lynn Gargan ◽  
Linda Margraf ◽  
Korgun Koral ◽  
Farideh Nejat ◽  
...  
Keyword(s):  
Risk Factors ◽  
Tumor Progression ◽  
Cox Regression ◽  
Tumor Resection ◽  
Progression Free Survival ◽  
Initial Presentation ◽  
Subtotal Resection ◽  
Low Grade ◽  
Cox Regression Analysis ◽  
Presenting Symptoms

Object Few reports describe the outcome and prognostic factors for children with gangliogliomas. The objective of this report was to describe the progression-free survival (PFS) for children with low-grade gangliogliomas and identify risk factors for tumor progression. Methods A retrospective study was performed in children with low-grade gangliogliomas who were evaluated and treated in the neuro-oncology department between 1986 and 2006 to determine risk factors for subsequent tumor progression. Results A total of 38 children with newly diagnosed gangliogliomas were included in this report. Thirty-four children were treated with surgery alone, 3 with subtotal resection and radiation therapy, and 1 with subtotal resection and chemotherapy. The follow-up ranged from 4 months to 15.8 years (mean 5.7 ± 4.2 years [± SD]). Seven children have experienced tumor progression, and 1 child died after his tumor subsequently underwent malignant transformation. The 5-year PFS was calculated to be 81.2% using Kaplan-Meier survival analysis. Initial presentation with seizures (p = 0.004), tumor location in the cerebral hemisphere (p = 0.020), and complete tumor resection (p = 0.035) were associated with prolonged PFS. Further analysis of the above significant variables by a Cox regression model identified initial presentation with seizures as being associated with prolonged PFS (p = 0.028). Conclusions The PFS and overall survival of children with gangliogliomas are good. Tumors located in the cerebral hemispheres, the achievement of total resection, and seizures at presentation were associated with prolonged PFS. Cox regression analysis identified presenting symptoms including seizures as significant predictive factors of PFS. Prospective studies with larger numbers of children are needed to define the significant factors of tumor progression.

scholarly journals Contributions of Aging to Cerebral Small Vessel Disease

2020 ◽  
Vol 82 (1) ◽  
pp. 275-295 ◽  
Author(s):  
T. Michael De Silva ◽  
Frank M. Faraci
Keyword(s):  
Recent Progress ◽  
Small Vessel Disease ◽  
Cerebral Small Vessel Disease ◽  
Small Vessel ◽  
Brain Health ◽  
Vessel Disease ◽  
Age Related ◽  
The Face ◽  
Basic Biology ◽  
The Impact

Cerebral small vessel disease (SVD) is characterized by changes in the pial and parenchymal microcirculations. SVD produces reductions in cerebral blood flow and impaired blood-brain barrier function, which are leading contributors to age-related reductions in brain health. End-organ effects are diverse, resulting in both cognitive and noncognitive deficits. Underlying phenotypes and mechanisms are multifactorial, with no specific treatments at this time. Despite consequences that are already considerable, the impact of SVD is predicted to increase substantially with the growing aging population. In the face of this health challenge, the basic biology, pathogenesis, and determinants of SVD are poorly defined. This review summarizes recent progress and concepts in this area, highlighting key findings and some major unanswered questions. We focus on phenotypes and mechanisms that underlie microvascular aging, the greatest risk factor for cerebrovascular disease and its subsequent effects.

scholarly journals Mycoplasmal upper respiratory infection presenting as leukocytoclastic vasculitis

2015 ◽  
Vol 7 (1) ◽  
Author(s):  
Mana Rao ◽  
Abhinav Agrawal ◽  
Manan Parikh ◽  
Rikka Banayat ◽  
Maria Joana Thomas ◽  
...  
Keyword(s):  
Respiratory Tract ◽  
Leukocytoclastic Vasculitis ◽  
Small Vessel ◽  
Stevens Johnson Syndrome ◽  
Small Vessel Vasculitis ◽  
Upper Respiratory Tract ◽  
Cutaneous Lesions ◽  
Upper Respiratory Infection ◽  
Mycoplasmal Infection ◽  
Upper Respiratory

Mycoplasma is a virulent organism that is known to primarily infect the respiratory tract; however, affection of the skin, nervous system, kidneys, heart and bloodstream has been observed in various forms, which include Stevens Johnson syndrome, erythema multiforme, toxic epidermal necrolysis, encephalitis, renal failure, conduction system abnormalities and hemolytic anemia. Small vessel vasculitis is a lesser-known complication of mycoplasma pneumonia infection. We report a case of mycoplasmal upper respiratory tract infection with striking cutaneous lesions as the presenting symptom. Mycoplasmal infection was confirmed by serology testing, skin biopsy was suggestive of leukocytoclastic vasculitis. This case brings forth an uncommon manifestation of mycoplasmal infection with extra-pulmonary affection, namely small vessel vasculitis.

scholarly journals Papular Purpuric Rash Due to Parvovirus B19 with Distribution on the Distal Extremities and the Face

2002 ◽  
Vol 35 (12) ◽  
pp. 1558-1561 ◽  
Author(s):  
Liora Harel ◽  
Ilan Straussberg ◽  
Abraham Zeharia ◽  
Dario Praiss ◽  
Jacob Amir
Keyword(s):  
Parvovirus B19 ◽  
The Face ◽  
Purpuric Rash

scholarly journals Coping in mental health during social isolation: analysis in light of Hildegard Peplau

2022 ◽  
Vol 75 (2) ◽  
Author(s):  
Eduardo Bassani Dal’Bosco ◽  
Lara Simone Messias Floriano ◽  
Amanda Gabrieli Schuber Spósito Rangel ◽  
Mirian Cristina Ribas ◽  
Ana Paula Garbuio Cavalheiro ◽  
...  
Keyword(s):  
Mental Health ◽  
Coping Strategies ◽  
Social Isolation ◽  
Interpersonal Relations ◽  
University Hospital ◽  
Self Awareness ◽  
Structured Interviews ◽  
Social And Emotional ◽  
The Face ◽  
Coronavirus Infection

ABSTRACT Objectives: to analyze the coping of individuals in social isolation due to suspicion or confirmation of coronavirus infection from the perspective of Hildegard Peplau’s Theory of Interpersonal Relations. Methods: this is a qualitative, descriptive research, carried out with 34 individuals in social isolation due to suspicion or confirmation of coronavirus infection who passed through a screening tent of a university hospital in Paraná. Data were collected through semi-structured interviews in June and July 2020. Empirical categories were interpreted by content analysis. Results: four categories emerged: Distance; Social and emotional support; Self-awareness and resolution; Learning. These categories established the coping strategies. Conclusions: individuals undergoing social isolation are more likely to present problems related to mental health. It was highlighted that coping strategies, motivated by nurses, anchored in Hildegard Peplau’s theoretical framework, promoted the necessary learning for promoting participants’ mental health in the face of a pandemic context.

scholarly journals Medical Support of Mass Events During the COVID-19 Pandemic: Problems and Possible Ways of their Solution

2021 ◽  
pp. 35-45
Author(s):  
V.V. Demenko ◽  
◽  
A.A. Cheplyaev ◽  
Yu.N. Savvin ◽  
G.P. Prostakishin ◽  
...  
Keyword(s):  
Disaster Medicine ◽  
Medical Documentation ◽  
Medical Support ◽  
Public Events ◽  
The Face ◽  
Medical Reports ◽  
Coronavirus Infection ◽  
The Republic ◽  
Medical Teams ◽  
Mass Events

The purpose of the study is to summarize the experience of organizing and implementing medical support for mass events by the specialists of the medical teams of the All-Russian Center for Disaster Medicine «Zashchita» in 2008–2019; to analyze and to assess the organization of medical support for the Tavrida Forum and Festival, as well as for the Final of the “Big Change” (“Bolshaya Peremena”) competition in the Republic of Crimea in 2020 in the face of the threat of the new coronavirus infection COVID-19 spread. Materials and research methods. We analyzed the data of medical reports of specialists of the Field Multidisciplinary Hospital of the All-Russian Center for Disaster Medicine «Zashchita», who participated in the medical support of mass events held in 2008–2020. The regulatory documents, scientific and methodological publications on the organization of medical support for public events, climatic and geographic conditions in the places of the Hospital’s deployment, legal and medical documentation on the prevention, diagnosis and treatment of COVID-19 were studied. Research results and their analysis. A brief description of the medical support of mass events by the specialists of the Field Multidisciplinary Hospital of the All-Russian Center for Disaster Medicine «Zashchita» in 2008–2019 is given. The organization and implementation of medical support for mass events held in 2020 in the Republic of Crimea in the context of the COVID-19 pandemic are presented. The work of the Consolidated Medical Unit of the FMBA of Russia with the participation of specialists from the All-Russian Center for Disaster Medicine «Zashchita» is analyzed.

scholarly journals LGG-27. TARGETED THERAPY FOR PEDIATRIC LOW-GRADE GLIOMAS AND PLEXIFORM NEUROFIBROMAS WITH TRAMETINIB

2020 ◽  
Vol 22 (Supplement_3) ◽  
pp. iii371-iii371
Author(s):  
Tiffany Nguyen ◽  
Kathleen McMahon ◽  
Molly Hemenway ◽  
Jean Mulcahy Levy ◽  
Nicholas Foreman ◽  
...  
Keyword(s):  
Targeted Therapy ◽  
Retrospective Chart Review ◽  
Neurofibromatosis Type ◽  
Mek Inhibitor ◽  
Low Grade ◽  
Plexiform Neurofibromas ◽  
Low Grade Gliomas ◽  
Common Location ◽  
Best Response ◽  
The Face

Abstract BACKGROUND Targeted therapy aimed at modulating the RAS/RAF/MEK/ERK pathway is of increasing interest for patients with plexiform neurofibromas and low-grade gliomas. Trametinib is an FDA-approved MEK inhibitor that has little published pediatric experience to date. METHODS A retrospective chart review of patients treated with trametinib for low-grade gliomas (LGG) and/or plexiform neurofibromas (PN) between 2015–2018 was conducted at Children’s Hospital Colorado. Data collected included patient demographics, lesion location, Neurofibromatosis type 1 (NF1) status, best response of PN/LGG to trametinib, duration of trametinib therapy, and reported toxicities at least possibly attributed to trametinib. RESULTS Thirty (57% male; 73% NF1) patients were identified. Sixteen (53%) patients had PN only, 12 (40%) had LGG only, and two (7%) patients had both PN and LGG. The most common LGG location was the optic pathway/hypothalamus (72%). The most common location of PN was the face (63%). Two-thirds (8/12) of patients with LGG had a BRAF alteration or NF1 mutation. The median age at start of trametinib therapy was 9.9 years (range, 2.0 – 18.8 years). The median duration of trametinib therapy was 0.8 years (range 0.1 – 2.9 years). The most commonly reported adverse event was rash. No patients developed retinal toxicity or cardiotoxicity. Only two (7%) patients discontinued for toxicity and one (3%) for progressive disease. CONCLUSIONS Trametinib can be administered without significant toxicity to children with PN or LGG. Clinical benefit is noted in this cohort; however, prospective clinical trials are necessary to characterize efficacy formally.

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