scholarly journals Osteopathic Manipulative Treatment Limits Chronic Constipation in a Child with Pitt-Hopkins Syndrome

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Alessandro Aquino ◽  
Mattia Perini ◽  
Silvia Cosmai ◽  
Silvia Zanon ◽  
Viviana Pisa ◽  
...  
Keyword(s):  
Chronic Constipation ◽  
Genetic Disorder ◽  
Gastrointestinal Disorders ◽  
Osteopathic Manipulative Treatment ◽  
Rare Genetic Disorder ◽  
Defecation Frequency ◽  
Stool Form ◽  
Severe Chronic Constipation

Pitt-Hopkins Syndrome (PTHS) is a rare genetic disorder caused by insufficient expression of the TCF4 gene. Children with PTHS typically present with gastrointestinal disorders and early severe chronic constipation is frequently found (75%). Here we describe the case of a PTHS male 10-year-old patient with chronic constipation in whom Osteopathic Manipulative Treatment (OMT) resulted in improved bowel functions, as assessed by the diary, the QPGS-Form A Section C questionnaire, and the Paediatric Bristol Stool Form Scale. The authors suggested that OMT may be a valid tool to improve the defecation frequency and reduce enema administration in PTHS patients.

Laron syndrome – A case Report

JMS SKIMS ◽  
2017 ◽  
Vol 20 (2) ◽  
pp. 104-106
Author(s):  
Javaid Ahmad Bhat ◽  
Moomin Hussain Bhat ◽  
Hilal Bhat ◽  
Mona Sood ◽  
Shariq Rashid Masoodi
Keyword(s):  
Growth Hormone ◽  
Case Report ◽  
Hormone Receptor ◽  
Growth Hormone Receptor ◽  
Genetic Disorder ◽  
Female Child ◽  
Receptor Signaling ◽  
Laron Syndrome ◽  
Rare Genetic Disorder ◽  
Igf I

Background : Laron & colleagues (1966) reported a rare genetic disorder in Israliei Jewish sublings which was characterized by insensitivity to growth hormone due to abnormality in growth hormone receptor or post receptor signaling pathway.Case Report: We hereby report a case of a 5 year old female child who presented to us with features similar to Laron syndrome. The diagnosis was made & confirmed by various Lab. investigations like low IGF-I levels and managed accordingly. JMS 2017; 20 (2):104-106  

Anesthesia in Carvajal syndrome; the first case report

2020 ◽  
Vol 24 (1) ◽  
pp. 105-107
Author(s):  
Sedighe Shahhosseini ◽  
Reza Aminnejad ◽  
Amir Shafa ◽  
Mehrdad Memarzade
Keyword(s):  
Intensive Care ◽  
Case Report ◽  
Surgical Resection ◽  
Genetic Disorder ◽  
Anesthetic Technique ◽  
Close Monitoring ◽  
Anesthesia Management ◽  
Rare Genetic Disorder ◽  
First Case ◽  
Anesthetic Considerations

Carvajal syndrome is a rare genetic disorder. Patients reporting for surgery pose some difficulties in anesthesia management. In this case report we present the case of a 12-year-old boy, who was a known case of Carvajal syndrome, referred for surgical resection of perianal condyloma. Close monitoring of hemodynamic status is the mainstay of anesthetic considerations in such patients. As in any other challenging scenario, it should be kept in mind that ‘there is no safest anesthetic agent, nor the safest anesthetic technique; there is only the safest anesthesiologist’. Citation: Shahhosseini S, Aminnejad R, Shafa A, Memarzadeh M. Anesthesia in Carvajal syndrome; the first case report. Anaesth pain intensive care 2020;24(1):___ DOI: https://doi.org/10.35975/apic.v24i1.

scholarly journals Obstructive Uropathy in a Child with Severe Chronic Constipation

2012 ◽  
Vol 21 (3) ◽  
pp. 209-212
Author(s):  
Veena Logarajah ◽  
Kong Boo Phua ◽  
Te Lu Yap ◽  
Christina Ong
Keyword(s):  
Chronic Constipation ◽  
Obstructive Uropathy ◽  
Severe Chronic Constipation

Capsule endoscopy findings in congenital afibrinogenemia-associated angiopathy

VASA ◽  
2008 ◽  
Vol 37 (4) ◽  
pp. 383-385 ◽  
Author(s):  
Katsinelos ◽  
Vasiliadis ◽  
Soufleris ◽  
Chatzimavroudis ◽  
Zavos ◽  
...  
Keyword(s):  
Arterial Hypertension ◽  
Capsule Endoscopy ◽  
Intestinal Ischemia ◽  
Genetic Disorder ◽  
Rare Genetic Disorder ◽  
Unusual Condition ◽  
Congenital Afibrinogenemia ◽  
Abdominal Arteries ◽  
First Time

Congenital afibrinogenemia is a rare genetic disorder characterized by the complete absence of functional fibrinogen. We report a 22-year-old female who developed nephrogenic arterial hypertension and intestinal ischemia due to congenital afibrinogenemia-associated angiopathy of large abdominal arteries. We describe, for the first time, the capsule findings and discuss the pathophysiology of this unusual condition.

scholarly journals Pitt–Hopkins syndrome with electrical stat us epileptic us in slo w-wave sleep: a case report

2019 ◽  
Vol 14 (2) ◽  
pp. 42-48
Author(s):  
N. G. Lyukshina
Keyword(s):  
Case Report ◽  
Intellectual Disability ◽  
Status Epilepticus ◽  
Neuronal Differentiation ◽  
Clinical Case ◽  
Genetic Disorder ◽  
Facial Dysmorphism ◽  
Autistic Behavior ◽  
Rare Genetic Disorder ◽  
Molecular Variant

Pitt–Hoppkins syndrome is rare genetic disorder caused by a molecular variant of TCF4 which is involved in embryologic neuronal differentiation. The syndrome is characterized by specific facial dysmorphism, phychomotor delay, autistic behavior and intellectual disability. Other associated features include ealy-onset myopia, seizures, constipation and hyperventilation-apneic spells. We introduced a clinical case of the patient with molecularly confirmed TCF4 variant and previously undescribed combination with syndrome of the electrical status epilepticus during sleep.

scholarly journals Prenatal presentation of a rare genetic disorder: a clinical, autopsy and molecular correlation

2019 ◽  
Vol 9 (4) ◽  
Author(s):  
Veronica Arora ◽  
Sunita Bijarnia-Mahay ◽  
Samarth Kulshreshtra ◽  
Kanika Singh ◽  
Ratna Dua Puri ◽  
...  
Keyword(s):  
Genetic Disorder ◽  
Rare Genetic Disorder ◽  
Molecular Correlation

Misoprostol is effective treatment for patients with severe chronic constipation

1994 ◽  
Vol 39 (5) ◽  
pp. 929-933 ◽  
Author(s):  
Edy E. Soffer ◽  
Amanda Metcalf ◽  
Janice Launspach
Keyword(s):  
Effective Treatment ◽  
Chronic Constipation ◽  
Severe Chronic Constipation
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