scholarly journals Suppressed Programmed Death 1 Expression on CD4+ and CD8+ T Cells in Psoriatic Patients

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Joanna Bartosińska ◽  
Ewelina Zakrzewska ◽  
Dorota Raczkiewicz ◽  
Joanna Purkot ◽  
Anna Michalak-Stoma ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Chronic Inflammatory Disease ◽  
Peripheral Tolerance ◽  
Control Group ◽  
Cell Immunity ◽  
Programmed Death ◽  
Peripheral T Cells ◽  
Programmed Death 1 ◽  
The Absolute

Psoriasis is a chronic inflammatory disease mediated by T cell immunity. Programmed death 1 (PD-1), a coinhibitory receptor, plays an important role in immune regulation and maintaining peripheral tolerance. The aim of the study was to compare the expression of PD-1 on the peripheral T cells between psoriatic patients and healthy controls. The study included 75 psoriatic patients and 52 healthy volunteers. The percentages and absolute numbers of CD3+, CD4+, CD8+, CD4+PD-1+, and CD8+PD-1+ T cells were analyzed using flow cytometry. The absolute numbers and percentages of CD4+PD-1+ and CD8+PD-1+ T cells were significantly decreased in the psoriatic patients in comparison with the control group. No significant correlations were found between the absolute numbers and percentages of CD4+PD-1+ or CD8+PD-1+ T cells and clinical characteristics of psoriasis. Decreased PD-1 expression on the T cells may be responsible for impaired negative regulation of immune response in psoriasis pathogenesis.

scholarly journals Increase of programmed death-1-expressing intratumoral CD8 T cells predicts a poor prognosis for nasopharyngeal carcinoma

2010 ◽  
Vol 23 (10) ◽  
pp. 1393-1403 ◽  
Author(s):  
Mei-Chi Hsu ◽  
Jenn-Ren Hsiao ◽  
Kung-Chao Chang ◽  
Yuan-Hua Wu ◽  
Ih-Jen Su ◽  
...  
Keyword(s):  
T Cells ◽  
Nasopharyngeal Carcinoma ◽  
Cd8 T Cells ◽  
Poor Prognosis ◽  
Programmed Death ◽  
Programmed Death 1

Expression of Programmed Death-1 (PD-1) on CD4+ and CD8+ T cells in Rheumatoid Arthritis

Inflammation ◽  
2013 ◽  
Vol 37 (1) ◽  
pp. 116-121 ◽  
Author(s):  
Shufeng Li ◽  
Wensheng Liao ◽  
Meng Chen ◽  
Shiying Shan ◽  
Yuanlin Song ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
T Cells ◽  
Cd8 T Cells ◽  
Programmed Death ◽  
Programmed Death 1

Abstract 4782: Expression of programmed death-1 in CD8+ T cells from patients bearing PCA upon stimulation with common γ-chain cytokines

2010 ◽  
Author(s):  
Chantal Mengus ◽  
Clémentine Le Magnen ◽  
Cyrill Rentsch ◽  
Alexander Bachmann ◽  
Michael Heberer ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Programmed Death ◽  
Programmed Death 1

scholarly journals Revisiting the PD-1 pathway

2020 ◽  
Vol 6 (38) ◽  
pp. eabd2712 ◽  
Author(s):  
Nikolaos Patsoukis ◽  
Qi Wang ◽  
Laura Strauss ◽  
Vassiliki A. Boussiotis
Keyword(s):  
T Cells ◽  
Molecular Targets ◽  
Peripheral Tolerance ◽  
Inhibitory Receptor ◽  
Activated T Cells ◽  
Therapeutic Success ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
And Function ◽  
Blocking Antibodies

Programmed Death-1 (PD-1; CD279) is an inhibitory receptor induced in activated T cells. PD-1 engagement by its ligands, PD-L1 and PD-L2, maintains peripheral tolerance but also compromises anti-tumor immunity. Blocking antibodies against PD-1 or its ligands have revolutionized cancer immunotherapy. However, only a fraction of patients develop durable antitumor responses. Clinical outcomes have reached a plateau without substantial advances by combinatorial approaches. Thus, great interest has recently emerged to investigate, in depth, the mechanisms by which the PD-1 pathway transmits inhibitory signals with the goal to identify molecular targets for improvement of the therapeutic success. These efforts have revealed unpredictable dimensions of the pathway and uncovered novel mechanisms involved in PD-1 and PD-L1 regulation and function. Here, we provide an overview of the recent advances on the mechanistic aspects of the PD-1 pathway and discuss the implications of these new discoveries and the gaps that remain to be filled.

scholarly journals Virus-Specific CD8+T Cells Upregulate Programmed Death-1 Expression during Acute Friend Retrovirus Infection but Are Highly Cytotoxic and Control Virus Replication

2011 ◽  
Vol 187 (7) ◽  
pp. 3730-3737 ◽  
Author(s):  
Gennadiy Zelinskyy ◽  
Lara Myers ◽  
Kirsten K. Dietze ◽  
Kathrin Gibbert ◽  
Michael Roggendorf ◽  
...  
Keyword(s):  
T Cells ◽  
Virus Replication ◽  
Cd8 T Cells ◽  
Friend Retrovirus ◽  
Programmed Death ◽  
Control Virus ◽  
Programmed Death 1 ◽  
Retrovirus Infection ◽  
And Control

scholarly journals Expression and clinical significance of LAG-3, FGL1, PD-L1 and CD8+T cells in hepatocellular carcinoma using Multiplex Quantitative Analysis

2020 ◽  
Author(s):  
Mengzhou Guo ◽  
Feifei Yuan ◽  
Feng Qi ◽  
Jialei Sun ◽  
Qianwen Rao ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
T Cells ◽  
Tumor Cells ◽  
Cd8 T Cells ◽  
Prognostic Significance ◽  
Normal Liver ◽  
Patient Stratification ◽  
Programmed Death ◽  
Programmed Death 1 ◽  
Low Levels

Abstract Background: fibrinogen-like protein 1 (FGL1) - Lymphocyte activating gene 3 (LAG-3) pathway is a promising immunotherapeutic target and has synergistic effect with programmed death 1 (PD-1)/programmed death ligand 1 (PD-L1). However, the prognostic significance of FGL1-LAG-3 pathway and the correlation with PD-L1 in hepatocellular carcinoma (HCC) remain unknown.Methods: The levels of LAG-3, FGL1, PD-L1 and cytotoxic T (CD8+T) cells in 143 HCC patients were assessed by multiplex immunofluorescence. Associations between the marker’s expression and clinical significances were studied.Results: We found FGL1 and LAG-3 densities were elevated while PD-L1 and CD8 were decreased in HCC tissues compared to adjacent normal liver tissues. High levels of FGL1 were strongly associated with high densities of LAG-3+cells but not PD-L1. CD8+ T cells densities had positive correlation with PD-L1 levels and negative association with FGL1 expression. Elevated densities of LAG-3+cells and low levels of CD8+ T cells were correlated with poor disease outcome. Moreover, LAG-3+cells deteriorated patient stratification based on the abundance of CD8+ T cells. Patients with positive PD-L1 expression on tumor cells (PD-L1 TC+) tended to have an improved survival than that with negative PD-L1 expression on tumor cells (PD-L1 TC-). Furthermore, PD-L1 TC- in combination with high densities of LAG-3+cells showed the worst prognosis, and PD-L1 TC+ patients with low densities of LAG-3+cells had the best prognosis.Conclusions: LAG-3, FGL1, PD-L1 and CD8 have distinct tissue distribution and relationships with each other. High levels of LAG-3+cells and CD8+ T cells represent unfavorable and favorable prognostic biomarkers for HCC respectively.

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