scholarly journals The Lumbodorsal Fascia as a Potential Source of Low Back Pain: A Narrative Review

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Jan Wilke ◽  
Robert Schleip ◽  
Werner Klingler ◽  
Carla Stecco
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Dorsal Horn ◽  
Morphological Changes ◽  
Low Back ◽  
Dorsal Horn Neurons ◽  
Potential Source ◽  
Stimulation Of

The lumbodorsal fascia (LF) has been proposed to represent a possible source of idiopathic low back pain. In fact, histological studies have demonstrated the presence of nociceptive free nerve endings within the LF, which, furthermore, appear to exhibit morphological changes in patients with chronic low back pain. However, it is unclear how these characteristics relate to the aetiology of the pain. In vivo elicitation of back pain via experimental stimulation of the LF suggests that dorsal horn neurons react by increasing their excitability. Such sensitization of fascia-related dorsal horn neurons, in turn, could be related to microinjuries and/or inflammation in the LF. Despite available data point towards a significant role of the LF in low back pain, further studies are needed to better understand the involved neurophysiological dynamics.

scholarly journals Prevention and reversal of latent sensitization of dorsal horn neurons by glial blockers in a model of low back pain in male rats

2017 ◽  
Vol 118 (4) ◽  
pp. 2059-2069 ◽  
Author(s):  
Juanjuan Zhang ◽  
Siegfried Mense ◽  
Rolf-Detlef Treede ◽  
Ulrich Hoheisel
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Nerve Growth Factor ◽  
Dorsal Horn ◽  
Microglial Activation ◽  
Low Back ◽  
Astrocyte Activation ◽  
Dorsal Horn Neurons ◽  
Resting Activity ◽  
Stimulation Of

In an animal model of nonspecific low back pain, recordings from dorsal horn neurons were made to investigate the influence of glial cells in the central sensitization process. To induce a latent sensitization of the neurons, nerve growth factor (NGF) was injected into the multifidus muscle; the manifest sensitization to a second NGF injection 5 days later was used as a read-out. The sensitization manifested in increased resting activity and in an increased proportion of neurons responding to stimulation of deep somatic tissues. To block microglial activation, minocycline was continuously administered intrathecally starting 1 day before or 2 days after the first NGF injection. The glia inhibitor fluorocitrate that also blocks astrocyte activation was administrated 2 days after the first injection. Minocycline applied before the first NGF injection reduced the manifest sensitization after the second NGF injection to control values. The proportion of neurons responsive to stimulation of deep tissues was reduced from 50% to 17.7% ( P < 0.01). No significant changes occurred when minocycline was applied after the first injection. In contrast, fluorocitrate administrated after the first NGF injection reduced significantly the proportion of neurons with deep input (15.8%, P < 0.01). A block of glia activation had no significant effect on the increased resting activity. The data suggest that blocking microglial activation prevented the NGF-induced latent spinal sensitization, whereas blocking astrocyte activation reversed it. The induction of spinal neuronal sensitization in this pain model appears to depend on microglia activation, whereas its maintenance is regulated by activated astrocytes. NEW & NOTEWORTHY Activated microglia and astrocytes mediate the latent sensitization induced by nerve growth factor in dorsal horn neurons that receive input from deep tissues of the low back. These processes may contribute to nonspecific low back pain.

Short-term swimming exercise attenuates the sensitization of dorsal horn neurons in rats with NGF-induced low back pain

2018 ◽  
Vol 22 (8) ◽  
pp. 1409-1418 ◽  
Author(s):  
G. de Azambuja ◽  
U. Hortscht ◽  
U. Hoheisel ◽  
M.C. Oliveira Fusaro ◽  
S. Mense ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Dorsal Horn ◽  
Swimming Exercise ◽  
Low Back ◽  
Short Term ◽  
Dorsal Horn Neurons

Role of Vaitarana Basti in the management of Gridhrasi w.s.r. to Sciatica

2018 ◽  
Vol 3 (5) ◽  
Author(s):  
Dr. Suresh N. Hakkandi ◽  
Dr. Manjunath Akki ◽  
Dr. Bhavana KS
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Clinical Practice ◽  
Routine Activity ◽  
Daily Routine ◽  
Low Back ◽  
Common Condition ◽  
Locomotor System

Vata Vyadhi is one of the most prevailing health problems in our day today clinical practice, Gridhrasi is one among them. Gridhrasi is Shoola Pradhana Nanatmaja Vatavyadhi, affecting the locomotor system and disable from daily routine activity. Gridhrasi the name itself indicates the way of gait shown by the patient due to extreme pain i.e. like Gridhra or Vulture. Gridhrasi is a condition characterized by Ruk, Toda, Stambha, Spandana in Sphik Pradesha and radiates downwards to Kati, Prusta, Uru, Janu, Jangha and Pada. Gridhrasi can be compared with Sciatica. Pain is the chief cause of person to visit a doctor. Although low back pain is a common condition that affects as many as 80 to 90 percent of people during their lifetime. Gridhrasi can be cured by the help of Vaitarana Basti. Hence in the case study of male patient of age 30 yrs presenting with cardinal clinical sign and symptoms of Gridhrasi are Ruka, Toda and Muhu Spandana in the Sphika, Kati, Uru, Janu, Jangha and Pada in order and Sakthikshepanigraha that is restricted lifting of the leg.

Role of growth plate (apophyseal ring fracture) in causing modic type changes in pediatric low back pain patients

2021 ◽  
Author(s):  
Hiroaki Manabe ◽  
Toshinori Sakai ◽  
Yasuyuki Omichi ◽  
Kosuke Sugiura ◽  
Masatoshi Morimoto ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Growth Plate ◽  
Low Back ◽  
Ring Fracture ◽  
Modic Type ◽  
Pain Patients ◽  
Apophyseal Ring Fracture

Low Back Pain: What is the Role of YouTube Content in Patient Education?

2021 ◽  
Author(s):  
Alexander L. Hornung ◽  
Samuel S. Rudisill ◽  
Rawan W. Suleiman ◽  
Zakariah K. Siyaji ◽  
Sahil Sood ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Patient Education ◽  
Low Back

A Fear-Avoidance Beliefs Questionnaire (FABQ) and the role of fear-avoidance beliefs in chronic low back pain and disability

Pain ◽  
1993 ◽  
Vol 52 (2) ◽  
pp. 157-168 ◽  
Author(s):  
Gordon Waddell ◽  
Mary Newton ◽  
Iain Henderson ◽  
Douglas Somerville ◽  
Chris J. Main
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Chronic Low Back Pain ◽  
Low Back ◽  
Fear Avoidance ◽  
Fear Avoidance Beliefs ◽  
Fear Avoidance Beliefs Questionnaire
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