scholarly journals Regeneration and Regrowth Potentials of Digit Tips in Amphibians and Mammals

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Yohan Choi ◽  
Fanwei Meng ◽  
Charles S. Cox ◽  
Kevin P. Lally ◽  
Johnny Huard ◽  
...  
Keyword(s):  
Wound Healing ◽  
Tissue Regeneration ◽  
Limb Regeneration ◽  
Scar Tissue ◽  
Medical Field ◽  
Digit Regeneration ◽  
Shed Light

Tissue regeneration and repair have received much attention in the medical field over the years. The study of amphibians, such as newts and salamanders, has uncovered many of the processes that occur in these animals during full-limb/digit regeneration, a process that is highly limited in mammals. Understanding these processes in amphibians could shed light on how to develop and improve this process in mammals. Amputation injuries in mammals usually result in the formation of scar tissue with limited regrowth of the limb/digit; however, it has been observed that the very tips of digits (fingers and toes) can partially regrow in humans and mice under certain conditions. This review will summarize and compare the processes involved in salamander limb regeneration, mammalian wound healing, and digit regeneration in mice and humans.

scholarly journals Nanocomposite scaffolds for accelerating chronic wound healing by enhancing angiogenesis

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Hamed Nosrati ◽  
Reza Aramideh Khouy ◽  
Ali Nosrati ◽  
Mohammad Khodaei ◽  
Mehdi Banitalebi-Dehkordi ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Wound Healing ◽  
Tissue Regeneration ◽  
Molecular Mechanisms ◽  
Healing Process ◽  
The Body ◽  
Key Factors ◽  
Potential Applications ◽  
Nanocomposite Scaffolds

AbstractSkin is the body’s first barrier against external pathogens that maintains the homeostasis of the body. Any serious damage to the skin could have an impact on human health and quality of life. Tissue engineering aims to improve the quality of damaged tissue regeneration. One of the most effective treatments for skin tissue regeneration is to improve angiogenesis during the healing period. Over the last decade, there has been an impressive growth of new potential applications for nanobiomaterials in tissue engineering. Various approaches have been developed to improve the rate and quality of the healing process using angiogenic nanomaterials. In this review, we focused on molecular mechanisms and key factors in angiogenesis, the role of nanobiomaterials in angiogenesis, and scaffold-based tissue engineering approaches for accelerated wound healing based on improved angiogenesis.

Mapping the dominant wound healing and soft tissue regeneration QTL in MRL × CAST

2005 ◽  
Vol 16 (12) ◽  
pp. 918-924 ◽  
Author(s):  
Hongrun Yu ◽  
Subburaman Mohan ◽  
Godfred L. Masinde ◽  
David J. Baylink
Keyword(s):  
Wound Healing ◽  
Soft Tissue ◽  
Tissue Regeneration ◽  
Soft Tissue Regeneration

scholarly journals Platelet rich plasma in dermatology and cosmetology

2020 ◽  
Vol 6 (2) ◽  
pp. 288
Author(s):  
Shobhit Mohan ◽  
Lalit Mohan ◽  
Renu Sangal ◽  
Neelu Singh
Keyword(s):  
Wound Healing ◽  
Tissue Regeneration ◽  
Blood Product ◽  
Platelet Rich Plasma ◽  
Autologous Blood ◽  
Detailed Knowledge ◽  
Skin Rejuvenation ◽  
Scar Revision ◽  
Current Review

<p class="abstract">Platelet rich plasma (PRP) therapies in medicine has become increasing popular during the last decade. The interest in in the application of PRP in dermatology and cosmetology has increased recently in different applications such as alopecia, skin rejuvenation, wound healing, scar revision, and tissue regeneration. PRP is an autologous blood product obtained from the blood of the patients. The detailed knowledge about PRP should help clinicians better understand this therapy. In this view, the current review was done for a better understanding of what pathologies can be corrected with PRP.</p>

Wound healing in a fetal, adult, and scar tissue model: A comparative study

2010 ◽  
Vol 18 (3) ◽  
pp. 291-301 ◽  
Author(s):  
Neeltje A. Coolen ◽  
Kelly C. W. M. Schouten ◽  
Bouke K. H. L. Boekema ◽  
Esther Middelkoop ◽  
Magda M. W. Ulrich
Keyword(s):  
Wound Healing ◽  
Comparative Study ◽  
Scar Tissue ◽  
Tissue Model

Role of prostaglandins in amphibian limb regeneration

1981 ◽  
Vol 59 (1) ◽  
pp. 136-137
Author(s):  
Steven R. Scadding
Keyword(s):  
Wound Healing ◽  
Acetylsalicylic Acid ◽  
Limb Regeneration ◽  
Limb Amputation ◽  
Prostaglandin E ◽  
Notophthalmus Viridescens ◽  
Bufo Americanus ◽  
Histological Appearance

Following limb amputation in the newt (Notophthalmus viridescens), the animals were given daily intraperitoneal injections of 0.1 or 1.0 mg of either indomethacin or acetylsalicylic acid. This had no observable influence on the rate or extent of limb regeneration or the histological appearance of the regenerating limb when compared with controls. Following limb amputation in toads (Bufo americanus), the limb stumps were injected daily for the first 15 days after amputation with 5 μg of either prostaglandin E1 or prostaglandin E2. Neither of these treatments had any observed effect on subsequent wound healing of the limbs when compared with controls. These observations suggest that prostaglandins do not play a major role in control of amphibian limb regeneration.

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