scholarly journals Insights into the Action Mechanisms of Traditional Chinese Medicine in Osteoarthritis

2017 ◽  
Vol 2017 ◽  
pp. 1-13 ◽  
Author(s):  
Linfu Li ◽  
Haiqing Liu ◽  
Weimei Shi ◽  
Hai Liu ◽  
Jianqiong Yang ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cartilage Destruction ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Action Mechanism ◽  
Action Mechanisms ◽  
Inflammatory Drugs ◽  
Anti Inflammation ◽  
Modern Technologies

Osteoarthritis (OA) is a chronic degenerative joint disease characterized by articular cartilage destruction, synovial inflammation, and osteophyte formation. No effective treatments are available. The current pharmacological medications such as nonsteroidal anti-inflammatory drugs (NSAIDs) and analgesics, accompanied by possible adverse effects, might ameliorate OA symptoms. But they do not arrest the progression of OA. Traditional Chinese medicine (TCM) provides medical value by modification of disease and symptoms in OA. Valuable work on exploring TCM merits for OA patients has been investigated using modern technologies, although the complicated interacting network among the numerous components indicates the uncertainty of target specification. This review will provide an overview of the action mechanism of TCM in the last 5 years, discussing the TCM activities of anti-inflammation, antiapoptosis, antioxidation, anticatabolism, and proliferation in OA. TCM is a proposed medical option for OA treatment.

scholarly journals Pemberian Akupresur Untuk Menurunkan Nyeri Dan Kadar Asam Urat Pada Klien Asam Urat Di Poncowarno Kecamatan Kalirejo Lampung Tengah

2021 ◽  
Vol 4 (3) ◽  
pp. 515-519
Author(s):  
Teguh Pribadi ◽  
Ainur Rahma ◽  
Rika Yulendasari
Keyword(s):  
Uric Acid ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Healing Process ◽  
Nutritional Therapy ◽  
Joint Disease ◽  
Herbal Therapy ◽  
Keywords Pain ◽  
Nonpharmacological Therapy

ABSTRAKPada tahun 2018, prevalensi penyakit sendi di Lampung berada pada urutan ke-12 di Indonesia yaitu sebesar 7,2%. Terapi nonfarmakologi untuk mempercepat proses penyembuhan pada pasien hiperurisemia yaitu terapi herbal, hemeopati, akupuntur, akupresur, terapi nutrisi, refleksologi, terapi garam, dan yoga. Akupresur merupakan salah satu teknik pengobatan tradisional Cina ang dapat digunakan untuk menurunkan nyeri, mengobati penyakit dan cidera. Tujuan setelah penyuluhan dan demonstrasi, diharapkan pemberian akupresur dapat untuk menurunkan kadar asam urat dan rasa nyeri pada klien Asam urat tinggi. Adapun kegiatan yang dilakukan berupa penyuluhan menggunakan leaflet dan demonstrasi akupresur. Terdapat penurunan kadar asam urat dan nyeri pada klien asam urat tinggi setelah pemberian akupresur selama 7 hari di Poncowarno Kecamatan Kalirejo, Lampung Tengah. Dengan demikian, pemberian akupresur pada klien asam urat sangat efektif dalam menurunkan kadar asam urat dan nyeri. Kata Kunci: Nyeri, Akupresur, Asam Urat ABSTRACTIn 2018, the prevalence of joint disease Lampung ranks 12th at Indonesia (7.2%). Nonpharmacological therapy to accelerate the healing process in hyperuricemia's patients that is herbal therapy, hemeopathy, acupuncture, acupressure, nutritional therapy, reflexology, salt therapy, and yoga. Acupressure is one of the traditional Chinese medicine techniques which can be used to reduce pain, treat illnesses and injuries. The purpose after counseling and demonstration, it is expected that the provision of acupressure can reduce uric acid levels and pain in high uric acid's client. The activities carried out in the form of counseling using leaflets and acupressure demonstrations. There was a decrease in uric acid levels and pain in high uric acid's clients after giving acupressure for 7 days at Poncowarno, Kalirejo District, Central Lampung. Thus, giving acupressure to uric acid clients is very effective in reducing uric acid levels and pain. Keywords: Pain, Acupressure, Gout

scholarly journals Application of Herbal Medicines with Heat-Clearing Property to Anti-Microinflammation in the Treatment of Diabetic Kidney Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-6 ◽  
Author(s):  
Jing Guo ◽  
Yabin Gao ◽  
Yaoxian Wang ◽  
Wei Jing Liu ◽  
Jingwei Zhou ◽  
...  
Keyword(s):  
Chinese Medicine ◽  
Kidney Disease ◽  
Traditional Chinese Medicine ◽  
Diabetic Kidney Disease ◽  
Herbal Medicines ◽  
Pathogenic Factor ◽  
Diabetic Kidney ◽  
Global Pandemic ◽  
Anti Inflammation ◽  
Made In

Diabetic kidney disease (DKD) is a global pandemic, and microinflammation has been reported as an important pathogenic factor of DKD. Traditional Chinese Medicine (TCM) has been used in the treatment of DKD for thousands of years, and modern Chinese medicine studies have found that herbal medicines with heat-clearing property have a curative anti-inflammation effect in DKD. This article reviews the new clinical and experimental progress made in herbal medicines with heat-clearing property, in the treatment of DKD, as well as their safety aspects.

scholarly journals Mitochondrial Transplantation Ameliorates The Development and Progression of Osteoarthritis.

2021 ◽  
Author(s):  
A Ram Lee ◽  
Jin Seok Woo ◽  
Seon-Yeong Lee ◽  
Hyun Sik Na ◽  
Keun-Hyung Cho ◽  
...  
Keyword(s):  
Mitochondrial Dysfunction ◽  
Mitochondrial Function ◽  
Therapeutic Potential ◽  
Interleukin 1 ◽  
Cartilage Destruction ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Necrosis Factor Alpha ◽  
Monocyte Chemoattractant Protein 1 ◽  
Monosodium Iodoacetate

Abstract Objective: Osteoarthritis (OA) is a common degenerative joint disease characterized by breakdown of joint cartilage. Mitochondrial dysfunction of the chondrocyte is a risk factor for OA progression. We examined the therapeutic potential of mitochondrial transplantation for OA.Methods: Mitochondria were injected into the knee joint of monosodium iodoacetate (MIA)-induced OA rats. Chondrocytes from OA rats or patients with OA were cultured to examine mitochondrial function in cellular pathophysiology.Results: Pain, cartilage destruction, and bone loss were improved in mitochondrial transplanted-OA rats. The transcript levels of interleukin 1 beta (IL-1β), tumor necrosis factor alpha (TNF-α), matrix metallopeptidase 13 (MMP13), and monocyte chemoattractant protein-1 (MCP-1) in cartilage were markedly decreased by mitochondrial transplantation. Mitochondrial function, as indicated by membrane potential and oxygen consumption rate, in chondrocytes from OA rats was improved by mitochondrial transplantation. Likewise, the mitochondrial function of chondrocytes from OA patients was improved by coculture with mitochondria. Furthermore, inflammatory cell death was significantly decreased by coculture with mitochondria.Conclusion: Mitochondrial transplantation ameliorated OA progression, which is caused by mitochondrial dysfunction. These results suggest the therapeutic potential of mitochondrial transplantation for OA.

scholarly journals Bioregulatory drugs in osteoarthritis management

2019 ◽  
pp. 76-83
Author(s):  
O. A. Shavlovskaya
Keyword(s):  
Chronic Pain ◽  
Pain Relief ◽  
Combined Treatment ◽  
Pain Syndrome ◽  
Cartilage Destruction ◽  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Functional Improvement ◽  
Chronic Pain Syndrome ◽  
Matrix Loss

Osteoarthritis (OA) is a degenerative joint disease. Modern theories consider various structural (cartilage destruction) and biophysical disorders (matrix loss of glycosaminoglycans) as the basis of acute and chronic pain syndrome. The main aim of OA therapy is pain relief and functional improvement. To manage pain syndrome in OA it is reasonable to use complex bioregulatory drugs (CBD) (Traumeel S, Zeel T, Discus compositum) both in monotherapy and in combined treatment. The effectiveness of CBD is comparable to that of NSAIDs and CS.

scholarly journals Chondroprotection and Molecular Mechanism of Action of Phytonutraceuticals on Osteoarthritis

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2391
Author(s):  
Stanislav Sukhikh ◽  
Svetlana Noskova ◽  
Svetlana Ivanova ◽  
Elena Ulrikh ◽  
Alexsander Izgaryshev ◽  
...  
Keyword(s):  
Degenerative Joint Disease ◽  
Joint Disease ◽  
Pharmacological Treatments ◽  
Action Mechanism ◽  
Herbal Products ◽  
Analgesic Effects ◽  
Molecular Mechanism Of Action ◽  
Favorable Safety ◽  
Alternative Drugs

Osteoarthritis (OA) is a degenerative joint disease and an important cause of incapacitation. There is a lack of drugs and effective treatments that stop or slow the OA progression. Modern pharmacological treatments, such as analgesics, have analgesic effects but do not affect the course of OA. Long-term use of these drugs can lead to serious side effects. Given the OA nature, it is likely that lifelong treatment will be required to stop or slow its progression. Therefore, there is an urgent need for disease-modifying OA treatments that are also safe for clinical use over long periods. Phytonutraceuticals are herbal products that provide a therapeutic effect, including disease prevention, which not only have favorable safety characteristics but may have an alleviating effect on the OA and its symptoms. An estimated 47% of OA patients use alternative drugs, including phytonutraceuticals. The review studies the efficacy and action mechanism of widely used phytonutraceuticals, analyzes the available experimental and clinical data on the effect of some phytonutraceuticals (phytoflavonoids, polyphenols, and bioflavonoids) on OA, and examines the known molecular effect and the possibility of their use for chondroprotection.

scholarly journals 3′-Sialyllactose Protects SW1353 Chondrocytic Cells From Interleukin-1β-Induced Oxidative Stress and Inflammation

2021 ◽  
Vol 12 ◽  
Author(s):  
Ahreum Baek ◽  
So Hee Jung ◽  
Soonil Pyo ◽  
Soo Yeon Kim ◽  
Seongmoon Jo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Inflammatory Responses ◽  
Antioxidant Defense System ◽  
Cartilage Destruction ◽  
Degenerative Joint Disease ◽  
Interleukin 1Β ◽  
Joint Disease ◽  
Enzymatic Antioxidants ◽  
Expression Levels ◽  
Apoptotic Protein

Osteoarthritis (OA) is a major degenerative joint disease. Oxidative stress and inflammation play key roles in the pathogenesis of OA. 3′-Sialyllactose (3′-SL) is derived from human milk and is known to regulate a variety of biological functions related to immune homeostasis. This study aimed to investigate the therapeutic mechanisms of 3′-SL in interleukin-1β (IL-1β)-treated SW1353 chondrocytic cells. 3′-SL potently suppressed IL-1β-induced oxidative stress by increasing the levels of enzymatic antioxidants. 3′-SL significantly reversed the IL-1β mediated expression levels of reactive oxygen species in IL-1β-stimulated chondrocytic cells. In addition, 3′-SL could reverse the increased levels of inflammatory markers such as nitrite, prostaglandin E2, inducible nitric oxide synthase, cyclooxygenase-2, IL-1β, and IL-6 in IL-1β-stimulated chondrocytic cells. Moreover, 3′-SL significantly inhibited the apoptotic process, as indicated by the downregulation of the pro-apoptotic protein Bax, upregulation of the anti-apoptotic protein Bcl-2 expression, and significant reduction in the number of TUNEL-positive cells in the IL-1β-treated chondrocytic cells. Furthermore, 3′-SL reversed cartilage destruction by decreasing the release of matrix metalloproteinases (MMP), such as MMP1, MMP3, and MMP13. In contrast, 3′-SL significantly increased the expression levels of matrix synthesis proteins, such as collagen II and aggrecan, in IL-1β-treated chondrocytic cells. 3′-SL dramatically suppressed the activation of mitogen-activated protein kinases (MAPK) and phosphatidylinositol-3-kinase (PI3K)/protein kinase B (AKT)/nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) signaling pathways, which are related to the pathogenesis of OA. Taken together, our data suggest that 3′-SL alleviates IL-1β-induced OA pathogenesis via inhibition of activated MAPK and PI3K/AKT/NF-κB signaling cascades with the downregulation of oxidative stress and inflammation. Therefore, 3′-SL has the potential to be used as a natural compound for OA therapy owing to its ability to activate the antioxidant defense system and suppress inflammatory responses.

scholarly journals Management of Early Osteoarthritis

2020 ◽  
Author(s):  
Ahmed Mostafa Kotb Aziz
Keyword(s):  
Cost Effective ◽  
Cyst Formation ◽  
Degenerative Joint Disease ◽  
Joint Arthroplasty ◽  
Joint Disease ◽  
Treatment Modalities ◽  
Cost Effective Treatment ◽  
Inflammatory Drugs ◽  
Lifestyle Physical Activity

Osteoarthritis (OA) is a chronic degenerative joint disease of dynamic pathology with multiple etiologies. It involves progressive process of softening, loss of articular cartilage, subchondral bone sclerosis, development of osteophytes, and cyst formation. OA usually contributes to decreased activity associated with aging, secondary to diminished function and pain, thus consequently impairing quality of life. It is well established that pain due to OA, swelling, or stiffness can make it difficult for individuals to perform simple daily living activities. Although OA is not curable, a variety of treatment modalities are available to improve symptoms. Main elements include pain management maneuvers, education, changing lifestyle physical activity (PA), and weight reduction in case of overweight. Although total joint arthroplasty (TJA) is considered a cost-effective treatment for people with OA, TJA should only be considered after failure of conservative treatments. Symptoms of OA are usually managed by either pharmachological or nonpharmachological protocols; joint replacement surgeries are considered in advanced cases. Analgesics remain the keystone of pharmacological treatment for OA symptoms, including paracetamol, topical and oral nonsteroidal anti-inflammatory drugs (NSAIDs), and opioids. However, benefits from paracetamol and opioids are minimal, and NSAIDs are not ideal for many patients because they have many side-effects. Intra-articular therapies such as corticosteroids are also commonly used, though usually with short-term benefits.

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