scholarly journals Oxidative Modification of Biomolecules in the Nonstimulated and Stimulated Saliva of Patients with Morbid Obesity Treated with Bariatric Surgery

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Katarzyna Fejfer ◽  
Piotr Buczko ◽  
Marek Niczyporuk ◽  
Jerzy R. Ładny ◽  
Hady R. Hady ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Oxidative Damage ◽  
Progressive Failure ◽  
Protein Carbonyl ◽  
Oxidative Modification ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Whole Saliva ◽  
Before And After

Morbid obesity leads to progressive failure of many human organs and systems; however, the role of oxidative damage to salivary composition is still unknown in the obese patients. In this study, we assessed the effect of bariatric surgery on oxidative damage in nonstimulated (NS) and stimulated (S) whole saliva. The study included 47 subjects with morbid obesity as well as 47 age- and gender-matched healthy volunteers. Oxidative modifications to lipids (4-hydroxynonenal (4-HNE) and 8-isoprostanes (8-isoP)), proteins (advanced oxidation protein products (AOPP) and protein carbonyl groups (PC)), and DNA (8-hydroxy-D-guanosine (8-OHdG)) were analyzed in morbidly obese patients before and after bariatric surgery as well as in the healthy controls. The concentrations of 8-isoP, AOPP, PC, and 8-OHdG were significantly higher in both NS and S of patients with morbid obesity than in the control patients and compared to the results obtained 6 months after bariatric surgery. The levels of oxidative damage markers were also higher in S versus NS of morbidly obese patients. In summary, morbid obesity is associated with oxidative damage to salivary proteins, lipids, and DNA, while bariatric treatment generally lowers the levels of salivary oxidative damage.

scholarly journals Bariatric Surgery Normalizes Protein Glycoxidation and Nitrosative Stress in Morbidly Obese Patients

Antioxidants ◽  
2020 ◽  
Vol 9 (11) ◽  
pp. 1087
Author(s):  
Barbara Choromańska ◽  
Piotr Myśliwiec ◽  
Magdalena Łuba ◽  
Piotr Wojskowicz ◽  
Hanna Myśliwiec ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Oxidative Damage ◽  
Nitrosative Stress ◽  
High Specificity ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Plasma Tryptophan ◽  
Nitrative Stress ◽  
Specificity And Sensitivity

The results of recent studies indicate the key role of nitrosative stress and protein oxidative damage in the development of morbid obesity. Nevertheless, the effect of bariatric surgery on protein oxidation/glycation and nitrosative/nitrative stress is not yet known. This is the first study evaluating protein glycoxidation and protein nitrosative damage in morbidly obese patients before and after (one, three, six and twelve months) laparoscopic sleeve gastrectomy. The study included 50 women with morbid obesity as well as 50 age- and gender-matched healthy controls. We demonstrated significant increases in serum myeloperoxidase, plasma glycooxidative products (dityrosine, kynurenine, N-formyl-kynurenine, amyloid, Amadori products, glycophore), protein oxidative damage (ischemia modified albumin) and nitrosative/nitrative stress (nitric oxide, peroxy-nitrite, S-nitrosothiols and nitro-tyrosine) in morbidly obese subjects as compared to lean controls, whereas plasma tryptophan and total thiols were statistically decreased. Bariatric surgery generally reduces the abnormalities in the glycoxidation of proteins and nitrosative/nitrative stress. Noteworthily, in the patients with metabolic syndrome (MS+), we showed no differences in most redox biomarkers, as compared to morbidly obese patients without MS (MS−). However, two markers: were able to differentiate MS+ and MS− with high specificity and sensitivity: peroxy-nitrite (>70%) and S-nitrosothiols (>60%). Further studies are required to confirm the diagnostic usefulness of such biomarkers.

scholarly journals A Longitudinal Study of the Antioxidant Barrier and Oxidative Stress in Morbidly Obese Patients after Bariatric Surgery. Does the Metabolic Syndrome Affect the Redox Homeostasis of Obese People?

2020 ◽  
Vol 9 (4) ◽  
pp. 976 ◽  
Author(s):  
Barbara Choromańska ◽  
Piotr Myśliwiec ◽  
Magdalena Łuba ◽  
Piotr Wojskowicz ◽  
Jacek Dadan ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Metabolic Syndrome ◽  
Superoxide Dismutase ◽  
Uric Acid ◽  
Oxidative Damage ◽  
Redox Homeostasis ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Obese People ◽  
Oxidative Damage To Proteins

This is the first study to evaluate both the antioxidant barrier, glutathione metabolism, and oxidative damage to proteins and lipids in morbidly obese patients undergoing bariatric treatment. The study included 65 patients with class 3 obesity divided into two subgroups: morbidly obese patients without metabolic syndrome (OB) and obese patients with metabolic syndrome (OB + MS). Blood samples were collected before surgery as well as one, three, six, and twelve months after the bariatric treatment. Superoxide dismutase and reduced glutathione (GSH) were significantly decreased, whereas glutathione reductase and uric acid were enhanced in morbidly obese patients before bariatric surgery as compared to lean control. Moreover, in the OB group, we observed the increase of superoxide dismutase (SOD) and the decrease of uric acid (UA) after the bariatric treatment; however, these changes were not observed in the OB + MS group. The oxidative damage to proteins (advanced glycation end products, AGE; advanced oxidation protein products, AOPP) and lipids (8-isoprostanes, 8-isop; 4-hydroxynoneal) was higher in OB as well as OB + MS patients. We noticed that AGE and AOPP levels diminished after the bariatric treatment, whereas redox status (ratio of GSH to oxidized glutathione) was still reduced in the OB + MS group. Summarizing, morbid obesity is associated with disturbances in the antioxidant barrier and enhanced oxidative damage to proteins and lipids. Although bariatric surgery improves redox homeostasis in obese patients, those with metabolic syndrome show a continuous decrease in the antioxidant status. In patients undergoing bariatric treatment, antioxidant supplementation may be considered.

Plasma Protein Carbonyl and Thiol Stress Before and After Laparoscopic Gastric Banding in Morbidly Obese Patients

2007 ◽  
Vol 17 (10) ◽  
pp. 1367-1373 ◽  
Author(s):  
Hafize Uzun ◽  
Dildar Konukoglu ◽  
Remisa Gelisgen ◽  
Kagan Zengin ◽  
Mustafa Taskin
Keyword(s):  
Gastric Banding ◽  
Plasma Protein ◽  
Laparoscopic Gastric Banding ◽  
Protein Carbonyl ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Before And After

Response to Starvation before and after a Jejuno-Ileal Bypass Operation for Morbid Obesity

1979 ◽  
Vol 24 (3) ◽  
pp. 206-210 ◽  
Author(s):  
G. A. A. Al Shamma ◽  
G. S. Fell ◽  
S. N. Joffe
Keyword(s):  
Morbid Obesity ◽  
Metabolic Response ◽  
Ketone Bodies ◽  
The Body ◽  
Metabolic Adaptation ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Bypass Operation ◽  
Before And After ◽  
Ileal Bypass

A greater metabolic response developed during a seven day starvation in two morbidly obese patients three months after a 90 per cent jejuno-ileal bypass operation when compared with a similar fast before operation. There was a greater degree of ketosis, a decreased urinary urea excretion and an earlier utilization of ketone bodies. These changes suggest a metabolic adaptation of the body to the semistarvation state caused by the operation with a more rapid utilization of adipose tissue as a fuel and a sparing of lean body mass.

Anti-Xa Levels in Morbidly Obese Patients Using Apixaban or Rivaroxaban, Before and After Bariatric Surgery

2021 ◽  
Author(s):  
Thom Kok ◽  
Hans de Boer ◽  
Bart Witteman ◽  
Marcel Hovens ◽  
Matthijs van Luin ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Before And After

scholarly journals VOCAL COMPLAINT, AUDITORY-PERCEPTUAL ASSESSMENT OF VOICE AND VOCAL SELF-ASSESSMENT IN WOMEN WITH MORBID OBESITY

2015 ◽  
Vol 28 (suppl 1) ◽  
pp. 23-25 ◽  
Author(s):  
Lourdes Bernadete Rocha de SOUZA ◽  
Leandro de Araujo PERNAMBUCO ◽  
Marquiony Marques dos SANTOS ◽  
Joana Cristina Vasconcelos da SILVA
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Morbidly Obese ◽  
Self Assessment ◽  
Obese People ◽  
Voice Production ◽  
Perceptual Evaluation ◽  
Before And After ◽  
Perceptual Assessment ◽  
The Voice

Background : Obese people often have altered breathing patterns and therefore may experience difficulties in voice production. Aim : To verify the presence of vocal complaints and the correlation between the auditory-perceptual analysis of voice and vocal self-assessment of a group of women with morbid obesity before and after bariatric surgery. Methods : A longitudinal, exploratory, descriptive study of 21 morbidly obese women aged between 28 and 68 years, assessed before and after bariatric surgery, was performed. The women filled out a form containing identification data and type of vocal complaint. Perceptual evaluation of voice and vocal self-assessment were performed using a visual analog scale. For perceptual assessment of voice the women were asked to say three sentences from the Consensus Auditory-Perceptual Evaluation of Voice. Results : Of the 21 patients, 14 (66.6%) reported vocal complaints, of which 10 (71%) vocal fatigue, eight (57.14%) voice failures and seven (50%) vocal effort. All participants reported improvements in the voice after surgery, irrespective of having reported vocal complaints before surgery. There was no correlation between vocal self-assessment and auditory-perceptual assessment of the voice before or after the procedure. There was no correlation between vocal self-assessment and perceptual evaluation of the voice before surgery. Conclusion : Obesity interfered with voice production and influenced negative perception and therefore vocal complaints. Complaints about vocal production cannot be perceived by a speech therapist with the same impact as by patients, as both employ different criteria for vocal evaluation. Vocal self-assessment is an important tool in voice evaluation.

scholarly journals Quantification of epicardial adipose tissue in morbidly obese patients before and after bariatric surgery

2014 ◽  
Vol 16 (S1) ◽  
Author(s):  
María Luaces ◽  
Victoria Cachofeiro ◽  
Jorge Cabezudo Pedrazo ◽  
Alfonso Antequera-Pérez ◽  
Manuel Medina-García ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Adipose Tissue ◽  
Epicardial Adipose Tissue ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Before And After

scholarly journals The Effect of Bariatric Surgery Volume on General Surgery Outcomes for Morbidly Obese Patients

2021 ◽  
Vol 2021 ◽  
pp. 1-10
Author(s):  
Katheryn Hope Wilkinson ◽  
Ruizhe Wu ◽  
Aniko Szabo ◽  
Rana Higgins ◽  
Jon Gould ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbid Obesity ◽  
Hernia Repair ◽  
Ventral Hernia ◽  
General Surgery ◽  
Ventral Hernia Repair ◽  
High Volume ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Procedure Volume

Introduction. Bariatric surgery performed at high volume centers decreases length of stay, cost, and morbidity and mortality. The effect of a high volume of bariatric surgery procedures on outcomes may extend not just to bariatric surgery but to any general surgical procedure in morbidly obese patients. We hypothesized that patients with morbid obesity (body mass index >40 kg/m2) undergoing common, nonbariatric general surgery would have decreased morbidity and mortality at centers performing high volumes of bariatric surgery. Methods. The 2016 National Inpatient Sample (NIS) was used to identify the number of laparoscopic gastric bypass and sleeve gastrectomy performed at each hospital. Hospitals were classified as high volume bariatric hospitals (HVBH) ≥10 reported cases (50 actual)/year or low volume bariatric hospitals (LVBH) <10 reported cases (50 actual)/year, as NIS reports a 20% sample of actual cases. Patients with morbid obesity undergoing laparoscopic or open appendectomy, cholecystectomy, or ventral hernia repair were included for analysis. Propensity scores were developed based on available demographics, comorbidities, and hospital procedure volume. Postoperative complications during the index hospital admission, determined by ICD-10 code, were compared using inverse propensity weights. Differences were considered significant with a p value of <0.05. Results. The total number of general surgery patient cases analyzed was 14,028 from 2,482 hospitals, representing 70,140 admissions. The cohort of patients undergoing operations treated at HVBH were younger ( p = 0.03 ) with higher rates of COPD ( p = 0.04 ). Patients at LVBH had higher rates of nicotine dependence ( p = 0.0001 ) and obstructive sleep apnea ( p < 0.001 ). On propensity-weighted analysis adjusting for preoperative comorbidities and hospital procedure volume, there were significantly higher rates of multiple postprocedure complications at LVBH, specifically, postprocedure respiratory failure for patients undergoing elective laparoscopic cholecystectomy, elective ventral hernia repair with mesh and appendectomy. Conclusion. Patients with morbid obesity may have an advantage in having general surgery procedures at HVBH. HVBH may have a volume-outcomes relationship where the hospital and staff familiarity with the management principles required to minimize the postoperative risk associated with morbid obesity and improve patient outcomes.

scholarly journals Sialometric and Sialochemical Changes in Morbidly Obese Patients before and after Bariatric Surgery

2018 ◽  
Vol 19 (7) ◽  
pp. 756-761
Author(s):  
Luiz CC Gambus ◽  
Aline CBR Johann ◽  
Patrícia VC Bettega ◽  
Edvaldo AR Rosa ◽  
Ivone MI Morimoto ◽  
...  
Keyword(s):  
Bariatric Surgery ◽  
Morbidly Obese ◽  
Obese Patients ◽  
Before And After
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