scholarly journals Effect of a Traditional Chinese Herbal Medicine Formulation on Cell Survival and Apoptosis of MPP+-Treated MES 23.5 Dopaminergic Cells

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Shuifen Ye ◽  
Ho Kee Koon ◽  
Wen Fan ◽  
Yihui Xu ◽  
Wei Wei ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Neurodegenerative Diseases ◽  
Cell Survival ◽  
Chinese Herbal Medicine ◽  
Chinese Herbs ◽  
Expression Ratio ◽  
Traditional Chinese Herbal Medicine ◽  
Dopaminergic Cells ◽  
Chinese Herbal ◽  
Bax Protein

Progressive degeneration of dopaminergic neurons in the substantia nigra (SN) is implicated in Parkinson’s disease (PD). The efficacy of these currently used drugs is limited while traditional Chinese medicine (TCM) has been used in the management of neurodegenerative diseases for many years. This study was designed to evaluate the effect of a modified traditional Chinese herbal medicine decoction, Cong Rong Jing (CRJ), on cell survival and apoptosis of 1-methyl-4-phenylpyridinium- (MPP+-) treated MES23.5 dopaminergic cells. CRJ was prepared as a decoction from three Chinese herbs, namely,Herba Cistanches,Herba Epimedii, andRhizoma Polygonati. We reported here that CRJ significantly enhanced the cell survival of MES23.5 cells after the exposure of MPP+and inhibited the production of intracellular reactive oxygen species (ROS) induced by MPP+. CRJ also prevented the MPP+-treated MES23.5 cells from apoptosis by reducing the externalization of phosphatidylserine and enhancing the Bcl-2/Bax protein expression ratio. Signaling proteins such as JAK2, STAT3, and ERK1/2 were also involved in the action of CRJ. Taken together, these results provide a preliminary mechanism to support clinical application of the TCM formulation in PD and possibly other neurodegenerative diseases associated with ROS injury and apoptosis.

Study of the ESI and APCI interfaces for the UPLC–MS/MS analysis of pesticides in traditional Chinese herbal medicine

2013 ◽  
Vol 406 (5) ◽  
pp. 1481-1491 ◽  
Author(s):  
Lina Chen ◽  
Fengrui Song ◽  
Zhiqiang Liu ◽  
Zhong Zheng ◽  
Junpeng Xing ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Ms Analysis

scholarly journals In defence of traditional Chinese herbal medicine

Anaesthesia ◽  
2003 ◽  
Vol 58 (3) ◽  
pp. 282-283 ◽  
Author(s):  
I. Hosbach ◽  
G. Neeb ◽  
S. Hager ◽  
S. Kirchhoff ◽  
B. Kirschbaum
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal

scholarly journals In vivo Anti-candidal Activity Induced by a Traditional Chinese Herbal Medicine, Ganoderma lucidum.

1992 ◽  
Vol 33 (4) ◽  
pp. 505-512
Author(s):  
Hour-Young Chen ◽  
Chien-Ho Chen ◽  
Min-Yang Yeh ◽  
Jau-Shin Wu ◽  
Katsukiyo Yazawa ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Ganoderma Lucidum ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal

scholarly journals Survival Benefit of Traditional Chinese Herbal Medicine (A Herbal Formula for Invigorating Spleen) in Gastric Cancer Patients with Peritoneal Metastasis

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Lu Zhao ◽  
Ai-Guang Zhao ◽  
Gang Zhao ◽  
Yan Xu ◽  
Xiao-Hong Zhu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Herbal Medicine ◽  
Cancer Patients ◽  
Chinese Herbal Medicine ◽  
Peritoneal Metastasis ◽  
Herbal Formula ◽  
First Line ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal ◽  
Gastric Cancer Patients

Objective.We evaluated the efficiency of traditional Chinese herbal medicine (a compound herbal formula for invigorating spleen) as a complementary and alternative therapy for gastric cancer patients with peritoneal metastasis.Methods.Between 2001 and 2012, 93 gastric cancer patients with peritoneal metastasis were enrolled in this study. The effect of traditional Chinese herbal medicine on their long-term outcome was investigated. Kaplan-Meier method was used to assess the difference in survival time, and Cox proportional hazards regression analysis was performed to identify independent prognostic factors.Result.First-line palliative chemotherapy plus traditional Chinese herbal medicine was performed in 47 patients and the other 46 patients received chemotherapy alone. The overall survival was different between patients with and without traditional Chinese herbal medicine (12.0 versus 10.5 months;P=0.046). According to the Cox proportional hazard model, first-line chemotherapy cycle (hazards ratio [HR] = 0.527; 95% CI = 0.323~0.860) and TCHM (hazards ratio [HR] = 0.644; 95% CI = 0.481~0.992) were selected as independent prognostic factors for survival.Conclusion.The results suggest that traditional Chinese herbal medicine could improve the prognosis of the gastric cancer patients with peritoneal metastasis.

Shengmai (a traditional Chinese herbal medicine) for heart failure

2014 ◽  
Author(s):  
Qin Zhou ◽  
Wen-Zhe Qin ◽  
Shuai-Bin Liu ◽  
Joey SW Kwong ◽  
Jing Zhou ◽  
...  
Keyword(s):  
Heart Failure ◽  
Herbal Medicine ◽  
Chinese Herbal Medicine ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal

Traditional Chinese herbal medicine for vascular dementia

2013 ◽  
Author(s):  
Edwin SY Chan ◽  
Dianne Bautista ◽  
Yong You ◽  
Jian Ting Long ◽  
Lu Ling ◽  
...  
Keyword(s):  
Herbal Medicine ◽  
Vascular Dementia ◽  
Chinese Herbal Medicine ◽  
Traditional Chinese Herbal Medicine ◽  
Chinese Herbal
Sign in / Sign up

Export Citation Format

Share Document