scholarly journals Impact of Pressurized Intraperitoneal Aerosol Chemotherapy on Quality of Life and Symptoms in Patients with Peritoneal Carcinomatosis: A Retrospective Cohort Study

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Hugo Teixeira Farinha ◽  
Fabian Grass ◽  
Amaniel Kefleyesus ◽  
Chahin Achtari ◽  
Benoit Romain ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cohort Study ◽  
Peritoneal Carcinomatosis ◽  
Retrospective Cohort ◽  
Negative Impact ◽  
Peritoneal Cancer ◽  
Before And After ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Background. Peritoneal cancer treatment aims to prolong survival, but preserving Quality of Life (QoL) under treatment is also a priority. Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC) is a novel minimally invasive repeatable treatment modality. The aim of the present study was to assess QoL in our cohort of PIPAC patients. Methods. Analysis of all consecutive patients included from the start of PIPAC program (January 2015). QoL (0–100: optimal) and symptoms (no symptom: 0–100) were measured prospectively before and after every PIPAC procedure using EORTC QLQ-C30. Results. Forty-two patients (M : F = 8 : 34, median age 66 (59–73) years) had 91 PIPAC procedures in total (1 : 4x, 17 : 3x, 12 : 2x, and 12 : 1x). Before first PIPAC, baseline QoL was measured as median of 66±2.64. Prominent complaints were fatigue (32±4.3) and digestive symptoms as diarrhea (17±3.75), constipation (17±4.13), and nausea (7±2.54). Overall Quality of Life was 64±3.75 after PIPAC#1 (p=0.57), 61±4.76 after PIPAC#2 (p=0.89), and 70±6.67 after PIPAC#3 (p=0.58). Fatigue symptom score was 44±4.86 after PIPAC#1 and 47±6.69 and 34±7.85 after second and third applications, respectively (p=0.40). Diarrhea (p=0.31), constipation (p=0.76), and nausea (p=0.66) did not change significantly under PIPAC treatment. Conclusion. PIPAC treatment of peritoneal carcinomatosis had no negative impact on patients’ overall QoL and its components or on main symptoms. This study was registered online on Research Registry (UIN: 1608).

scholarly journals Quality of Life Variables Assessment, Before and After Pancreatoduodenectomy (PD): Prospective Study

2015 ◽  
Vol 8 (6) ◽  
pp. 203 ◽  
Author(s):  
Maria Arvaniti ◽  
Nikolaos Danias ◽  
Eleni Theodosopoulou ◽  
Vassilis Smyrniotis ◽  
M. Karaoglou ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Pancreatic Cancer ◽  
Surgical Treatment ◽  
Gastrointestinal Symptoms ◽  
The Body ◽  
Full Data ◽  
Before And After ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

<p><strong>INTRODUCTION: </strong>The treatment of pancreatic cancer is a complex problem, due to late diagnosis, the need for specialized surgical treatment, the large number of relapses and poor survival.</p><p><strong>OBJECTIVE: </strong>To evaluate the quality of life of patients with periampulary pancreatic cancer before and after pancreatoduodenectomy (PD).</p><p><strong>MATERIAL &amp; METHOD: </strong>The sample was collected in the "Attikon" University General Hospital (Chaidari)<strong>.</strong> It consists of 20 subjects with a mean age of 65.9 years (SD = 10,2 years). For the quality of life measurement, we used the (EORTC) QLQ-C30 version 3.0., as well as the EORTC QOL-PAN26.</p><p><strong>RESULTS: </strong>From<strong> </strong>the sample of 20 patients who participated, full data were collected for 18 of them during the first month, 17 during the third month and 16 during the sixth month.</p><p>Regarding symptoms, as they were recorded with the QLQ-30 questionnaire, there was a significant increase of fatigue, a significant reduction of pain and constipation, while economic difficulties increased.  As for the mean and median values for the dimensions of the PAN-26 questionnaire during monitoring, there was a significant decrease in pancreatic and liver pain symptoms during follow-up, while the gastrointestinal symptoms increased in frequency. In addition, the body image and sexuality worsened.</p><p><strong>CONCLUSIONS: </strong>The surgical treatment of pancreatic cancer with pancreatoduodenectomy (PD), according to the early survey data using the (EORTC) QLQ-C30 version3.0, and the EORTC QOL-PAN26 questionnaires, seems to have a favorable impact on quality of life, as evidenced by the improvement of most parameters evaluated during the study period.</p>

scholarly journals A study of patients` quality of life before and after resections of brain meningioma

2020 ◽  
Vol 26 (3) ◽  
pp. 64-69
Author(s):  
V. Yu. Cherebillo ◽  
M. Yu. Kurnukhina
Keyword(s):  
Quality Of Life ◽  
Postoperative Period ◽  
Laboratory Data ◽  
Early Postoperative Period ◽  
Before And After ◽  
Eortc Qlq C30 ◽  
Assess Quality ◽  
Eortc Qlq ◽  
Instrumental Methods

The objective was to analyze and evaluate patients` quality of life before and after resection of brain meningioma.Methods and materials. We performed study of 31 patients with brain meningioma. The diagnosis of the studied patients was based on clinical and laboratory data, data of radiation and instrumental methods of research. The analysis of patients` quality of life was carried out in the preoperative, early and late postoperative periods. The patient` age ranged from 37 to 65 years; the median age was 57 years. We chose a special questionnaire-EORTC QLQ-C30 to assess quality of life of the studied pre- and postoperative periods. The questionnaire has been tested in many international clinical studies.Results. In the early postoperative period, the severity of pain increased in the patients under study, nausea and vomiting, constipation occurred more often. However, patients assessed their General health in both early and late postoperative periods better than before the operation. In the late postoperative period, there was a positive dynamics in all scales of the questionnaire.Conclusion. On examination of various parameters of quality of life before and after surgery in patients with brain meningioma, it was found that surgical intervention led to an improvement in the quality of life of patients.

scholarly journals PENILAIAN KUALITAS HIDUP EORTC QLQ-C30 DAN EORTC QLQ-BN20 PADA PASIEN TUMOR PRIMER INTRAKRANIAL PASCATERAPI

2018 ◽  
Vol 35 (3) ◽  
Author(s):  
Ratih Puspa ◽  
Yusuf Wibisono ◽  
Henny Ang
Keyword(s):  
Quality Of Life ◽  
Intracranial Tumor ◽  
Life Questionnaire ◽  
Tumor Patients ◽  
Cancer Module ◽  
Before And After ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Primary Intracranial Tumor

QUALITY OF LIFE ASSESSMENT IN PRIMARY INTRACRANIAL TUMOR AFTER TREATMENT USING EORTC QLQ-C30 AND EORTC QLQ-BN20ABSTRACTIntroduction: Increasing number of surviving primary intracranial tumor patients in line with discovery of new treatment will increase the patient’s morbidity.This makes quality of life of patient need to be evaluated.Aims: Assessed quality of life in primary intracranial tumor patients post treatment using European Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) along with EORTC QLQ-Brain Cancer Module (EORTC QLQ-BN20).Methods: This was descriptive analytics-cross sectional study. Performed on primary intracranial tumor subjects during Desember 2017-January 2018 at neurology, neurosurgery, and radiotherapy outpatient Dr. Hasan Sadikin central general hospital Bandung. The obtained average value and the relationship between characteristics with quality of life were assessed using cross tabulation and analyzed with Statistical Package for Social Science (SPSS) version 24.0.Results: There were 42 subjects. Highest scale group based on EORTC QLQ-C30 was cognitive function of func- tional scale 81,4+30,2 and quality of life scale 68,3+19,7. Most symptom scale was pain 40,5+35,3. Whereas based onEORTC QLQ-BN20, most symptom was headache 49,2+37,7. Tumor location was factor that affects quality of life.Discussions: Subjects’ quality of life were good based on EORTC QLQ-C30 and EORTC QLQ-BN20. Results were accordance with some previous studies, but assessment has done before and after treatment. Evaluation quality of life should be made before and after treatment. This study only assessed subject after treatment in Outpatient Installation. For future, it is necessary to conduct cohort study for quality of life evaluation.Keywords: EORTC QLQ-BN20, EORTC QLQ-C30, primary intracranial tumor, quality of lifeABSTRAKPendahuluan: Meningkatnya jumlah pasien tumor primer intrakranial yang bertahan hidup sejalan dengan ditemu- kannya terapi baru akan meningkatkan morbiditas pasien. Hal ini membuat kualitas hidup pasien perlu dievaluasi.Tujuan: Menilai kualitas hidup pada pasien tumor primer intrakranial pascatindakan dengan menggunakan Euro- pean Organization for Research and Treatment of Cancer Quality of Life Questionnaire (EORTC QLQ-C30) bersamaan dengan EORTC QLQ-Brain Cancer Module (EORTC QLQ-BN20).Metode: Penelitian deskriptif analitik yang dilakukan secara potong lintang, dilakukan pada subjek tumor primer intrakranial selama Desember 2017-Januari 2018 di instalasi rawat jalan neurologi, bedah saraf, dan radioterapi RSUP Dr. Hasan Sadikin, Bandung. Uji statistik untuk menilai rerata nilai yang didapat serta hubungan karakteristik dan kualitas hidup dengan tabulasi silang, kemudian diolah dengan Statistical Package for Social Science (SPSS) versi 24.0.Hasil: Didapatkan 42 subjek. Kelompok skala paling tinggi berdasarkan EORTC QLQ-C30 adalah skala fungsional yaitu fungsi kognitif 81,4 + 30,2 dan skala kualitas hidup 68,3 + 19,7. Skala keluhan terbanyak nyeri 40,5+35,3. Sedang- kan berdasarkan EORTC QLQ-BN20, keluhan terbanyak nyeri kepala 49,2+37,7. Lokasi tumor merupakan faktor yang memengaruhi kualitas hidup.Diskusi: Kualitas hidup subjek penelitian baik berdasarkan EORTC QLQ-C30 dan EORTC QLQ-BN20. Hasil sesuai dengan beberapa penelitian sebelumnya, namun penilaian dilakukan sebelum dan setelah tindakan. Evaluasi adanya perubahan kualitas hidup seharusnya dilakukan sebelum dan setelah tindakan. Penelitian ini hanya menilai subjek setelah tindakan di instalasi rawat jalan. Untuk kedepannya, perlu dilakukan penelitian kohort untuk penilaian kualitas hidup.Kata kunci: EORTC QLQ-BN20, EORTC QLQ-C30, kualitas hidup, tumor primer intrakranial

scholarly journals Psychometric validation of the Moroccan version of the EORTC QLQ-C30 in colorectal Cancer patients: cross-sectional study and systematic literature review

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yacir El Alami ◽  
Hajar Essangri ◽  
Mohammed Anass Majbar ◽  
Saber Boutayeb ◽  
Said Benamr ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Colorectal Cancer ◽  
Discriminant Validity ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Related Quality ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Colorectal Cancer Patients

Abstract Background Health-related quality of life is mainly impacted by colorectal cancer which justified the major importance addressed to the development and validation of assessment questionnaires. We aimed to assess the validity and reliability of the Moroccan Arabic Dialectal version of the European Organization for Research and Treatment of Cancer (EORTC) Quality of Life Core Questionnaire (QLQ-C30) in patients with colorectal cancer. Methods We conducted a cross-sectional study using the Moroccan version of the EORTC QLQ-C30 on colorectal cancer patients from the National Oncology Institute of Rabat, in the period from February 2015 to June 2017. The QLQ-C30 was administered to 120 patients. Statistical analysis included reliability, convergent, and discriminant validity as well as known-groups comparisons. Results In total, 120 patients with colorectal cancer were included in the study with 38 (32%) patients diagnosed with colon cancers. Eighty-two patients (68%) had rectal cancer, among which 29 (24%) patients with a stoma. The mean age of diagnosis was 54 years (+/− 13.3). The reliability and validity of the Arabic dialectal Moroccan version of the EORTC QLQ-C30 were satisfactory. [Cronbach’s alpha (α =0.74)]. All items accomplished the criteria for convergent and discriminant validity except for question number 5, which did not complete the minimum required correlation with its own scale (physical functioning). Patients with rectal cancer presented with bad Global health status and quality of life (GHS/QOL), emotional functioning as well as higher fatigue symptoms compared to patients with colon cancer. The difference between patients with and without stoma was significant for diarrhea and financial difficulty. Conclusions The Moroccan Arabic Dialectal version of the QLQ-C30 is a valid and reliable measure of health-related quality of life (HRQOL) in patients with colorectal cancer.

scholarly journals Impact of individualized management of breakthrough cancer pain on quality of life in advanced cancer patients: CAVIDIOPAL study

2021 ◽  
Author(s):  
Albert Tuca Rodríguez ◽  
Miguel Núñez Viejo ◽  
Pablo Maradey ◽  
Jaume Canal-Sotelo ◽  
Plácido Guardia Mancilla ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Cancer Pain ◽  
Advanced Cancer ◽  
Low Doses ◽  
Breakthrough Cancer Pain ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
Individualized Management ◽  
The Impact

Abstract Purpose The main aim of the study was to assess the impact of individualized management of breakthrough cancer pain (BTcP) on quality of life (QoL) of patients with advanced cancer in clinical practice. Methods A prospective, observational, multicenter study was conducted in patients with advanced cancer that were assisted by palliative care units. QoL was assessed with the EORTC QLQ-C30 questionnaire at baseline (V0) and after 28 days (V28) of individualized BTcP therapy. Data on background pain, BTcP, comorbidities, and frailty were also recorded. Results Ninety-three patients completed the study. Intensity, duration, and number of BTcP episodes were reduced (p < 0.001) at V28 with individualized therapy. Transmucosal fentanyl was used in 93.8% of patients, mainly by sublingual route. Fentanyl titration was initiated at low doses (78.3% of patients received doses of 67 μg, 100 μg, or 133 μg) according to physician evaluation. At V28, mean perception of global health status had increased from 31.1 to 53.1 (p < 0.001). All scales of EORTC QLQ-C30 significantly improved (p < 0.001) except physical functioning, diarrhea, and financial difficulties. Pain scale improved from 73.6 ± 22.6 to 35.7 ± 22.3 (p < 0.001). Moreover, 85.9% of patients reported pain improvement. Probability of no ≥ 25% improvement in QoL was significantly higher in patients ≥ 65 years old (OR 1.39; 95% CI 1.001–1.079) and patients hospitalized at baseline (OR 4.126; 95% CI 1.227–13.873). Conclusion Individualized BTcP therapy improved QoL of patients with advanced cancer. Transmucosal fentanyl at low doses was the most used drug. Trial registration This study was registered at ClinicalTrials.gov database (NCT02840500) on July 19, 2016.

United States Utility Algorithm for the EORTC QLU-C10D, a Multiattribute Utility Instrument Based on a Cancer-Specific Quality-of-Life Instrument

2021 ◽  
pp. 0272989X2110035
Author(s):  
Dennis A. Revicki ◽  
Madeleine T. King ◽  
Rosalie Viney ◽  
A. Simon Pickard ◽  
Rebecca Mercieca-Bebber ◽  
...  
Keyword(s):  
Quality Of Life ◽  
United States ◽  
Emotional Functioning ◽  
Health State ◽  
Life Questionnaire ◽  
Multiattribute Utility ◽  
Value Set ◽  
Eortc Qlq C30 ◽  
Eortc Qlq

Background The EORTC QLU-C10D is a multiattribute utility measure derived from the cancer-specific quality-of-life questionnaire, the EORTC QLQ-C30. The QLU-C10D contains 10 dimensions (physical, role, social and emotional functioning, pain, fatigue, sleep, appetite, nausea, bowel problems). The objective of this study was to develop a United States value set for the QLU-C10D. Methods A US online panel was quota recruited to achieve a representative sample for sex, age (≥18 y), race, and ethnicity. Respondents undertook a discrete choice experiment, each completing 16 choice-pairs, randomly assigned from a total of 960 choice-pairs. Each pair included 2 QLU-C10D health states and duration. Data were analyzed using conditional logistic regression, parameterized to fit the quality-adjusted life-year framework. Utility weights were calculated as the ratio of each dimension-level coefficient to the coefficient for life expectancy. Results A total of 2480 panel members opted in, 2333 (94%) completed at least 1 choice-pair, and 2273 (92%) completed all choice-pairs. Within dimensions, weights were generally monotonic. Physical functioning, role functioning, and pain were associated with the largest utility weights. Cancer-specific dimensions, such as nausea and bowel problems, were associated with moderate utility decrements, as were general issues such as problems with emotional functioning and social functioning. Sleep problems and fatigue were associated with smaller utility decrements. The value of the worst health state was 0.032, which was slightly greater than 0 (equivalent to being dead). Conclusions This study provides the US-specific value set for the QLU-C10D. These estimated health state scores, based on responses to the EORTC QLQ-C30 questionnaire, can be used to evaluate the cost-utility of oncology treatments.

Quality of Life Among Disease-Free Survivors of Rectal Cancer

2004 ◽  
Vol 22 (2) ◽  
pp. 354-360 ◽  
Author(s):  
Philippe Rauch ◽  
Joelle Miny ◽  
Thierry Conroy ◽  
Lionel Neyton ◽  
Francis Guillemin
Keyword(s):  
Quality Of Life ◽  
Rectal Cancer ◽  
Cancer Survivors ◽  
German Population ◽  
European Organization ◽  
Eortc Qlq C30 ◽  
Eortc Qlq ◽  
The Impact ◽  
Disease Free

Purpose To identify factors affecting the quality of life (QoL) of disease-free survivors of rectal cancer. Patients and Methods One hundred twenty-one patients in complete remission more than 2 years after diagnosis were asked to complete three QoL questionnaires: the European Organization for Research and Treatment of Cancer (EORTC) QLQ-C30; its colorectal module, QLQ-CR38; and the Duke generic instrument. Results Patients reported less pain (P = .002) than did controls drawn from the general population. EORTC QLQ-C30 physical scores were also higher among rectal cancer survivors than in the general Norwegian or German population (P = .0005 and P = .002, respectively). Unexpectedly, stoma patients reported better social functioning than did nonstoma patients (P = .005), with less anxiety (P = .008) and higher self-esteem (P = .0002). In the present authors' experience, the QLQ-CR38 does not discriminate between these groups. Residual abdominal or pelvic pain and constipation had the most negative influence on QoL. Conclusion QoL is high among rectal cancer survivors, including stoma patients. Simultaneous use of several QoL questionnaires appears to have value in follow-up and in monitoring the effects of therapy. The impact of residual pain and constipation on long-term QoL should be considered when establishing a treatment regimen.

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