scholarly journals NADPH Oxidase Deficiency: A Multisystem Approach

2017 ◽  
Vol 2017 ◽  
pp. 1-23 ◽  
Author(s):  
Giuliana Giardino ◽  
Maria Pia Cicalese ◽  
Ottavia Delmonte ◽  
Maddalena Migliavacca ◽  
Boaz Palterer ◽  
...  
Keyword(s):  
Nadph Oxidase ◽  
Protective Role ◽  
Biological Processes ◽  
The Novel ◽  
Many Body ◽  
Phagocytic Cells ◽  
Oxidase Deficiency ◽  
Oxidative Balance ◽  
Many Body Systems

The immune system is a complex system able to recognize a wide variety of host agents, through different biological processes. For example, controlled changes in the redox state are able to start different pathways in immune cells and are involved in the killing of microbes. The generation and release of ROS in the form of an “oxidative burst” represent the pivotal mechanism by which phagocytic cells are able to destroy pathogens. On the other hand, impaired oxidative balance is also implicated in the pathogenesis of inflammatory complications, which may affect the function of many body systems. NADPH oxidase (NOX) plays a pivotal role in the production of ROS, and the defect of its different subunits leads to the development of chronic granulomatous disease (CGD). The defect of the different NOX subunits in CGD affects different organs. In this context, this review will be focused on the description of the effect of NOX2 deficiency in different body systems. Moreover, we will also focus our attention on the novel insight in the pathogenesis of immunodeficiency and inflammation-related manifestations and on the protective role of NOX2 deficiency against the development of atherosclerosis.

scholarly journals Universal relations for ultracold reactive molecules

2020 ◽  
Vol 6 (51) ◽  
pp. eabd4699
Author(s):  
Mingyuan He ◽  
Chenwei Lv ◽  
Hai-Qing Lin ◽  
Qi Zhou
Keyword(s):  
Critical Role ◽  
Interaction Strength ◽  
Quantum Correlations ◽  
Polar Molecules ◽  
Many Body ◽  
Density Correlation ◽  
Ultracold Polar Molecules ◽  
Unexplored Area ◽  
Many Body Systems

The realization of ultracold polar molecules in laboratories has pushed physics and chemistry to new realms. In particular, these polar molecules offer scientists unprecedented opportunities to explore chemical reactions in the ultracold regime where quantum effects become profound. However, a key question about how two-body losses depend on quantum correlations in interacting many-body systems remains open so far. Here, we present a number of universal relations that directly connect two-body losses to other physical observables, including the momentum distribution and density correlation functions. These relations, which are valid for arbitrary microscopic parameters, such as the particle number, the temperature, and the interaction strength, unfold the critical role of contacts, a fundamental quantity of dilute quantum systems, in determining the reaction rate of quantum reactive molecules in a many-body environment. Our work opens the door to an unexplored area intertwining quantum chemistry; atomic, molecular, and optical physics; and condensed matter physics.

NADPH oxidase participates in the oxidative damage caused by fluoride in rat spermatozoa. Protective role of α-tocopherol

2010 ◽  
Vol 31 (6) ◽  
pp. 579-588 ◽  
Author(s):  
Jeannett A. Izquierdo-Vega ◽  
Manuel Sánchez-Gutiérrez ◽  
Luz María Del Razo
Keyword(s):  
Oxidative Damage ◽  
Nadph Oxidase ◽  
Protective Role

scholarly journals On the widths and binding energies of K− nuclear states and the role of K− multi-nucleon interactions

2018 ◽  
Vol 181 ◽  
pp. 01009
Author(s):  
Jaroslava Hrtankova ◽  
Jiří Mareš
Keyword(s):  
Bound States ◽  
Binding Energies ◽  
Many Body ◽  
Nucleon Interaction ◽  
Substantial Impact ◽  
Coupled Channels ◽  
Self Consistent ◽  
Interaction Term ◽  
Many Body Systems

We report on our recent self-consistent calculations of K− nuclear quasi-bound states using K− optical potentials derived from chirally motivated meson-baryon coupled channels models [1, 2]. The K− single-nucleon potentials were supplemented by a phenomenological K− multi-nucleon interaction term introduced to achieve good fits to K− atom data. We demonstrate a substantial impact of the K− multi-nucleon absorption on the widths of K− nuclear states. If such states ever exist in nuclear many-body systems, their widths are excessively large to allow observation.

The protective role of NADPH oxidase in ANCA-induced vasculitis

2013 ◽  
Vol 42 (4) ◽  
pp. 688-689
Author(s):  
A. Schreiber ◽  
S. Krueger ◽  
C. Luft ◽  
R. Kettritz
Keyword(s):  
Nadph Oxidase ◽  
Protective Role

scholarly journals The novel protective role of P27 in MLN4924-treated gastric cancer cells

2015 ◽  
Vol 6 (8) ◽  
pp. e1867-e1867 ◽  
Author(s):  
Q Zhang ◽  
D Hou ◽  
Z Luo ◽  
P Chen ◽  
B Lv ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cancer Cells ◽  
Protective Role ◽  
The Novel ◽  
Gastric Cancer Cells

scholarly journals Role of Flavonoids against COVID-19

2021 ◽  
Vol 9 (1) ◽  
pp. 47-55
Author(s):  
Ambreen Fatima ◽  
Yasir H. Siddique
Keyword(s):  
Treatment Strategy ◽  
Protective Role ◽  
The Novel ◽  
Loss Of Life ◽  
The World ◽  
Health Promoting ◽  
Ancient Times ◽  
Novel Coronavirus ◽  
Old Drugs

The novel coronavirus disease (COVID-19) has entered a threatening stage all over the world. Many lives have been lost, and many more are in need of treatment. The mild symptoms may include fever and dry cough, but in severe cases, it could lead to pneumonia and ultimately death in some instances. Though medical scientists all over the globe are working hard to develop a treatment for this disease, yet no definite cure has been found. To date, the treatment strategy is based on adopting strategies to break the transmission of the virus and repurposing of the old drugs to prevent the loss of life. Among the various potent candidates, flavonoids may play a protective role in these times. Studies have already proven various health-promoting properties of flavonoids in earlier viral diseases, like SARS and MERS. Since ancient times, been plants have used to treat a number of human diseases. Different phytoproducts have been previously described to inhibit the replication of numerous viruses. Despite the positive reports for plant-based medications, no successful clinical trials on phytoproducts as anti-COVID agents have been conducted to date. This review highlights the efficacy of flavonoids as a treatment strategy either alone or in combination with other drugs.

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