scholarly journals Measurements of Corneal Thickness in Eyes with Pseudoexfoliation Syndrome: Comparative Study of Different Image Processing Protocols

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Katarzyna Krysik ◽  
Dariusz Dobrowolski ◽  
Katarzyna Polanowska ◽  
Anita Lyssek-Boron ◽  
Edward A. Wylegala
Keyword(s):  
Time Domain ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Imaging Systems ◽  
Pressure Measurements ◽  
Swept Source ◽  
Swept Source Oct ◽  
The Mean ◽  
Thickness Measurements ◽  
Cataract Patients

Purpose. Comparative analysis of central and peripheral corneal thickness in PEX patients using three different imaging systems: Pentacam-Scheimpflug device, time-domain optical coherence tomography (OCT) Visante, and swept-source OCT Casia. Materials and Methods. 128 eyes of 80 patients with diagnosed PEX were examined and compared with 112 normal, non-PEX eyes of 72 cataract patients. The study parameters included 5 measured zones: central and 4 peripheral (superior, inferior, nasal, and temporal). Results. The mean CCT in eyes with PEX syndrome measured with all three instruments was thicker than that in normal eyes. Corneal thickness measurements in the PEX group were statistically significantly different between Pentacam and OCT Casia: central corneal thickness (p=0.04), inferior corneal zone (p=0.01), and nasal and temporal corneal zones (p<0.01). Between Pentacam and OCT Visante inferior, nasal and temporal corneal zones were statistically significantly different (p<0.01). Between OCT Casia and OCT Visante, there were no statistically significant differences in measured parameters values. Conclusion. The central corneal thickness in eyes with PEX syndrome measured with three different independent methods is higher than that in the non-PEX group, and despite variable peripheral corneal thickness, this one parameter is still crucial in intraocular pressure measurements.

scholarly journals Evaluation of Anterior Chamber Depth in 28,709 Adult Cataract Patients in China using Swept-Source Optical Biometry

2021 ◽  
Author(s):  
Qiong Lei ◽  
Haixia Tu ◽  
Xi Feng ◽  
Yong Wang
Keyword(s):  
Cataract Surgery ◽  
Anterior Chamber ◽  
Axial Length ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Multivariate Regression Analysis ◽  
Swept Source ◽  
Mean Values ◽  
The Mean ◽  
Cataract Patients

Abstract Background: To create an anterior chamber depth (ACD) regression model for adult cataract surgery candidates from China, and to evaluate the distribution of their ocular biometric parameters.Methods: The ocular biometric records of 28,709 right eyes of cataract surgery candidates who were treated at Aier Eye Hospitals in nine cities from 2018 to 2019 were retrospectively analyzed. All measurements were taken with IOLMaster 700. We included patients who were at least 40 years old and were diagnosed with cataract.Results: The mean age of the patients was 68.6 ± 11.0 years. The mean values recorded were as follows: axial length (AL), 24.17 ± 2.47 mm; mean keratometry (Km) value, 44.09 ± 3.25 D; corneal astigmatism (CA), 1.06 ± 0.98 D; ACD, 3.02 ± 0.45 mm; lens thickness (LT), 4.52 ± 0.45 mm; central corneal thickness (CCT), 0.534 ± 0.04 mm; and white to white (WTW) corneal diameter, 11.64 ± 0.46 mm. The proportion of patients with long axial length (AL >25 mm) decreased with age. ACD, LT, AL, Km, WTW, and age were correlated. In the multivariate regression analysis of ACD, which included LT, AL, WTW, sex, Km, CCT, and age, there was a reasonable prediction with adjusted R2 = 0.629.Conclusions: The results show that high myopes are inclined to schedule cataract surgery at a younger age. LT and AL were found to be important factors that affect ACD. This study provides reference data for cataract patients from China.

scholarly journals Analysis of Lens Thickness Distribution Based on Swept-Source Optical Coherence Tomography (SS-OCT)

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xi Feng ◽  
Yong Wang ◽  
Jianheng Liang ◽  
Yali Xu ◽  
Julio Ortega-Usobiaga ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Negative Correlation ◽  
Axial Length ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Biometric Data ◽  
Swept Source ◽  
Age Related ◽  
Cataract Patients

Objective. This study aimed to analyze the distribution of lens thickness (LT) and its associations in age-related cataract patients based on swept-source optical coherence tomography (SS-OCT). Methods. This cross-sectional study included 59,726 Chinese age-related cataract patients. Only right-eye data were included in the study. Repeated measures of ocular parameters were performed using an IOL Master 700 device. The distributions of ocular biometric data including anterior chamber depth (ACD), LT, axial length (AL), central corneal thickness (CCT), white-to-white (WTW), and mean keratometry (MK) and their associations with age were assessed. The anterior segment (AS) was measured as the sum of CCT, ACD, and LT, while the vitreous chamber depth (VCD) was calculated as the difference between AL and AS. The values of LT : AL, AS : AL, and VCD : AL in different AL groups and their changes are the main outcome measures used to observe the proportion of the anterior and posterior segments of the eye. Results. Biometric data were available for 59,726 individuals. The mean age was 68.81 years (range = 40–100); 40.62% were male and 59.38% were female. Mean anterior chamber depth (ACD) was 3.02 ± 0.44 mm, mean LT was 4.51 ± 0.44 mm, mean axial length (AL) was 23.89 ± 1.92 mm, mean central corneal thickness (CCT) was 0.53 ± 0.03 mm, mean white-to-white (WTW) was 11.64 ± 0.44 mm, and mean keratometry (MK) was 44.27 ± 1.65 diopter. Female patients had shorter AL, shallower ACD, smaller CCT and WTW, decreased LT, and steeper corneas ( p  < 0.005). ACD revealed the strongest negative correlation ( p  ≤ 0.001, r = –0.682) with LT. Age ( p  ≤ 0.001, r = 0.348) showed a moderate positive correlation, whereas MK ( p  ＜ 0.05, r = 0.011), CCT ( p  ≤ 0.001, r = 0.041) had a weak positive correlation and WTW ( p  ≤ 0.001, r = –0.034) had a weak negative correlation with LT. A nonlinear correlation was found between LT and AL. LT increased with age in both males and females. LT changed variably in eyes with AL less than 27 mm, LT decreased as AL increased, then LT gradually increased as AL increased in extremely long and extra-long eyes ( p  ≤ 0.001). LT : AL and AS : AL decreased as AL increased, VCD : AL gradually increased as AL increased in highly myopic eyes, and VCD : AL increased by about 0.01 for every 1 mm increase in AL. Conclusions. Among Chinese age-related cataract patients, we found LT to have the strongest relation with ACD. The lens was thicker in elderly patients and women. The correlation between LT and AL is not a simple negative correlation; with the increase of age, LT decreases first and then increases. The proportion of VCD is constantly rising with the elongation of AL.

scholarly journals Comparison of Central Corneal Thickness Measurements between Angiovue Optical Coherence Tomography, Ultrasound Pachymetry and Ocular Biometry

2020 ◽  
pp. 1-9
Author(s):  
E. Pateras ◽  
A. I. Kouroupaki
Keyword(s):  
Optical Coherence Tomography ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Repeated Measurements ◽  
Optical Coherence ◽  
Swept Source ◽  
Ocular Biometry ◽  
Significant Linear Correlation ◽  
Ultrasound Pachymetry ◽  
The Mean

Purpose: To compare central corneal thickness (CCT) measurements and their reproducibility when taken by Ultrasound Pachymetry, Ocular Biometry and Angiovue Optical Coherence Tomography (OCT). Methods: Twenty-five healthy volunteers were recruited creating a sample size of 50 eyes. All subjects had pachymetric measurements by Ultrasound pachymetry (PachPen Handheld Pachymeter, Keeler Instruments Inc), Ocular biometry (IOL Master 700 Swept Source Biometry, Zeiss) and Angiovue Optical Coherence Tomography (Optovue Avanti RTVue XR Angiovue). The measurements of central corneal thickness for the three devices were taken by the same examiner twice for more accuracy. Results: The average measurements of central corneal thickness by Ultrasound pachymetry (PachPen Handheld Pachymeter, Keeler Instruments Inc), Ocular biometry (IOL Master 700 Swept Source Biometry, Zeiss) and Angiovue Optical Coherence Tomography (Optovue Avanti RTVue XR Angiovue) were 547.26 μm, 551.36 μm, and 536.42 μm, respectively. The mean standard deviation (SD) of repeated measurements by Ocular biometry was 48.87 μm, which was greater than the mean SD of 44.24 μm and 40.35 μm (P < 0.001) by ultrasound pachymetry and Angiovue optical coherence tomography, respectively. There were statistically significant differences in the measurement results among the 3 methods (Ultrasound pachymetry vs. Ocular biometry P = 0.019; Ultrasound pachymetry vs. Angiovue Optical Coherence Tomography; P < 0.001; Ocular biometry vs. Angiovue Optical Coherence Tomography P < 0.001). There was a significant linear correlation between the Ultrasound pachymetry and Ocular biometry (r = 0.945, P<0.001), Ultrasound pachymetry and Angiovue Optical Coherence Tomography (r = 0.895, P<0.001), and Ocular biometry and Angiovue Optical Coherence Tomography (r = 0.902, P<0.001). Conclusion: Central corneal thickness readings were comparable between PachPen Handheld Pachymeter, IOL Master 700 Biometry and Angiovue Optical Coherence Tomography; Angiovue optical coherence tomography gave significantly smaller values. The measurements of the 3 methods showed significant linear correlations with one another. All methods provided acceptable repeatability of measurements.

scholarly journals Comparison of central corneal thickness measurements with three different optical devices

2021 ◽  
Vol 13 ◽  
pp. 251584142199563
Author(s):  
Mehmet Barış Üçer ◽  
Erdinç Bozkurt
Keyword(s):  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Correlation Coefficients ◽  
Limits Of Agreement ◽  
The Mean ◽  
Mean Differences ◽  
High Level ◽  
Thickness Measurements

Purpose: The purpose of this study was to compare and evaluate the agreement of central corneal thickness (CCT) values obtained with three different devices working according to optical principle in healthy eyes. Methods: 60 eyes of 60 individuals (30 men and 30 women) were enrolled in this study. CCT measurements performed with Scheimpflug–Placido topographer (Sirius), spectral-domain optical coherence tomography (RTVue) with an anterior segment module, and optical biometer (AL-Scan) were compared. Bland–Altman analysis was used to demonstrate agreement between methods. Results: The mean age was 30.07 ± 7.313 years (range, 18–47 years). The mean CCT values obtained by RTVue, Sirius, and AL-Scan were 518.25 ± 36.38 µm, 526.08 ± 36.33 µm, and 513.50 ± 39.09 µm, respectively. The mean differences in CCT were 7.83 ± 14.15 µm between Sirius and RTVue, 12.58 ± 11.87 µm between Sirius and AL-Scan, and 4.75 ± 4.50 µm between RTVue and AL-Scan. The mean CCT was statistically different among the three groups ( p < 0.05). All three modalities of CCT measurements correlated closely with each other, with Pearson’s correlation coefficients ranging from 0.924 to 0.961. The 95% limits of agreement were −19.90 to 35.56 µm between Sirius and RTVue, −10.69 to 35.85 µm between Sirius and AL-Scan, and −4.07 to 13.58 µm between RTVue and AL-Scan. Conclusion: Different results could be obtained through different noncontact devices in CCT measurements. Although the measurement values obtained by these devices show a high level of correlation, it would be a more correct approach to not use them directly interchangeably in clinical practice. Evaluation and follow-up of CCT should be performed using the same device.

scholarly journals Distribution of ocular biometric parameters and optimal model of anterior chamber depth regression in 28,709 adult cataract patients in China using swept‐source optical biometry

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Qiong Lei ◽  
Haixia Tu ◽  
Xi Feng ◽  
Julio Ortega-Usobiaga ◽  
Danmin Cao ◽  
...  
Keyword(s):  
Regression Analysis ◽  
Anterior Chamber ◽  
Multivariate Regression ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Multivariate Regression Analysis ◽  
Swept Source ◽  
Biometric Parameters ◽  
The Mean ◽  
Cataract Patients

Abstract Background The purpose of this study was to evaluate the ocular biometric parameters in adult cataract patients from China and create an anterior chamber depth (ACD) regression model. Methods The ocular biometric records of 28,709 right eyes of cataract surgery candidates who were treated at Aier Eye Hospitals in nine cities from 2018 to 2019 were retrospectively analyzed. All measurements were taken with IOLMaster 700. We included patients who were at least 40 years old and were diagnosed with cataract. Results The mean age of the patients was 68.6 ± 11.0 years. The mean values recorded were as follows: axial length (AL), 24.17 ± 2.47 mm; mean keratometry (Km) value, 44.26 ± 1.70 D; corneal astigmatism (CA), 1.06 ± 0.96 D; ACD, 3.02 ± 0.45 mm; lens thickness (LT), 4.52 ± 0.45 mm; central corneal thickness (CCT), 0.534 ± 0.04 mm; and white to white (WTW) corneal diameter, 11.64 ± 0.46 mm. ACD correlated positively with AL (Spearman coefficient, 0.544) and WTW (0.300), but negatively with LT (-0.660) and age (-0.285) (all P < 0.01). In the multivariate regression analysis of ACD, which included LT, AL, WTW, sex, Km, CCT, and age, there was a reasonable prediction with adjusted R2 = 0.641. Conclusions Cataract patients with longer AL and wider WTW have deeper ACD. With increasing age and lens thickening ACD becomes shallower. Based on the standardized coefficients of ACD multivariate regression analysis from the study, LT is the main factor that affects ACD, and is followed by AL.

scholarly journals Difference in Central Corneal Thickness between Applanation Ultrasound and Oculus Wave � 152 Light Occulyzer II

2019 ◽  
Vol 35 (3) ◽  
Author(s):  
Munira Shakir, Ronak Afza Memon Sahira Wasim Shakir Zafar
Keyword(s):  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Clinical Settings ◽  
Exclusion Criteria ◽  
Cross Sectional ◽  
Ultrasound Pachymetry ◽  
Department Of Ophthalmology ◽  
The Mean ◽  
Thickness Measurements ◽  
Applanation Ultrasound

Purpose: To determine the mean difference of central corneal thickness measurements by using ultrasound Pachymetry and oculus Wave light Occulyzer II. Study Design: Cross-sectional comparative study using non-probability consecutive sampling. Place and Duration of Study: This study was conducted at Department of Ophthalmology, Liaquat National Hospital Karachi from November 2018 to June 2019. Material & Methods: After approval from ethical committee, patients were included in our study on the basis of inclusion & exclusion criteria. Central corneal thickness measurements were taken by using ultrasound Pachymetry & oculus Wave light Occulyzer II. All the data was collected by single researcher. The results were plotted, compared & analyzed. Paired t-test was used for the comparison of quantitative variables. Results: There were 130 patients included in the study out of which 73 (56.2%) were males and 57 (43.8%) were females. Mean age of these patients was 33.9 � 8.9 years. The mean � SD thinnest oculus Wave light Occulyzer II measurement was 538.61 � 23.46 ?m and ranged between 476.0 and 619.0 ?m whereas the mean thinnest ultrasound Pachymetry measurement was 535.1 � 21.816 ?m and ranged between 482 and 601 ?m. There was highly significant correlation of central corneal thickness between both the instruments. (r = 0.96, p < 0.001). Conclusion: There is a high correlation of central corneal thickness between the readings obtained from ultrasound and optical pachymetry machines therefore oculus Wave light Occulyzer II can be used as an alternative technique to ultrasound pachymetry while assessing CCT in clinical settings. Key Words: Central corneal thickness, Ultrasound Pachymetry, Optical Pachymetry.

scholarly journals Lens thickness and associated ocular biometric factors among cataract patients in Shanghai

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Jiaqi Meng ◽  
Ling Wei ◽  
Wenwen He ◽  
Jiao Qi ◽  
Yi Lu ◽  
...  
Keyword(s):  
Older Patients ◽  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Chamber Depth ◽  
Male Gender ◽  
Older Age ◽  
Corneal Curvature ◽  
Lens Thickness ◽  
The Mean ◽  
Cataract Patients

Abstract Background To evaluate the distribution of lens thickness (LT) and its associations with other ocular biometric factors among cataract patients in Shanghai. Methods Twenty-four thousand thirteen eyes from 24,013 cataract patients were retrospectively included. Ocular biometric factors including LT, central corneal thickness (CCT), anterior chamber depth (ACD), white-to-white (WTW) distance, anterior corneal curvature, and axial length (AL) were obtained using the IOLMaster700. The associations between LT and general or ocular factors were assessed. Results The mean age was 62.5 ± 13.6 years and 56.1% were female. The mean LT was 4.51 ± 0.46 mm. The LT was greater in older patients (P < 0.001). LT was positively correlated with CCT, while negatively correlated with ACD, WTW, and anterior corneal curvature (P < 0.001). Multivariate analysis revealed that increased LT was associated with older age, male gender, thicker CCT, shallower ACD, larger WTW, and flatter anterior corneal curvature (P < 0.001). LT changed with a variable behavior according to AL. In short eyes LT increased as AL increased, then decreased with longer AL in normal eyes and moderate myopic eyes, but increased again as AL increased in highly myopic eyes. Thickest LT was found in the 20.01–22 mm AL group. The correlation between LT and other biometric factors remained significant when stratified by ALs. Conclusions In a large Chinese cataractous population, we found that the thicker lens may be associated with older age, male gender, thicker CCT, shallower ACD, larger WTW, and flatter anterior corneal curvature. As AL increased, the change of LT was nonlinear, with the thickest lens seen in the 20–22 mm AL group.

scholarly journals Determining the mean difference in central corneal thickness measured by applanation ultrasound and oculus Wavelight Occulyzer II

2021 ◽  
Vol 35 (3) ◽  
Author(s):  
Dr Ronak afza Memon ◽  
Dr munira Shakir ◽  
Dr Sahira Wasim
Keyword(s):  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Mean Difference ◽  
Topical Anesthetic ◽  
Cross Sectional ◽  
Anesthetic Agents ◽  
Department Of Ophthalmology ◽  
The Mean ◽  
Thickness Measurements ◽  
Ultrasound Pachymeter

Abstract Objective: The objective is to determine the mean difference of central corneal thickness measurements by using ultrasound pachymeter and oculus Wavelight Occulyzer II. Patients & Methods: This prospective cross-sectional comparative study was conducted at Department of Ophthalmology, Liaquat National Hospital, Karachi for 6 months duration, after the approval from ethical committee. Patients were included in our study on the basis of inclusion & exclusion criteria. Central corneal thickness measurements was taken by using ultrasound pachymeter & oculus Wavelight Occulyzer II. All the data was collected by single researcher. The results were plotted, compared & analyzed. Results: 130 patients attending ophthalmology department and fulfilling the inclusion criteria were assessed. One eye of each patient was measured (65 were right eye and 65 were left eye). 73(56.2%) were male and 57(43.8%) were females. Mean age of these patients was 33.9 ±8.9 years. The mean ± SD thinnest oculus Wavelight Occulyzer II measurement was 538.61±23.46 ?m and ranged between 476.0 and 619.0 ?m whereas the mean thinnest ultrasound pachymeter measurement was 535.1±21.816?m and ranged between 482 and 601 ?m. There was highly significant correlation of central corneal thickness between both the instruments. (r=0.96, p<0.001)  Conclusion: According to the results of our study there is a highly correlation of central corneal thickness was found between the readings obtained from both UP and oculus Wavelight Occulyzer II. So we concluded that oculus Wavelight Occulyzer II can be used as an alternative technique to ultrasound pachymetry while assessing CCT in clinical settings to  decrease the risk of procedure associated problems with UP like epithelial trauma and infection, to decrease the frequent use of topical anesthetic agents, for early detection and management of glaucoma & in anxious patients also. Keywords: Central corneal thickness, ultrasound pachymeter, oculus Wavelight Occulyzer II  

scholarly journals Reproducibility of Central Corneal Thickness Measurements in Normal Eyes Using the Zeiss Cirrus 5000 HD-OCT and Pentacam HR

2018 ◽  
Vol 12 (1) ◽  
pp. 72-83 ◽  
Author(s):  
Elmira Baghdasaryan ◽  
Xiwen Huang ◽  
Kenneth M. Marion ◽  
Tudor C. Tepelus ◽  
Homayoun Bagherinia ◽  
...  
Keyword(s):  
Central Corneal Thickness ◽  
Corneal Thickness ◽  
Anterior Segment ◽  
Test Analysis ◽  
Cirrus Oct ◽  
Repeatability And Reproducibility ◽  
The Mean ◽  
Highly Correlated ◽  
Thickness Measurements ◽  
Intra Class Correlation Coefficient

Objectives:To determine the repeatability and reproducibility of Central Corneal Thickness (CCT) measurements using two different anterior segment imaging modalities, including those obtained with the new anterior segment lens attachments for the Cirrus 5000 HD-OCT.Methods:A total of 32 eyes from 16 normal volunteers (8 male, 8 female) were enrolled in this prospective study. CCT was measured by the same examiner using the Cirrus 5000 HD-OCT and Pentacam HR. The results of CCT obtained by each method were averaged and compared using t-test analysis. The agreement between the measurement methods was evaluated. Coefficient of Repeatability (CoR) and Intra-Class Correlation Coefficient (ICC) were computed.Results:The mean measurements taken with the Cirrus OCT anterior chamber lens (CCTAC), HD cornea lens (CCTHDC) and pachymetry scans (CCTPach) were 545.35 ± 31.02, 537.87 ± 26.82, and 532.04 ± 29.82 µm, respectively. The mean CCT obtained with the Pentacam (CCTPent) was 545.51 ± 30.71 µm. CCTPentwere significantly higher than CCTHDCand CCTPach(p< 0.0001). In contrast, the CCTPentand CCTACwere similar (p=0.87). CCT, as evaluated by the two different instruments, showed excellent correlation (r> 0.98,p< 0.0001) with an ICC > 0.99 (95% CI, 0.97 – 0.99). CoR was the highest for CCTPach(3.7 ± 1.4, 95% CI (3.0- 4.6)).Conclusion:CCT measurements from the Cirrus OCT using the new anterior segment lens attachments and the Pentacam HR are highly correlated. This should allow the use of a standardized correction factor if necessary to inter-relate the measurements between the two devices.

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