scholarly journals In VivoEvaluation ofGalla chinensisSolution in the Topical Treatment of Dermatophytosis

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Kai Sun ◽  
Xu Song ◽  
RenYong Jia ◽  
Zhongqiong Yin ◽  
Yuanfeng Zou ◽  
...  
Keyword(s):  
Trichophyton Mentagrophytes ◽  
Clinical Score ◽  
Skin Lesions ◽  
Positive Control ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Pharmacological Effects ◽  
Mycological Cure ◽  
Candidate Drug ◽  
Cure Rates

Aim. Dermatophytosis is one of the main fungal diseases in humans and animals all over the world.Galla chinensis, a traditional medicine, has various pharmacological effects. The goal of this study was to evaluate the treatment effect ofGalla chinensissolution (GCS) on dermatophytosis-infected dogs (Microsporum canis,Microsporum gypseum, andTrichophyton mentagrophytes, resp.).Methods. The treatment effects of GCS were evaluated by mycological cure rates and clinical score comprised of three indices, including inflammation, hair loss, and lesion scale.Results. The results showed that, in the three models of dermatophytosis, GCS significantly (P<0.05) improved skin lesions and fungal eradication. GCS (10% and 5%) had higher efficacy compared to the positive control (Tujingpi Tincture). The fungal eradication efficacy exceeds 85% after treatment with GCS (10%, 5%, and 2.5%) on day 14.Conclusion. The GCS has antidermatophytosis effect in dogs, which may be a candidate drug for the treatment of dermatophytosis.

scholarly journals Dermatofitosis humana en una comunidad con desigualdad social, Ayacucho 2018

2019 ◽  
Vol 27 (1) ◽  
Author(s):  
Serapio Romero Gavilán
Keyword(s):  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum

Trabajo de investigación desarrollado con el objetivo de conocer la frecuencia de la dermatofitosis humana en una comunidad con desigualdad social. Hipótesis: la dermatofitosis humana es una afección fúngica muy frecuente en comunidades con desigualdad social. Zona de estudio: comunidad con desigualdad social periurbana de la ciudad de Ayacucho. Tipo de estudio: no experimental. Diseño de estudio: descriptivo-transversal. Muestra: no probabilística, individuos con signos de afecciones compatibles a micosis superficial. Metodología: muestras de escamas de piel, pelos, fragmentos de uñas de pies y manos, escamas de planta, espacios interdigitales y otras partes de cuerpo, fueron tomadas con una hoja de bisturí de filo romo o con el borde de un portaobjetos previa desinfección con alcohol al 70% y colocadas en sobres de papel oscuro etiquetados, en el laboratorio de Epidemiología y Micología de la Universidad Nacional de San Cristóbal de Huamanga, se realizó la observación directa con KOH al 20% y la siembra en placas Petri conteniendo Agar Sabouraud y Agar selectivo para hongos patógenos, después de una incubación a 25ºC por hasta 14 días; las colonias coincidentes con dermatofitos fueron observados al microscopio para identificarlos. Resultados: se ha encontrado que 85/153 (55,5%) presentaron diversas formas de dermatofitosis, no se observó preferencia de la dermatofitosis humana con relación al género (p> 0,05), los factores asociados a la dermatofitosis determinados estadísticamente (p< 0,05) fueron la higiene, el piso de la vivienda y la crianza de animales, se han identificado las especies de Trichophyton rubrum, Trichophyton mentagrophytes, Microsporum canis y Microsporum gypseum.

scholarly journals Los animales domésticos (perros y gatos) como reservorio fúngico

2019 ◽  
Vol 3 (2) ◽  
Author(s):  
E. Piontelli L. ◽  
M. A. Toro S. M.
Keyword(s):  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Phialophora Verrucosa ◽  
Exophiala Jeanselmei ◽  
Trichophyton Terrestre

En una investigación epidemiológica efectuada en la ciudad de Valparaíso y sus alrededores, entre los años 1985-86, se estudió mediante la técnica del tapete la presencia de hongos patógenos y oportunistas en 278 animales domésticos -191 perros y 87 gatos- sin lesiones clínicas aparentes de dermatofitosis en su pelaje.En los 191 perros, un 6,3% presentó dermatófitos zoofíficos (4 Trichophyton mentagrophytes y 8 Microsporum canis) y un 17,3% de dermatofitos geofílicos (2 Microsporum gypseum-fulvum complex, 6 Keratinomyces ajelloi y 24 Trichophyton terrestre). Los 87 gatos presentaron un 18,4% de zoofíficos (2 T. mentogrophytes, 14 M. canis) y un 12,6% de geofí1icos (1 M. gypseum-fulvum complex, 4 K. ajelloi y 4 T. terrestre).La mayor frecuencia de M. canis (16,1% en gatos y solo un 4,2% en perros}, indica que este agente es capaz de sobrevivir en el pelaje sin causar lesiones aparentes y debe considerarse la especie Zoo-antropofílica más común transmisible al hombre en la edad pediátrica.Entre los Onygenales e Hyphomycetes relacionados, la mayoría de los aislamientos corresponde a las especies de chrysosporium (30,9% del total de perros y 50,6% del total de gatos).Entre las especies fúngicas potencialmente patógenas, puede apreciarse una franca predominancia de los géneros Scopulariopsis, Altenaria y Aspergillus en perros y de Scopulariopsis y Alrernaria. en gatos. Phialophora verrucosa y Exophiala jeanselmei, se destacan como hallazgos interesantes

scholarly journals Essential Oil Composition and Biological Activity of “Pompia”, a Sardinian Citrus Ecotype

Molecules ◽  
2019 ◽  
Vol 24 (5) ◽  
pp. 908 ◽  
Author(s):  
Guido Flamini ◽  
Laura Pistelli ◽  
Simona Nardoni ◽  
Valentina Ebani ◽  
Angela Zinnai ◽  
...  
Keyword(s):  
Essential Oil ◽  
Trichophyton Mentagrophytes ◽  
Antimicrobial Activities ◽  
Essential Oil Composition ◽  
Citrus Limon ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Oil Composition ◽  
Antioxidant Power ◽  
First Time

Pompia is a Sardinian citrus ecotype whose botanical classification is still being debated. In the present study, the composition of Pompia peel essential oil (EO) is reported for the first time, along with that of the leaf EO, as a phytochemical contribution to the classification of this ecotype. The peel EO was tested for its antioxidant ability (with both the 2,2-diphenyl-1-picarylhydrazyl (DPPH) and ferric reducing antioxidant power (FRAP) assays). Moreover, its antimicrobial activities were tested for the first time on dermatophytes (Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes), on potentially toxigenic fungi (Fusarium solani, Aspergillus flavus, and Aspergillus niger) as well on bacteria (Escherichia coli, Staphylococcus aureus, and Staphylococcus pseudointermedius). The dominant abundance of limonene in the peel EO seems to distinguish Pompia from the Citrus spp. to which it had previously been associated. It lacks γ-terpinene, relevant in Citrus medica EO. Its relative content of α- and β-pinene is lower than 0.5%, in contrast to Citrus limon peel EO. Pompia peel and leaf EOs did not show significant amounts of linalool and linalyl acetate, which are typically found in Citrus aurantium. Pompia peel EO antioxidant activity was weak, possibly because of its lack of γ-terpinene. Moreover, it did not exert any antimicrobial effects either towards the tested bacteria strains, or to dermatophytes and environmental fungi.

CLINICO-MYCOLOGICAL PROFILE OF DERMATOPHYTOSIS AND DERMATOMYCOSIS AMONG PATIENTS ATTENDING OUTPATIENT DEPARTMENT IN A TERTIARY CARE HOSPITAL.

2021 ◽  
pp. 1-3
Author(s):  
Kapaganty V Chakradhar ◽  
Dilruba Begum ◽  
Ruby Devi N ◽  
Raya Roja
Keyword(s):  
Tertiary Care ◽  
Fungal Growth ◽  
Trichophyton Mentagrophytes ◽  
Skin Lesions ◽  
Microsporum Gypseum ◽  
Care Hospital ◽  
Female Ratio ◽  
Hair Samples ◽  
Mycological Examination ◽  
Male To Female

This study was conducted to determine the common isolates causing dermatophytosis and other fungi causing dermatomycosis in patients presenting with skin lesions with or without involvement of hair and nails. A total of 75 patients were included in the study with 86 distinctive clinical lesions, of which Tinea corporis (46.7%,) was the most predominant followed by T. cruris (22.7%), T. unguium (14.7%) with a male to female ratio of 1.3:1. KOH mounts were made from samples and examined for fungal elements and samples were sent to Microbiology laboratory for culture, and identication among them 77.3% were skin scrapings alone and 14.7% were nail clippings along with skin scrapings and 8% were hair samples along with skin scrapings. Most common isolate was Trichophyton rubrum (40%) followed by Trichophyton mentagrophytes (17.3%), Trichophyton tonsurans (9.3%), Microsporum gypseum (4%) and no fungal growth was found in 17.3% of the samples. The study signies the importance of mycological examination in the diagnosis of dermatophytosis.

scholarly journals The presence of dermatophytes in infected pets and their household environment

2018 ◽  
Vol 70 (6) ◽  
pp. 1747-1753 ◽  
Author(s):  
J.J.A. Neves ◽  
A.O. Paulino ◽  
R.G. Vieira ◽  
E.K. Nishida ◽  
S.D.A. Coutinho
Keyword(s):  
Home Environment ◽  
Guinea Pigs ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Hair Coat ◽  
Indirect Contact ◽  
Household Environment ◽  
Trichophyton Quinckeanum ◽  
Prevalent Species

ABSTRACT The aim of this study was to diagnose dermatophytosis in pets and investigate the presence of dermatophytes in their home environment. Samples from hair coat were collected from 70 pets: 47 dogs, 19 cats, three guinea pigs and one rabbit. After mycological culture, 188 samples were collected from the household environments in 26 homes: 78 from places were of predominantly used by the tutors, 66 from places used by the animals, 44 from flooring, and 24 samples from contactees. Samples were seeded on Mycosel agar, incubated at 25°C, and the colonies were identified by their macro-and-microscopic characteristics. Dermatophytes were found in 37.1% of the samples originating from the sick animals. Microsporum canis was the most prevalent species, isolated in 12 dogs and eight cats; Trichophyton quinckeanum in three guinea pigs, Microsporum gypseum in two dogs and Trichophyton mentagrophytes in one cat. Dermatophytes were found in 69.2% of the surveyed homes; 29.5% of the places/objects predominantly used by the tutors, 42.4% mainly used by the animals, 31.8% from floors, and 50% from contactees. The meeting of dermatophytes in animals and in the household environment confirms the possibility of transmission by direct or indirect contact and their importance in public health.

scholarly journals Efficacy of itraconazole oral solution using an alternating-week pulse therapy regimen for treatment of cats with experimental Microsporum canis infection

2017 ◽  
Vol 20 (10) ◽  
pp. 869-874 ◽  
Author(s):  
Christopher Puls ◽  
Aaron Johnson ◽  
Karrie Young ◽  
Jonathan Hare ◽  
Kelly Rosenkrans ◽  
...  
Keyword(s):  
Clinical Cure ◽  
Pulse Therapy ◽  
Oral Solution ◽  
Controlled Study ◽  
Microsporum Canis ◽  
Fungal Culture ◽  
Mycological Cure ◽  
Therapy Regimen ◽  
Treatment Groups ◽  
Cure Rates

Objectives The objective of this study was to evaluate itraconazole 10 mg/ml oral solution for the treatment of Microsporum canis infection using an alternating-week pulse therapy regimen in a controlled laboratory setting. Methods Eighty cats with experimentally induced infections were randomly assigned to treatment (itraconazole vs control [sterile water]), administered 5 mg/kg PO q24h for 1 week on alternate weeks for 5 weeks, followed by a 4 week follow-up period. Topical therapeutic treatment was not administered. Cats were individually housed in stainless steel cages that were cleaned and disinfected daily. Study measures included weekly fungal cultures, clinical lesion scores, Wood’s lamp examination and periodic laboratory monitoring. Mycological cure was defined as two consecutive negative cultures. Results Itraconazole-treated cats had significantly greater ( P = 0.0003) mycological cure compared with untreated controls (24/40 [60%] vs 1/40 [2.5%], respectively) and all of these reached clinical cure and had negative final Wood’s lamp examinations. Furthermore, 36/40 (90%) treated cats had at least one negative fungal culture by the end of the study vs only 3/40 (7.5%) control cats. For both treatment groups, prevalence of clinical cure peaked at the end of the study (week 9), with 39/40 (97.5%) itraconazole-treated cats and 6/40 (15%) control cats achieving clinical cure. Wood’s lamp negative examination rates were significantly greater ( P <0.0001) for itraconazole-treated cats compared with controls (39/40 cats [97.5%] vs 6/40 [15%], respectively) and followed the same pattern of improvement as primary clinical lesions. Conclusions and relevance In this controlled study, orally administered itraconazole using a 5 mg/kg pulse-dose treatment regimen reduced the time to mycological cure and increased both mycological and clinical cure rates compared with untreated controls.

scholarly journals Tinha do couro cabeludo em crianças de Goiânia, Brasil

2003 ◽  
Vol 36 (6) ◽  
pp. 653-655 ◽  
Author(s):  
Tatiana Dias ◽  
Orionalda de Fátima Lisboa Fernandes ◽  
Ailton José Soares ◽  
Xisto Sena Passos ◽  
Milce Costa ◽  
...  
Keyword(s):  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Trichophyton Tonsurans

Durante o período de janeiro de 1999 a julho de 2002 um total de 164 casos de tinha do couro cabeludo foram diagnosticados através de exames micológicos, realizados no Instituto de Patologia Tropical e Saúde Pública da Universidade Federal de Goiás. Destes pacientes, 94 (57,3%) pertenciam ao sexo masculino, com idades variando de 3 meses a 13 anos. O diagnóstico e identificação dos agentes de dermatofitoses do couro cabeludo foram feitos utilizando-se exame direto com KOH a 20% e cultivo em ágar Mycobiotic e em ágar Sabouraud dextrose acrescido de cloranfenicol. As seguintes espécies foram identificadas: Microsporum canis (71,3%), Trichophyton tonsurans (11%), Trichophyton mentagrophytes (7,9%), Trichophyton rubrum (6,7%) and Microsporum gypseum (3%). Nossos estudos mostraram que o fungo de habitat natural no animal (zoofílico), Microsporum canis foi o agente mais comum de lesões no couro cabeludo em humanos.

scholarly journals Chemical Composition, Antifungal and Insecticidal Activities of the Essential Oils from Tunisian Clinopodium nepeta subsp. nepeta and Clinopodium nepeta subsp. glandulosum

Molecules ◽  
2020 ◽  
Vol 25 (9) ◽  
pp. 2137 ◽  
Author(s):  
Haïfa Debbabi ◽  
Ridha El Mokni ◽  
Ikbal Chaieb ◽  
Simona Nardoni ◽  
Filippo Maggi ◽  
...  
Keyword(s):  
Chemical Composition ◽  
Essential Oil ◽  
Essential Oils ◽  
Aspergillus Terreus ◽  
Biological Activities ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Stored Product Pests

The present investigation was focused on the study of the chemical composition variability and biological activities of the essential oils from Clinopodium nepeta subsp. nepeta and subsp. glandulosum. Essential oils extraction was performed using hydrodistillation and the separation of the constituents was carried out by gas chromatography coupled with mass spectrometry (GC-MS). Antifungal activities were tested against Aspergillus flavus, Aspergillus terreus, Microsporum canis, Microsporum gypseum, Trichophyton mentagrophytes, and Candida albicans. Toxicity and repellency were evaluated against the stored product pests Tribolium confusum and Sitophilus zeamais. Both essential oils were characterized by a high content of oxygenated monoterpenes. Piperitone ranks first in the subspecies nepeta and piperitenone oxide is the dominant constituent in the subspecies glandulosum. All tested samples displayed noteworthy antifungal properties, with the highest activity observed for the essential oil of C. nepeta subsp. glandulosum, collected in Béni-M’tir, against T. mentagrophytes (MIC = 40 µg/mL). The essential oil samples of C. nepeta subsp. glandulosum were strongly repellent to the insect species (PR > 80%, after 2h) and highly toxic to S. zeamais reaching 97.5%–100% mortality after 24 h of exposure. In conclusion, this study showed considerable intra-specific changes in the quality of C. nepeta essential oils, which is reflected in different rates of antifungal and insecticidal activity.

Antifungal effects of the biological agent Pythium oligandrum observed in vitro

2016 ◽  
Vol 19 (8) ◽  
pp. 817-823 ◽  
Author(s):  
Martina Načeradská ◽  
Michaela Fridrichová ◽  
Dita Kellnerová ◽  
Soňa Peková ◽  
Petr Lány
Keyword(s):  
Fungal Infections ◽  
Trichophyton Mentagrophytes ◽  
Microsporum Canis ◽  
Microsporum Gypseum ◽  
Pythium Oligandrum ◽  
Nutrient Media ◽  
Therapeutic Concentration ◽  
Common Causes ◽  
Antifungal Effects

Objectives Dermatophytosis, commonly known as ringworm, is a superficial fungal skin disease and zoonosis. Pythium oligandrum is a micromycete with mycoparasitic properties that is used in agriculture to control fungal infections on plants. Formulations containing P oligandrum were also developed for the treatment of dermatophytoses, but only a small number of case studies have been published. In order to document the process in simplified conditions in vitro, we investigated the effectiveness of P oligandrum against three pathogenic dermatophytes common in domestic animals. Methods Cultures of the pathogens grown on nutrient media and experimentally infected cat hair were treated with P oligandrum preparations in therapeutic concentration and the changes were documented by microscopic videos and scanning electron microscopy. Results There was strong mycoparasitic activity of P oligandrum against Microsporum canis, Microsporum gypseum and Trichophyton mentagrophytes. Conclusions and relevance P oligandrum was demonstrated to be effective against three common causes of dermatophytosis in vitro.

scholarly journals Dermatophytes in clinically healthy laboratory animals

1981 ◽  
Vol 15 (1) ◽  
pp. 75-78 ◽  
Author(s):  
A. Balsari ◽  
C. Bianchi ◽  
Alessandra Cocilovo ◽  
I. Dragoni ◽  
G. Poli ◽  
...  
Keyword(s):  
Small Proportion ◽  
Trichophyton Rubrum ◽  
Trichophyton Mentagrophytes ◽  
Skin Lesions ◽  
Laboratory Animals ◽  
Microsporum Canis ◽  
Apparently Healthy

Mice, rats, guineapigs and rabbits that were apparently healthy and did not present skin lesions were examined for the presence of dermatophytes. A small proportion of them were found to be carriers of Trichophyton mentagrophytes, Trichophyton rubrum, Microsporum canis (8/140 = 5·7% of mice; 2/185 = 1·1% of rats; 1/70 = 1·4% of guineapigs; 1/215 = 0·5% of rabbits).

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