scholarly journals Oxidative Stress as a Physiological Pain Response in Full-Term Newborns

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
S. Perrone ◽  
C. V. Bellieni ◽  
S. Negro ◽  
M. Longini ◽  
A. Santacroce ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Pain Score ◽  
Full Term ◽  
Oral Glucose ◽  
Oxidative Stress Biomarkers ◽  
Term Newborns ◽  
Heel Prick ◽  
Abc Scale ◽  
Lower Pain Score ◽  
Early Sample

This research paper aims to investigate if oxidative stress biomarkers increase after a painful procedure in term newborns and if nonpharmacological approaches, or sex, influence pain degree, and the subsequent OS. 83 healthy term newborns were enrolled to receive 10% oral glucose or sensorial saturation (SS) for analgesia during heel prick (HP). The ABC scale was used to score the pain. Advanced oxidation protein products (AOPP) and total hydroperoxides (TH) as biomarkers of OS were measured at the beginning (early-sample) and at the end (late-sample) of HP. The early-sample/late-sample ratio for AOPP and TH was used to evaluate the increase in OS biomarkers after HP. Higher levels of both AOPP and TH ratio were observed in high degree pain (4–6) compared with low degree pain score (0–3) (AOPP:p=0.049; TH:p=0.001). Newborns receiving SS showed a significantly lower pain score (p=0.000) and AOPP ratio levels (p=0.021) than those without. Males showed higher TH levels at the end of HP (p=0.005) compared to females. The current study demonstrates that a relationship between pain degree and OS exists in healthy full-term newborns. The amount of OS is gender related, being higher in males. SS reduces pain score together with pain-related OS in the newborns.

scholarly journals Efficacy of Oral Glucose in Reducing Behavioural Responses to a Noxious Stimulus in Healthy Term Neonates

2021 ◽  
Author(s):  
Amal Naous ◽  
Hassan El Khatib ◽  
Bilal Azakir ◽  
Farah Hajjar ◽  
Hanan Baltaji ◽  
...  
Keyword(s):  
Controlled Trial ◽  
Pain Scale ◽  
Full Term ◽  
Oral Glucose ◽  
Pain Response ◽  
Double Blind ◽  
Term Neonates ◽  
Neonatal Pain ◽  
Infant Pain ◽  
Heel Prick

Abstract The aim of the study is to evaluate the effect of orally administered glucose, at concentrations of 5% and 30%, on the nociceptive behavioural pain response among full-term neonates who underwent the heel puncture technique. This is a prospective, randomized, double-blind, placebo-controlled trial which was registered at clinicaltrials.gov under the number Makassed General Hospital Protocol Record 1722017 in July 2017. This trial studied the effect of glucose solution on pain relief in 244 full-term healthy neonates who underwent a heel prick procedure. Neonatal pain was assessed using the Neonatal Infant Pain Scale (NIPS) and the duration of cry. The results showed that neonates receiving 30% glucose during the procedure had significantly the lowest mean NIPS (mean=4.89) compared to placebo and 5% group (mean=5.8 and 5.2 respectively) (p=0.03). Neonates in the glucose groups of both 5% (65.9%) and 30% (70.4%) scored significantly as having less pain compared with the placebo group (86.4%) (p=0.01). The neonates in the 30% glucose group cried less and had a significantly shorter crying duration (mean: 39.9 seconds) than in the 5% and placebo groups (p=0.04). Conclusion: 30% glucose and, to a lesser extent, 5% glucose were effective in reducing the behavioral pain response from heel prick procedures in term neonates.

scholarly journals Oxidative Stress Biomarkers: Establishment of Reference Values for Isoprostanes, AOPP, and NPBI in Cord Blood

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Mariangela Longini ◽  
Elisa Belvisi ◽  
Fabrizio Proietti ◽  
Francesco Bazzini ◽  
Giuseppe Buonocore ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Reference Values ◽  
Ischemia Reperfusion ◽  
Public Health Problem ◽  
Perinatal Period ◽  
Healthy Population ◽  
Oxidative Stress Biomarkers ◽  
Fenton Chemistry ◽  
Term Newborns

Oxidative stress (OS) is a common pathogenic factor involved in the onset of several diseases in humans, from immunologic disorders to malignancy, being a serious public health problem. In perinatal period, OS has been associated with adverse outcome of pregnancy and neonatal diseases. Dangerous effects of OS are mediated by increased production of free radicals (FRs) following various mechanisms, such as hypoxia, ischemia reperfusion, hyperoxia, inflammation, mitochondrial dysfunction, Fenton chemistry, and prostaglandin metabolism. FRs have short half-life, and their measurement in vivo is faced with many challenges. However, oxyradical derivatives are stable and thus may be measured and monitored repeatedly. The quantification of OS is based on the measurement of specific biomarkers in biologic fluids and tissues, which reflect induced oxidative damage to lipids, proteins, and DNA. Prostanoids, non–protein-bound iron (NPBI), and advanced oxidation protein products (AOPP) are actually considered truly specific and reliable for neonatal injury. Defining reference values for these biomarkers is necessary to investigate their role in neonatal diseases or also to evaluate the success of treatments. In this work, we wanted to define laboratory reference values for biomarkers of OS in a healthy population of term newborns.

The effect of early-onset infections on serum apelin-12 concentration in full-term newborns

2018 ◽  
Vol 2018 (2) ◽  
pp. 81-85
Author(s):  
Urszula Godula-Stuglik ◽  
Małgorzata Koba ◽  
Aneta Stachurska ◽  
Alicja Nawrat ◽  
Katarzyna Staśkiewicz ◽  
...  
Keyword(s):  
Early Onset ◽  
Full Term ◽  
Term Newborns

Nonalcoholic Fatty Liver Disease and Vitamin E - A Promising Relationship?

2019 ◽  
Vol 70 (1) ◽  
pp. 78-83
Author(s):  
Alexandra Totan ◽  
Daniela Gabriela Balan ◽  
Daniela Miricescu ◽  
Radu Radulescu ◽  
Iulia Ioana Stanescu ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Vitamin E ◽  
Therapeutic Potential ◽  
Plga Nanoparticles ◽  
Diet Group ◽  
Normal Diet ◽  
Oxidative Stress Biomarkers ◽  
Promising Alternative ◽  
Nonalcoholic Fatty Liver ◽  
High Caloric Diet

Oxidative stress (OS) plays an important role in NAFLD molecular mechanism. Nanoencapsulation represents a novel strategy to enhance therapeutic potential of conventional drugs. Our study analyses the encapsulated vitamin E effect on lipid metabolism and oxidative stress biomarkers in NAFLD rats. Animals were divided into 3 groups : G1 - the normal diet group; G2- the high caloric diet group ; G3 - high-caloric diet group receiving PLGA-vit E, 50 mg / kg. Serum advanced human oxidative protein (AOPP), total antioxidant capacity (TAC) and vitamin E were analysed using ELISA technique. Our results showed significant increase of G2 GPT, ALP, GGT, TG, glucose, TC and AOPP, versus G1 ( P [ 0.05) and a significant decrease of G2 serum TAC and vitamin E versus G1 results ( p = 0.01 and 0.01). Vitamin E nanoparticles (G3) caused a significant increase of TAC and significant decrease of serum AOPP, versus G2 (p [ 0.01). Results showed a significant reduction of GPT, GGT, ALP, TG and total cholesterol ( p [0.05) in G3 versus G2. PLGA nanoparticles should be considered an attractive and promising alternative to improve the bioavailability and biological activity of vitaminE.

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