scholarly journals A Case of Sevoflurane Use during Pregnancy in the Management of Persistent Status Asthmaticus

2017 ◽  
Vol 2017 ◽  
pp. 1-4
Author(s):  
Jessica Parrott ◽  
Mitch Tener ◽  
Katie Dennis ◽  
Matthew Sharpe ◽  
Cecily Clark-Ganheart
Keyword(s):  
Liver Biopsy ◽  
Hepatic Injury ◽  
Status Asthmaticus ◽  
Atypical Presentation ◽  
Short Term ◽  
Drug Induced ◽  
Respiratory Status ◽  
Maternal Hypertension ◽  
Spectrum Disorders ◽  
In Pregnancy

Background. Sevoflurane is rarely used for the treatment of status asthmaticus. We report a case of sevoflurane hepatotoxicity in pregnancy with presentation similar to HELLP syndrome. Case. A G2P1001 at 23 weeks in status asthmaticus presented with pCO2 > 130 and pH < 7. She was nonresponsive to traditional therapy. Sevoflurane was added for a 24 hr period. Respiratory status improved. Extubation occurred on day 12. Workup for preeclampsia spectrum disorders occurred due to maternal hypertension. Given the atypical presentation and hepatotoxicity, a liver biopsy was performed. Histologic features suggested drug induced hepatic injury. Liver function subsequently normalized. She delivered a term neonate without short-term complications. Conclusion. The use of sevoflurane is a treatment option of status asthmaticus during pregnancy. Providers should be aware of the potential for hepatotoxicity.

scholarly journals A Fatal Case of Nafcillin-Induced Hepatotoxicity: A Case Report and the Literature Review

2012 ◽  
Vol 2012 ◽  
pp. 1-3 ◽  
Author(s):  
Mian Bilal Alam ◽  
Amin Kadoura ◽  
Magesh Sathaiah
Keyword(s):  
Case Report ◽  
Liver Biopsy ◽  
Hepatic Injury ◽  
Total Bilirubin ◽  
Fatal Case ◽  
Fulminant Liver Failure ◽  
Drug Induced ◽  
Common Cause ◽  
Extensive Evaluation ◽  
Extensive List

Background. Drug-induced hepatotoxicity (DIH) is quite common, and there are several recommendations for its treatment based upon its etiology. DIH may range from mild and subclinical to fulminant liver failure and death. Even though there is extensive list of drugs causing DIH, antibiotics, as a class of drugs, are the most common cause of DIH. Here, we present a fatal case of nafcillin-induced hepatotoxicity confirmed by liver biopsy, with total bilirubin peaking to 21.8 mg/dl and subsequent further extensive evaluation for hepatic injury turning out to be negative.

Acetaminophen: Macula densa hypersecretory activity by induced hepatotoxicity

1987 ◽  
Vol 45 ◽  
pp. 934-935
Author(s):  
S.S. Poolsawat ◽  
C.A. Huerta ◽  
S.TY. Lae ◽  
G.A. Miranda
Keyword(s):  
Cell Proliferation ◽  
Liver Function ◽  
Chronic Inflammation ◽  
Foam Cell ◽  
Term Effect ◽  
Short Term ◽  
Drug Induced ◽  
Experimental Induction ◽  
Tissue Alterations ◽  
Toxic Responses

Introduction. Experimental induction of altered histology by chemical toxins is of particular importance if its outcome resembles histopathological phenomena. Hepatotoxic drugs and chemicals are agents that can be converted by the liver into various metabolites which consequently evoke toxic responses. Very often, these drugs are intentionally administered to resolve an illness unrelated to liver function. Because of hepatic detoxification, the resulting metabolites are suggested to be integrated into the macromolecular processes of liver function and cause an array of cellular and tissue alterations, such as increased cytoplasmic lysis, centrilobular and localized necroses, chronic inflammation and “foam cell” proliferation of the hepatic sinusoids (1-4).Most experimentally drug-induced toxicity studies have concentrated primarily on the hepatic response, frequently overlooking other physiological phenomena which are directly related to liver function. Categorically, many studies have been short-term effect investigations which seldom have followed up the complications to other tissues and organs when the liver has failed to function normally.

The stability and short-term fluctuation in serum oxytocinase activity in pregnancy

1989 ◽  
Vol 28 (4) ◽  
pp. 331-335
Author(s):  
A.A. Edebiri ◽  
D.S. Mack ◽  
D.J. McDonald ◽  
J. Philips
Keyword(s):  
Short Term ◽  
The Stability ◽  
Term Fluctuation ◽  
In Pregnancy

Liver Biopsy in Pregnancy: Two Case Reports and Review of the Literature

2021 ◽  
Author(s):  
Kemmian D. Johnson ◽  
Abhilash Perisetti ◽  
Hemant Goyal ◽  
Ragesh Thandassery ◽  
Mahesh Gajendran ◽  
...  
Keyword(s):  
Liver Biopsy ◽  
Case Reports ◽  
Review Of The Literature ◽  
In Pregnancy

scholarly journals Drug-Induced Hepatic Injury in Newborns and Children in Intensive Care Unit: A Retrospective Study of China

2021 ◽  
Author(s):  
Ling Ye ◽  
Chengxian Guo ◽  
Zeying Feng ◽  
Longjian Huang ◽  
Chengjun Guo ◽  
...  
Keyword(s):  
Intensive Care ◽  
Liver Injury ◽  
Hepatic Injury ◽  
Sodium Succinate ◽  
Drug Combinations ◽  
Fat Emulsion ◽  
Drug Induced ◽  
Multiple Drugs ◽  
Enzyme Metabolism ◽  
Long Chain

Abstract Purpose Drug-induced liver injury (DILI) is a common adverse reaction in the clinic; however, there are relatively few reports of DILI in critically ill newborns and children. Making use of the Pediatric Intensive Care database (PIC), this study identifies which drugs are related to DILI in neonates and children in China. Methods Using the PIC, we screened for patients whose liver was suspected of being injured by drugs during hospitalization. The medicine they used was then assessed by the Roussel Uclaf Causality Assessment Method (RUCAM). We also collated drug combinations that may affect CYP enzyme metabolism, which may be one of the mechanisms that lead to DILI. Results A total of 13,449 patients were assessed, of whom 77 newborns and 261 children were finally included. The main type of liver injury in neonates was mixed (83.1%), while children’s hepatic injury types were mostly distributed between hepatocellular (59.4%) and cholestatic (28.4%). In terms of the assessment by the RUCAM, in newborns, the drugs that were most considered to cause or associated with hepatic injury comprised medium and long chain fat emulsion (17%), sodium glycerophosphate (12%) and meropenem (9%); while omeprazole (11%), methylprednisolone sodium succinate (10%) and meropenem (8%) are the primary culprit of DILI in children. Drug combinations that may affect CYP enzyme metabolism frequently seen in neonates are omeprazole + budesonide (16.9%), dexamethasone + midazolam (10.4%) and midazolam + sildenafil (10.4%). In children, the commonly used drug combinations are fentanyl + midazolam (20.7%), ibuprofen + furosemide (18.4%) and diazepam + omeprazole (15.3%). Conclusions The drugs that have been found to have hepatotoxicity (meropenem, medium and long chain fat emulsion, ibuprofen.etc.) are also related to DILI in newborns and children. When giving these drugs to newborns and children, physicians need to be more cautious. Also, pay attention to the effect on CYP 450 enzymes when using multiple drugs at the same time.

Offspring of mothers with hyperglycaemia in pregnancy: The short term and long-term impact. What is new?

2018 ◽  
Vol 145 ◽  
pp. 155-166 ◽  
Author(s):  
Jean-Baptiste Armengaud ◽  
Ronald C.W. Ma ◽  
Benazir Siddeek ◽  
Gerard H.A. Visser ◽  
Umberto Simeoni
Keyword(s):  
Short Term ◽  
Long Term Impact ◽  
In Pregnancy

scholarly journals Hallucinations Under Psychedelics and in the Schizophrenia Spectrum: An Interdisciplinary and Multiscale Comparison

2020 ◽  
Vol 46 (6) ◽  
pp. 1396-1408 ◽  
Author(s):  
Pantelis Leptourgos ◽  
Martin Fortier-Davy ◽  
Robin Carhart-Harris ◽  
Philip R Corlett ◽  
David Dupuis ◽  
...  
Keyword(s):  
Brain Imaging ◽  
Working Group ◽  
Future Research ◽  
Schizophrenia Spectrum Disorders ◽  
Drug Induced ◽  
Computational Approaches ◽  
Schizophrenia Spectrum ◽  
Multidisciplinary Working ◽  
Similarities And Differences ◽  
Spectrum Disorders

Abstract The recent renaissance of psychedelic science has reignited interest in the similarity of drug-induced experiences to those more commonly observed in psychiatric contexts such as the schizophrenia-spectrum. This report from a multidisciplinary working group of the International Consortium on Hallucinations Research (ICHR) addresses this issue, putting special emphasis on hallucinatory experiences. We review evidence collected at different scales of understanding, from pharmacology to brain-imaging, phenomenology and anthropology, highlighting similarities and differences between hallucinations under psychedelics and in the schizophrenia-spectrum disorders. Finally, we attempt to integrate these findings using computational approaches and conclude with recommendations for future research.

scholarly journals Use of machine learning methods in prediction of short-term outcome in autism spectrum disorders

2018 ◽  
Vol 29 (3) ◽  
pp. 320-325 ◽  
Author(s):  
Mirac Baris Usta ◽  
Koray Karabekiroglu ◽  
Berkan Sahin ◽  
Muazzez Aydin ◽  
Abdullah Bozkurt ◽  
...  
Keyword(s):  
Machine Learning ◽  
Autism Spectrum Disorders ◽  
Autism Spectrum ◽  
Short Term ◽  
Learning Methods ◽  
Term Outcome ◽  
Machine Learning Methods ◽  
Short Term Outcome ◽  
Spectrum Disorders
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