scholarly journals Retracted: Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-1
Keyword(s):  
Cell Migration ◽  
Gallbladder Cancer ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Migration And Invasion ◽  
Cell Migration And Invasion

scholarly journals Long Noncoding RNA KIAA0125 Potentiates Cell Migration and Invasion in Gallbladder Cancer

2015 ◽  
Vol 2015 ◽  
pp. 1-9 ◽  
Author(s):  
Wenjie Lv ◽  
Lei Wang ◽  
Jianhua Lu ◽  
Jiasheng Mu ◽  
Yingbin Liu ◽  
...  
Keyword(s):  
Cell Migration ◽  
Gallbladder Cancer ◽  
Noncoding Rna ◽  
Poor Prognosis ◽  
Noncoding Rnas ◽  
Migration And Invasion ◽  
Potential Therapeutic Target ◽  
Cell Migration And Invasion ◽  
Underlying Mechanisms ◽  
Insight Into

Gallbladder cancer (GBC) is one of the mostly aggressive diseases with poor prognosis due to the lack of severe symptoms. To date, little is known about the potential roles and underlying mechanisms of long noncoding RNAs (lncRNAs) in GBC initiation and progression. Thus, it provides us with a novel insight into the contribution of lncRNAs to GBC development. Remarkably, we found the differential expression of a lncRNA, namely, KIAA0125, in a pair of GBC cell sublines which possess different metastatic potentials. Then the effects of KIAA0125 on GBC cell migration, invasion, and epithelial-mesenchymal transitions (EMT) were investigated by using a lentivirus-mediated RNA interference (RNAi) system. Notably, cell migration and invasion were strongly inhibited by KIAA0125 suppression. Moreover, the expression ofβ-Catenin was increased and the expression of Vimentin was decreased in GBC-SD/M cells after KIAA0125 knockdown. Thus, our findings suggested that KIAA0125 promoted the migration and invasion of GBC cells and could serve as a potential therapeutic target in advanced GBC.

scholarly journals The histone demethylase JMJD1A induces cell migration and invasion by up-regulating the expression of the long noncoding RNA MALAT1

Oncotarget ◽  
2014 ◽  
Vol 5 (7) ◽  
pp. 1793-1804 ◽  
Author(s):  
Andrew E. Tee ◽  
Dora Ling ◽  
Charlotte Nelson ◽  
Bernard Atmadibrata ◽  
Marcel E. Dinger ◽  
...  
Keyword(s):  
Cell Migration ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Histone Demethylase ◽  
Migration And Invasion ◽  
Cell Migration And Invasion
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