scholarly journals Festination Correlates with SNCA Polymorphism in Chinese Patients with Parkinson’s Disease

2017 ◽  
Vol 2017 ◽  
pp. 1-4 ◽  
Author(s):  
Jinhua Zheng ◽  
Xinglong Yang ◽  
Quanzhen Zhao ◽  
Sijia Tian ◽  
Hongyan Huang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Logistic Regression ◽  
Genetic Basis ◽  
Univariate Analysis ◽  
Alpha Synuclein ◽  
Chinese Patients ◽  
Motor Symptom ◽  
Consecutive Series ◽  
Snca Gene

The genetic basis of festination, a common motor symptom in Parkinson’s disease (PD), remains unclear. Since polymorphism in the alpha-synuclein (SNCA) gene is associated with PD phenotype, we examined whether such polymorphism is also associated with festination. SNCA polymorphisms rs11931074 and rs894278 were genotyped in a consecutive series of 258 patients with PD, of whom 122 (47.3%) suffered festination. Univariate analysis revealed significant differences in genotype and minor allele frequencies at rs11931074 or rs894278 between patients with festination and those without it (all p<0.05). Based on logistic regression, a GG or GT genotype at rs11931074 was associated with higher risk of festination among patients with PD (OR 2.077, 95% CI 1.111–3.883, p=0.022), as was the TT genotype at rs894278 (OR 2.271, 95% CI 1.246–4.139, p=0.007). Therefore, we conclude that festination is associated with polymorphism at rs11931074 or rs894278 among patients with PD.

scholarly journals Deep Brain Stimulation Complications in Patients With Parkinson’s Disease and Surgical Modifications: A Single-Center Retrospective Analysis

2021 ◽  
Vol 15 ◽  
Author(s):  
Shuo Xu ◽  
Wenfei Wang ◽  
Si Chen ◽  
Qianqian Wu ◽  
Chao Li ◽  
...  
Keyword(s):  
Risk Factors ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Deep Brain Stimulation ◽  
Brain Stimulation ◽  
Early Stage ◽  
Univariate Analysis ◽  
Unplanned Readmission ◽  
Consecutive Series ◽  
Deep Brain

BackgroundAs a complication-prone operation, deep brain stimulation (DBS) has become the first-line surgical approach for patients with advanced Parkinson’s disease (PD). This study aimed to evaluate the incidence and risk factors of DBS-associated complications.MethodsWe have reviewed a consecutive series of patients with PD undergoing DBS procedures to describe the type, severity, management, and outcome of postoperative complications from January 2011 to December 2018. Both univariate and multivariate analyses were performed to identify statistically significant risk factors. We also described our surgical strategies to minimize the adverse events.ResultsA total of 225 patients underwent 229 DBS implantation procedures (440 electrodes), of whom 20 patients experienced 23 DBS-associated complications, including ten operation-related complications and 13 hardware-related ones. Univariate analysis elucidated that comorbid medical conditions (P = 0.024), hypertension (P = 0.003), early-stage operation (P &lt; 0.001), and unilateral electrode implantation (P = 0.029) as risk factors for overall complications, or more specifically, operation-related complications demonstrated in the stratified analysis. In contrast, no risk factor for hardware-related complications was identified. Statistical significances of hypertension (OR = 3.33, 95% CI: 1.14–9.71, P = 0.027) and early-stage (OR = 11.04, 95% CI: 2.42–50.45, P = 0.002) were further validated via multivariate analysis. As the annual number of DBS procedures increased, the incidence of complications gradually decreased (R = −0.699, P &lt; 0.01). Additionally, there was a strong correlation between surgical complications and unplanned readmission (R = 0.730, P &lt; 0.01).ConclusionThe importance of cumulative experience and relevant technique modifications should be addressed to prevent DBS-associated complications and unplanned readmission.

scholarly journals Gastrointestinal Dysfunction in Chinese Patients with Parkinson’s Disease

2019 ◽  
Vol 2019 ◽  
pp. 1-6
Author(s):  
Xiaoling Qin ◽  
Xue Li ◽  
Zai’e Xin ◽  
Zaili Li
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Digestive System ◽  
Dry Mouth ◽  
Chinese Patients ◽  
Motor Symptom ◽  
Symptom Scale ◽  
Early Satiety ◽  
Significant Difference ◽  
Loss Of Appetite

Purpose. To observe the occurrence and influencing factors of the symptoms related to the digestive system of people at the early and middle stages of PD and of healthy controls (HCs) using a questionnaire. Method. The questionnaire was given to 108 PD patients at early and middle stages. Twelve symptoms related to the digestive system, of which seven were listed on the Parkinson’s Disease Non-Motor Symptom Scale (PD-NMSS) and the Scale for Outcomes in Parkinson’s disease-Autonomic (SCOPA-AUT) (dysgeusia, dysphagia/choking, salivation, early satiety, constipation, loose stools, and fecal incontinence) and five symptoms used in the diagnosis and treatment of PD (loss of appetite, dry mouth, mouth pain, nausea and vomiting), were used. The questionnaire was also given to HCs. Results. There was no significant difference in age, sex, height, weight, or body mass index (BMI) between the PD group and HCs. Of the 108 people at the early and middle stages of PD, the most common symptoms related to the digestive system were 64 cases of dry mouth (59.26%), 53 cases of constipation (49.07%), and 40 cases of dysgeusia (37.04%). Multivariate binary logistics regression revealed that dysgeusia (P<0.001), dysphagia (P=0.004), early satiety (P=0.001), and constipation (P=0.007) were more likely to occur in males. BMI, disease duration, and motor symptoms had no significant correlation with the symptoms related to the digestive system (P>0.05 for all). Conclusions. Dry mouth, constipation, dysgeusia, loss of appetite, early satiety, and dysphagia are the most common (and possibly characteristic symptoms) related to the digestive system in people at the early and middle stages of PD. Being male is a risk factor for dysgeusia, dysphagia, early satiety, and constipation.

scholarly journals Integration of Aluminium Interdigitated Electrodes with Zinc Oxide as Nanocomposite for Selectively Detect Alpha-Synuclein for Parkinson’s Disease Diagnosis

2021 ◽  
Vol 2129 (1) ◽  
pp. 012094
Author(s):  
Hussaini Adam ◽  
Subash C. B Gopinath ◽  
Uda Hashim
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Zinc Oxide ◽  
Disease Diagnosis ◽  
Alpha Synuclein ◽  
Diagnostic Methods ◽  
Motor Symptom ◽  
Interdigitated Electrodes ◽  
Coating Method ◽  
Surface Modified

Abstract Parkinson’s disease is associated with motor and non-motor symptoms, mostly a motor symptom such as tremor is said to be an early indication for Parkinson’s disease development. Because of higher demands for faster and more precise diagnostic methods, it has sparked trends in the development of a biosensor for the diagnosis of Parkinson’s disease. Therefore, this study has fabricated a biosensor that is capable of detecting a specific Parkinson’s disease biomarker such as aggregation of alpha synuclein and this is crucial in reducing the burden of Parkinson’s disease and to be able to detect the disease at the earlier stage. Finding the inconsistent aggregation of alpha-synuclein is a promising method for the early detection of Parkinson’s disease. Using conventional photographic process, aluminium interdigitated electrodes (ALIDEs) have been fabricated and employed with sensitive electrochemical strategy for the specific detection of the Parkinson’s disease antigen (alpha synuclein). The microelectrode was developed based on aluminium electrode sputtered on silicon substrate. Further, zinc oxide (ZnO) was deposited by sputtering on the working electrode of the ALIDEs using a spin-coating method. The ZnO nanocomposite onto aluminium microelectrode surface provides a favourable platform for efficient loading of antibody via binding with antigen alpha synuclein. The effective loading of the biomolecules (antibody and antigen) on the ZnO nanocomposite surface modified aluminium microelectrode was observed by SEM, AFM and 3D Profilometer. The current flow for each concentration of alpha synuclein was observed at 7.5×10−6 A (10 fM), 8.8×10−6 A (100 fM), and 8.5×10−6 A (1 pM) respectively.

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