scholarly journals Association between Hemoglobin Levels and Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes: A Cross-Sectional Study Using Electronic Health Records

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Jun Yang ◽  
Pi-jun Yan ◽  
Qin Wan ◽  
Hua Li
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Patient Characteristics ◽  
Continuous Variable ◽  
Perception Threshold ◽  
Cross Sectional ◽  
Increased Risk ◽  
The Impact

Objective. To investigate the relationship between hemoglobin levels and diabetic peripheral neuropathy (DPN) in type 2 diabetes mellitus (T2DM). Methods. 1511 patients with T2DM were included in the study. DPN was diagnosed based on symptoms, signs, and laboratory tests. Hemoglobin was defined as both a continuous variable and a quartile category variable. We compared patient characteristics between the no diabetic peripheral neuropathy (NDPN) and DPN groups. Logistic regression was conducted to investigate the association of DPN with hemoglobin in all T2DM patients. Linear regression was also performed to investigate the impact of hemoglobin on the vibrating perception threshold (VPT). Results. Compared with the NDPN group, hemoglobin level in the DPN group was significantly lower (118.54 ± 16.91 versus 131.62 ± 18.32 g/L, P<0.01). The prevalence of DPN increased by 50.1% (95% CI: 42.2–57.0%; P<0.001) per standard deviation decrease in hemoglobin. Compared to the highest quartile of hemoglobin, the lower quartiles were associated with a significantly increased risk of DPN in the entire T2DM population (all P<0.01). A per unit decrease in hemoglobin leads to a 0.12 (95% CI: 0.07–0.168) unit increase in VPT after adjustment for possible confounders (P<0.001). Conclusions. Lower hemoglobin levels were associated with increased prevalence of DPN and higher VPT.

scholarly journals Association between Circulating B-Type Natriuretic Peptide and Diabetic Peripheral Neuropathy: A Cross-Sectional Study of a Chinese Type 2 Diabetic Population

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Pijun Yan ◽  
Qin Wan ◽  
Zhihong Zhang ◽  
Yong Xu ◽  
Ying Miao ◽  
...  
Keyword(s):  
Peripheral Neuropathy ◽  
Natriuretic Peptide ◽  
Diabetic Peripheral Neuropathy ◽  
Ankle Brachial Index ◽  
Perception Threshold ◽  
Cross Sectional ◽  
Potential Biomarker ◽  
Increased Risk ◽  
Circulating Levels

Cardiovascular disease which is associated with cardiac dysfunction, usually measured with circulating levels of B-type natriuretic peptide (BNP), has been associated with incidence and progression of diabetic peripheral neuropathy (DPN). The potential relationship of circulating physiological levels of BNP with DPN, however, has not been reported. Circulating levels of BNP were measured in 258 patients with type 2 diabetes mellitus (T2DM), and participants were divided into a DPN group ( n = 61 ) and no DPN group ( n = 197 ). The relationship between circulating physiological levels of BNP and DPN and other parameters was analyzed. Circulating levels of BNP were significantly elevated in T2DM patients with DPN compared to those without ( P = 0.001 ). Circulating levels of BNP were significantly and positively associated with systolic blood pressure ( P = 0.035 ), neutrophil-to-lymphocyte ratio ( P = 0.007 ), creatinine ( P = 0.030 ), vibration perception threshold values ( P = 0.021 ), and the prevalence of diabetic foot ulceration ( P = 0.039 ), peripheral arterial disease ( P = 0.013 ), DPN ( P = 0.032 ), and diabetic nephropathy ( P = 0.020 ) and negatively with lymphocyte count ( P = 0.003 ) and ankle-brachial index ( P = 0.038 ), irrespective of age, sex, and body mass index. Moreover, circulating levels of BNP was an independent decisive factor for the presence of DPN after multivariate adjustment (odds ratio, 1.044; 95% confidence interval, 1.006-1.084; P = 0.024 ). Additionally, the higher quartiles of circulating BNP were related significantly to an increased risk of DPN compared to the lowest quartile ( P = 0.003 ). Last but most importantly, the analysis of receiver operating characteristic curves revealed that the best cutoff value for circulating levels of BNP to predict DPN was 15.18 pg/mL (sensitivity 78.7% and specificity 48.2%). These findings suggest that high circulating physiological levels of BNP may be associated with the development of DPN and may be a potential biomarker for DPN in patients with T2DM.

scholarly journals Lama menderita diabetes mellitus tipe 2 sebagai faktor risiko neuropati perifer diabetik

2020 ◽  
Vol 14 (1) ◽  
pp. 96-100
Author(s):  
Galvani Volta Simanjuntak ◽  
Marthalena Simamora
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Sensory Neuropathy ◽  
Simple Random Sampling ◽  
P Value ◽  
Cross Sectional

Sensory neuropathy in type 2 diabetes mellitus and its correlation with duration of diseaseBackground: Diabetic peripheral neuropathy is a complication of type 2 diabetes mellitus (T2DM) that results in harm to the nervous system. It is a progressive disease, and symptoms get worse over time.Purpose: To exploration the sensory neuropathy in type 2 diabetes mellitus and its correlation with duration of disease.Method: An observational analytic with cross sectional design with population was patients with T2DM without diabetic ulcers in diabetic clinic Sari Mutiara Hospital. The number of samples  was 86 respondents by  a simple random sampling. Measuring the risk of diabetic peripheral neuropathy used 10 gram monofilament.Results: Showed the majority of the duration of T2DM >5 years (53,5%) and the majority of respondents had neuropathy (54,7%). The results of the Spearman rank correlation test showed that there was a significant correlation between duration of T2DM and risk of diabetic peripheral neuropathy (p-value = 0,023 and r= -0,438). Conclusion: The majority respondents has a diabetic peripheral neuropathy and also has a risk of diabetic peripheral neuropathy who are suffering >5 years. It is recommended that they need a regularly asses and educate to prevent further complication.Keywords: Sensory neuropathy; Type 2 diabetes mellitus; Duration of diseasePendahuluan: Neuropati perifer diabetes adalah komplikasi diabetes yang mengakibatkan kerusakan sistem saraf. Ini adalah penyakit progresif, dan gejalanya bertambah buruk seiring waktu.Tujuan: Untuk mengetahui hubungan lama menderita dengan risiko neuropati pada pasien DM tipe 2.Metode: Desain analitik korelasi dengan pendekatan cross sectional dan populasinya seluruh pasien DM tipe 2 yang tidak memiliki ulkus diabetik di klinik diabetes RSU Sari Mutiara. Sampelnya sebanyak 86 yang diambil dengan teknik simple random sampling. Risiko neuropati perifer diabetik diukur menggunakan monofilament 10 gram.Hasil: Analisis data menunjukkan mayoritas pasien menderita DM tipe 2  yang  >5 tahun (53,5%) dan mayoritas pasien telah mengalami neuropati (54,7%). Hasil uji statistik menggunakan korelasi spearman menunjukan adanya hubungan lama menderita DM tipe 2 dengan risiko neuropati (p-value = 0,023<0,05 dan  nilai r = -0,438).Simpulan: Mayoritas responden yang mengalami Neuropati perifer diabetes maupun resiko terjadinya Neuropati perifer diabetes pada mereka kelompok yang menderita DM tipe 2  yang  >5 tahun. Sangat dianjurkan pada pasien tersebut untuk dilakukan pengkajian secara teratur  dan pendidikan untuk mencegah komplikasi lebih lanjut. 

scholarly journals PREVALENCE AND IMPACT OF PAINFUL DIABETIC PERIPHERAL NEUROPATHY IN PATIENTS WITH TYPE-2 DIABETES MELLITUS WITH LOW ECONOMIC STATUS

2018 ◽  
Vol 11 (6) ◽  
pp. 377
Author(s):  
Nishitha Chowdary Dl ◽  
Somasundaram I
Keyword(s):  
Quality Of Life ◽  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Diabetic Peripheral Neuropathy ◽  
Patient Counseling ◽  
Duration Of Diabetes ◽  
Painful Diabetic Peripheral Neuropathy ◽  
The Impact

Objectives: The objectives of the study were to study the prevalence of painful diabetic peripheral neuropathy (PDPN) in patients with type-2 diabetes and to access the health-related quality of life of patient by collecting and documenting the information of patient using sf-15 questionnaire.Methods: The present study involves prospective analysis of quality of life in both men and women with PDPN with type-2 diabetes. The methodology involves collection and documentation of patients medical and medication history, blood glucose levels, and duration of diabetes. Further, the quality of life of patient is documented using Michigan neuropathic scaling instrument (sf-15 questionnaire) through which we can assess the impact of PDPN.Results: It can be seen that there are no significant changes in the prevalence of PDPN when compared gender wise and based on age, but there are an extremely statistically significant (*p<0.05) values obtained when the presence of PDPN is compared between duration of diabetes.Conclusion: Patients with duration of diabetes type-2 between 5 and 10 years are mostly presented with PDPN. Early detection, nutritious diet, and patient counseling help in management of PDPN.

scholarly journals Diabetic Peripheral Neuropathy as a Predictor of Asymptomatic Myocardial Ischemia in Type 2 Diabetes Mellitus: A Cross-Sectional Study

2016 ◽  
Vol 33 (10) ◽  
pp. 1840-1847 ◽  
Author(s):  
Dimitrios Baltzis ◽  
Matthieu Roustit ◽  
Maria G. Grammatikopoulou ◽  
Dimitrios Katsaboukas ◽  
Vassileios Athanasiou ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Type 2 Diabetes Mellitus ◽  
Peripheral Neuropathy ◽  
Myocardial Ischemia ◽  
Diabetic Peripheral Neuropathy ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Cross Sectional

scholarly journals Balance and motion coordination parameters can be improved in patients with type 2 diabetes with physical balance training: non-randomized controlled trial

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Artur Stolarczyk ◽  
Igor Jarzemski ◽  
Bartosz M. Maciąg ◽  
Kuba Radzimowski ◽  
Maciej Świercz ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Peripheral Neuropathy ◽  
Balance Control ◽  
Balance Training ◽  
Control Group ◽  
Study Group ◽  
Muscle Coordination ◽  
Risk Of Falling ◽  
Increased Risk

Abstract Background Type 2 diabetes (T2D) is a cause of multiple complications, including retinopathy and peripheral neuropathy. These complications are well understood and believed to contribute to gait instability. Poor balance control and increased falling risk have also been reported in people with diabetic peripheral neuropathy (DPN). Patients with DPN have increased risk of falling due to decreased proprioceptive feedback. Effective balance training should improve postural control in patients with DPN. For this purpose further evaluation was conducted and balance training was designed. Methods The goal of our study was to determine values of proprioception, balance, muscle coordination and strength in patients with T2D and analyze whether biofeedback balance training with use of the Biodex Balance System could improve these parameters. To assess the fall risk the general stability index (GSI), the index of frontal-posterior (FPI) and medial–lateral (MLI) stability were evaluated. 37 patients with diagnosed type 2 diabetes mellitus were recruited to this study. Their results were compared with control group consisting of 41 healthy participants who were homogenic to the study group in terms of age and body mass index (BMI). Results There were statistically significant differences between patients with diabetes compared to healthy subjects in GSI (2.79 vs 1.1), FPI (1.66 vs 0.7), MLI (0.88 vs 0.52) and risk of falling (5.18 vs 2.72) p < 0.05. There were also statistically significant changes before and after training in all stability indices (GSI: 2.79 vs 1.26, FPI: 1.66 vs 0.77, MLI: 0.88 vs 0.54 accordingly) p < 0.05 and risk of falling (5.18 vs 3.87) p < 0.05 in the study group who had undergone training with biofeedback. Conclusions This study found that there is a decreased balance and motor coordination and an increased risk of falling in patients with type 2 diabetes. These parameters improved in patients who have undergone training programme with biofeedback. Furthermore, an age-dependent deprivation of static balance was observed along with an increased risk of falling as a result of increasing BMI.

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