scholarly journals The Association of Serum Thrombomodulin with Endothelial Injuring Factors in Abdominal Aortic Aneurysm

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Magdalena Budzyń ◽  
Bogna Gryszczyńska ◽  
Wacław Majewski ◽  
Zbigniew Krasiński ◽  
Magdalena Paulina Kasprzak ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Abdominal Aortic Aneurysm ◽  
Endothelial Damage ◽  
Enzyme Linked Immunosorbent Assay ◽  
Advanced Glycation ◽  
Abdominal Aortic ◽  
Glycation End Products ◽  
End Products ◽  
And Oxidative Stress ◽  
Age And Sex

Background.The aim of the present study was to evaluate the concentration of serum thrombomodulin (sTM) in the AAA patients and to examine its correlation with various factors which may potentially participate in the endothelial injury.Materials and Methods.Forty-one patients with AAA were involved and divided into subgroups based on different criteria. Concentration of sTM was measured using enzyme-linked-immunosorbent assay (ELISA). The results were compared with those obtained in 30 healthy age- and sex-matched volunteers.Results.The higher concentration of sTM was observed in AAA patients compared with those in controls volunteers [2.37 (1.97–2.82) ng/mL versus 3.93 (2.43–9.20) ng/mL,P< 0.001]. An elevated sTM associated significantly with increased triglycerides (TAG) [P= 0.022], cholesterol [P= 0.029], hsCRP [P= 0.031], and advanced glycation end products (AGEs) [P= 0.033].Conclusions.The elevation of serum sTM level suggests that endothelial damage occurs in AAA pathogenesis. The correlations observed indicate that lipids abnormalities, inflammation, and oxidative stress may be involved in this destructive process.

scholarly journals Advanced Glycation End Products and Oxidative Stress in a Hyperglycaemic Environment

2021 ◽  
Author(s):  
Akio Nakamura ◽  
Ritsuko Kawahrada
Keyword(s):  
Oxidative Stress ◽  
Reactive Oxygen Species ◽  
Advanced Glycation End Products ◽  
Reactive Oxygen ◽  
Protein Glycation ◽  
Oxygen Species ◽  
Advanced Glycation ◽  
Glycation End Products ◽  
End Products ◽  
And Oxidative Stress

Protein glycation is the random, nonenzymatic reaction of sugar and protein induced by diabetes and ageing; this process is quite different from glycosylation mediated by the enzymatic reactions catalysed by glycosyltransferases. Schiff bases form advanced glycation end products (AGEs) via intermediates, such as Amadori compounds. Although these AGEs form various molecular species, only a few of their structures have been determined. AGEs bind to different AGE receptors on the cell membrane and transmit signals to the cell. Signal transduction via the receptor of AGEs produces reactive oxygen species in cells, and oxidative stress is responsible for the onset of diabetic complications. This chapter introduces the molecular mechanisms of disease onset due to oxidative stress, including reactive oxygen species, caused by AGEs generated by protein glycation in a hyperglycaemic environment.

scholarly journals Skin accumulation of advanced glycation end products is increased in patients with an abdominal aortic aneurysm

2017 ◽  
Vol 66 (6) ◽  
pp. 1696-1703.e1 ◽  
Author(s):  
Jeltje Boersema ◽  
Lisanne C. de Vos ◽  
Thera P. Links ◽  
Douwe J. Mulder ◽  
Andries J. Smit ◽  
...  
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Advanced Glycation End Products ◽  
Advanced Glycation ◽  
Abdominal Aortic ◽  
Skin Accumulation ◽  
Glycation End Products ◽  
End Products

scholarly journals Calprotectin and Receptor for Advanced Glycation End Products as a Potential Biomarker in Abdominal Aortic Aneurysm

2020 ◽  
Vol 9 (4) ◽  
pp. 927
Author(s):  
Willy Hauzer ◽  
Wojciech Witkiewicz ◽  
Jan Gnus
Keyword(s):  
Abdominal Aortic Aneurysm ◽  
Aortic Aneurysm ◽  
Advanced Glycation End Products ◽  
Endovascular Aneurysm Repair ◽  
Control Group ◽  
Advanced Glycation ◽  
Abdominal Aortic ◽  
Potential Biomarker ◽  
Glycation End Products ◽  
End Products

Experiments conducted in recent years on animals and research works worldwide show a linkage between calprotectin and occurrence and development of the abdominal aortic aneurysm (AAA). Additionally, a correlation between the level of the receptor for advanced glycation end products (RAGE) and the diameter of the abdominal aorta was found. The purpose of this study was to investigate whether calprotectin and the RAGE plasma level may be a biomarker of human AAA occurrence. We determined two groups of research participants: a group of 32 patients aged 53–88 undergoing primary endovascular aneurysm repair and a control group of 43 volunteers aged 59–82 without the AAA. All the patients from the study group had their blood samples drawn in order to determine the level of calprotectin and RAGE in plasma. The second follow-up examination was carried out after three months. The concentration of calprotectin and RAGE in plasma was determined with the use of the immunoenzymatic method (ELISA). The study showed that patients with the AAA had significantly higher mean calprotectin and RAGE plasma levels (p = 0.0001 and p = 0.0002, respectively) as compared to the control group. After the AAA repair operations, the level of concentration of the calprotectin decreased significantly (p = 0.0002). So far, no studies on the connection between the increase of the calprotectin and RAGE in the patient’s plasma with the AAA have been published. Calprotectin may be a promising biomarker related to the occurrence of AAA. Larger studies are needed to fully elucidate and confirm the role of calprotectin in the development and progression of the aneurysm.

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