scholarly journals Relationships between Global DNA Methylation in Circulating White Blood Cells and Breast Cancer Risk Factors

2017 ◽  
Vol 2017 ◽  
pp. 1-25 ◽  
Author(s):  
Nayha Chopra-Tandon ◽  
Haotian Wu ◽  
Kathleen F. Arcaro ◽  
Susan R. Sturgeon
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
The Other ◽  
Global Dna Methylation ◽  
Cancer Risk Factors ◽  
Wide Range ◽  
Breast Cancer Risk Factors

It is not yet clear whether white blood cell DNA global methylation is associated with breast cancer risk. In this review we examine the relationships between multiple breast cancer risk factors and three markers of global DNA methylation:LINE-1, 5-mdC, andAlu. A literature search was conducted using Pubmed up to April 1, 2016, using combinations of relevant outcomes such as “WBC methylation,” “blood methylation,” “bloodLINE-1methylation,” and a comprehensive list of known and suspected breast cancer risk factors. Overall, the vast majority of reports in the literature have focused onLINE-1. There was reasonably consistent evidence across the studies examined that males have higher levels ofLINE-1methylation in WBC DNA than females. None of the other demographic, lifestyle, dietary, or health condition risk factors were consistently associated withLINE-1DNA methylation across studies. With the possible exception of sex, there was also little evidence that the wide range of breast cancer risk factors we examined were associated with either of the other two global DNA methylation markers: 5-mdC andAlu. One possible implication of the observed lack of association between global WBC DNA methylation and known breast cancer risk factors is that the association between global WBC DNA methylation and breast cancer, if it exists, is due to a disease effect.

scholarly journals DNA methylation level in blood and relations to breast cancer, risk factors and environmental exposure in Greenlandic Inuit women

2020 ◽  
Vol 127 (4) ◽  
pp. 338-350
Author(s):  
Maria Wielsøe ◽  
Letizia Tarantini ◽  
Valentina Bollati ◽  
Manhai Long ◽  
Eva Cecilie Bonefeld‐Jørgensen
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Environmental Exposure ◽  
Methylation Level ◽  
Cancer Risk Factors ◽  
Breast Cancer Risk Factors

scholarly journals DNA methylation-based biological age, genome-wide average DNA methylation, and conventional breast cancer risk factors

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Minyuan Chen ◽  
Ee Ming Wong ◽  
Tuong L. Nguyen ◽  
Gillian S. Dite ◽  
Jennifer Stone ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Biological Age ◽  
Age At Menarche ◽  
Cancer Risk Factors ◽  
Genome Wide ◽  
Breast Cancer Risk Factors

Abstract DNA methylation-based biological age (DNAm age), as well as genome-wide average DNA methylation, have been reported to predict breast cancer risk. We aimed to investigate the associations between these DNA methylation-based risk factors and 18 conventional breast cancer risk factors for disease-free women. A sample of 479 individuals from the Australian Mammographic Density Twins and Sisters was used for discovery, a sample of 3354 individuals from the Melbourne Collaborative Cohort Study was used for replication, and meta-analyses pooling results from the two studies were conducted. DNAm age based on three epigenetic clocks (Hannum, Horvath and Levine) and genome-wide average DNA methylation were calculated using the HumanMethylation 450 K BeadChip assay data. The DNAm age measures were positively associated with body mass index (BMI), smoking, alcohol drinking and age at menarche (all nominal P < 0.05). Genome-wide average DNA methylation was negatively associated with smoking and number of live births, and positively associated with age at first live birth (all nominal P < 0.05). The association of DNAm age with BMI was also evident in within-twin-pair analyses that control for familial factors. This study suggests that some lifestyle and hormonal risk factors are associated with these DNA methylation-based breast cancer risk factors, and the observed associations are unlikely to be due to familial confounding but are likely causal. DNA methylation-based risk factors could interplay with conventional risk factors in modifying breast cancer risk.

scholarly journals DNA methylation differences at regulatory elements are associated with the cancer risk factor age in normal breast tissue

2017 ◽  
Author(s):  
Kevin C. Johnson ◽  
E. Andres Houseman ◽  
Jessica E. King ◽  
Brock C. Christensen
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Dna Methylation ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Breast Tissue ◽  
Normal Breast ◽  
Cancer Risk Factors ◽  
Age Related ◽  
Breast Cancer Risk Factors

AbstractBackgroundThe underlying biological mechanisms through which epidemiologically defined breast cancer risk factors contribute to disease risk remain poorly understood. Identification of the molecular changes associated with cancer risk factors in normal tissues may aid in determining the earliest events of carcinogenesis and informing cancer prevention strategies.ResultsHere we investigated the impact cancer risk factors have on the normal breast epigenome by analyzing DNA methylation genome-wide (Infinium 450K array) in cancer-free women from the Susan G. Komen Tissue Bank (n = 100). We tested the relation of established breast cancer risk factors: age, body mass index, parity, and family history of disease with DNA methylation adjusting for potential variation in cell-type proportions. We identified 787 CpG sites that demonstrated significant associations (Q-value < 0.01) with subject age. Notably, DNA methylation was not strongly associated with the other evaluated breast cancer risk factors. Age-related DNA methylation changes are primarily increases in methylation enriched at breast epithelial cell enhancer regions (P = 7.1E-20), and binding sites of chromatin remodelers (MYC and CTCF). We validated the age-related associations in two independent populations of normal breast tissue (n = 18) and normal-adjacent to tumor tissue (n = 97). The genomic regions classified as age-related were more likely to be regions altered in cancer in both pre-invasive (n = 40, P=3.0E-03) and invasive breast tumors (n = 731, P=1.1E-13).ConclusionsDNA methylation changes with age occur at regulatory regions, and are further exacerbated in cancer suggesting that age influences breast cancer risk in part through its contribution to epigenetic dysregulation in normal breast tissue.

Potential breast cancer risk factors among Saudi women aged 19–50 years in Jeddah

2013 ◽  
Vol 88 (3) ◽  
pp. 165-170 ◽  
Author(s):  
Sulafa T. Al-Qutub ◽  
Rajaa M. Al-Raddadi ◽  
Bakr M. Bin Sadiq ◽  
Wafa Sait ◽  
Aboelkhair Al-Gahmi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Risk Factors ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Cancer Risk Factors ◽  
Saudi Women ◽  
Breast Cancer Risk Factors
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