scholarly journals The Association of Haptoglobin Gene Variants and Retinopathy in Type 2 Diabetic Patients: A Meta-Analysis

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Huiqun Wu ◽  
Huan Wu ◽  
Lili Shi ◽  
Xinlu Yuan ◽  
Ying Yin ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Additive Model ◽  
Recessive Model ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Gene Variants ◽  
Type 2 Diabetic Patients ◽  
Allele Model

Aims/Introduction. To collectively evaluate the association between haptoglobin (Hp) gene variants and diabetic retinopathy (DR) in patients with type 2 diabetes mellitus (T2DM).Methods. A comprehensive literature review was performed for eligible studies. After inclusion and exclusion selection as well as quality assessment, those studies meeting quality standards were included. In this study, diabetic patients with retinopathy were selected as the case group and those ones without DR were treated as the control group. The recessive model, allele model, additive model, heterozygote model, and homozygote model were utilized to investigate the association of three Hp gene variants and DR. Subgroup analysis on different severity of DR including nonproliferative diabetic retinopathy (NPDR) and proliferative diabetic retinopathy (PDR) was also conducted.Results. Six trials from different regions were finally included. A total of 1145 subjects containing 564 T2DM patients with retinopathy were included. The recessive model, allele model, additive model, and homozygote model results showed that Hp gene variants were not associated with DR, NPDR, and PDR. However, the heterozygote model indicated the association of Hp gene variants with DR.Conclusions. No association was found between the Hp gene variants and PDR and NPDR. More studies are required to verify these findings.

scholarly journals FAKTOR-FAKTOR YANG BERPENGARUH TERHADAP TERJADINYA HIPERTENSI PADA PENDERITA DIABETES MELITUS TIPE II (Studi di Wilayah Puskesmas Kabupaten Pati)

2017 ◽  
Vol 13 (1) ◽  
pp. 47-59
Author(s):  
Gracilaria Puspa Sari ◽  
Marek Samekto ◽  
Mateus Sakundarno Adi
Keyword(s):  
Risk Factors ◽  
Type 2 Diabetes ◽  
Control Group ◽  
Case Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Chi Square ◽  
Type 2 Diabetic ◽  
Ethical Clearance

ENGLISHThe prevalence of hypertension in type 2 diabetic patients is 1,5-3 times higher than in nondiabetic The objectives of this research is to explain the risk factors affecting hypertension in type 2 diabetic patients. The research used an observational studies with case-control study design in Primary Healthcare Centers patients in Pati Regency of 2014. Case group were 57 patients with hypertension in type 2 diabetes, while control group were the type 2 diabetes patients without hypertension. Data were obtained from medical records and qualitative interviews. Chi-square test in bivariate and multiple logistic regression in multivariate analysis. This study has been obtained ethical clearance from The Ethical Committee of Health Research Medical Faculty of Diponegoro University or dr. Kariadi Hospital. Results : factors that influence hypertension in type 2 diabetic patients were physical activity (OR=6.4; 95% CI: 2.18-18.77; p=0.001), diabetes duration ≥ 5 years (OR=5.4; 95% CI: 1.97 – 14.704; p=0.001), and medication adherence (OR=3.6; 95% CI: 1.32-9.83; p=0.012). Other risk factors that not significantly influenced were age ≥45 years, male, diet compliance, history of hypertension, smoking, salt consumption, coffee consumption, and sleep duration. INDONESIAPrevalensi hipertensi pada penderita DM tipe 2 lebih tinggi dibandingkan non DM tipe 2. Tujuan penelitian untuk menjelaskan faktor yang berpengaruh terhadap terjadinya hipertensi pada penderita DM tipe 2 di wilayah kerja Puskesmas Kabupaten Pati tahun 2014. Jenis Penelitian observasional dengan rancangan studi kasus kontrol pada pasien Puskesmas. Kelompok kasus adalah 57 pasien DM tipe 2 dengan hipertensi sedangkan kelompok kontrol adalah 57 pasien DM tipe 2 tanpa hipertensi. Data diperoleh dari observasi catatan medis dan wawancara. Uji chi-square pada analisis bivariat dan analisis multivariat dengan regresi logistik ganda. Penelitian ini telah memdapatkan Ethical clearance dari Komisi Etik FK UNDIP/RSUP dr. Kariadi Semarang. Hasil Penelitian : faktor yang berpengaruh terhadap terjadinya hipertensi pada penderita DM tipe 2 adalah aktivitas fisik kurang (OR=6,4; 95% CI: 2,18 - 18,77; p=0,001), lama menderita DM ≥5 tahun (OR=5,4; 95% CI: 1,97 - 14,704; p=0,001), dan kepatuhan minum obat DM (OR=3,6; 95% CI: 1,32 - 9,83; p=0,012). Faktor yang tidak berpengaruh adalah : usia ≥45 tahun, jenis kelamin laki-laki, kepatuhan diet DM, riwayat hipertensi, kebiasaan merokok, kebiasaan makan asin, kebiasaan minum kopi, dan lama waktu tidur.

scholarly journals Qualitative and Quantitative Analysis of B-Cell-Produced Antibodies in Vitreous Humor of Type 2 Diabetic Patients with Diabetic Retinopathy

2020 ◽  
Vol 2020 ◽  
pp. 1-7
Author(s):  
Baoyi Liu ◽  
Yijun Hu ◽  
Qiaowei Wu ◽  
Yunkao Zeng ◽  
Yu Xiao ◽  
...  
Keyword(s):  
Diabetes Mellitus ◽  
Diabetic Retinopathy ◽  
B Cell ◽  
Linear Regression Analysis ◽  
Vitreous Humor ◽  
Control Group ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Significant Difference

Aim. To analyze the levels of B-cell-produced antibodies in the vitreous humor of patients with or without diabetic retinopathy (DR) both qualitatively and quantitatively. Methods. A total of 52 type 2 diabetes mellitus (T2DM) with DR patients and 52 control subjects without diabetes mellitus or inflammatory diseases were included in this prospective study. The levels of immunoglobulin (Ig)A, IgM, and IgG subtypes were measured using a magnetic color-bead-based multiplex assay. Results. The concentrations of IgA, IgM, and total antibodies in the DR group were significantly higher than those in the control group (all p<0.001), but there was no significant difference in the 4 IgG subtypes between the two groups after Bonferroni correction. Pearson’s correlation analysis revealed low negative correlations between levels of antibodies (IgA, IgM) and estimated glomerular filtration rate (eGFR, r=−0.443, r=−0.377, respectively, both p<0.05). Furthermore, multiple linear regression analysis yielded three equations to predict the concentrations of IgA, IgM, and total antibodies in the vitreous humor according to eGFR and other clinical variables (r=0.542, r=0.461, and r=0.312, respectively, all p<0.05). Conclusion. Increased levels of IgA, IgM, and total antibodies produced by B cells were observed in the vitreous humor of T2DM patients with DR. There were low negative correlations between levels of antibodies (IgA, IgM) and eGFR.

Male Type 2 Diabetic Patients Have Higher Diabetic Retinopathy Prevalence

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 599-P ◽  
Author(s):  
SARA CHERCHI ◽  
ALFONSO GIGANTE ◽  
PIERPAOLO CONTINI ◽  
DANILA PISTIS ◽  
ROSANGELA M. PILOSU ◽  
...  
Keyword(s):  
Diabetic Retinopathy ◽  
Diabetic Patients ◽  
Type 2 Diabetic Patients ◽  
Male Type ◽  
Type 2 Diabetic

Antihypertensive Drugs and Diabetic Retinopathy in Patients with Type 2 Diabetes

2015 ◽  
Vol 235 (2) ◽  
pp. 87-96
Author(s):  
Jen-Chieh Lin ◽  
Mei-Shu Lai
Keyword(s):  
Diabetic Retinopathy ◽  
Antihypertensive Drugs ◽  
Angiotensin Receptor Blockers ◽  
Incidence Rates ◽  
Diabetic Patients ◽  
Channel Blockers ◽  
Type 2 Diabetic Patients ◽  
Converting Enzyme Inhibitors ◽  
Type 2 Diabetic

Objective: To evaluate the association between the development of sight-threatening diabetic retinopathy (STDR) and antihypertensive drugs (AHDs) use among type 2 diabetic patients with concomitant hypertension. Methods: Type 2 diabetic patients aged 20-100 years who had at least one prescription for AHDs between 2000 and 2011 were identified from the Longitudinal Health Insurance Database (LHID) 2005. The incidence rates of STDR were followed and Cox proportional hazard models were used to analyze the risk associated with AHDs. Results: Users of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) were associated with a significantly higher risk than users of calcium channel blockers (CCBs), independent of baseline characteristics. After adjusting for time-varying use of concomitant medications for propensity score-matched or -unmatched cohorts, the results showed that patients receiving ACEIs/ARBs and CCBs were associated with a significantly greater risk compared with β-blocker users. Conclusions: Our study did not support a superiority of ACEIs/ARBs and CCBs over β-blockers for lowering the progression of diabetic retinopathy.

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