scholarly journals Potential of Lichen Compounds as Antidiabetic Agents with Antioxidative Properties: A Review

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Vinitha M. Thadhani ◽  
Veranja Karunaratne
Keyword(s):  
Biological Activities ◽  
Usnic Acid ◽  
Antioxidant Potential ◽  
Antidiabetic Activity ◽  
Diabetic Mellitus ◽  
Effective Utilization ◽  
Antioxidant Assays ◽  
Good Accordance ◽  
Lichen Compounds ◽  
Gyrophoric Acid

The advancement in the knowledge of potent antioxidants has uncovered the way for greater insight in the treatment of diabetic complications. Lichens are a rich resource of novel bioactive compounds and their antioxidant potential is well documented. Herein we review the antidiabetic potential of lichens which have received considerable attention, in the recent past. We have correlated the antidiabetic and the antioxidant potential of lichen compounds. The study shows a good accordance between antioxidant and antidiabetic activity of lichens and points out the need to look into gathering the scarce and scattered data on biological activities for effective utilization. The review establishes that the lichen extracts, especially ofParmotremasp. andRamalinasp. have shown promising potential in both antidiabetic and antioxidant assays. Ubiquitous compounds, namely, zeorin, methylorsellinate, methyl-β-orcinol carboxylate, methyl haematommate, lecanoric acid, salazinic acid, sekikaic acid, usnic acid, gyrophoric acid, and lobaric acid have shown promising potential in both antidiabetic as well as antioxidant assays highlighting their potential for effective treatment of diabetic mellitus and its associated complications. The available compilation of this data provides the future perspectives and highlight the need for further studies of this potent herbal source to harvest more beneficial therapeutic antidiabetic drugs.

Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid

2011 ◽  
Vol 25 (1) ◽  
pp. 37-44 ◽  
Author(s):  
M. Bačkorová ◽  
M. Bačkor ◽  
J. Mikeš ◽  
R. Jendželovský ◽  
P. Fedoročko
Keyword(s):  
Cancer Cells ◽  
Human Cancer ◽  
Usnic Acid ◽  
Human Cancer Cells ◽  
Lichen Compounds ◽  
Gyrophoric Acid

Synthesis, Characterization, and Evaluation of Antimicrobial and Antioxidant Potential of Polyalthia longifolia Mediated Copper Nanoparticles

2021 ◽  
Vol 68 ◽  
pp. 35-51
Author(s):  
Sumaira Mumtaz ◽  
Raziya Nadeem ◽  
Raja Adil Sarfraz ◽  
Muhammad Shahid
Keyword(s):  
Copper Nanoparticles ◽  
Biological Activities ◽  
Low Cost ◽  
Copper Surface ◽  
Antioxidant Potential ◽  
Synthesis Process ◽  
Synthesis Of Nanoparticles ◽  
Characteristic Features ◽  
Antibacterial And Antifungal ◽  
Polyalthia Longifolia

Synthesis of nanoparticles of transition metals by using medicinal plants has been outstreched in recent years because of the characteristic features which are embodied in the end product. This work is proceded with the aim to synthesize and optimize copper nanoparticles (CuNPs-Pl) using aqueous extract of Polyalthia longifolia leaves (PlL) for characterization and evaluation of antimicrobial and antioxidant potential. The synthesis of CuNPs-Pl was confirmed by visual inspection of the dark brown residues in the reaction flask and via absorption band around 580nm by UV/Visible spectroscopy. Synthesis process was optimized through investigation of environmental variables. FTIR analysis was carried out for both PIL and CuNPs-Pl which identified the presence of alkanes, alcoholic, and aldehydic groups in the PlL and their encapsulation on the copper surface. The synthesized CuNPs-Pl were found to be spherical and rod shaped, and polydispersed when investigated through SEM study. Similarly, these nanoparticles had monoclinic structure and crystalline nature when analyzed by XRD. Moreover, these nanoparticles showed metallic form when EDX examination was done. Further, biological activities were performed. The synthesized nanoparticles showed considerable inhibition zones against Escherichia coli (12mm), Bacillus subtilis (11mm), Aspergillus niger (10mm), and Schyzophyllum commune (16mm) which depicted their powerful antibacterial and antifungal activity. Likewise, CuNPs-Pl were effeciently able to quench free radicals as indicated from the 2, 2-diphenyl-1-picrylhydrazyl (DPPH), hydrogen peroxide (H2O2), and nitric oxide (NO) assays by exhibiting 86.32, 50.45, and 48.23% inhibition respectively. Thus, the contemporary work has substantiated that low cost CuNPs-Pl can be highly proficient alternate or substitute of synthetic formulations.

scholarly journals In vitro antimicrobial activity of the organic extract of Cladonia substellata Vainio and usnic acid against Staphylococcus spp. obtained from cats and dogs

2017 ◽  
Vol 37 (4) ◽  
pp. 368-378 ◽  
Author(s):  
Jusciêne B. Moura ◽  
Agueda C. de Vargas ◽  
Gisele V. Gouveia ◽  
João J. de S. Gouveia ◽  
Juracy C. Ramos-Júnior ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Biological Activities ◽  
Meca Gene ◽  
Usnic Acid ◽  
Organic Extract ◽  
In Vitro Antimicrobial Activity ◽  
Low Concentrations ◽  
Wide Range ◽  
Staphylococcus Spp

ABSTRACT: Cladonia substellata Vainio is a lichen found in different regions of the world, including the Northeast of Brazil. It contains several secondary metabolites with biological activity, including usnic acid, which has exhibited a wide range of biological activities. The aim of this study was to evaluate the in vitro antimicrobial activity of the organic extract of C. substellata and purified usnic acid. Initially, Staphylococcus spp., derived from samples of skin and ears of dogs and cats with suspected pyoderma and otitis, were isolated and analyzed. In antimicrobial susceptibility testing against Staphylococcus spp., 77% (105/136) of the isolates were resistant to the antimicrobials tested. In the assessment of biofilm production, 83% (113/136) were classified as producing biofilm. In genetic characterization, 32% (44/136) were positive for blaZ, no isolate (0/136) was positive for the mecA gene, and 2% (3/136) were positive for the icaD gene. The in vitro antimicrobial activity of the organic extract of C. substellata and purified usnic acid against Staphylococcus spp. ranged from 0.25mg/mL to 0.0019mg/mL, inhibiting bacterial growth at low concentrations. The substances were more effective against biofilm-producing bacteria (0.65mg/mL-0.42mg/mL) when compared to non-biofilm producing bacteria (2.52mg/mL-2.71mg/mL). Usnic acid and the organic extract of C. substellata can be effective in the treatment of pyoderma and otitis in dogs and cats caused by Staphylococcus spp.

scholarly journals Teratogenic Effect of Usnic Acid from Cladonia substellata Vainio during Organogenesis

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
C. R. Silva ◽  
K. S. N. Marinho ◽  
T. D. S. Silva ◽  
D. K. S. Ferreira ◽  
G. M. Aguiar ◽  
...  
Keyword(s):  
Body Weight ◽  
Histological Analysis ◽  
Morphological Changes ◽  
Biological Activities ◽  
Usnic Acid ◽  
Teratogenic Effect ◽  
Oral Toxicity ◽  
Control Groups ◽  
Natural Substances ◽  
Weight Gain During Pregnancy

Studies about toxicological potential of usnic acid are limited. This way, the vast majority of data available in the literature are related only to biological activities. This is the first study that aimed to evaluate the oral toxicity of usnic acid during the period of organogenesis. Females rats were distributed in the control groups, treated I and II, at doses of 15 and 25 mg/kg, administered by gavage during the 6° to 15° days of pregnancy. After 20 days the fetuses were removed and analyzed. A reduction in weight gain during pregnancy, increased resorption, reduction in the number of viable fetuses, and their body weight were observed. Morphological changes in the litter were visualized as exposure of the eye and atrophy of the limbs at the dose of 25 mg/kg. Histological analysis of the liver of the fetus showed reduction in the number of megakaryocytes between experimental groups and increase in the number of hepatocytes in a dose of 25 mg/kg. The experimental model used in this study reveals teratogenic effect of usnic acid in the period of organogenesis. Since this achievement, the importance of evaluating the toxic effects of natural substances is imperative, in order to elucidate the care in their indication as drug.

scholarly journals The Natural Compound Hydrophobic Usnic Acid and Hydrophilic Potassium Usnate Derivative: Applications and Comparisons

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5995
Author(s):  
Hallysson Douglas Andrade de Araújo ◽  
Hianna Arely Milca Fagundes Silva ◽  
José Guedes da Silva Júnior ◽  
Mônica Camelo Pessoa de Azevedo Albuquerque ◽  
Luana Cassandra Breitenbach Barroso Coelho ◽  
...  
Keyword(s):  
Biological Activities ◽  
Structural Characteristics ◽  
Usnic Acid ◽  
Raw Material ◽  
Structural Modifications ◽  
Hydrophobic Molecule ◽  
Antiparasitic Agents ◽  
Toxic Molecule

Usnic acid is the best-studied lichen metabolite, presenting several biological activities, such as antibacterial, immunostimulating, antiviral, antifungal, anti-inflammatory, and antiparasitic agents; despite these relevant properties, it is a hydrophobic and toxic molecule. In this context, scientific research has driven the development of innovative alternatives, considering usnic acid as a source of raw material in obtaining new molecules, allowing structural modifications (syntheses) from it. The purpose is to optimize biological activities and toxicity, with less concentration and/or response time. This work presents a literature review with an analogy of the hydrophobic molecule of usnic acid with its hydrophilic derivative of potassium usnate, emphasizing the elucidation and structural characteristics, biological activities, and toxicological aspects of both molecules, and the advantages of using the promising derivative hydrophilic in different in vitro and in vivo assays when compared to usnic acid.

Zawartość związków fenolowych w ekstrakcie z propolisu oraz ocena jego aktywności przeciwutleniającej i cytoochronnej względem erytrocytów ludzkich w warunkach stresu oksydacyjnego in vitro

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
Magdalena Woźniak ◽  
Lucyna Mrówczyńska ◽  
Agnieszka Waśkiewicz ◽  
Marta Babicka ◽  
Elżbieta Hołderna-Kędzia ◽  
...  
Keyword(s):  
Free Radicals ◽  
Phenolic Acids ◽  
Biological Activities ◽  
Radical Scavenging ◽  
Reducing Power ◽  
Human Erythrocytes ◽  
Antioxidant Potential ◽  
Natural Material ◽  
Propolis Extract

Introduction. Propolis (bee glue) is a natural product collected by honeybees from buds of various trees, shrubs and other plant species. Extracts of propolis possess numerous biological activities, including antioxidant, antibacterial, antifungal and anticancer. For this reason, propolis is currently used in many applications, such as preparations for cold syndrome, dermatological preparations or as a constituent of nutritional supplements and health food. The chemical composition of this natural material is very complex and depending on many factors, including method of extraction and selection of the solvent for the extraction process. Aim. The aim of the study was to determine concentration of selected phenolic compounds (flavonoids and phenolic acids) in extract of Polish propolis and estimate its antioxidant activity and effect on human red blood cells. Material and methods. In the propolis extract was determined concentration of 14 flavonoids and 9 phenolic acids using ultra-performance liquid chromatography equipped with a photodiode detector and a triple quadrupole mass spectrometer. The antioxidant potential of propolis extract was evaluated applying DPPH˙ free radical scavenging activity assay and Fe3+ reducing power assay. Moreover, the cytotoxicity and cytoprotective potential of propolis extract was estimated using human erythrocytes in vitro. Results. The propolis extract contained high concentration of pinocembrin, galangin, chrysin, apigenin, kaempferol, coumaric acid and cinnamic acid. It exhibited also high antioxidant potential. The antiradical activity of examined propolis extract was equal to 75% approx. activity of both standard antioxidants used in the study, namely Trolox and BHT. The reducing power of extract was equal to 65% approx. of Trolox and 80% of BHT, respectively. The propolis extract had no hemolytic activity, moreover, effectively protected human erythrocytes against free radicals-induced damage in vitro. Conclusions. The results of this study indicate that the propolis extract of national origin is a rich source of flavonoids and phenolic acids. Therefore, the propolis extract possesses a high antioxidant potential and can protect erythrocytes against free radicals-induced oxidative hemolysis.

scholarly journals ANTIOXIDANT POTENTIAL OF PIPERIDINE CONTAINING COMPOUNDS-A SHORT REVIEW

2018 ◽  
Vol 11 (8) ◽  
pp. 66
Author(s):  
Manjusha R K ◽  
Shaheen Begum ◽  
Arifa Begum ◽  
Bharathi K
Keyword(s):  
Biological Activities ◽  
Short Review ◽  
Heterocyclic Ring ◽  
Antioxidant Potential ◽  
Naturally Occurring ◽  
Antioxidant Profile ◽  
Antioxidant Agents ◽  
Wide Range ◽  
Privileged Scaffold ◽  
Candidate Molecule

Piperidine is a saturated heterocyclic ring, considered as a privileged scaffold in view of its role in wide range of biological activities. Piperidine is good candidate molecule for obtaining potent antioxidant agents. The planar nature of this heterocyclic nucleus allows the introduction of substituent groups at different positions on the ring. In the present review, the antioxidant profile of piperidine containing compounds has been focused. The compounds were classified into naturally occurring piperidines, unsaturated piperidines, N-substituted piperidines, piperamides, piperanols, piperidine oximes, and hydrazides.

scholarly journals A First Approach to the Chemical Composition and Antioxidant Potential of Guinea-Bissau Propolis

2019 ◽  
Vol 14 (5) ◽  
pp. 1934578X1984413 ◽  
Author(s):  
Soraia I. Falcão ◽  
Mélissa Lopes ◽  
Miguel Vilas-Boas
Keyword(s):  
Antioxidant Activity ◽  
Chemical Composition ◽  
Physicochemical Properties ◽  
Natural Product ◽  
Broad Spectrum ◽  
Biological Activities ◽  
Chemical Diversity ◽  
Antioxidant Potential ◽  
Phenolic Composition ◽  
First Time

Propolis is a natural product derived from plant resins collected by honeybees and used in the beehive as a construction and defensive material. The broad spectrum of biological activities is dependent on the chemical diversity of its composition which is determined by the floral sources at the site of collection. For the first time, the chemical composition of Guinean propolis as well as its physicochemical properties, phenolic composition, and antioxidant activity was assessed. Eight compounds were identified through LC/DAD/ESI-MS n , mostly isoflavonoids, resembling Nigerian and Brazilian red propolis from the genus Dalbergia.

Difference in secondary compounds and chlorophylls between fibrils and main stems in the lichen Usnea longissima suggests different functional roles

2007 ◽  
Vol 39 (5) ◽  
pp. 491-494 ◽  
Author(s):  
Line Nybakken ◽  
Yngvar Gauslaa
Keyword(s):  
Quantitative Data ◽  
Usnic Acid ◽  
Secondary Compounds ◽  
Forest Canopies ◽  
Functional Roles ◽  
Wide Range ◽  
Usnea Longissima ◽  
Lichen Compounds ◽  
Fungal Genus

Usnea is a species-rich and widespread lichenized fungal genus of well-lit parts of forest canopies (Motyka 1936, 1947; Clerc 1998). The bright greenish colour of these beard lichens reflects the presence of usnic acid in the cortex, which forms a thin, but dense sleeve around the trebouxioid photobiont in the outermost parts of the medulla. Usnic acid, a widely distributed dibenzofuran derivative produced by various mycobiont genera, strongly absorbs UV-B, but also the shortest PAR wavelengths (e.g. McEvoy et al. 2006, M. McEvoy, K. A. Solhaug and Y Gauslaa unpublished). Depending on species (Halonen et al. 1998), Usnea also contains a wide range of UV-B absorbing depsidones and depsides, though these are usually assumed to be confined to the medulla. Quantitative data on lichen compounds are rare in Usnea species, particularly with respect to the intrathalline variation.

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