scholarly journals Concentration Distribution of Chloride Ion under the Influence of the Convection-Diffusion Coupling

2017 ◽  
Vol 2017 ◽  
pp. 1-10 ◽  
Author(s):  
Q. L. Zhao ◽  
Y. Z. Zhang
Keyword(s):  
Early Period ◽  
Chloride Ion ◽  
Convection Velocity ◽  
Ion Concentration ◽  
Transfer Model ◽  
Ion Transfer ◽  
Coupling Region ◽  
Diffusion Coupling ◽  
Convection Diffusion ◽  
The Moment

The transfer process of chloride ion under the action of the convection-diffusion coupling was analyzed in order to predict the corrosion of reinforcement and the durability of structure more accurately. Considering the time-varying properties of diffusion coefficient and the space-time effect of the convection velocity, the differential equation for chloride ion transfer under the action of the convection-diffusion coupling was constructed. And then the chloride ion transfer model was validated by the existing experimental datum and the actual project datum. The results showed that when only diffusion was considered, the chlorine ion concentration increased with the time and decreased with the decay index of time. Under the action of the convection-diffusion coupling, at each point of coupling region, the chloride ion concentration first increased and then decreased and tended to stabilize, and the maximum appeared at the moment of convection velocity being 0; in the diffusion zone, the chloride ion concentration increased over time, and the chloride ion concentration of the same location increased with the depth of convection (in the later period), the velocity of convection (in the early period), and the chloride ion concentration of the surface.

scholarly journals Durability of Subsea Tunnels under the Coupled Action of Stress and Chloride Ions

2019 ◽  
Vol 9 (10) ◽  
pp. 1984
Author(s):  
Qingli Zhao ◽  
Limin Lu
Keyword(s):  
Differential Equation ◽  
Partial Differential Equation ◽  
Service Life ◽  
Reliability Index ◽  
Chloride Ion ◽  
Chloride Ions ◽  
Ion Concentration ◽  
Influence Coefficient ◽  
Partial Differential ◽  
Convection Diffusion

The durability of subsea tunnels under the coupled action of stress and chloride ions was analyzed to estimate the service life and provide a theoretical foundation for durability design. The influence coefficient of the stress on chloride ion transmission at lower stress levels was discussed according to the material mechanics, and was verified by experimental data. A stress calculation model of a subsea tunnel’s lining section is proposed based on the plane-section assumption. Considering the space-time effect of the convection velocity, a partial differential equation was constructed to calculate the chloride ion transfer condition under the coupled action of stress-convection-diffusion. The numerical solution of the partial differential equation was solved and the sensitivity of the parameters was analyzed. The subsea tunnel’s time-varying reliability index was calculated following the Monte Carlo method, and was used to predict the service life. The results show that the chloride ion concentration calculated by considering the coupled action is larger and the reliability index is lower than calculated only considering diffusion. Our findings contribute to the conclusion that durability designs of subsea tunnels should consider the coupled action of stress-convection-diffusion. An effective method to improve the service life of a subsea tunnel is to reduce the water–binder ratio or increase the thickness of protective cover.

scholarly journals First Attempts of the Use of 195Pt NMR of Phenylbenzothiazole Complexes as Spectroscopic Technique for the Cancer Diagnosis

Molecules ◽  
2019 ◽  
Vol 24 (21) ◽  
pp. 3970 ◽  
Author(s):  
Bruna T. L. Pereira ◽  
Mateus A. Gonçalves ◽  
Daiana T. Mancini ◽  
Kamil Kuca ◽  
Teodorico C. Ramalho
Keyword(s):  
Cancer Treatment ◽  
Cancer Diagnosis ◽  
Density Functional ◽  
Chemical Shifts ◽  
Chloride Ion ◽  
Platinum Complexes ◽  
Dft Method ◽  
Ion Concentration ◽  
Implicit Solvent ◽  
Early Cancer Diagnosis

Platinum complexes have been studied for cancer treatment for several decades. Furthermore, another important platinum characteristic is related to its chemical shifts, in which some studies have shown that the 195Pt chemical shifts are very sensitive to the environment, coordination sphere, and oxidation state. Based on this relevant feature, Pt complexes can be proposed as potential probes for NMR spectroscopy, as the chemical shifts values will be different in different tissues (healthy and damaged) Therefore, in this paper, the main goal was to investigate the behavior of Pt chemical shifts in the different environments. Calculations were carried out in vacuum, implicit solvent, and inside the active site of P13K enzyme, which is related with breast cancer, using the density functional theory (DFT) method. Moreover, the investigation of platinum complexes with a selective moiety can contribute to early cancer diagnosis. Accordingly, the Pt complexes selected for this study presented a selective moiety, the 2-(4′aminophenyl)benzothiazole derivative. More specifically, two Pt complexes were used herein: One containing chlorine ligands and one containing water in place of chlorine. Some studies have shown that platinum complexes coordinated to chlorine atoms may suffer hydrolyses inside the cell due to the low chloride ion concentration. Thus, the same calculations were performed for both complexes. The results showed that both complexes presented different chemical shift values in the different proposed environments. Therefore, this paper shows that platinum complexes can be a potential probe in biological systems, and they should be studied not only for cancer treatment, but also for diagnosis.

scholarly journals Broadband dielectric spectroscopy for monitoring temperature-dependent chloride ion motion in BiOCl plates

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Adrian Radoń ◽  
Dariusz Łukowiec ◽  
Patryk Włodarczyk
Keyword(s):  
Electrical Conductivity ◽  
Dielectric Spectroscopy ◽  
Low Frequency ◽  
Chloride Ion ◽  
Ion Source ◽  
Chloride Ions ◽  
Ion Concentration ◽  
Broadband Dielectric Spectroscopy ◽  
Free Chloride ◽  
Structure Rebuilding

AbstractThe dielectric properties and electrical conduction mechanism of bismuth oxychloride (BiOCl) plates synthesized using chloramine-T as the chloride ion source were investigated. Thermally-activated structure rebuilding was monitored using broadband dielectric spectroscopy, which showed that the onset temperature of this process was 283 K. This rebuilding was related to the introduction of free chloride ions into [Bi2O2]2+ layers and their growth, which increased the intensity of the (101) diffraction peak. The electrical conductivity and dielectric permittivity were related to the movement of chloride ions between plates (in the low-frequency region), the interplanar motion of Cl− ions at higher frequencies, vibrations of these ions, and charge carrier hopping at frequencies above 10 kHz. The influence of the free chloride ion concentration on the electrical conductivity was also described. Structure rebuilding was associated with a lower concentration of free chloride ions, which significantly decreased the conductivity. According to the analysis, the BiOCl plate conductivity was related to the movement of Cl− ions, not electrons.

scholarly journals Chloride-ion concentration dependence of molecular dimension in the acid-denatured state of equine β-lactoglobulin

2007 ◽  
Vol 40 (s1) ◽  
pp. s213-s216 ◽  
Author(s):  
Yoshiteru Yamada ◽  
Takeo Yajima ◽  
Seiichi Tsukamoto ◽  
Kanako Nakagawa ◽  
Kazuo Fujiwara ◽  
...  
Keyword(s):  
Concentration Dependence ◽  
Chloride Ion ◽  
Ion Concentration ◽  
Denatured State ◽  
Molecular Dimension ◽  
Β Lactoglobulin

GABA responses in rat dentate granule neurons are mediated by chloride

1988 ◽  
Vol 66 (5) ◽  
pp. 637-642 ◽  
Author(s):  
Timothy J. Blaxter ◽  
Peter L. Carlen
Keyword(s):  
Granule Cells ◽  
Hippocampal Slices ◽  
Reversal Potential ◽  
Chloride Ion ◽  
Chloride Ions ◽  
Ion Concentration ◽  
Aminobutyric Acid ◽  
Granule Neurons ◽  
Nernst Equation ◽  
Central Neurons

The dendrites of granule cells in hippocampal slices responded to γ-aminobutyric acid (GABA) with a depolarization. The response was blocked by picrotoxin in a noncompetitive manner. Reductions in the extracellular chloride ion concentration changed the reversal potential of the response by an amount predicted from the Nernst equation for chloride ion. Chloride-dependent hyperpolarizing responses were sometimes also found in the cell body of the granule cells. Since the reversal potential followed that predicted from the Nernst equation for chloride, we conclude that the response was mediated by chloride ions alone with no contribution from other ions. This has not previously been shown for the depolarizing response to GABA in central neurons.

scholarly journals Novel activity of angiotensin-converting enzyme. Hydrolysis of cholecystokinin and gastrin analogues with release of the amidated C-terminal dipeptide

1989 ◽  
Vol 262 (1) ◽  
pp. 125-130 ◽  
Author(s):  
P Dubreuil ◽  
P Fulcrand ◽  
M Rodriguez ◽  
H Fulcrand ◽  
J Laur ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Chloride Ion ◽  
Peptide Bond ◽  
Major Product ◽  
Enzyme Hydrolysis ◽  
Ion Concentration ◽  
Converting Enzyme ◽  
Rabbit Lung ◽  
Hydrolysis Of

ACE (angiotensin-converting enzyme; peptidyl dipeptidase A; EC 3.4.15.1), cleaves C-terminal dipeptides from active peptides containing a free C-terminus. We investigated the hydrolysis of cholecystokinin-8 [CCK-8; Asp-Tyr(SO3H)-Met-Gly-Trp-Met-Asp-Phe-NH2] and of various gastrin analogues by purified rabbit lung ACE. Although these peptides are amidated at their C-terminal end, they were metabolized by ACE to several peptide fragments. These fragments were analysed by h.p.l.c., isolated and identified by comparison with synthetic fragments, and by amino acid analysis. The initial and major site of hydrolysis was the penultimate peptide bond, which generated a major product, the C-terminal amidated dipeptide Asp-Phe-NH2. As a secondary cleavage, ACE subsequently released di- or tri-peptides from the C-terminal end of the remaining N-terminal fragments. The cleavage of CCK-8 and gastrin analogues was inhibited by ACE inhibitors (Captopril and EDTA), but not by other enzyme inhibitors (phosphoramidon, thiorphan, bestatin etc.). Hydrolysis of [Leu15]gastrin-(14-17)-peptide [Boc (t-butoxycarbonyl)-Trp-Leu-Asp-Phe-NH2] in the presence of ACE was found to be dependent on the chloride-ion concentration. Km values for the hydrolysis of CCK-8, [Leu15]gastrin-(11-17)-peptide and Boc-[Leu15]gastrin-(14-17)-peptide at an NaCl concentration of 300 mM were respectively 115, 420 and 3280 microM, and the catalytic constants were about 33, 115 and 885 min-1. The kcat/Km for the reactions at 37 degrees C was approx. 0.28 microM-1.min-1, which is approx. 35 times less than that reported for the cleavage of angiotensin I. These results suggest that ACE might be involved in the metabolism in vivo of CCK and gastrin short fragments.

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