scholarly journals The Use of Endothelial Progenitor Cells for the Regeneration of Musculoskeletal and Neural Tissues

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Naosuke Kamei ◽  
Kivanc Atesok ◽  
Mitsuo Ochi
Keyword(s):  
Bone Marrow ◽  
Clinical Trials ◽  
Endothelial Cells ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Tissue Repair ◽  
Cell Populations ◽  
Neural Tissues ◽  
Cell Source ◽  
Stem Cell Populations

Endothelial progenitor cells (EPCs) derived from bone marrow and blood can differentiate into endothelial cells and promote neovascularization. In addition, EPCs are a promising cell source for the repair of various types of vascularized tissues and have been used in animal experiments and clinical trials for tissue repair. In this review, we focused on the kinetics of endogenous EPCs during tissue repair and the application of EPCs or stem cell populations containing EPCs for tissue regeneration in musculoskeletal and neural tissues including the bone, skeletal muscle, ligaments, spinal cord, and peripheral nerves. EPCs can be mobilized from bone marrow and recruited to injured tissue to contribute to neovascularization and tissue repair. In addition, EPCs or stem cell populations containing EPCs promote neovascularization and tissue repair through their differentiation to endothelial cells or tissue-specific cells, the upregulation of growth factors, and the induction and activation of endogenous stem cells. Human peripheral blood CD34(+) cells containing EPCs have been used in clinical trials of bone repair. Thus, EPCs are a promising cell source for the treatment of musculoskeletal and neural tissue injury.

Proteomic Profiling Identifies Distinct Bone Marrow Niche Mesenchymal Stem Cell Populations In AML Patients

2015 ◽  
Vol 15 ◽  
pp. S19
Author(s):  
Peter P. Ruvolo ◽  
Rui-Yu Wang ◽  
Vivian Ruvolo ◽  
Zhihong Zeng ◽  
YiHua Qiu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Cell Populations ◽  
Bone Marrow Niche ◽  
Proteomic Profiling ◽  
Stem Cell Populations

scholarly journals The alliance between nerve fibers and stem cell populations in bone marrow: life partners in sickness and health

2019 ◽  
Vol 33 (8) ◽  
pp. 8697-8710 ◽  
Author(s):  
Luís Leitão ◽  
Cecília J. Alves ◽  
Daniela M. Sousa ◽  
Estrela Neto ◽  
Francisco Conceição ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Nerve Fibers ◽  
Cell Populations ◽  
Stem Cell Populations

scholarly journals CD146/MCAM defines functionality of human bone marrow stromal stem cell populations

2016 ◽  
Vol 7 (1) ◽  
Author(s):  
Linda Harkness ◽  
Walid Zaher ◽  
Nicholas Ditzel ◽  
Adiba Isa ◽  
Moustapha Kassem
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Human Bone ◽  
Human Bone Marrow ◽  
Cell Populations ◽  
Stromal Stem Cell ◽  
Stem Cell Populations

scholarly journals 1104-191 Nicotine administration significantly alters peripheral, bone marrow and splenic stem cell populations in C57/B16 mice

2004 ◽  
Vol 43 (5) ◽  
pp. A490
Author(s):  
Edwin Chang ◽  
Bingyin Wang ◽  
Camilla Forsberg ◽  
Rich Allsopp ◽  
Irving L Weissman ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Stem Cell ◽  
Cell Populations ◽  
Nicotine Administration ◽  
Stem Cell Populations ◽  
Peripheral Bone

Abstract 15440: Dynamics of Adipocyte and Endothelial Progenitor Cell Pools in Expanding Adipose Tissue

Circulation ◽  
2014 ◽  
Vol 130 (suppl_2) ◽  
Author(s):  
Candice R Holden ◽  
Marcin Wysoczynski ◽  
Brian Sansbury ◽  
Jason Hellmann ◽  
Nagma Zafar ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Adipose Tissue ◽  
Stem Cell ◽  
Progenitor Cells ◽  
Progenitor Cell ◽  
Stromal Vascular Fraction ◽  
Cell Populations ◽  
Adipose Organ ◽  
The Impact

Objective: Obesity is a major risk factor for the development of several chronic diseases including type 2 diabetes and cardiovascular disease. Proper fat storage in white adipose tissue (WAT) is required to maintain insulin sensitivity and to preserve (cardio)vascular health. We hypothesize that endothelial and adipocyte progenitor cell populations (EPCs and APCs, respectively) must be appropriately balanced for physiological, as opposed to pathological, remodeling of WAT. Methods and Results: To determine the impact of nutrient excess on stem/progenitor cells in epididymal WAT, male C57BL/6J mice were placed on a high fat diet (HFD; 60% fat) for 12 weeks and changes in WAT stem cell populations were measured in the stromal vascular fraction by flow cytometry. Although the APC (CD24+/CD29+/Sca+/CD14-/CD45-) population, which has the capacity to differentiate into adipocytes both in vitro and in vivo , was not significantly changed with diet, Flk+/Sca+ EPCs were diminished, promoting a 4-fold decrease in the EPC/APC ratio (p <0.05, n = 6/group). To determine whether this deficit may be due to poor stem cell recruitment, mice were irradiated, and the bone marrow was repopulated with GFP+ donor marrow. The transplanted mice were then placed on a low fat diet (LFD; 10% fat) or HFD for 12 weeks, and WAT progenitor cells were again measured. Greater than 95% of the putative APCs in the WAT of HF-fed mice were GFP+ (p<0.0001, n=7-8/group), indicating a bone marrow-derived origin. Unexpectedly, less than 1% of the EPCs were GFP+ (p<0.001, n=7-8/group), which suggests that EPCs present in WAT are not derived from bone marrow in adult mice. Confocal analysis of WAT from HF-fed, bone marrow-transplanted mice showed little evidence of significant APC differentiation into triglyceride-laden adipocytes, suggesting that conditions associated with nutrient excess may impair the ability of the adipose organ to store fat properly. Conclusions: These results demonstrate that putative APCs, and not EPCs, in epididymal WAT are derived from bone marrow. Furthermore, our data suggest that conditions of nutrient excess promote an imbalance in EPCs and APCs, the stoichiometry of which may be critical for the development of new adipocytes and for proper storage of fat.

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