scholarly journals Hip Osteonecrosis Is Associated with Increased Plasma IL-33 Level

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
Jinhui Ma ◽  
Wanshou Guo ◽  
Zirong Li ◽  
Bailiang Wang ◽  
Shirui Li ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Femoral Head ◽  
Prospective Study ◽  
Family Member ◽  
Healthy Subjects ◽  
Potential Role ◽  
Osteonecrosis Of Femoral Head ◽  
Elisa Kit ◽  
L1 And L2

The recently discovered IL-33 as an IL-1 cytokine family member has been proved to be specifically released from osteonecrotic bones. We aimed to investigate the potential role of IL-33 in the development of osteonecrosis of femoral head (ONFH). Forty patients diagnosed with ONFH and forty age-, sex-, and body mass index- (BMI-) matched healthy subjects were included in this prospective study between March 2016 and September 2016. A commercially available ELISA kit was used to test the level of plasma IL-33. The IL-33 levels were compared among different ARCO stages, CJFH types, and etiology groups. Plasma IL-33 levels were significantly higher in the ONFH patients than that in the control subjects. The levels of IL-33 did not differ significantly among the ONFH patients with different ARCO stages. The IL-33 levels of patients with CJFH type L3 were significantly higher than that of patients with types L1 and L2. No significant differences were observed in IL-33 levels between steroid-induced, alcohol-induced, and idiopathic patients. Our findings seem to indicate that IL-33 effects may be detrimental during ONFH, which appeared to be associated with the prognosis of ONFH. The IL-33 deserves particular attention in the pathogenesis of ONFH.

scholarly journals Body mass index and adipokines/cytokines dysregulation in Systemic Sclerosis

2021 ◽  
Author(s):  
F Iannone ◽  
Emanuela Praino ◽  
Cinzia Rotondo ◽  
Dorotea Natuzzi ◽  
Rita Bizzoca ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Systemic Sclerosis ◽  
Body Mass ◽  
Potential Role ◽  
Serum Levels ◽  
Waist To Hip Ratio ◽  
Healthy Donors ◽  
Underweight Patients ◽  
Regulatory Functions

Body fat has regulatory functions through producing cytokines and adipokines whose role in the pathogenesis of Systemic Sclerosis (SSc) is currently emerging. Changes in body mass, either overweight or underweight status, entail a dysregulation of the cytokines/adipokines network that may impact on SSc disease activity. We evaluated serum levels of adipokines and cytokines in SSc patients and correlated them to clinical features and body mass index (BMI) categories. The study included 89 SSc patients and 26 healthy donors (HD). Serum levels of adiponectin, leptin, resistin, visfatin, TNFα, IFNγ, IL-2, IL-10, and IL-17A were measured by Multiplex Immunoassay, and correlated to BMI, waist to hip ratio, and disease specific features. Mann-Whitney U-test or t-Student for unpaired data, Kruskal-Wallis test or ANOVA, were used for comparisons between groups. Spearman’s or Pearson’s test were used for correlation analysis. Serum levels of TNFα, IL-2, leptin, and resistin, were significantly higher in SSc than in HD. The highest levels of IL-17A, IL-2, IL-10, leptin and visfatin were detected in obese SSc patients (p <0.01). Conversely, underweight SSc patients showed the highest TNFα levels (p<0.05), which were negatively correlated with BMI (p=0.05). No correlation between adipokines/cytokines and clinical characteristics was found. Adipokines, IL-2, IL-10 and IL-17A were found to be increased in obese SSc patients, but whether they play a role in the pathogenesis of the disease remains to be investigated. Intriguingly, underweight patients had higher TNFα levels, suggesting a potential role of TNFα in inducing the cachexia observed in long-lasting disease.

scholarly journals Infant Feeding and Ethnic Differences in Body Mass Index during Childhood: A Prospective Study

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2291
Author(s):  
Outi Sirkka ◽  
Tanja Vrijkotte ◽  
Lieke van Houtum ◽  
Marieke Abrahamse-Berkeveld ◽  
Jutka Halberstadt ◽  
...  
Keyword(s):  
Body Mass Index ◽  
Prospective Study ◽  
Infant Feeding ◽  
Body Mass ◽  
Ethnic Differences ◽  
Full Model ◽  
Turkish Children ◽  
A Prospective Study ◽  
Milk Feeding

This study investigated ethnic differences in childhood body mass index (BMI) in children from Dutch and Turkish descent and the role of infant feeding factors (breastfeeding duration, milk feeding frequency, as well as the timing, frequency and variety of complementary feeding (CF)). We used data from 244 children (116 Dutch and 128 Turkish) participating in a prospective study in the Netherlands. BMI was measured at 2, 3 and 5 years and standard deviation scores (sds) were derived using WHO references. Using linear mixed regression analyses, we examined ethnic differences in BMI-sds between 2 and 5 years, and the role of infant feeding in separate models including milk or CF factors, or both (full model). Relative to Dutch children, Turkish children had higher BMI-sds at age 3 (mean difference: 0.26; 95%CI: 0.04,0.48) and 5 (0.63; 0.39,0.88), but not at 2 years (0.08; −0.16,0.31). Ethnic differences in BMI-sds were somewhat attenuated by CF factors at age 3 (0.16; −0.07,0.40) and 5 years (0.50; 0.24,0.77), whereas milk feeding had a minor impact. Of all factors, only CF variety was associated with BMI-sds in the full model. CF factors, particularly CF variety, explain a small fraction of the BMI-sds differences between Dutch and Turkish children. The role of CF variety on childhood BMI requires further investigation.

scholarly journals The Role of Immune Regulatory Cells in Nontraumatic Osteonecrosis of the Femoral Head: A Retrospective Clinical Study

2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Jinhui Ma ◽  
Juncheng Ge ◽  
Fuqiang Gao ◽  
Bailiang Wang ◽  
Debo Yue ◽  
...  
Keyword(s):  
Femoral Head ◽  
T Lymphocytes ◽  
Lymphocyte Count ◽  
B Lymphocyte ◽  
Total Lymphocyte Count ◽  
Regulatory Cells ◽  
Total Lymphocyte ◽  
Retrospective Clinical Study ◽  
L1 And L2

The immunologic factors have been implicated in the pathogenesis of osteonecrosis. We aimed to investigate the potential role of immune regulatory cells in the development of osteonecrosis of femoral head (ONFH). Sixty-seven patients diagnosed with ONFH and fifty-eight age-, height-, and weight-matched healthy subjects were included in this retrospective study between September 2015 and September 2018. The flow cytometry was used to test the count, percentage, and ratio of T and B lymphocyte subsets in peripheral blood. The T and B lymphocyte levels were compared among different ARCO stages, CJFH types, and etiology groups. The total lymphocyte count, CD3+T cells, Ts cells (CD3+CD8+), B-1 cell count, and B-1 cells (CD5+CD19+) were significantly higher in the patients with ONFH than those in the control subjects. The percentage of T lymphocytes in the patients with ARCO IV stage was significantly smaller than that in the ONFH patients with ARCO II and III stages. The percentage of inhibitory T lymphocytes in patients with CJFH type L3 was significantly smaller than that in the patients with types L1 and L2. In terms of the different ONFH etiologies, the total lymphocyte count and Ts cells (CD3+CD8+) were significantly lower in the ONFH patients induced by excessive alcohol intake than those in the idiopathic ONFH patients. Our results seem to indicate that immune regulatory cells, such as T and B lymphocytes, play an important role in the pathogenesis of ONFH. The development and progression of ONFH may be associated with immune system imbalance.

Evaluation Of The Potential Role Of Shear Wave Elastography As A Promising Predictor Of Sperm Retrieval In Non‐Obstructive Azoospermic Patients: A Prospective Study

Andrology ◽  
2021 ◽  
Author(s):  
Alaaeldien Mohamed Abdelmoniem Abdelaal ◽  
Hatem Mohamed El‐Azizi ◽  
Sameh Fayek GamalEl Din ◽  
Omar Azzazi ◽  
Mohamed Shokr Mohamed
Keyword(s):  
Prospective Study ◽  
Shear Wave ◽  
Potential Role ◽  
Shear Wave Elastography ◽  
Sperm Retrieval ◽  
A Prospective Study
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