scholarly journals X-Linked Retinoschisis in Juveniles: Follow-Up by Optical Coherence Tomography

2017 ◽  
Vol 2017 ◽  
pp. 1-5 ◽  
Author(s):  
Qin-rui Hu ◽  
Lv-zhen Huang ◽  
Xiao-li Chen ◽  
Hui-ka Xia ◽  
Tian-qi Li ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Thickness ◽  
Optical Coherence ◽  
Clinical Protocol ◽  
Juvenile Period ◽  
Corrected Visual Acuity ◽  
Structural Progression ◽  
One Year ◽  
Sd Oct

Purpose.To explore the structural progression of X-linked retinoschisis (XLRS) in patients by using spectral-domain optical coherence tomography (SD-OCT).Design.Retrospective, observational study.Methods.Patients who were diagnosed with XLRS by genetic testing underwent comprehensive ophthalmological examinations from December 2014 to October 2016. Each eye was measured by SD-OCT using the same clinical protocol. A correlation between best-corrected visual acuity (VA) and SD-OCT measurements was observed.Results.Six patients demonstrated retinoschisis (12 eyes) and typical foveal cyst-like cavities (10 eyes) on SD-OCT images with a mean logMAR VA of 0.48. The median age was 7.5 years at the initial visit. Their foveal retinal thickness (516.9 μm) and choroid thickness (351.4 μm) decreased at a rate of 38.1 and 7.5 μm, respectively, at the 10.5-month follow-up visit; however, there were no significant differences (P=0.622andP=0.406, resp.). There was no significant correlation between VA, the foveal retinal thickness, and subfoveal choroid thickness.Conclusions.SD-OCT images for XLRS patients during the juvenile period revealed no significant changes in the fundus structure, including the foveal retinal thickness and choroid thickness within one-year follow-up. There was a lack of correlation between VA, foveal retinal thickness, and subfoveal choroid thickness.

Analysis of the process of recovery of the foveolar region after surgery of idiopathic macular ruptures by the «temporal inverted VPM flap» method

2021 ◽  
pp. 159-163
Author(s):  
S.D. Stebnev ◽  
◽  
V.S. Stebnev ◽  
N.I. Skladchikova ◽  
T.Y. Vashchenko ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Visual Acuity ◽  
Retinal Thickness ◽  
Outer Boundary ◽  
Optical Coherence ◽  
Photoreceptor Layer ◽  
Corrected Distance Visual Acuity ◽  
One Year ◽  
Boundary Membrane

Purpose. To analyze the recovery of the foveolar region after successful surgery of idiopathic macular rupture (IMR) using the "temporal inverted VPM flap" method. Material and methods. In 33 patients (34 eyes) aged 65.2±8.1 years, operated on for stage II-IV IMR according to J. Gass (1995), in the postoperative period for up to 1 year, changes in the foveolar region were studied by optical coherence tomography (OCT). Results. Recovery of the foveolar area began from the first days after the operation and lasted for 12 months. In the period from 1 week to 1 month, the recovery and approximation to the U-shaped foveolar contour was noted in all patients. At the final follow-up period: the outer boundary membrane and the ellipsoid zone were completely restored in 26/44 (76%) and 23/34 (68%) eyes, respectively; the average central retinal thickness decreased from 396±62.6 microns to 194±66 microns (p<0.05); the corrected distance visual acuity (CDVA) increased from 0.07±0.04 to 0.35±0.21 (p<0.05). Conclusion The "temporal inverted VPM flap" method is highly effective in the surgery of idiopathic macular ruptures. The process of restoring the microstructures of the foveolar zone begins from the first days after the IMR surgery using the "temporal inverted VPM flap" method, is gradual and lasts up to one year from the start of treatment. The main stages of restoration of the microstructures of the foveolar region are: mechanical overlap of the macular rupture with HPV flaps, filling of the IMR lumen with a "glial plug", restoration of the external photoreceptor layer of the fovea. Key words: foveolar region, outer layers of the retina, idiopathic macular rupture, temporal inverted VPM flap, optical coherence tomography.

scholarly journals Morphological Changes in Lamellar Macular Holes According to SD-OCT Examination over a Long Observation Period

Diagnostics ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 1145
Author(s):  
Magdalena Kal ◽  
Izabela Chojnowska-Ćwiąkała ◽  
Mateusz Winiarczyk ◽  
Monika Jasielska ◽  
Jerzy Mackiewicz
Keyword(s):  
Retinal Thickness ◽  
Morphological Changes ◽  
Outer Diameter ◽  
Corrected Visual Acuity ◽  
Macular Holes ◽  
Kolmogorov Smirnov ◽  
Inner Diameter ◽  
Observation Period ◽  
Sd Oct

Background: The aim of this study was to evaluate the quantitative morphological changes in lamellar macular holes (LMHs) based on SD-OCT examinations and to assess the correlations among minimal retinal thickness (MRT), reading vision (RV), and best corrected visual acuity (BCVA) over a 36-month follow-up period. Methods: A group of 40 patients (44 eyes) with LMH was evaluated, with an average age of 69.87 (SD = 10.14). The quantitative parameters monitored in the follow-up period (at 0, 3, 6, 12, 18, 24, 30, and 36 months) were tested for normality of distribution by Shapiro–Wilk and Kolmogorov–Smirnov tests. Results: The RV and BCVA values were stable, and no significant changes were found at any of the check-ups during the 36-month follow-up period (BCVA p = 0.435 and RV p = 0.0999). The analysis of individual quantitative LMH parameters during the 36-month follow-up period did not demonstrate statistically significant differences: MRT (p = 0.461), Max RT temporal (p = 0.051), Max RT nasal (p = 0.364), inner diameter (ID) (p = 0.089), and outer diameter (OD) (p = 0.985). Conclusions: The observations at 0, 6, 12, 18, 24, 30, and 36 months revealed moderate and significant correlations between RV and MRT. No significant correlation between BCVA and MRT was observed.

Sub-Threshold Micro Pulse Laser (810NM): Treatment for Chronic Central Serous Retinopathy

2021 ◽  
Vol 37 (2) ◽  
Author(s):  
Mariam Shamim Kashif ◽  
Najia Uzair ◽  
Lubna Feroz ◽  
Asaad Mehmood
Keyword(s):  
Retinal Thickness ◽  
Case Series ◽  
Central Retinal Thickness ◽  
Central Serous Retinopathy ◽  
Invasive Treatment ◽  
Micropulse Laser ◽  
Corrected Visual Acuity ◽  
Best Corrected Visual Acuity ◽  
Sd Oct

Purpose:  To find the effectiveness of sub-threshold (810nm) micropulse diode laser treatment (SMT) in chronic central serous retinopathy (CSR). Study Design:  Interventional case series. Place and Duration of Study:  Layton Rahmatulla benevolent trust eye hospital, from April 2019 to July 2020. Methods:  The patients of chronic CSR (≥ 6 months) participated in the study. We used Spectral Domain Optical coherence tomography (SD-OCT) to record baseline central retinal thickness (CT). Best corrected visual acuity (BCVA) was recorded with Snellen’s chart and converted to Log MAR for statistical analysis. All patients underwent treatment with sub-threshold laser (810nm) in micropulse mode with 5% duty cycle (DC). Results:  Twenty five eyes with chronic CSR were enrolled in the study. The patients were treated with laser and final assessment was made at 6 months. Mean BCVA at presentation was 0.46 Log MAR ± 0.12 and a mean baseline CT of 362.2 μm ± 32.6µm. At final follow-up there was a mean decrease in CT of 97.2 μm ± 21.8 from the baseline. After treatment mean BCVA was 0.33 Log MAR ± 0.12 and mean CT was 266 μm ± 20.9. Nineteen out of twenty-five eyes (76%) achieved a gain of vision between 1 to 3 lines and gain of 3 lines was achieved in 8% of cases. At the final follow-up there was incomplete resolution of sub retinal fluid in 4 eyes (16%) with no improvement in BCVA. Conclusion:  SMT (810 nm) is an effective and minimally invasive treatment modality for chronic CSR. Key Words:  Sub-Threshold micropulse laser, Central serous retinopathy, Central retinal thickness, sub retinal fluid.

Effects of Retinal Angiography on Optical Coherence Tomography Measurements

2015 ◽  
Vol 234 (3) ◽  
pp. 160-166 ◽  
Author(s):  
Young-Joon Jo ◽  
Hyung-Bin Lim ◽  
Soo-Hyun Lee ◽  
Jung-Yeul Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Indocyanine Green ◽  
Retinal Thickness ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer Thickness ◽  
Interclass Correlation ◽  
Significant Difference ◽  
Before And After ◽  
Sd Oct

Purpose: To evaluate the effects of retinal angiography, using fluorescein and indocyanine green dyes, on optical coherence tomography (OCT) measurements. Methods: In total, 76 eyes from 76 consecutive patients were included. Macular cube 512 × 128 combination scanning and optic disc 200 × 200 scanning using spectral-domain (SD)-OCT were performed twice, before and after retinal angiography, with fluorescein or indocyanine green. Signal strength, regional retinal thickness of the 9 Early Treatment Diabetic Retinopathy Study subfields, total macular volume, and retinal nerve fiber layer thickness obtained before and after angiography were compared. Repeatability was also investigated. Results: Comparing the results of OCT measured before and after retinal angiography, there was no statistically significant difference in any parameter assessed. The interclass correlation values for each measurement were all >0.808 (range 0.808-0.999). Conclusion: Retinal angiography using fluorescein and indocyanine green dyes has no significant effect on OCT measurements.

scholarly journals Retinal Vascular Changes in Radiation Maculopathy after Intravitreal Ranibizumab by Optical Coherence Tomography Angiography

2020 ◽  
Vol 9 (6) ◽  
pp. 1618 ◽  
Author(s):  
Gilda Cennamo ◽  
Daniela Montorio ◽  
Roberta Bernardo ◽  
Antonio Farella ◽  
Raffaele Liuzzi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Choroidal Melanoma ◽  
Predictive Biomarkers ◽  
Foveal Avascular Zone ◽  
Functional Improvement ◽  
Optical Coherence ◽  
Foveal Thickness ◽  
Capillary Plexus ◽  
Sd Oct

In this prospective study, we investigated the structural and vascular retinal changes at baseline and after Ranibizumab injections at the last follow up to one year in patients affected by Radiation Maculopathy (RM) after plaque brachytheraphy in choroidal melanoma, using Spectral Domain Optical Coherence Tomography (SD-OCT) and OCT Angiography (OCTA). A total of 40 eyes with RM of 40 patients (18 females, 22 males, mean age 51.9 ± 11 years) that underwent ruthenium-106 plaque brachytherapy were included. All patients received one monthly intravitreal injection of Ranibizumab (Pro Re Nata regimen). We analyzed the Foveal Avascular Zone (FAZ) area, the retinal vessel density (VD) of the superficial capillary plexus (SCP) and of the deep capillary plexus (DCP), using OCTA, and we detected the Central Foveal Thickness (CFT) by SD-OCT at baseline and after treatment. At the last follow up, we found a significant improvement of the CFT (p < 0.001) while OCTA parameters revealed no change in VD of the SCP (p = 0.402), DCP (p = 0.282), and FAZ area (p = 0.255), resulting in a stabilization of the visual acuity (p = 0.210) respect to baseline. The absence of functional improvement, despite the anatomical recovery of the macula, could be due to the absence of improvement in FAZ area and in retinal VD after treatment. OCTA parameters could represent predictive biomarkers to anti-vascular endothelial growth factor (anti-VEGF) intravitreal response and to help to better understand the physiopathological mechanisms of the RM.

scholarly journals Significance of outer retinal undulation on preoperative optical coherence tomography in rhegmatogenous retinal detachment

2020 ◽  
Vol 10 (1) ◽  
Author(s):  
Young Do Yeo ◽  
Yu Cheol Kim
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Detachment ◽  
Rhegmatogenous Retinal Detachment ◽  
Clinical Findings ◽  
Symptom Duration ◽  
Retinal Damage ◽  
Optical Coherence ◽  
Corrected Visual Acuity ◽  
Best Corrected Visual Acuity

Abstract Rhegmatogenous retinal detachment (RRD) is a vision-threatening pathology. Optical coherence tomography (OCT) is useful for evaluating retinal damage and visual prognosis in patients with RRD. Outer retinal undulation (ORU) is often observed on preoperative OCT in RRD. Therefore, we evaluated the correlation between ORU seen on preoperative OCT and pre/post-operative factors in RRD. Patients with RRD (114 eyes) underwent reattachment surgery and ≥ 6 months of follow-up. According to the condition of the macula on preoperative OCT, cases were divided into macula-on RRD (65 eyes) or macula-off RRD (49 eyes). Patients were classified into acute (< 10 days), subacute (10–30 days), and chronic (> 30 days) symptom duration groups. Clinical findings, histories, and relationships with OCT findings, including ORU, were analyzed. Subacute symptom duration was significantly associated with ORU on preoperative OCT (p = 0.001) and had a higher prevalence of ORU (73.7%) than did acute (OR = 4.48) or chronic (OR = 7.467) durations. Ellipsoid zone (EZ) disruption was significantly associated with poorer best-corrected visual acuity (BCVA) than normal EZ integrity at 6 months postoperatively (p = 0.012). ORU on preoperative OCT suggests a 10–30 days morbidity duration in RRD. EZ integrity is useful for predicting postoperative BCVA in macula-off RRD.

Evolution of retinal changes measured by optical coherence tomography in the assessment of hydroxychloroquine ocular safety in patients with systemic lupus erythematosus

Lupus ◽  
2019 ◽  
Vol 28 (4) ◽  
pp. 555-559 ◽  
Author(s):  
D Martín-Iglesias ◽  
J Artaraz ◽  
A Fonollosa ◽  
A Ugarte ◽  
A Arteagabeitia ◽  
...  
Keyword(s):  
Risk Factors ◽  
Optical Coherence Tomography ◽  
Lupus Erythematosus ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Optical Coherence ◽  
The Mean ◽  
Sd Oct

Objective The objective of this report is to analyse retinal changes over a five-year period, assessed by spectral domain-optical coherence tomography (SD-OCT), in patients from the Lupus-Cruces cohort treated with hydroxychloroquine (HCQ). Methods SD-OCT screening was performed annually between 2012 and 2017. Average macular thickness (AMT), ganglion cell layer thickness (GCLT) and qualitative data of retinal pigment epithelium (RPE) and external retina (ExtR) were collected prospectively. We compared data from 2012 (first) and 2017 (second) SD-OCT. Results We studied 110 patients and 195 eyes. No cases of HCQ toxicity were detected. At the time of the second SD-OCT, 99% patients had taken a daily dose of HCQ ≤5 mg/kg/day. The median time on HCQ was 133 months. The mean AMT and GCLT were significantly lower in both eyes at the second SD-OCT; however, all the differences were clinically insignificant at less than 1%. Qualitative analysis of RPE and ExtR showed no significant changes. Similar results were found among patients with risk factors for retinopathy. The comparison of patients with and without risk factors showed no differences. Conclusions This study shows clinically irrelevant retinal changes in an SLE cohort on HCQ treatment over a five-year follow-up. Our findings support the safety of long-term HCQ at doses ≤5 mg/kg/day.

scholarly journals “En-Face” Spectral-Domain Optical Coherence Tomography Findings in Multiple Evanescent White Dot Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-6 ◽  
Author(s):  
Flore De bats ◽  
Benjamin Wolff ◽  
Vivien Vasseur ◽  
Aude Affortit ◽  
Laurent Kodjikian ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Spectral Domain ◽  
Enhanced Depth Imaging ◽  
Optical Coherence ◽  
Retinal Layers ◽  
White Dot Syndrome ◽  
En Face Oct ◽  
En Face ◽  
Sd Oct

Purpose. The recent use of “en-face” enhanced-depth imaging spectral-domain optical coherence tomography (EDI SD-OCT) helps distinguish the retinal layers involved in the physiopathology of multiple evanescent white dot syndrome (MEWDS).Methods. Four patients presenting with MEWDS underwent a comprehensive ocular examination including C-scan (“en-face”) EDI SD-OCT at the initial visit and during follow-up.Results. C-scans combined with the other multimodal imaging enabled the visualization of retinal damage. Acute lesions appeared as diffuse and focal disruptions occurring in the ellipsoid and interdigitation zones. The match between autofluorescence imaging, indocyanine green angiography, and “en-face” OCT helped identify the acute microstructural damages in the outer retina further than the choroid. Follow-up using “en-face” EDI-OCT revealed progressive and complete recovery of the central outer retinal layers.Conclusion. “En-face” EDI SD-OCT identified the site of initial damage in MEWDS as the photoreceptors and the interdigitation layers rather than the choroid. Moreover, “en-face” OCT is helpful in the follow-up of these lesions by being able to show the recovery of the outer retinal layers.

scholarly journals Low-Reflectivity Drusen With Overlying RPE Damage Revealed by Spectral-Domain OCT: Hint for the Development of Age-Related Macular Degeneration

2021 ◽  
Vol 8 ◽  
Author(s):  
Shasha Yang ◽  
Zongyin Gao ◽  
Haijiang Qiu ◽  
Chengguo Zuo ◽  
Lan Mi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Macular Degeneration ◽  
Retinal Pigment ◽  
Morphological Characteristics ◽  
Age Related Macular Degeneration ◽  
Spectral Domain ◽  
Optical Coherence ◽  
Age Related ◽  
Sd Oct

Purpose: To observe the relationship between the characteristic changes in the drusen morphology revealed by the spectral-domain optical coherence tomography (SD-OCT) and the progression of age-related macular degeneration (AMD).Methods: A total of 380 drusen in 45 eyes in 35 patients with the intermediate drusen were longitudinally followed up every 6 months by SD-OCT for a period of 24 months. The drusen were divided into the dynamic group and stable group according to the following parameters: number, volume, concurrent retinal pigment epithelium (RPE)/ellipsoid zone (EZ) damage, and the development of advanced AMD. The morphological characteristics of the progressive or stable drusen were further analyzed. Odds ratios (ORs) and the risk for the drusen progression were calculated.Results: The level of interobserver and intraobserver agreement for each drusen tomographic morphological parameters ranged from 82.7 to 90%. At the end of an average follow-up of 15.92 ± 6.99 months, six patients developed choroidal neovascularization and no patients developed geographic atrophy. Finally, 139 drusen changed and 241 drusen remained stable. The drusen with low reflectivity (p &lt; 0.001; OR: 5.26; 95% CI: 2.24–12.36), non-homogeneity without a core (p &lt; 0.001; OR: 4.31; 95% CI: 2.08–8.92), RPE damage (p &lt; 0.001; OR: 28.12; 95% CI: 9.43–83.85), and the EZ damage (p &lt; 0.001; OR: 14.01; 95% CI: 5.28–37.18) were significantly associated with active change; the drusen with low reflectivity (p = 0.01; OR: 2.95; 95% CI: 1.29–6.75) and decreased overlying RPE reflectivity (p &lt; 0.001; OR: 21.67; 95% CI: 9.20–51.02) were the independent predictors for progression. The drusen with high reflectivity were significantly associated with stabilization (p = 0.03; OR: 0.17; 95% CI: 0.04–0.84).Conclusion: Spectral-domain optical coherence tomography is an optimized, accurate, and efficient method to follow-up the drusen. The intermediate non-exudative AMD prognosis of the patient was most strongly correlated with the drusen reflectivity and disruption of the overlying RPE layer. The drusen with low reflectivity and overlying RPE damage were more likely to progress and required frequent follow-up.

scholarly journals Macular Thickness and Volume Assessed by Spectral-Domain Optical Coherence Tomography in Patients With Coronavirus Disease 2019: A Case-Control Study

2020 ◽  
Author(s):  
Mojtaba Abrishami ◽  
Fariba Tohidinezhad ◽  
Zahra Emamverdian ◽  
Ramin Daneshvar ◽  
Neda Saeedian ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Retinal Thickness ◽  
Spectral Domain ◽  
Case Group ◽  
Special Focus ◽  
Optical Coherence ◽  
Cross Sectional ◽  
Significant Difference ◽  
Normal Controls ◽  
Sd Oct

Abstract Purpose: To quantify the retinal thickness and volume using spectral-domain optical coherence tomography (SD-OCT) analysis in the macular region of patients with Coronavirus Disease 2019 (COVID-19).Methods: In a comparative cross-sectional, observational study, patients recovered from COVID-19 were included. All included subjects had a reverse transcription-polymerase chain reaction (RT-PCR) - confirmed diagnosis of COVID-19. Macular SD-OCT was performed at least two weeks after recovery from systemic COVID-19. Inner, outer and full retinal thicknesses and volumes were measured in COVID-19 recovered patients versus age-matched normal controls.Results: Twenty-five patients (11 male) with a mean age of 36.4 ± 11 years and 60 healthy controls (31 males) with a mean age of 39.3 ± 7.7 years were enrolled in the study. There was no statistically significant difference in the retinal thickness or volume measures between the two groups. However, the thickness in the case group was minimally more than the controls. Conclusion: Retinal thickness in COVID-19 patients may be higher than healthy subjects. Comprehensive ocular examination with special focus on posterior segment manifestations should be considered in these patients.

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