scholarly journals Metastatic Spinal Cord Compression Secondary to Liver Cancer

2017 ◽  
Vol 2017 ◽  
pp. 1-3
Author(s):  
Daniel Gams Massi ◽  
Japhari Nyassinde ◽  
Ngor Side Diagne ◽  
Ramy Abdennaji ◽  
Kamadore Toure ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Liver Cancer ◽  
Spinal Cord Compression ◽  
Hepatitis B Surface Antigen ◽  
Multidisciplinary Treatment ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression ◽  
Diagnosis And Treatment ◽  
Medical Emergency ◽  
The Right

Metastatic spinal cord compression (MSCC) is a medical emergency that requires rapid diagnosis and treatment to reduce pain, to preserve neurological functioning, and to prolong survival. The diagnosis of liver cancer is often neglected in the differential diagnosis of MSCC. Treatment is usually palliative and evolution is often fatal. This is a case report of a 28-year-old patient living in Mauritania hospitalized in November 2014 at the neurology department of Fann national teaching hospital in Dakar, for the management of a chronic dorsal spinal cord compression. The radiological and laboratory investigations done revealed the metastatic compression originating from a liver cancer with elevated alpha-fetoprotein and aspartate transaminase, positive hepatitis B surface antigen, and multiple metastasis in the lungs, mediastinum, ribs, iliac, and peritoneum. The hip joint X-ray showed a spontaneous fracture of the right femoral neck. The multidisciplinary treatment was palliative and the evolution was fatal within the month of hospitalization. Earlier diagnosis and treatment of MSCC may not have saved the life of the patient but may have prevented much suffering and would likely have prolonged the life of a young man.

Assessment and Management of Patients With Metastatic Spinal Cord Compression: A Multidisciplinary Review

2019 ◽  
Vol 37 (1) ◽  
pp. 61-71 ◽  
Author(s):  
Andrew J. Lawton ◽  
Kathleen A. Lee ◽  
Andrea L. Cheville ◽  
Marco L. Ferrone ◽  
Dirk Rades ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Radiation Therapy ◽  
Spinal Cord Compression ◽  
Treatment Plan ◽  
Relevant Literature ◽  
Cord Compression ◽  
Narrative Review ◽  
Metastatic Spinal Cord Compression ◽  
Diagnosis And Treatment ◽  
Management Decision

Purpose Metastatic spinal cord compression (MSCC) can be a catastrophic manifestation of advanced cancer that causes immobilizing pain and significant neurologic impairment. Oncologists can protect their patients by having a high index of suspicion for MSCC when patients present with new or worsening back pain before motor, sensory, bowel, or bladder deficits develop. We provide an updated, evidence-based narrative review of the presentation, diagnosis, and treatment of MSCC. Methods This narrative review was conducted by searching MEDLINE and Cochrane Database of Systematic Reviews for relevant literature on the presentation, diagnosis, and treatment of patients with MSCC. The article addresses the key elements of MSCC management germane to the medical oncologist, with special attention given to pain and symptom management, decision making with regard to surgery and radiation therapy, the importance of rehabilitative care, and the value of a multidisciplinary approach. Results Magnetic resonance imaging of the entire spine is recommended for the diagnosis of MSCC. Treatment includes glucocorticoid therapy, pain management, radiation therapy with or without surgery, and specialized rehabilitation. When formulating a treatment plan, clinicians should consider the patient’s care goals and psychosocial needs. Conclusion Prompt diagnosis and treatment of MSCC can reduce pain and prevent irreversible functional loss. Regular collaboration among multidisciplinary providers may streamline care and enhance achievement of treatment goals.

Radiotherapy of metastatic spinal cord compression in very elderly patients

2007 ◽  
Vol 67 (1) ◽  
pp. 256-263 ◽  
Author(s):  
Dirk Rades ◽  
Peter J. Hoskin ◽  
Johann H. Karstens ◽  
Volker Rudat ◽  
Theo Veninga ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Elderly Patients ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression ◽  
Very Elderly

scholarly journals Diagnosis and Treatment of Bone Disease in Multiple Myeloma: Spotlight on Spinal Involvement

Scientifica ◽  
2013 ◽  
Vol 2013 ◽  
pp. 1-12 ◽  
Author(s):  
Patrizia Tosi
Keyword(s):  
Spinal Cord ◽  
Multiple Myeloma ◽  
Bone Marrow ◽  
Bone Resorption ◽  
Spinal Cord Compression ◽  
Bone Disease ◽  
Cord Compression ◽  
Diagnosis And Treatment ◽  
Conventional Chemotherapy ◽  
Spinal Involvement

Bone disease is observed in almost 80% of newly diagnosed symptomatic multiple myeloma patients, and spine is the bone site that is more frequently affected by myeloma-induced osteoporosis, osteolyses, or compression fractures. In almost 20% of the cases, spinal cord compression may occur; diagnosis and treatment must be carried out rapidly in order to avoid a permanent sensitive or motor defect. Although whole body skeletal X-ray is considered mandatory for multiple myeloma staging, magnetic resonance imaging is presently considered the most appropriate diagnostic technique for the evaluation of vertebral alterations, as it allows to detect not only the exact morphology of the lesions, but also the pattern of bone marrow infiltration by the disease. Multiple treatment modalities can be used to manage multiple myeloma-related vertebral lesions. Surgery or radiotherapy is mainly employed in case of spinal cord compression, impending fractures, or intractable pain. Percutaneous vertebroplasty or balloon kyphoplasty can reduce local pain in a significant fraction of treated patients, without interfering with subsequent therapeutic programs. Systemic antimyeloma therapy with conventional chemotherapy or, more appropriately, with combinations of conventional chemotherapy and compounds acting on both neoplastic plasma cells and bone marrow microenvironment must be soon initiated in order to reduce bone resorption and, possibly, promote bone formation. Bisphosphonates should also be used in combination with antimyeloma therapy as they reduce bone resorption and prolong patients survival. A multidisciplinary approach is thus needed in order to properly manage spinal involvement in multiple myeloma.

Audit of metastatic spinal cord compression

2016 ◽  
Vol 28 ◽  
pp. S2
Author(s):  
A. Cole ◽  
J. O'Hare ◽  
K. Harpur ◽  
C. O'Brien ◽  
N. Evans ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression

scholarly journals Effectiveness of radiotherapy for metastatic spinal cord compression in patients with short life expectancy

2017 ◽  
Vol 22 (1) ◽  
pp. 58-63 ◽  
Author(s):  
Alexandra Giraldo ◽  
Sergi Benavente ◽  
Mónica Ramos ◽  
Ramona Vergés ◽  
Odimar Coronil ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Life Expectancy ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression ◽  
Short Life ◽  
Short Life Expectancy

Developing an early alert system for metastatic spinal cord compression (MSCC): Red Flag credit cards

2013 ◽  
Vol 16 (01) ◽  
pp. 14-20 ◽  
Author(s):  
Jackie Turnpenney ◽  
Sue Greenhalgh ◽  
Lena Richards ◽  
Annamaria Crabtree ◽  
James Selfe
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Credit Cards ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression ◽  
Alert System ◽  
Red Flag ◽  
Early Alert

115 An Audit on Dexamethasone Prescribing Practice on Surgically Managed Metastatic Spinal Cord Compression Patients in the Manchester Centre for Clinical Neurosciences: Lessons Learned in Closing the Loop

2021 ◽  
Vol 108 (Supplement_2) ◽  
Author(s):  
R Laurente ◽  
R Mohammed ◽  
M Elmalky
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Compression ◽  
Cord Compression ◽  
Lessons Learned ◽  
Metastatic Spinal Cord Compression ◽  
Loading Dose ◽  
The Past ◽  
Prescribing Practice ◽  
Closing The Loop ◽  
Almost All

Abstract Metastatic Spinal Cord Compression is a surgical emergency owing to its propensity to cause significant morbidity and mortality. Dexamethasone is prescribed to reduce oedema and promote vascular membrane stabilization. The is done so until a more definitive management has been performed. This is a retrospective study evaluating the steroid-prescribing practice for MSCC patients in 2018 at a tertiary spinal unit in Greater Manchester. Thirty-three patients who underwent stabilisation were evaluated in terms of both steroid prescribing and weaning practices. Standards used against for both were the NICE guidelines and the Edinburgh/Christie’s guidelines. Of the 33 patients evaluated, only 1 patient received the correct loading dose of 16mg, whilst 27 went straight to being given 8mg BD. 5 did not receive dexamethasone at all. In terms of discontinuation/weaning, 26 were weaned accordingly and 2 were not weaned to continue as adjuvant treatment. Dexamethasone prescribing practises has since improved over the past two years. 93% of the patients have been correctly weaned as compared to 38% in the past. In terms of prescription, much needs to be done as almost all the patients evaluated did not get the correct loading dose despite receiving the appropriate maintenance.

OC-0408 Higher-dose radiotherapy for metastatic spinal cord compression: First results of a phase II trial

2021 ◽  
Vol 161 ◽  
pp. S303-S304
Author(s):  
D. Rades ◽  
C. Staackmann ◽  
D. Lomidze ◽  
D. Lomidze ◽  
N. Jankarashvili ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Phase Ii ◽  
Spinal Cord Compression ◽  
Phase Ii Trial ◽  
Cord Compression ◽  
Metastatic Spinal Cord Compression ◽  
First Results
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