scholarly journals Human Papillomavirus Genotype Distribution among Cervical Cancer Patients prior to Brazilian National HPV Immunization Program

2017 ◽  
Vol 2017 ◽  
pp. 1-9 ◽  
Author(s):  
Liz M. de Almeida ◽  
Luís Felipe L. Martins ◽  
Valéria B. Pontes ◽  
Flávia M. Corrêa ◽  
Raquel C. Montenegro ◽  
...  

To evaluate the impact of HPV immunization and possible changes in virus type-specific prevalence associated with cervical cancer, it is important to obtain baseline information based on socioeconomic, educational, and environmental characteristics in human populations. We describe these characteristics and the type-specific HPV distribution in 1,183 women diagnosed with cervical cancer in two Brazilian healthcare institutions located at the Southeastern (Rio de Janeiro/RJ) and the Amazonian (Belém/PA) regions. Large differences were observed between women in these regions regarding economic, educational, and reproductive characteristics. The eight most frequent HPV types found in tumor samples were the following: 16, 18, 31, 33, 35, 45, 52, and 58. Some HPV types classified as unknown or low risk were found in tumor samples with single infections, HPV 83 in RJ and HPV 11, 61, and 69 in PA. The proportion of squamous cervical cancer was lower in RJ than in PA (76.3% versus 87.3%, p<0.001). Adenocarcinoma was more frequent in RJ than in PA (13.5% versus 6.9%, p<0.001). The frequency of HPV 16 in PA was higher in younger women (p<0.05). The success of a cervical cancer control program should consider HPV types, local health system organization, and sociodemographic diversity of Brazilian regions.

2018 ◽  
Vol 4 (Supplement 2) ◽  
pp. 148s-148s
Author(s):  
Z. Said

Background and context: Cervical cancer remains a major burden to many countries worldwide particularly in underdeveloped and developing countries. It continues to have a huge impact on women not only physically but also socially and sexually. However, the good news, because of its slow progression and cytologic identifiable precursors and provided it is detected early and managed effectively, it is herald as one of the preventable and treatable forms of cancer. Despite the decades of awareness campaigns and progress in technology, the coverage and uptake remains low, more so among the younger and high risk women. Sadly too of those diagnosed, more than 76% were at stage II and above when intensive and invasive treatment will be required. Conventional Papanicolaou test is the only primary screening tool available since 1969 and it is considered the most successful cancer screening program to date. Nevertheless, cytology has its limitations especially technical limitations regarding sampling and laboratory errors in screening and interpretation. Noticing the laggardness of a single approach, Malaysia doubles up her strategy by introducing primary prevention using the HPV immunization to hasten reduction of cervical cancer. While Pap smear remain as a strategy, improving the quality of the laboratory services is paramount to ensure effective early detection of precancerous lesion. In 2015 the Ministry of Health introduced the liquid-based cytology in a phased implementation starting with Kelantan, Johor, Negeri Sembilan and Selangor gradually the whole country. Does HPV DNA testing be available soon to further enhance diagnosis? The topic has a fair share of several rounds of discussions. Aim: To share the latest challenge, gap, strategy and the way forward for the transformation of the cervical cancer prevention and control program comprehensively taking into consideration of HPV DNA test as a screening tool. Strategy/Tactics: The milestone of the Papanicolaou test program was analyzed to see the gap and the options of the improvement. The performances of Papanicolaou test services were analyzed through the annual data and report of Papanicolaou test services from all the states. Later, we also map the analysis with the latest incidence of cervical cancer in Malaysia to see the impact of the program. Program/Policy process: The planning process involved several discussions at ministry level, series of workshop to develop the important documents for the implementation, being collaborative partner in organizing HPV workshop and effective discussions with VCS, Australia. Outcomes: Mandate of the way forward of comprehensive strategy for cervical cancer control program being approved. What was learned: Malaysia is optimistic that cervical cancer reduction program remain a high-profile agenda in the country and therefore we are ready for the change to give a better impact of the program.


2021 ◽  
pp. 100281
Author(s):  
Dorothy Lombe ◽  
Susan Msadabwe ◽  
Mbaita Maka ◽  
Memory Samboko ◽  
Prudence Haimbe ◽  
...  

PEDIATRICS ◽  
1967 ◽  
Vol 40 (3) ◽  
pp. 527-528
Author(s):  
Charles J. A. Schulte

ON JANUARY 1, 1967, the Cancer Control Program will become part of the National Center for Chronic Disease Control within the Public Health Service's new Bureau of Disease Prevention and Environmental Control. Our primary mission is to stimulate and encourage the application of currently available techniques of cancer prevention, cancer detection, and cancer control to the community at the grass roots level. If this will be the case after the reorganization remains to be seen. Figure 1 shows the new organization of the Public Health Service. By way of illustration, I think it would be well to briefly outline a few of our activities. An area of heavy emphasis has been the use of the Papanicolaou smears for cervical cancer control. These programs have been responsible for developing certified cytotechnology training schools, supporting and training large numbers of cytotechnicians. In addition, we are supporting some 90 hospital-based cervical cancer screening projects across the country. A program to encourage the general practitioner to screen his private patients in the office is jointly sponsored by the American Academy of General Practice and the Cancer Control Program. The very grave problem in the United States of smoking and carcinoma of the lung is the major responsibility of tile National Clearinghouse for Smoking and Health, a part of the Division of Chronic Diseases which developed out of the Cancer Control Program. We are engaged in a number of developmental projects, such as the flexible fiber optic proctosigmoidoscope. We hope to be able to produce a proctosigmoidoscope that will reach the splenic flexure.


2009 ◽  
Vol 24 (4) ◽  
pp. 257-260 ◽  
Author(s):  
Karen Patricia Williams ◽  
Athur Mabiso ◽  
Tedra Jackson ◽  
Dorothy Lawshe ◽  
Joel Maurer

Dynamis ◽  
2014 ◽  
Vol 34 (1) ◽  
pp. 101-123 ◽  
Author(s):  
Marco Antonio Porto ◽  
Paula Arantes Botelho Briglia Habib

2017 ◽  
Vol 31 (1) ◽  
pp. 5-8
Author(s):  
John French ◽  
Simon B. Sutcliffe

Cancer is a significant challenge globally. Reducing the impact of cancer requires a program and plans that address the main aspects of cancer from prevention through to end-of-life care. This article summarizes the requirements of a robust cancer control program and outlines the contextual and leadership considerations that are required to ensure that the planning and implementation of a control program can achieve improved cancer outcomes.


2019 ◽  
Vol 2019 ◽  
pp. 1-7 ◽  
Author(s):  
Saul Rassy Carneiro ◽  
Abner Ariel da Silva Lima ◽  
Gleyce de Fátima Silva Santos ◽  
Cláudia Simone Baltazar de Oliveira ◽  
Maria Cláudia Valente Almeida ◽  
...  

Human papillomavirus (HPV) infection is recognized as the most common sexually transmitted disease in the world, and there is a consensus on its role in the etiology of preneoplastic epithelial changes in the cervix. Through the process of lipid peroxidation, oxidative stress is found in the course of premalignant and malignant changes. Moreover, the level of physical activity can exert an influence on markers of oxidative stress, lowering the serum levels of these markers. Objective. To determine the relationship between levels of malondialdehyde (MDA) and the level of physical activity in women with squamous intraepithelial lesion (SIL) of the cervix. Methods. A cross-sectional study was conducted with 46 women participating in a cervical cancer control program. The women had been submitted to the cytopathological exam and were divided into two groups: 18 with SIL and 28 controls. MDA concentrations were determined, and the International Physical Activity Questionnaire (IPAQ) was administered on the same day as the gynecological appointment (prior to the Papanicolaou test). Results. The SIL group had higher MDA levels than the control group (mean: 47.63±9.57 vs. 9.32±4.79, respectively) and a lower IPAQ score (median: 713.5 vs. 1875, respectively). A weak correlation was found between the MDA level and IPAQ score (r2=−0.34, p=0.018). Conclusion. The women with SIL had higher levels of oxidative stress and were less physically active than the women in the control group. These findings suggest that physical exercise exerts an influence on markers of oxidative stress in the development of intraepithelial squamous lesions.


Author(s):  
Yu-Han Hung ◽  
Yu-Chieh Chung ◽  
Pi-Yueh Lee ◽  
Hao-Yun Kao

Background: Causing more than 40,000 deaths each year, cancer is one of the leading causes of mortality and preventable hospitalizations (PH) in Taiwan. To reduce the incidence and severity of cancer, the National Cancer Control Program (NCCP) includes screening for various types of cancer. A cohort study was conducted to explore the long-term trends in PH/person-years following NCCP intervention from 1997 to 2013. Methods: Trend analysis was carried out for long-term hospitalization. The Poisson regression model was used to compare PH/person-years before (1997–2004) and after intervention (2005–2013), and to explore the impact of policy intervention. Results: The policy response reduced 26% for the risk of hospitalization; in terms of comorbidity, each additional point increased the risk of hospitalization by 2.15 times. The risk of hospitalization doubled for each 10-year increase but was not statistically significant. Trend analysis validates changes in the number of hospitalizations/person-years in 2005. Conclusions: PH is adopted as an indicator for monitoring primary care quality, providing governments with a useful reference for which to gauge the adequacy, accessibility, and quality of health care. Differences in PH rates between rural and urban areas can also be used as a reference for achieving equitable distribution of medical resources.


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