scholarly journals Antimicrobial Properties of Copper Nanoparticles and Amino Acid Chelated Copper Nanoparticles Produced by Using a Soya Extract

2017 ◽  
Vol 2017 ◽  
pp. 1-6 ◽  
Author(s):  
I. DeAlba-Montero ◽  
Jesús Guajardo-Pacheco ◽  
Elpidio Morales-Sánchez ◽  
Rene Araujo-Martínez ◽  
G. M. Loredo-Becerra ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antibacterial Activity ◽  
Copper Nanoparticles ◽  
Copper Ions ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Bacterial Cells ◽  
Microdilution Method ◽  
Diphenyltetrazolium Bromide ◽  
Specific Strain

This paper reports a comparison of the antibacterial properties of copper-amino acids chelates and copper nanoparticles againstEscherichia coli,Staphylococcus aureus, andEnterococcus faecalis. These copper-amino acids chelates were synthesized by using a soybean aqueous extract and copper nanoparticles were produced using as a starting material the copper-amino acids chelates species. The antibacterial activity of the samples was evaluated by using the standard microdilution method (CLSI M100-S25 January 2015). In the antibacterial activity assays copper ions and copper-EDTA chelates were included as references, so that copper-amino acids chelates can be particularly suitable for acting as an antibacterial agent, so they are excellent candidates for specific applications. Additionally, to confirm the antimicrobial mechanism on bacterial cells, MTT assay (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide) was carried out. A significant enhanced antimicrobial activity and a specific strain were found for copper chelates overE. faecalis. Its results would eventually lead to better utilization of copper-amino acids chelate for specific application where copper nanoparticles can be not used.

scholarly journals Zinc(II) Complexes with Amino Acids for Potential Use in Dermatology: Synthesis, Crystal Structures, and Antibacterial Activity

Molecules ◽  
2020 ◽  
Vol 25 (4) ◽  
pp. 951 ◽  
Author(s):  
Michał Abendrot ◽  
Lilianna Chęcińska ◽  
Joachim Kusz ◽  
Katarzyna Lisowska ◽  
Katarzyna Zawadzka ◽  
...  
Keyword(s):  
Amino Acids ◽  
Antibacterial Activity ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
X Ray Diffraction ◽  
Organic Zinc ◽  
Counter Ions ◽  
Open Issue ◽  
Potential Use ◽  
Active Substances

The multifunctional profile of Zn2+ has influenced its great popularity in various pharmaceutical, food, and cosmetic products. Despite the use of different inorganic and organic zinc derivatives, the search for new zinc-containing compounds with a safer skin profile still remains an open issue. The present paper describes the synthesis, structural characterization, and antibacterial activity of zinc(II) complexes with proteinogenic amino acids as potential candidates for dermatological treatments. The obtained complexes are of the general formula [Zn(AA)2], where AA represents an amino acid (L-Glu, Gly, L-His, L-Pro, L-Met, and L-Trp). Their synthesis was designed in such a way that the final bis(aminoacidate) zinc(II) complexes did not contain any counter-ions such as Cl−, NO3−, or SO42− that can cause some skin irritations. The chemical structure and composition of the compounds were identified by 1H NMR spectroscopy and elemental analysis, and four were also characterized by single-crystal X-ray diffraction. The Hirshfeld surface analysis for the Zn2+ metallic center helped to determine its coordination number and geometry for each complex. Finally, the antibacterial properties of the complexes were determined with respect to three Gram-positive strains, viz. Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, and Streptococcus pyogenes ATCC 19615, and two Gram-negative bacteria, viz. Escherichia coli ATCC 25992 and Pseudomonas aeruginosa ATCC 27853, and were compared with the activity of zinc 2-pirrolidone 5-carboxylate (ZnPCA), commonly applied in dermatology. It was found that the Zn(II) complexes with methionine and glycine exhibited a higher antibacterial activity than the tested standard, and the antimicrobial properties of complex with Trp were satisfactory. The results of the antimicrobial activity examination allow us to postulate that the obtained zinc complexes might become new active substances for use in dermatological products.

scholarly journals Study antimicrobial properties of hemp materials modified by copper nanoparticles

2021 ◽  
pp. 5-9
Author(s):  
B. R. Tausarova ◽  
A. M. Sharipbek
Keyword(s):  
Antibacterial Activity ◽  
Copper Nanoparticles ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Optimal Conditions ◽  
E Coli

Optimal conditions for the processing of hemp materials with copper nanoparticles have been developed. The antibacterial properties of hemp materials modified by copper nanoparticles have been investigated. It has been shown that hemp materials modified by copper nanoparticles have antibacterial activity to bacteria and mold fungi E-Coli, Pennicillium brevi.

scholarly journals Synthesis of Copper Nanoparticles by Thermal Decomposition and Their Antimicrobial Properties

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
R. Betancourt-Galindo ◽  
P. Y. Reyes-Rodriguez ◽  
B. A. Puente-Urbina ◽  
C. A. Avila-Orta ◽  
O. S. Rodríguez-Fernández ◽  
...  
Keyword(s):  
Thermal Decomposition ◽  
Copper Nanoparticles ◽  
Copper Chloride ◽  
Metallic Copper ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Face Centered Cubic ◽  
Bacterial Strains ◽  
Tem Analysis

Copper nanoparticles were synthesized by thermal decomposition using copper chloride, sodium oleate, and phenyl ether as solvent agents. The formation of nanoparticles was evidenced by the X-ray diffraction and transmission electron microscopy. The peaks in the XRD pattern correspond to the standard values of the face centered cubic (fcc) structure of metallic copper and no peaks of other impurity crystalline phases were detected. TEM analysis showed spherical nanoparticles with sizes in the range of 4 to 18 nm. The antibacterial properties of copper nanoparticles were evaluatedin vitroagainst strains ofStaphylococcus aureusandPseudomonas aeruginosa. The antibacterial activity of copper nanoparticles synthesized by thermal decomposition showed significant inhibitory effect against these highly multidrug-resistant bacterial strains.

scholarly journals Relationship between Dislocation Density and Antibacterial Activity of Cryo-Rolled and Cold-Rolled Copper

Materials ◽  
2019 ◽  
Vol 12 (2) ◽  
pp. 200 ◽  
Author(s):  
Vinod Parmar ◽  
Kandarp Changela ◽  
B. Srinivas ◽  
Manimuthu Mani Sankar ◽  
Sujata Mohanty ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Dislocation Density ◽  
Inductively Coupled Plasma ◽  
Copper Ions ◽  
Pure Copper ◽  
Bacterial Cells ◽  
Inductively Coupled ◽  
Initial Adhesion ◽  
Elemental Copper ◽  
Cold Rolled

In the present work, cold rolling and cryo-rolling were performed on 99% commercially pure copper substrates. Both cold and cryo-rolling processes caused severe plastic deformation that led to an increase in dislocation density by 14× and 28× respectively, as compared to the pristine material. Increases in average tensile strengths, by 75% (488 MPa) and 150% (698 MPa), were observed in the two rolled materials as the result of the enhancement in dislocation density. In addition to strength, enhanced antibacterial property of cryo-rolled copper was observed in comparison to cold rolled and pristine copper. Initial adhesion and subsequent proliferation of bio-film forming Gram-positive bacteria Staphylococcus aureus was reduced by 66% and 100% respectively for cryo-rolled copper. Approximately 55% protein leakage, as well as ethidium bromide (EtBr) uptake, were observed confirming rupture of cell membrane of S. aureus. Inductively coupled plasma-mass spectroscopy reveals higher leaching of elemental copper in nutrient broth media from the cryo-rolled copper. Detailed investigations showed that increased dislocation led to leaching of copper ions that caused damage to the bacterial cell wall and consequently killing of bacterial cells. Cryo-rolling enhanced both strength, as well as antibacterial activity, due to the presence of dislocations.

scholarly journals Synthesis, Characterization and Antibacterial Activity of Carbamate Derivatives of Isatin

2018 ◽  
Vol 34 (4) ◽  
pp. 2026-2030 ◽  
Author(s):  
Sarrah Sattar Jabbar
Keyword(s):  
Amino Acids ◽  
Antibacterial Activity ◽  
Antibacterial Agent ◽  
Antibacterial Properties ◽  
E Coli ◽  
Good Antibacterial Activity ◽  
Diffusion Technique ◽  
Derivatives Of ◽  
Isatin Derivatives

In search of novel antibacterial agent, a series of new isatin derivatives (3a-d) have been synthesized by condensation isatin (2,3-indolinendione) with piperidine (hexahydropyridine), hydrazine hydrate and Boc-amino acids respectively. Compounds synthesized have been characterized by IR spectroscopy and elemental analysis. In addition, the in vitro antibacterial properties have been tested against E. coli, P. aeruginosa, and Bacillus cereus, S. aureus by employing the well diffusion technique. A majority of the synthesized compounds were showing good antibacterial activity and from comparisons of the compounds, compound 3d has been determined to be the most active compound.

Granule contents from rat polymorphonuclear leukocytes: antimicrobial properties and characterization

1986 ◽  
Vol 32 (6) ◽  
pp. 498-504 ◽  
Author(s):  
Richard L. Hodinka ◽  
Malcolm C. Modrzakowski
Keyword(s):  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Bacterial Cells ◽  
Gram Positive Bacteria ◽  
Properties And Characterization ◽  
Bacterial Mutants ◽  
Killing Action ◽  
Gram Negative Organisms ◽  
Ph Range ◽  
Static Conditions

The nonoxidative antibacterial properties of isolated rat polymorphonuclear leukocyte granule contents were examined using Salmonella typhimurium LT-2 and a series of progressively rough lipopolysaccharide mutants of this strain as target bacteria. The granule extract was most active at 37 °C, with a substantial decrease in activity observed at lower temperatures. Deep rough bacterial mutants were killed best within a pH range of 6–8, while killing of mutants with increased lipopolysaccharide content was most efficient at an acid pH of 5. The activity of the extract was dependent on incubation time but was independent of the number of bacterial cells present in the assay mixture. The killing action of the granule extract was inhibited by the cations Na+, K+, Mg2+, Ca, and Fe2+. The degree of inhibition was dependent on the type and concentration of ion used. Rough mutants grown with aeration to log phase were killed more efficiently than the same mutants grown to stationary phase under static conditions. Also, gram-positive bacteria were more susceptible to the extract than were gram-negative organisms.

scholarly journals Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

2016 ◽  
Vol 61 (1) ◽  
pp. 213-216
Author(s):  
A. Roguska ◽  
A. Belcarz ◽  
P. Suchecki ◽  
M. Andrzejczuk ◽  
M. Lewandowska
Keyword(s):  
Zno Nanoparticles ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Bacterial Cells ◽  
Metallic Oxide ◽  
Moderate Amount ◽  
Orthopaedic Infections ◽  
Composite Layers ◽  
Biomedical Coatings

Problem of Post-operative infections of implant materials caused by bacterial adhesion to their surfaces is very serious. Enhancement of antibacterial properties is potentially beneficial for biomaterials value. Therefore, the metallic and metallic oxide nanoparticles attract particular attention as antimicrobial factors. The aim of this work was to create nanotubular (NT) oxide layers on Ti with the addition of ZnO nanoparticles, designed for antibacterial biomedical coatings. Antimicrobial activities of titanium, TiO2NT and ZnO/TiO2NT surfaces were evaluated against bacterial strain typical for orthopaedic infections: S. epidermidis. TiO2NT alone killed the free bacterial cells significantly but promoted their adhesion to the surfaces. The presence of moderate amount of ZnO nanoparticles significantly reduced the S. epidermidis cells adhesion and viability of bacterial cells in contact with modified surfaces. However, higher amount of loaded nanoZnO showed the reduced antimicrobial properties than the medium amount, suggesting the overdose effect.

scholarly journals Antibacterial Composite Layers on Ti: Role of ZnO Nanoparticles

2016 ◽  
Vol 61 (2) ◽  
pp. 937-940 ◽  
Author(s):  
A. Roguska ◽  
A. Belcarz ◽  
P. Suchecki ◽  
M. Andrzejczuk ◽  
M. Lewandowska
Keyword(s):  
Zno Nanoparticles ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Antimicrobial Activities ◽  
Bacterial Cells ◽  
Metallic Oxide ◽  
Moderate Amount ◽  
Orthopaedic Infections ◽  
Composite Layers ◽  
Biomedical Coatings

Abstract Problem of post-operative infections of implant materials caused by bacterial adhesion to their surfaces is very serious. Enhancement of antibacterial properties is potentially beneficial for biomaterials value. Therefore, the metallic and metallic oxide nanoparticles attract particular attention as antimicrobial factors. The aim of this work was to create nanotubular (NT) oxide layers on Ti with the addition of ZnO nanoparticles, designed for antibacterial biomedical coatings. Antimicrobial activities of titanium, TiO2 NT and ZnO/TiO2 NT surfaces were evaluated against bacterial strain typical for orthopaedic infections: S. epidermidis. TiO2 NT alone killed the free bacterial cells significantly but promoted their adhesion to the surfaces. The presence of moderate amount of ZnO nanoparticles significantly reduced the S. epidermidis cells adhesion and viability of bacterial cells in contact with modified surfaces. However, higher amount of loaded nanoZnO showed the reduced antimicrobial properties than the medium amount, suggesting the overdose effect.

scholarly journals Antibacterial Activity of Copper and Cobalt Amino Acids Complexes

2011 ◽  
Vol 39 (2) ◽  
pp. 124 ◽  
Author(s):  
ANDREEA STĂNILĂ ◽  
Cornelia BRAICU ◽  
Sorin STĂNILĂ ◽  
Raluca M. POP
Keyword(s):  
Escherichia Coli ◽  
Amino Acids ◽  
Antibacterial Activity ◽  
Bacillus Cereus ◽  
Copper Complexes ◽  
Micrococcus Luteus ◽  
Bacterial Species ◽  
Free Ligand ◽  
Antibacterial Properties ◽  
Moderate Activity

The antibacterial properties of differently copper and cobalt amino acids complexes on agar plates was investigated in the present study. The antibacterial activity of amino acid complexes was evaluated against on three bacteria strains (Escherichia coli, Bacillus cereus, Micrococcus luteus). Generally, the amino acids complexes were mainly active against gram-positive organisms, species like Micrococcus luteus being the most susceptible strain tested. It was registered a moderate antibacterial activity against Bacillus cereus. The microorganisms Escherichia coli, which are already known to be multi-resistant to drugs, were also resistant to the amino acids complexes but also to the free salts tested. Escherichia coli were susceptible only to the CoCl2 and copper complex with phenylalanine. The complexes with leucine and histidine seem to be more active than the parent free ligand against one or more bacterial species. Moderate activity was registered in the case of complexes with methionine and phenylalanine. From the complexes tested less efficient antibacterial activity was noted in the case of complexes with lysine and valine. These results show that cobalt and copper complexes have an antibacterial activity and suggest their potential application as antibacterial agents.

scholarly journals Antibacterial activity of ethyl acetate fraction from methanolic extracts of ant-plant tubers towards Streptococcus sanguis ATCC 10566

2018 ◽  
Vol 30 (3) ◽  
pp. 190
Author(s):  
Fajar Fatriadi ◽  
Dikdik Kurnia ◽  
Mieke Hemiawati Satari
Keyword(s):  
Antibacterial Activity ◽  
Ethyl Acetate ◽  
Antibacterial Properties ◽  
Ethyl Acetate Fraction ◽  
Positive Control ◽  
Chlorhexidine Gluconate ◽  
Streptococcus Sanguis ◽  
Microdilution Method ◽  
Methanolic Extracts ◽  
Natural Remedies

Introduction: Streptococcus sanguis is an initial cause of dental plaque formation which is the initial cause of caries. One of the preventive treatments can be done by using the mouthwash containing antibacterial substances. Along time, natural remedies are proven to be having more antibacterial properties. Ant-plant (Myrmecodia pendens Merr. & Perry) tubers are types of epiphytic plant that grows in many parts of Papua, with many health benefits, and are known to contain flavonoids, tannins, and tocopherols. This study was aimed to determine the antibacterial activity of ethyl acetate fraction from methanolic extracts of ant-plant tubers on the growth of Streptococcus sanguis ATCC 10566. Methods: The ant-plant tubers were extracted with soxhletation method using the methanol solvent. The fractionation was then performed using ethyl acetate to obtain the ethyl acetate fraction. Result: The phytochemical test showed that the ethyl acetate fraction of the ant-plant contained phenolics, tannins, flavonoids, and terpenoids. The bacterial test in this study was using the microdilution method using the ELISA Reader by measuring the Minimum Inhibitory Concentration (MIC) of ethyl acetate fraction of ant-plant tubers towards Streptococcus sanguis with positive control was using the chlorhexidine gluconate as the golden standard medication. The ethyl acetate fraction of ant-plant tuber had an antibacterial effect towards Streptococcus sanguis in the MIC of 31.25 ppm, while chlorhexidine gluconate was 0.49 ppm. Conclusion: The ethyl acetate fraction of ant-plant had a lower antibacterial activity compared to chlorhexidine gluconate on the growth of Streptococcus sanguis ATCC 10566.Keywords: Ant-plant tubers, Myrmecodia pendens Merr. & Perry, antibacterial activity, Streptococcus sanguis ATCC 10566.

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