scholarly journals Practical Solution for Effective Whole-Body Magnetic Fluid Hyperthermia Treatment

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Hiroaki Mamiya ◽  
Yoshihiko Takeda ◽  
Takashi Naka ◽  
Naoki Kawazoe ◽  
Guoping Chen ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Magnetic Fluid ◽  
Human Body ◽  
Short Pulse ◽  
Alternative Methods ◽  
Whole Body ◽  
Human Body Model ◽  
Hyperthermia Treatment ◽  
Shell Nanoparticles ◽  
Magnetic Fluid Hyperthermia

Magnetic fluid hyperthermia therapy is considered as a promising treatment for cancers including unidentifiable metastatic cancers that are scattered across the whole body. However, a recent study on heat transfer simulated on a human body model showed a serious side effect: occurrences of hot spots in normal tissues due to eddy current loss induced by variation in the irradiated magnetic field. The indicated allowable upper limit of field amplitude Hac for constant irradiation over the entire human body corresponded to approximately 100 Oe at a frequency f of 25 kHz. The limit corresponds to the value Hacf of 2.5 × 106 Oe·s−1 and is significantly lower than the conventionally accepted criteria of 6 × 107 Oe·s−1. The present study involved evaluating maximum performance of conventional magnetic fluid hyperthermia cancer therapy below the afore-mentioned limit, and this was followed by discussing alternative methods not bound by standard frameworks by considering steady heat flow from equilibrium responses of stable nanoparticles. Consequently, the clarified potentials of quasi-stable core-shell nanoparticles, dynamic alignment of easy axes, and short pulse irradiation indicate that the whole-body magnetic fluid hyperthermia treatment is still a possible candidate for future cancer therapy.

scholarly journals Correction: Cancer cell extinction through a magnetic fluid hyperthermia treatment produced by superparamagnetic Co–Zn ferrite nanoparticles

RSC Advances ◽  
2015 ◽  
Vol 5 (127) ◽  
pp. 104612-104612 ◽  
Author(s):  
Raghvendra A. Bohara ◽  
Nanasaheb D. Thorat ◽  
Akhilesh K. Chaurasia ◽  
Shivaji H. Pawar
Keyword(s):  
Cancer Cell ◽  
Magnetic Fluid ◽  
Ferrite Nanoparticles ◽  
Hyperthermia Treatment ◽  
Magnetic Fluid Hyperthermia ◽  
Zn Ferrite

Correction for ‘Cancer cell extinction through a magnetic fluid hyperthermia treatment produced by superparamagnetic Co–Zn ferrite nanoparticles’ by Raghvendra A. Bohara et al., RSC Adv., 2015, 5, 47225–47234.

scholarly journals Core/Shell Nanoparticles of Non-Stoichiometric Zn–Mn and Zn–Co Ferrites as Thermosensitive Heat Sources for Magnetic Fluid Hyperthermia

2018 ◽  
Vol 122 (5) ◽  
pp. 3028-3038 ◽  
Author(s):  
Vanessa Pilati ◽  
Rafael Cabreira Gomes ◽  
Guilherme Gomide ◽  
Priscilla Coppola ◽  
Franciscarlos G. Silva ◽  
...  
Keyword(s):  
Magnetic Fluid ◽  
Core Shell ◽  
Heat Sources ◽  
Shell Nanoparticles ◽  
Magnetic Fluid Hyperthermia ◽  
Core Shell Nanoparticles

scholarly journals Modeling Human Body Using Four-Pole Debye Model in Piecewise Linear Recursive Convolution FDTD Method for the SAR Calculation in the Case of Vehicular Antenna

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Ammar Guellab ◽  
Qun Wu
Keyword(s):  
Experimental Data ◽  
Human Body ◽  
Piecewise Linear ◽  
Broad Band ◽  
Fdtd Method ◽  
Debye Model ◽  
Whole Body ◽  
Human Body Model ◽  
Body Tissues ◽  
Recursive Convolution

We propose an efficient finite difference time domain (FDTD) method based on the piecewise linear recursive convolution (PLRC) technique to evaluate the human body exposure to electromagnetic (EM) radiation. The source of radiation considered in this study is a high-power antenna, mounted on a military vehicle, covering a broad band of frequency (100 MHz–3 GHz). The simulation is carried out using a nonhomogeneous human body model which takes into consideration most of the internal body tissues. The human tissues are modeled by a four-pole Debye model which is derived from experimental data by using particle swarm optimization (PSO). The human exposure to EM radiation is evaluated by computing the local and whole-body average specific absorption rate (SAR) for each occupant. The higher in-tissue electric field intensity points are localized, and the SAR values are compared with the crew safety standard recommendations. The accuracy of the proposed PLRC-FDTD approach and the matching of the Debye model with the experimental data are verified in this study.

scholarly journals Spine injury assessment under spaceflight landing conditions using multibody model

2018 ◽  
Vol 232 (4) ◽  
pp. 555-567
Author(s):  
AA Pasha Zanoosi ◽  
R Kalantarinejad ◽  
M Haghpanahi
Keyword(s):  
Finite Element ◽  
Human Body ◽  
Sagittal Plane ◽  
Rigid Bodies ◽  
Whole Body ◽  
Spine Injury ◽  
Human Body Model ◽  
Multibody Modeling ◽  
Multibody Model ◽  
Injury Assessment

The novelty of the study relies on the fact that current simulations of human body to assess spine injury are based on finite element method. Spine injury assessment is an important point in designing spacecraft seat especially during landing. The finite element-based human body simulations are very time-consuming and computationally expensive. These problems make it difficult to perform high computational simulations such as optimization, sensitivity analysis, and so forth. Hence, in this study, it is tried to resolve these problems by developing a multibody model of human body in landing phase of spacecraft. This model makes designers able to perform corresponding simulations faster with acceptable accuracy. This study presents a dynamic multibody model of spacecraft seat-occupant system for spine injury assessment under landing conditions. The landing situation of spacecraft exposes shock loads to the spacecraft and astronaut. Hence, spine injury assessment under landing conditions enables optimal injury design of seat-occupant system. The modeling method is based on using the multibody modeling to achieve a detailed description containing the nonlinear properties and the accuracy of a multibody dynamic model considering whole body comprising stretching of vertebrae. The human body model comprises head, spine, femur, and shank lying on a flexible polyurethane foam as seat cushion. To model the spine, viscera, and pelvis in the sagittal plane, the spine column considered to be rigid bodies accompanied by spring-damper elements. To validate the developed model, the modal analysis and seat-to-head transmissibility of the spine has been validated by comparing with previously published models. Finally, as an application, the developed model has been exposed to a landing shock load for spine injury assessment.

scholarly journals Micron-sized iron oxide particles for both MRI cell tracking and magnetic fluid hyperthermia treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Laurence Dallet ◽  
Dimitri Stanicki ◽  
Pierre Voisin ◽  
Sylvain Miraux ◽  
Emeline J. Ribot
Keyword(s):  
Iron Oxide ◽  
Magnetic Fluid ◽  
Cell Tracking ◽  
Significant Rise ◽  
Iron Oxide Particles ◽  
Hyperthermia Treatment ◽  
Magnetic Fluid Hyperthermia ◽  
Oxide Particles ◽  
Endocytic Pathways

AbstractIron oxide particles (IOP) are commonly used for Cellular Magnetic Resonance Imaging (MRI) and in combination with several treatments, like Magnetic Fluid Hyperthermia (MFH), due to the rise in temperature they provoke under an Alternating Magnetic Field (AMF). Micrometric IOP have a high sensitivity of detection. Nevertheless, little is known about their internalization processes or their potential heat power. Two micrometric commercial IOP (from Bangs Laboratories and Chemicell) were characterized by Transmission Electron Microscopy (TEM) and their endocytic pathways into glioma cells were analyzed. Their Specific Absorption Rate (SAR) and cytotoxicity were evaluated using a commercial AMF inductor. T2-weighted imaging was used to monitor tumor growth in vivo after MFH treatment in mice. The two micron-sized IOP had similar structures and r2 relaxivities (100 mM−1 s−1) but involved different endocytic pathways. Only ScreenMAG particles generated a significant rise in temperature following AMF (SAR = 113 W g−1 Fe). After 1 h of AMF exposure, 60% of ScreenMAG-labeled cells died. Translated to a glioma model, 89% of mice responded to the treatment with smaller tumor volume 42 days post-implantation. Micrometric particles were investigated from their characterization to their intracellular internalization pathways and applied in one in vivo cancer treatment, i.e. MFH.

A MODEL FOR HUMAN VIBRATION STUDIES AND FOR PREDICTING RESPONSE TO JOLTING AND JARRING

2002 ◽  
Vol 02 (01) ◽  
pp. 37-52 ◽  
Author(s):  
SHYH-CHOUR HUANG ◽  
RONALD L. HUSTON
Keyword(s):  
Human Body ◽  
Multibody System ◽  
Whole Body Vibration ◽  
Impulsive Loading ◽  
Whole Body ◽  
Human Response ◽  
Human Body Model ◽  
Finite Segment ◽  
Body Vibration ◽  
Nonlinear Springs

This paper presents a finite-segment, human-body model for studying whole body vibration and for studying human response to jarring and jolting (impulses). The model is a multibody system based upon previously developed models for simulating vehicle occupant response in crashes. The model has 17 bodies representing the various limbs of the human body. Nonlinear springs and dampers are used at the joints to represent soft tissue restraint forces. The model is tested and validated with experimental data. It is then illustrated with application with random whole-body vibration and impulsive loading simulating jarring and jolting.

The Contribution of Pre-impact Spine Posture on Human Body Model Response in Whole-body Side Impact

2014 ◽  
Author(s):  
David Poulard ◽  
Damien Subit ◽  
John-Paul Donlon ◽  
David J. Lessley ◽  
Taewung Kim ◽  
...  
Keyword(s):  
Human Body ◽  
Side Impact ◽  
Whole Body ◽  
Human Body Model ◽  
Body Side ◽  
Body Model ◽  
Model Response
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