scholarly journals A Case of Proliferative Glomerulonephritis with Monoclonal IgG Deposits That Showed Predominantly Membranous Features

2017 ◽  
Vol 2017 ◽  
pp. 1-5
Author(s):  
Homare Shimohata ◽  
Kentaro Ohgi ◽  
Hiroshi Maruyama ◽  
Yasunori Miyamoto ◽  
Mamiko Takayashu ◽  
...  
Keyword(s):  
Light Microscopy ◽  
Proliferative Glomerulonephritis ◽  
Light Chains ◽  
The Novel ◽  
Immunofluorescence Study ◽  
Pathological Findings ◽  
Mesangial Proliferation ◽  
Glomerular Capillary ◽  
Almost All ◽  
Capillary Walls

In 2004, the novel category of monoclonal IgG deposition disease has been proposed and termed “proliferative glomerulonephritis with monoclonal IgG deposits” (PGNMID). This disease is characterized by membranoproliferative glomerulonephritis and staining for a single light-chain isotype and gamma heavy-chain subclass. A 76-year-old male who had monoclonal gammopathy was referred to our hospital because of proteinuria. The renal biopsy showed diffuse thickening of the glomerular capillary walls with focal mesangial proliferation. On immunofluorescence study, only IgG1 among the four subclasses and lambda light chains were detected mainly in the glomerular capillary walls. From these results, we diagnosed our case as PGNMID showing predominantly membranous features. Almost all pathological findings on light microscopy of PGNMID are membranoproliferative GN or endocapillary proliferative GN, while membranous GN cases are rare. Here, we present the case of PGNMID that showed predominantly membranous features on light microscopy.

scholarly journals Glomerulonephritis in schistosomiasis with mesangial IgM deposits

1981 ◽  
Vol 76 (2) ◽  
pp. 181-188 ◽  
Author(s):  
Ageu Godoy Magalhães Filho ◽  
Antônio Victoriano Barbosa ◽  
Teresa Cristina Ferreira
Keyword(s):  
Cell Proliferation ◽  
Light Microscopy ◽  
Immunofluorescence Microscopy ◽  
The Other ◽  
Proliferative Glomerulonephritis ◽  
Mesangial Proliferative Glomerulonephritis ◽  
Normal Pattern ◽  
Glomerular Lesions ◽  
Capillary Walls ◽  
Igm Deposits

Twenty one cases of hepatoesplenic schistosomiasis patients without clinical and laboratory evidence of renal disease, were studied by surgical biopsies using light microscopy and immunofluorescence. The cases were classified histologically as: normal pattern (6 cases); minimal changes (6 cases); and mesangial proliferative glomerulonephritis (9 cases). By the immunofluorescence microscopy using anti IgM, IgG, IgA and C3, the predominant finding in all biopsies, except the normal cases, was granular deposits of IgM in the mesangium along with C3. On the other hand, IgG was present in all cases including normal biopsies along the capillary walls. However IgG was also present in the mesangium only in cases with glomerular lesions. This finding may well be similar to that recently described as IgM mesangial nephropathy. According to our cases a mesangial proliferative glomerulonephritis, characterized by segmental cell proliferation and deposition of IgM in the mesangium, is probably the entity found in the early stages of mansonic schistosomiasis.

scholarly journals Diagnosis of Collagen Type III Glomerulopathy Using Picrosirius Red and PASH/Masson’s Trichrome Stain

2020 ◽  
Vol 57 (5) ◽  
pp. 675-680
Author(s):  
Katelin L. Davis ◽  
Anne L. Burnum ◽  
Jessica A. Beck ◽  
Shannon G. M. Kirejczyk ◽  
Margaret A. Miller ◽  
...  
Keyword(s):  
Light Microscopy ◽  
Collagen Type ◽  
Type Iii Collagen ◽  
Fibrillar Collagen ◽  
Collagen Type Iii ◽  
Type Iii ◽  
Glomerular Capillary ◽  
Collagen Type Iii Glomerulopathy ◽  
Picrosirius Red ◽  
Capillary Walls

Canine collagen type III glomerulopathy (Col3GP) is a rare juvenile nephropathy in which irregular type III collagen fibrils and fibronectin accumulate in glomerular capillary walls and the mesangium. Necropsy findings were reviewed from 5 puppies diagnosed with Col3GP at 6 to 18 weeks of age. Histologically, with hematoxylin and eosin stain, the glomerular capillary walls and mesangium were diffusely and globally expanded by homogeneous pale eosinophilic material. Ultrastructurally, the subendothelial zone and mesangium were expanded by fibronectin and cross-banded collagen type III fibrils, diagnostic of Col3GP. Two additional stains were employed to identify the material within glomeruli as fibrillar collagen using light microscopy. In all 5 cases, the material was red with picrosirius red and birefringent under polarized light, and was blue with periodic acid-Schiff/hematoxylin/trichrome (PASH/TRI), thereby identifying it as fibrillar collagen. Based on these unique staining characteristics with picrosirius red and PASH/TRI, Col3GP may be reliably diagnosed with light microscopy alone.

Canine Nephrotoxic Glomerulonephritis: A Combined Light, Immunofluorescent, and Ultrastructural Study

1973 ◽  
Vol 10 (1) ◽  
pp. 69-86 ◽  
Author(s):  
N. G. Wright ◽  
H. Thompson ◽  
H. J. C. Cornwell
Keyword(s):  
Electron Microscopy ◽  
Basement Membrane ◽  
Light Microscopy ◽  
Intravenous Administration ◽  
Ultrastructural Study ◽  
Complement C3 ◽  
Rabbit Serum ◽  
Mesangial Proliferation ◽  
Experimental Animals ◽  
Glomerular Capillary

The sequential pathology of canine nephrotoxic glomerulonephritis was studied by light microscopy, immunofluorescence and electron microscopy. The disease was induced by intravenous administration of antiglomerular basement membrane serum, and experimental animals were examined from 4 h up to 60 days after administration of nephrotoxic serum. During the first few days there was extensive glomerular capillary necrosis and infiltration by neutrophils. This was followed by mesangial proliferation and glomerular scarring. Using immunofluorescence, nephrotoxic (rabbit) serum and host IgG and complement (C3) were detected in damaged glomeruli.

Diligent Notes on Laziness: Oblomov, Lenin and the Capitalization of Laziness

2019 ◽  
Vol 29 (1) ◽  
pp. 243-258
Keyword(s):  
Psychiatric Hospital ◽  
The Novel ◽  
Work Analysis ◽  
Main Obstacle ◽  
Almost All ◽  
Russian Linguistic ◽  
The Way

The essay investigates the phenomenon of laziness by first analyzing the opposition between laziness and the good. Both utility and the good make reference to labor. This opposition between labor and laziness is pivotal in Oblomov, Ivan Goncharov’s famous novel written in 1859. It marks a radical transition from a feudal paradigm to a capitalistic one. The two main characters in the novel are Ilya Ilyich Oblomov, a Russian, and Andrey Ivanovich Stolz, a German, who together seem to personify the contradiction between laziness and labor. But the purpose of the essay is to deconstruct that opposition. In this connection, one can cite Kazimir Malevich, who maintained that laziness is the Mother of Perfection and is always unconsciously inherent in the conscious intent to work. Analysis of the Latin concepts of otium and negotium indicates that the laziness/labor opposition may be deconstructed as a dialectic between labor and its opposite. In other words, laziness does not stand in contradiction to labor but is instead its inseparable dialectical other. In the last part of the essay, the article considers the thinking of Anatoly Peregud, a poet who spent almost all his life in a psychiatric hospital. According to Peregud, Lenin derived his pseudonym from the Russian linguistic root “len” (laziness) in order to make laziness central to communism. For his part, Lenin saw Oblomov as an emblem of the main obstacle standing in the way of communism.

scholarly journals Modelling spreading of an infection using time series by a novel family of models; fitting the time series of the confirmed cases of COVID-19 in China

2020 ◽  
Vol 9 (s1) ◽  
Author(s):  
Babak Jamshidi ◽  
Shahriar Jamshidi Zargaran ◽  
Mansour Rezaei
Keyword(s):  
Infectious Disease ◽  
Time Series ◽  
Communicable Disease ◽  
Time Series Models ◽  
Cumulative Number ◽  
The Novel ◽  
New Family ◽  
Two Samples ◽  
Almost All ◽  
Number Of Individuals

AbstractIntroductionTime series models are one of the frequently used methods to describe the pattern of spreading an epidemic.MethodsWe presented a new family of time series models able to represent the cumulative number of individuals that contracted an infectious disease from the start to the end of the first wave of spreading. This family is flexible enough to model the propagation of almost all infectious diseases. After a general discussion on competent time series to model the outbreak of a communicable disease, we introduced the new family through one of its examples.ResultsWe estimated the parameters of two samples of the novel family to model the spreading of COVID-19 in China.DiscussionOur model does not work well when the decreasing trend of the rate of growth is absent because it is the main presumption of the model. In addition, since the information on the initial days is of the utmost importance for this model, one of the challenges about this model is modifying it to get qualified to model datasets that lack the information on the first days.

scholarly journals Barley Seeds miRNome Stability during Long-Term Storage and Aging

2021 ◽  
Vol 22 (9) ◽  
pp. 4315
Author(s):  
Marta Puchta ◽  
Jolanta Groszyk ◽  
Magdalena Małecka ◽  
Marek D. Koter ◽  
Maciej Niedzielski ◽  
...  
Keyword(s):  
Seed Viability ◽  
Small Rna Sequencing ◽  
The Novel ◽  
Seed Aging ◽  
Long Term Storage ◽  
Novel Mirna ◽  
Complex Biological Process ◽  
Almost All ◽  
Term Storage

Seed aging is a complex biological process that has been attracting scientists’ attention for many years. High-throughput small RNA sequencing was applied to examine microRNAs contribution in barley seeds senescence. Unique samples of seeds that, despite having the same genetic makeup, differed in viability after over 45 years of storage in a dry state were investigated. In total, 61 known and 81 novel miRNA were identified in dry seeds. The highest level of expression was found in four conserved miRNA families, i.e., miR159, miR156, miR166, and miR168. However, the most astonishing result was the lack of significant differences in the level of almost all miRNAs in seed samples with significantly different viability. This result reveals that miRNAs in dry seeds are extremely stable. This is also the first identified RNA fraction that is not deteriorating along with the loss of seed viability. Moreover, the novel miRNA hvu-new41, with higher expression in seeds with the lowest viability as detected by RT-qPCR, has the potential to become an indicator of the decreasing viability of seeds during storage in a dry state.

scholarly journals Current Understanding of Exosomal MicroRNAs in Glioma Immune Regulation and Therapeutic Responses

2022 ◽  
Vol 12 ◽  
Author(s):  
Jinwu Peng ◽  
Qiuju Liang ◽  
Zhijie Xu ◽  
Yuan Cai ◽  
Bi Peng ◽  
...  
Keyword(s):  
Immune Regulation ◽  
Response Prediction ◽  
Cell Types ◽  
Clinicopathological Characteristics ◽  
The Novel ◽  
Multiple Cancer ◽  
Exosomal Mirnas ◽  
Multiple Cell ◽  
Almost All ◽  
Therapeutic Responses

Exosomes, the small extracellular vesicles, are released by multiple cell types, including tumor cells, and represent a novel avenue for intercellular communication via transferring diverse biomolecules. Recently, microRNAs (miRNAs) were demonstrated to be enclosed in exosomes and therefore was protected from degradation. Such exosomal miRNAs can be transmitted to recipient cells where they could regulate multiple cancer-associated biological processes. Accumulative evidence suggests that exosomal miRNAs serve essential roles in modifying the glioma immune microenvironment and potentially affecting the malignant behaviors and therapeutic responses. As exosomal miRNAs are detectable in almost all kinds of biofluids and correlated with clinicopathological characteristics of glioma, they might be served as promising biomarkers for gliomas. We reviewed the novel findings regarding the biological functions of exosomal miRNAs during glioma pathogenesis and immune regulation. Furthermore, we elaborated on their potential clinical applications as biomarkers in glioma diagnosis, prognosis and treatment response prediction. Finally, we summarized the accessible databases that can be employed for exosome-associated miRNAs identification and functional exploration of cancers, including glioma.

scholarly journals Portrayal of Bangladeshi Existentialism: “Like a Diamond in the Sky” in Context

2021 ◽  
Vol 9 (2) ◽  
pp. 51-58
Author(s):  
Moniruzzaman ◽  
Safi Ullah
Keyword(s):  
Drug Addiction ◽  
Meaning Of Life ◽  
The Novel ◽  
Dhaka City ◽  
Meaningful Life ◽  
Capacity Limitation ◽  
Existential Crisis ◽  
The People ◽  
Almost All ◽  
Power Play

Shazia Omar, a Bangladeshi novelist, depicts the less-known imagery of modern Dhaka in her debut novel “Like a Diamond in the Sky” (2009) where she portrays Bangladesh infected with depression, drug addiction, power-play, corruption and fundamentalism. Deen, the protagonist, is lost in addiction, isolated from his mother and outer world but in love with Maria, aware of the future of Bangladesh and eager to search for the meaning of life. Deen, which literally implies the earthly life in Bangla, is an existentialist who is conscious of himself and the people around him. He is aware of his capacity, limitation, existence and essence. He comments on different orders and institutions that hinder at the path of freedom, and about politicization and islamisation in Bangladesh. Not only Deen but also his widowed mother, his friend AJ, drug peddler Falani, the sergeant of the Police, Deen’s girlfriend Maria- all are conscious of their existence and essence. This novel is about a journey from a dark and aimless world to redemption, to a meaningful life. Omar presents existentialism and existential crisis as noticed in Bangladesh in her novel where almost all characters try to find the meaning of life, though in different ways. Omar says in an interview that the novel “explores their feeling of alienation in the chaotic metropolis of Dhaka city” and her protagonist struggles “to find a spiritual connection”. Before writing this novel, Shazia Omar researched in a rehab in Mumbai, visited slums of    Bangladesh and thus shaded light on the darker and less-discussed imagery of Bangladesh. “Like a Diamond in the Sky” is thoroughly examined in the light of existentialism, developed by Descartes, Kierkegaard, Sartre and Heidegger. This paper analyses how “Like a Diamond in the Sky” represents Bangladeshi existentialism, and existentialists who are conscious of existence and essence. It also discusses the observation, of Omar’s characters projected in the novel, about established orders and institutions and finally, desire for freedom and searching for meaning of life.

scholarly journals Respiratory Care in Corona

2021 ◽  
Vol 58 (2) ◽  
pp. 613-620
Author(s):  
Mustafa Amdani, Dr. Swaroopa Chakole
Keyword(s):  
Severe Acute Respiratory Syndrome ◽  
Human Life ◽  
The Body ◽  
Respiratory Care ◽  
The Novel ◽  
Specific Therapy ◽  
History Of ◽  
Novel Coronavirus ◽  
Almost All ◽  
The Impact

BACKGROUND The expanse of the coronavirus disease 2019 or COVID-19 is huge. The impact is multispectral and affected almost all aspects of human life. SUMMARY Respiratory impact of the COVID-19 is the most felt and widely reported impact. As the novel coronavirus maintained its history of affecting lungs as seen previously in severe acute respiratory syndrome (SARS) outbreak. Ventilators and oxygen support system are required mostly in comorbid patients particularly amongpatientsbearing illnesses like asthma, bronchial impairment and so on. CONCLUSION More study needs to be done in order to assess the impact on the respiratory functioning of the body. Respiratory care must be including proper instruments so that more efficient result can be obtained. Research is needed to promote the invention of specific therapy for targeted action for respiratory functioning improvement.

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