scholarly journals Plasmablastic Lymphoma Mimicking Acute Pancreatitis

2016 ◽  
Vol 2016 ◽  
pp. 1-4
Author(s):  
Faisal Inayat ◽  
Hafeez Ul Hassan Virk ◽  
Ahmad R. Cheema ◽  
Muhammad Wasif Saif
Keyword(s):  
Acute Pancreatitis ◽  
Histopathological Examination ◽  
Plasmablastic Lymphoma ◽  
Hiv Positive ◽  
Case Presentation ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Rna In Situ Hybridization ◽  
Epstein Barr

Background.Plasmablastic lymphoma (PBL) is a rare B-cell neoplasm. It predominantly occurs in the oral cavity of human immunodeficiency virus (HIV)-positive patients and exhibits a highly aggressive clinical behavior.Case Presentation.We describe an unusual case of a 37-year-old HIV-positive male who presented with acute pancreatitis secondary to multiple peripancreatic masses compressing the pancreas. Histopathological examination of the lesions showed diffuse and cohesive pattern of large B-cells resembling immunoblasts or plasmablasts. The neoplastic cells were positive for BOB1 and MUM1, partially positive for CD79a, and negative for CD20, CD56, CD138, CD3, CD5, AE1/AE3, and HHV8. Epstein-Barr virus-encoded RNA in situ hybridization was positive. These features were consistent with PBL. The patient was initiated on cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy, demonstrating a striking response.Conclusion.To our research, this is the first report of PBL with the initial presentation of acute pancreatitis. The findings in this case suggest that PBL should be included in the differential diagnosis of pancreatic and peripancreatic tumors.

scholarly journals Transient Atypical Lymphoplasmacytic Proliferation in Endometrium Associated With Pyometra: a Case Report

2021 ◽  
Author(s):  
Tomoyuki Otani ◽  
Kosuke Murakami ◽  
Masatomo Kimura ◽  
Mitsuru Matsuki ◽  
Takao Satou ◽  
...  
Keyword(s):  
Endometrial Biopsy ◽  
Plasmablastic Lymphoma ◽  
Mri Findings ◽  
Case Presentation ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Negative Woman ◽  
Epstein Barr ◽  
Abnormal Vaginal Bleeding ◽  
Hiv Negative

Abstract Background Plasmablastic lymphoma is a mature B-cell neoplasm with plasmablastic differentiation, often associated with human immunodeficiency virus (HIV) infection and other forms of immunosuppression. Although it is usually an aggressive disease, spontaneous regression has been seen in a few cases. Plasmablastic lymphoma in the uterus is rare. Here we report a case of atypical lymphoplasmacytic proliferation resembling plasmablastic lymphoma associated with pyometra that disappeared completely as the pyometra resolved. Case presentation A 76-year-old HIV-negative woman presented with abnormal vaginal bleeding. Ultrasound and MRI findings were consistent with pyometra diagnosis. Endometrial biopsy revealed large plasmablastoid cells with abundant cytoplasms and prominent nucleoli proliferating in the endometrium. Immunohistochemistry showed that large cells stained positive for CD138, CD79a, and MUM1, and negative for CD20, PAX5, CD3, and CD5. Ki67 labelled at least 80% of the large cells. Epstein–Barr virus was detected in a small number of cells. The histological picture was highly indicative of lymphoma, especially plasmablastic lymphoma, though the clinical context was unusual. As the pyometra was treated and resolved, the intrauterine abnormality disappeared completely. The patient has been well after 16 months with no sign of recurrent disease. Conclusions This case underscores the sometimes blurry distinction between benign inflammation and lymphomas.

scholarly journals Relapse of Plasmablastic Lymphoma With Cutaneous Involvement in an Immunocompetent Male

2020 ◽  
pp. 014556132095219
Author(s):  
Samantha Shwe ◽  
Aditi A. Sharma ◽  
Bonnie A. Lee ◽  
Janellen E. Smith
Keyword(s):  
Nasal Cavity ◽  
Epstein Barr Virus ◽  
Recurrent Disease ◽  
Excisional Biopsy ◽  
Plasmablastic Lymphoma ◽  
Rare Type ◽  
Barr Virus ◽  
Non Hodgkin Lymphoma ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Plasmablastic lymphoma (PBL) is a rare type of non-Hodgkin lymphoma frequently found in the context of immunosuppression and infection with human immunodeficiency virus (HIV) and/or Epstein-Barr virus (EBV). A 33-year-old immunocompetent male presented with recurrent episodes of epistaxis and a growing intranasal mass. Excisional biopsy of the mass revealed an immunohistochemical profile diagnostic of PBL. Upon completion of chemoradiation, he underwent a transnasal endoscopic mucosal flap tissue rearrangement to restore patency for both functional and surveillance purposes. There was no endoscopic evidence of residual or recurrent disease. However, 8 months later, he was found to have a relapse involving the skin. The nasal cavity is one of the most common sites affected by PBL. Involvement of the nasal cavity may present with symptoms of persistent epistaxis accompanied by an enlarging mass. A plasmablastic immunophenotype in combination with HIV or EBV positivity can aid diagnosis.

scholarly journals Epstein-Barr virus in oral mucosa from human immunodeficiency virus positive patients

2014 ◽  
Vol 60 (3) ◽  
pp. 262-269 ◽  
Author(s):  
Larissa Santos ◽  
Kátia Azevedo ◽  
Licinio Silva ◽  
Ledy Oliveira
Keyword(s):  
Human Immunodeficiency Virus ◽  
Oral Mucosa ◽  
Epstein Barr Virus ◽  
Hiv Positive ◽  
Hiv Viral Load ◽  
Nested Polymerase Chain Reaction ◽  
Cross Sectional ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr

Objective: the detection rate of Epstein-Barr virus (EBV) is higher in people living with human immunodeficiency virus (HIV). In an attempt to contribute to our epidemiological understanding of this coinfection and to investigate the activity of EBV in normal oral mucosa, we performed a cross-sectional study with HIV-positive patients. Methods: oral smears from 145 HIV-positive patients were collected between March 2010 and March 2011. Nested polymerase chain reaction (PCR) and reverse transcriptase-PCR (RT-PCR) were used to genotype EBV and to detect EBNA-2 expression, respectively. Results: EBV DNA was detected in 48.3% of the study participants, of whom 32.85% were EBV-1 and 45.71% were EBV-2 carriers. Additionally, 14.28% were coinfected with both types. EBNA-2 mRNA was expressed in 45.7% of the EBV -positive samples, including 20.0% with EBV-1 only, 20.0% with EBV-2 only and 1.4% with both genotypes. Immune status affected the overall EBV infection, and EBV-2 positivity was significantly correlated with sexual lifestyle of the participants. EBV co-infection with both viral types was dependent upon HIV viral load and the activity of the EBNA-2 gene. Conclusion: we report a high prevalence of active EBV in the oral mucosa of asymptomatic HIV-seropositive individuals. This study addresses the need for monitoring and treatment of HIV-infected patients with EBV reactivation.

Epstein-Barr Encephalitis in a Child with Congenital Human Immunodeficiency Virus Infection: A Case Report Calling for No Forgetfulness

2020 ◽  
Vol 18 (1) ◽  
pp. 63-66
Author(s):  
Olga Tsiatsiou ◽  
Savvas Papachristou ◽  
Eleni Papadimitriou ◽  
Elisavet Michailidou ◽  
Dimitrios Chatzidimitriou ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Hiv Infection ◽  
Epstein Barr Virus ◽  
Preventive Strategies ◽  
Child Transmission ◽  
Case Presentation ◽  
Barr Virus ◽  
Immunodeficiency Virus ◽  
Epstein Barr ◽  
Mother To Child

Background: In resource-rich settings, the rate of mother-to-child transmission of human immunodeficiency virus (HIV) has dramatically decreased by virtue of a combination of preventive strategies during the last two decades. Case Presentation: We present a case of progressive developmental milestone loss in a toddler with previously unknown congenitally acquired human immunodeficiency virus (HIV) infection, complicated by an Epstein-Barr virus (EBV) coinfection. Conclusion: Our report underscores the differential diagnosis between HIV encephalopathy and EBV encephalitis and the vertical transmission of the HIV infection, which constitutes an alarming issue in terms of public health.

scholarly journals Concurrence of talaromycosis and Kaposi sarcoma in a HIV-infected Patient: A case report

2020 ◽  
Author(s):  
Feifei Su ◽  
Xingguo Miao ◽  
Hui Ye ◽  
Shoufeng Yang
Keyword(s):  
Fungal Pathogen ◽  
Histopathological Examination ◽  
Management Strategies ◽  
Kaposi Sarcoma ◽  
Vascular Tumor ◽  
Hiv Positive ◽  
Comorbid Conditions ◽  
Successful Management ◽  
Case Presentation ◽  
Immunodeficiency Virus

Abstract Background: Concurrence of talaromycosis, an opportunistic infection caused by the fungal pathogen Talaromyces marneffei and Kaposi sarcoma, a common vascular tumor in patients infected with human immunodeficiency virus (HIV) has only been rarely reported. Despite poor outcome, clinical characteristics and management strategies for HIV-infected patients with comorbid Kaposi sarcoma and talaromycosis has not been very well described.Case presentation: A 33-year-old, HIV-positive male patient presented to the Department of Infectious Diseases at Wenzhou Central Hospital with cough, sputum expectoration, hemoptysis, rashes on the feet and violaceous plaques in the oral cavity. Chest computed tomography (CT) showed bilateral nodular, patchy shadows and lymphadenectasis. Skin biopsy and histopathological examination indicated Kaposi sarcoma. T. marneffei was isolated from blood cultures and suggested talaromycosis. The patient’s conditions significantly improved following initiation of antiretroviral therapy and chemotherapy for Kaposi sarcoma in combination with antifungal treatment for talaromycosis.Conclusions: Severe medical conditions such as Kaposi sarcoma and talaromycosis may coexist in HIV-infected patients and pose a high mortality risk. Etiological diagnosis and treatment are the key to successful management of HIV-infected patients who has severe comorbid conditions.

Sign in / Sign up

Export Citation Format

Share Document