scholarly journals Impact of Recipient and Donor Obesity Match on the Outcomes of Liver Transplantation: All Matches Are Not Perfect

2016 ◽  
Vol 2016 ◽  
pp. 1-9 ◽  
Author(s):  
Eliza W. Beal ◽  
Dmitry Tumin ◽  
Lanla F. Conteh ◽  
A. James Hanje ◽  
Anthony J. Michaels ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Graft Loss ◽  
Long Term Outcomes ◽  
Survival Curves ◽  
Liver Retransplantation ◽  
First Time ◽  
Transplantation Outcomes ◽  
Patient And Graft Survival ◽  
United Network

There is a paucity of literature examining recipient-donor obesity matching on liver transplantation outcomes. The United Network for Organ Sharing database was queried for first-time recipients of liver transplant whose age was ≥18 between January 2003 and September 2013. Outcomes including patient and graft survival at 30 days, 1 year, and 5 years and overall, liver retransplantation, and length of stay were compared between nonobese recipients receiving a graft from nonobese donors and obese recipient-obese donor, obese recipient-nonobese donor, and nonobese recipient-obese donor pairs. 51,556 LT recipients were identified, including 34,217 (66%) nonobese and 17,339 (34%) obese recipients. The proportions of patients receiving an allograft from an obese donor were 24% and 29%, respectively, among nonobese and obese recipients. Graft loss (HR: 1.27; 95% CI: 1.09–1.46;p=0.002) and mortality (HR: 1.38; 95% CI: 1.16–1.65;p<0.001) at 30 days were increased in the obese recipient-obese donor pair. However, 1-year graft (HR: 0.83; 95% CI: 0.74–0.93;p=0.002) and patient (HR: 0.84; 95% CI: 0.74–0.95;p=0.007) survival and overall patient (HR: 0.93; 95% CI: 0.86–1.00;p=0.042) survival were favorable. There is evidence of recipient and donor obesity disadvantage early, but survival curves demonstrate improved long-term outcomes. It is important to consider obesity in the donor-recipient match.

scholarly journals Recipient-Specific Risk Factors Impairing Patient and Graft Outcome after Pediatric Liver Transplantation—Analysis of 858 Transplantations in 38 Years

Children ◽  
2021 ◽  
Vol 8 (8) ◽  
pp. 641
Author(s):  
Christoph Leiskau ◽  
Norman Junge ◽  
Eva-Doreen Pfister ◽  
Imeke Goldschmidt ◽  
Frauke Mutschler ◽  
...  
Keyword(s):  
Risk Factors ◽  
Liver Transplantation ◽  
Graft Survival ◽  
Graft Loss ◽  
Single Center ◽  
Vein Thrombosis ◽  
Pediatric Liver ◽  
High Urgency ◽  
Patient And Graft Survival

(1) Background and Aim: Despite excellent long-term results in pediatric liver transplantation (pLTx), mortality and graft loss still are to be diminished. We aim to describe time-dependent changes and long-term outcome of a large single-center pLTx cohort and to identify independent recipient-related risk factors impairing patient and graft survival. (2) Methods: This is a retrospective single-center study analyzing all pediatric liver transplants from 1983–2020. Risk factors for mortality and graft loss were identified by univariable and multi-linear regression analysis. (3) Results: We analyzed 858 liver transplantations in 705 pediatric patients. Five-year patient/graft survival increased from 60.9%/48.0% (1983–1992) to 97.5%/86.5% (OR = 12.5; p < 0.0001/OR = 6.5; p < 0.0001) (2014–2020). Indications changed significantly over time, with a higher proportion of patients being transplanted for malignancies and metabolic disease and indications of PFIC and α1AT-deficiency declining. The era of transplantation (log7.378/9.657; p < 0.0001) and indication of acute liver failure (log = 1.944/2.667; HR = 2.015/1.772; p = 0.0114/0.002) impairs patient/graft survival significantly in the multivariate analysis. Furthermore, patient survival is worsened by re-transplantation (log = 1.755; HR = 1.744; p = 0.0176) and prolonged waiting times in high-urgency status (log = 2.588; HR = 1.073; p = 0.0026), whereas the indication of biliary atresia improved outcome (log = 1.502; HR = 0.575; p = 0.0315). Graft survival was additionally impaired by pre-existing portal vein thrombosis (log = 1.482; HR = 2.016; p = 0.0330). (4) Conclusions: Despite more complex indications, patient and graft survival after pLTx continue to improve.. Acute liver failure remains the indication with poorest outcome, and listing for high urgency liver transplantation should be considered carefully and early to keep waiting time on HU list short. Furthermore, pre-transplant portal vein thrombosis should be prevented whenever possible to improve graft survival.

Donor Age-Based Analysis of Liver Transplantation Outcomes: Short- and Long-Term Outcomes Are Similar Regardless of Donor Age

2015 ◽  
Vol 221 (1) ◽  
pp. 59-69 ◽  
Author(s):  
William C. Chapman ◽  
Neeta Vachharajani ◽  
Kelly M. Collins ◽  
Jackie Garonzik-Wang ◽  
Yikyung Park ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Donor Age ◽  
Long Term Outcomes ◽  
Short And Long Term ◽  
Transplantation Outcomes

Short-term and long-term outcomes in living donors for liver transplantation: Cohort study

2020 ◽  
Vol 84 ◽  
pp. 147-153
Author(s):  
Kosei Takagi ◽  
Yuzo Umeda ◽  
Ryuichi Yoshida ◽  
Nobuyuki Watanabe ◽  
Takashi Kuise ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Cohort Study ◽  
Living Donors ◽  
Long Term Outcomes ◽  
Short Term

scholarly journals Is the use of intra-operative blood salvage autotransfusion in hepatocellular carcinoma liver transplantation safe? A comparative analysis of long-term outcomes

HPB ◽  
2019 ◽  
Vol 21 ◽  
pp. S366
Author(s):  
Kah Wai Lai ◽  
Jarrod Tan ◽  
Glenn Bonney ◽  
Iyer Shridhar ◽  
Krishnakumar Madhavan ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Liver Transplantation ◽  
Comparative Analysis ◽  
Long Term Outcomes ◽  
Blood Salvage
Sign in / Sign up

Export Citation Format

Share Document