scholarly journals Evaluation of the Effects ofPinus koraiensisNeedle Extracts on Serum Lipid and Oxidative Stress in Adults with Borderline Dyslipidemia: A Randomized, Double-Blind, and Placebo-Controlled Clinical Trial

2016 ◽  
Vol 2016 ◽  
pp. 1-6
Author(s):  
Hansongyi Lee ◽  
Hyerang Kim ◽  
Ryowon Choue ◽  
Hyunjung Lim
Keyword(s):  
Oxidative Stress ◽  
Blood Pressure ◽  
Superoxide Dismutase ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Blood Cholesterol ◽  
Low Density ◽  
Vldl Cholesterol ◽  
Before And After ◽  
And Oxidative Stress

Background.Dyslipidemia has been well-known as a common metabolic disorder contributing to cardiovascular disease. The aim of this study was to evaluate the effect of thePinus koraiensisneedle extracts (PKE) on the blood cholesterol and oxidative stress.Method.We conducted a 12-week randomized, double-blinded controlled trial to examine the effect of PKE on blood lipid profiles in adults with borderline dyslipidemia. Thirty-three eligible persons were recruited and randomly assigned into PKE (n=20) and placebo groups (n=13). Serum lipids including total cholesterol, low-density lipoprotein- (LDL-) cholesterol, high-density lipoprotein- (HDL-) cholesterol, very low-density lipoprotein- (VLDL-) cholesterol, and triglyceride were measured before and after trial. Serum insulin, glucose, and antioxidant indicators were also analyzed before and after trial and anthropometry and blood pressure were measured every 4 weeks.Results.After 12 weeks, PKE statically significant decreases in systolic blood pressure (p<0.05) and waist circumference (p<0.05) were observed. Also, VLDL-cholesterol significantly decreased (from24.4±10.0 mg/dL at baseline to18.4±4.1 mg/dL after 12 weeks) (p<0.05) and superoxide dismutase (SOD) increased (6.12±0.41 U/mL to9.06±0.62 U/mL) (p<0.01) in PKE group. However, after adjustment with WC, VLDL-cholesterol was not significant between groups (p=0.095) and while SOD remained significant between groups (p=0.013).Conclusion.The results show that PKE was effective in improving the superoxide dismutase in the individuals with borderline dyslipidemia.

scholarly journals Effects of zinc supplementation on oxidant/antioxidant and lipids status of pesticides sprayers

2019 ◽  
Vol 17 (1) ◽  
Author(s):  
Amal Saad-Hussein ◽  
Khadiga S Ibrahim ◽  
Mohgah Sh Abdalla ◽  
Hatem A El-Mezayen ◽  
Nehal F A Osman
Keyword(s):  
Oxidative Stress ◽  
Superoxide Dismutase ◽  
Blood Lipids ◽  
Zinc Supplementation ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Very Low Density Lipoprotein ◽  
Low Density ◽  
Lipid Status ◽  
Before And After

AbstractBackgroundExcess exposure to pesticides induces oxidative stress and causes alteration in the lipid profileObjectivesThe study aimed to evaluate the effects of Zinc (Zn) supplementation on the oxidant/antioxidant and lipid status in pesticide sprayers.MethodsForty pesticide sprayers were included in the study. Blood lipids, malondialdehyde (MDA), glutathione peroxidase (GPx), superoxide dismutase (SOD), and Zn were estimated; before and after Zn supplementation.ResultsStatistical analysis revealed that after Zn supplementation, total cholesterol (TC), triglycerides (TG), low density lipoprotein (LDL), very low density lipoprotein (VLDL), and MDA were significantly decreased. However, there was a significant increase in the high density lipoprotein (HDL), SOD, GPx, and Zn levels. After Zn supplementation, significant inverse correlations were detected between the Zn and the levels of MDA, TG, and VLDL, while positive correlation between Zn and the levels of HDL and TC.ConclusionsZn supplementation improves the oxidative/antioxidants and lipid status in pesticide sprayers.

scholarly journals The effect of a fibre extract from the red seaweed, Palmaria palmata, on lipid metabolism and inflammation in healthy adults

2020 ◽  
Vol 79 (OCE2) ◽  
Author(s):  
Zoe Irwin ◽  
Emeir M. McSorley ◽  
Mary M. Slevin ◽  
Lisa Rowan ◽  
Paul McMillen ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Metabolism ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Lipoprotein Cholesterol ◽  
Palmaria Palmata ◽  
Low Density ◽  
Low Density Lipoprotein Cholesterol ◽  
Markers Of Inflammation ◽  
And Oxidative Stress

AbstractEvidence from observational studies indicates that seaweed consumption may reduce the risk of non-communicable diseases such as cardiovascular disease, type two diabetes, and obesity. Accumulating evidence from in vitro and animal studies suggest seaweed have antihyperlipidemic, anti-inflammatory and antioxidant properties which may in part be attributed to the high content of soluble dietary fibre in seaweeds. The viscosity of seaweed fibres is suggested to mediate antihyperlipdiemic effects via the alteration of lipid/bile acid absorption kinetics to decrease low-density lipoprotein cholesterol (LDL). Thus, there is a need to evaluate the efficacy of seaweed derived dietary fibre in the management of dyslipidemia. Therefore, the aim of this study was to determine the effect of a fibre rich extract from Palmaria palmata on the lipid profile as well as markers of inflammation and oxidative stress in healthy adults. A total of 60 healthy participants (30 male and 30 female) aged 20 to 58 years, were assigned to consume the Palmaria palmata fibre extract (5g/day), Synergy-1 and the placebo (maltodextrin) for a duration of 4 weeks with a minimum 4 week washout between each treatment in a double blind, randomised crossover study conducted over 5 months. Fasting concentrations of cholesterol, triglycerides and high-density lipoprotein cholesterol (HDL) were analysed and low-density lipoprotein cholesterol (LDL) and LDL: HDL ratio was calculated. C-reactive protein (CRP) and Ferric Reducing Ability of Plasma (FRAP) were analysed as markers of inflammation and oxidative stress, respectively. Supplementation for 4 weeks with Palmaria palmata resulted in favourable changes to lipid profiles with a reduced LDL:HDL ratio; however intention-to-treat univariate ANCOVA identified no significant difference between the treatment groups over time on any of the lipid profile markers. A non-significant increase in CRP and triglyceride concentration along with lower FRAP was also observed with Palmaria palmata supplementation. Evidence from this study suggests that Palmaria palmata may have effects on lipid metabolism and appears to mobilise triglycerides. More research is needed in individuals with dyslipidaemia to fully elucidate these effects.

scholarly journals APO B/APO A1 RATIO AND ITS CORRELATION WITH CARDIOMETABOLIC RISK FACTORS AND OXIDATIVE STRESS IN SUBJECTS WITH METABOLIC SYNDROME

2020 ◽  
pp. 1-3
Author(s):  
Deepthy C Sahadevan* ◽  
Archna Sing ◽  
Busi Karunanand ◽  
Himani Thakkar ◽  
Ajay Kumar Gautam
Keyword(s):  
Oxidative Stress ◽  
Risk Factors ◽  
Cardiometabolic Risk ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Cardiometabolic Risk Factors ◽  
Oxidative Stress Marker ◽  
Low Density ◽  
Apo B ◽  
And Oxidative Stress

Objective: This study was designed to assess the apolipoprotein B (Apo-B), apolipoprotein A (Apo A) and Apo B/Apo A-I ratio in subjects with and withoutmetabolic syndrome andtoevaluate the correlationofApoB/ApoA-Iratiowithoxidative stressmarker andcardiovasculardisease risk. Methods:Atotal of 308 subjects including one hundred and fty- ve cases and one hundred and fty- three controls were recruited for this study. All the subjects were classied according to the NCEPATP III (National cholesterol education program – Adult treatment panel III) criteria for MetS. Anthropometric and clinical characteristics were recorded using clinical Proforma. Blood samples were collected for doing plasma glucose, Lipid prole analysis [Total Cholesterol (TC), Triglyceride (TG), high-density lipoprotein (HDL)], ApoA1, Apo B and oxidative stress marker - Malondialdehyde (MDA). Serum low-density lipoprotein (LDL), very-low-density lipoprotein (VLDL) and Apo B/Apo A-I ratio were calculated. Comparison of data between the two groups was done by t test. Correlation coefcient of Apo B/ Apo A1 ratio with cadiometabolic risk factors were calculated. Result: We found that cardiometabolic risk factors like abdominal obesity, systolic and diastolic blood pressure, fasting plasma glucose, TG, atherogenic lipoproteins LDL, Apo B, Apo B/Apo A-I ratio and MDA were signicantly high in subjects with MetS whereas anti-atherogenic factor Apo A1 was signicantly low. We also observed that Apo B/AI ratio was positively related to cardiometabolic risk factors and with oxidative stress marker. Conclusion:Apo B/AI ratio was related to metabolic syndrome and was found to be a reliable indicator of cardiovascular risk in MetS.

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